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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

POU domain, class 2, associating factor 1

OCA-B, OBF-1, Bob1, BOB.1, OBF.1
Top mentioned proteins: Oct-2, OCT, GPR15, Izumo, Oct-1
Papers on OCA-B
Primary Cutaneous Follicle Center Lymphomas Expressing BCL2 Protein Frequently Harbor BCL2 Gene Break and May Present 1p36 Deletion: A Study of 20 Cases.
New
Ortonne et al., Créteil, France. In Am J Surg Pathol, Jan 2016
To investigate these issues and to further characterize PCFCL, we studied a series of 25 CFLs without any extracutaneous disease at diagnosis, selected on the basis of BCL2 protein expression using 2 BCL2 antibodies (clones 124 and E17) and BOB1/BCL2 double immunostaining.
NF-κB-dependent signals control BOB.1/OBF.1 and Oct2 transcriptional activity in B cells.
New
Brunner et al., Ulm, Germany. In Eur J Immunol, Dec 2015
The transcriptional co-activator BOB.1/OBF.1 is crucial for Octamer-driven transcription in B cells.
Oct1 and OCA-B are selectively required for CD4 memory T cell function.
New
Tantin et al., Salt Lake City, United States. In J Exp Med, Dec 2015
We find that the transcription factor Oct1 and its cofactor OCA-B are selectively required for the in vivo generation of CD4(+) memory T cells.
Distinguishing Classical Hodgkin Lymphoma, Gray Zone Lymphoma, and Large B-cell Lymphoma: A Proposed Scoring System.
New
Weiss et al., Chapel Hill, United States. In Appl Immunohistochem Mol Morphol, Nov 2015
MATERIALS AND METHODS: This system emphasized known criteria used to diagnose CHL that are rare in B-cell lymphoma (BCL) [CD15+, CD45-, CD20- or weak/variable, PAX5+ (weak or moderate), CD79a-, OCT-2-/BOB.1- or OCT-2+/BOB.1- or OCT-2-/BOB.1+,
Hodgkin Lymphoma of the Nasopharynx: Case Report with Review of the Literature.
Review
New
McBee et al., Pittsburgh, United States. In Head Neck Pathol, Sep 2015
Immunohistochemical analysis revealed CD15, CD30, OCT-2, BOB.1, and MUM-1 expression by the neoplastic cells and a lack of expression of CD45, CD20, CD3, EMA, and EBER.
[Primary pulmonary Hodgkin lymphoma diagnosed by CT-guided percutaneous biopsy].
Komatsu et al., In Rinsho Ketsueki, 2015
Immunological staining revealed the specimens to be CD30- and PAX5-positive, with large dysplastic lymphocytes negative for Bob-1 and Oct-2 with a background of small lymphocytes and eosinophils.
Nodular lymphocyte predominant hodgkin lymphoma: biology, diagnosis and treatment.
Review
Grossbard et al., New York City, United States. In Clin Lymphoma Myeloma Leuk, 2014
It is characterized histologically by presence of lymphohistiocytic cells which have B-cell phenotype, are positive for CD19, CD20, CD45, CD79a, BOB.1, Oct.2, and negative for CD15 and CD30.
Discovery and characterization of super-enhancer-associated dependencies in diffuse large B cell lymphoma.
Impact
Bradner et al., Boston, United States. In Cancer Cell, 2014
Functional study of genes marked by super-enhancers identifies DLBCLs dependent on OCA-B and suggests a strategy for discovering unrecognized cancer dependencies.
Epstein-Barr virus-positive diffuse large B-cell lymphomas of the elderly.
Review
Quintanilla-Martínez et al., Tübingen, Germany. In Adv Anat Pathol, 2011
Strong, homogeneous expression of B-cell markers, including transcription factors OCT2 and BOB.1, and lack of CD15 support a diagnosis of EBV+ DLBCL.
Direct interactions of OCA-B and TFII-I regulate immunoglobulin heavy-chain gene transcription by facilitating enhancer-promoter communication.
GeneRIF
Roeder et al., New York City, United States. In Mol Cell, 2011
Data show that Igh 3' enhancer-bound OCA-B and promoter-bound TFII-I mediate promoter-enhancer interactions, in both cis and trans, that are important for Igh transcription.
B-cell transcription factors Pax-5, Oct-2, BOB.1, Bcl-6, and MUM1 are useful markers for the diagnosis of nodular lymphocyte predominant Hodgkin lymphoma.
GeneRIF
Ioniţă et al., Timişoara / Temesvár, Romania. In Rom J Morphol Embryol, 2010
Twenty-two cases of nodular lymphocyte predominant Hodgkin lymphoma were studied for the immunohistochemical expression of Pax-5, Oct-2, BOB.1, Bcl-6 protein and MUM1/IRF-4.
Evaluation of CARMA1/CARD11 and Bob1 as candidate genes in common variable immunodeficiency.
GeneRIF
Lougaris et al., Brescia, Italy. In J Investig Allergol Clin Immunol, 2010
genetic polymorphism is associated with common variable immunodeficiency
Anaplastic lymphoma kinase-positive diffuse large B-cell lymphoma presenting as an isolated nasopharyngeal mass: a case report and review of literature.
Review
Wang et al., San Diego, United States. In Int J Clin Exp Pathol, 2010
Histologically, the tumor cells exhibited plasmablastic morphology with expression of Bob-1, CD4, CD10, CD45, CD56, CD138, EMA, MUM1, Oct-2, and kappa immunoglobulin light chain, but negative for CD20, CD30, CD79a, PAX-5, and lambda.
B-cell lymphomas with features intermediate between distinct pathologic entities. From pathogenesis to pathology.
Review
Cabras et al., Milano, Italy. In Hum Pathol, 2010
Alternatively, these cases may resemble primary mediastinal large B-cell lymphoma but contain tumor cells resembling Reed-Sternberg cells and displaying an aberrant phenotype such as CD20(-), CD15(-/+) CD45(+), CD30(+), Pax5(+), OCT2(+/-), and BOB1(+/-).
OCT-2 expression and OCT-2/BOB.1 co-expression predict prognosis in patients with newly diagnosed acute myeloid leukemia.
GeneRIF
Hsi et al., Cleveland, United States. In Leuk Lymphoma, 2010
On multivariate analysis, co-expression of OCT-2/BOB.1 remained predictive for achievement of complete remission and increased risk of relapse.
BOB.1, CD79a and cyclin E are the most appropriate markers to discriminate classical Hodgkin's lymphoma from primary mediastinal large B-cell lymphoma.
GeneRIF
Tzankov et al., Basel, Switzerland. In Histopathology, 2010
BOB.1 may be helpful marker in the differential diagnosis of classical Hodgkin's lymphoma and primary mediastinal B-cell lymphoma
Nontranscriptional regulation of SYK by the coactivator OCA-B is required at multiple stages of B cell development.
Impact
GeneRIF
Roeder et al., New York City, United States. In Cell, 2006
Results suggest that OCA-B is required for pre-BCR and BCR signaling at multiple stages of B cell development through its nontranscriptional regulation of SYK.
OcaB is required for normal transcription and V(D)J recombination of a subset of immunoglobulin kappa genes.
Impact
GeneRIF
Nussenzweig et al., New York City, United States. In Cell, 2002
OcaB is essential for V(D)J recombination of a subset of Igkappa genes. We show that OcaB modulates recombination by directly enhancing Igkappa gene transcription in vivo.
Identification and characterization of a novel OCA-B isoform. implications for a role in B cell signaling pathways.
Impact
Roeder et al., New York City, United States. In Immunity, 2001
OCA-B is a B lymphocyte-specific transcription coactivator that mediates tissue- and stage-restricted transcription of immunoglobulin genes.
Synergism with the coactivator OBF-1 (OCA-B, BOB-1) is mediated by a specific POU dimer configuration.
Impact
Schöler et al., United States. In Cell, 2001
The POU dimer formed on the PORE (ATTTGAAATGCAAAT) can recruit the transcriptional coactivator OBF-1, whereas POU dimers formed on the consensus MORE (ATGCATATGCAT) or on MOREs from immunoglobulin heavy chain promoters (AT[G/A][C/A]ATATGCAA) fail to interact.
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