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Solute carrier organic anion transporter family, member 1B1

OATP1B1, Oatp2, SLCO1B1, OATP-C, SLC21A6
This gene encodes a liver-specific member of the organic anion transporter family. The encoded protein is a transmembrane receptor that mediates the sodium-independent uptake of numerous endogenous compounds including bilirubin, 17-beta-glucuronosyl estradiol and leukotriene C4. This protein is also involved in the removal of drug compounds such as statins, bromosulfophthalein and rifampin from the blood into the hepatocytes. Polymorphisms in the gene encoding this protein are associated with impaired transporter function. [provided by RefSeq, Mar 2009] (from NCBI)
Papers on OATP1B1
SLCO1B1 *15 haplotype is associated with rifampin-induced liver injury.
Chen et al., Chongqing, China. In Mol Med Report, 2012
the OATP1B1 *15 haplotype is an important predisposing factor for rifampin-induced liver injury.
Alteration in placental expression of bile acids transporters OATP1A2, OATP1B1, OATP1B3 in intrahepatic cholestasis of pregnancy.
Wang et al., Hangzhou, China. In Arch Gynecol Obstet, 2012
OATP1B1 mRNA was detected in intrahepatic cholestasis of pregnancy placentas and control placentas, but protein expression of OATP1B1 was not found in any of the placentas.
SLCO1B1 gene variability influences lipid-lowering efficacy on simvastatin therapy in Southern Brazilians.
Hutz et al., Porto Alegre, Brazil. In Clin Chem Lab Med, 2012
SLCO1B1 c.388A>G polymorphism could play a role in the inter-individual variation of clinical response to simvastatin in Brazilians
Complete OATP1B1 and OATP1B3 deficiency causes human Rotor syndrome by interrupting conjugated bilirubin reuptake into the liver.
Schinkel et al., Amsterdam, Netherlands. In J Clin Invest, 2012
Data show that Rotor syndrome was linked to mutations predicted to cause complete and simultaneous deficiencies of the organic anion transporting polypeptides OATP1B1 and OATP1B3.
Identification of amino acids essential for estrone-3-sulfate transport within transmembrane domain 2 of organic anion transporting polypeptide 1B1.
Hong et al., Guangzhou, China. In Plos One, 2011
amino acids essential for estrone-3-sulfate transport function of OATP1B1
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