The role of mitochondria in statin-induced myopathy.
Düsseldorf, Germany. In Eur J Clin Invest, Jul 2015
Some patients are susceptible to statin-induced myopathy due to variations in genes encoding proteins involved in statin uptake and biotransformation such as the solute carrier organic anion transporter family member 1B1 (SLCO1B1) or cytochrome P450 (CYP2D6, CYP3A4, CYP3A5).
Pharmacogenomics of glinides.
Shanghai, China. In Pharmacogenomics, 2015
Polymorphisms of genes involved in drug metabolism, such as CYP2C9, CYP2C8 and SLCO1B1, may influence the efficacy of glinides and the incidence of adverse effects.