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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Solute carrier organic anion transporter family, member 1a1

OATP, Oatp1, OATP-A, OATP1A2
mediates the transport of sulfated, amidated bile acid, sulfolithocholyltaurine, into rat hepatocytes [RGD, Feb 2006] (from NCBI)
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Top mentioned proteins: OATP1B1, ACID, OATP1B3, CAN, CD45
Papers on OATP
Down-Regulation of Organic Anion Transporting Polypeptide (OATP) 1B1 Transport Function by Lysosomotropic Drug Chloroquine.
New
Yue et al., In Mol Pharm, Feb 2016
UNASSIGNED: Organic anion transporting polypeptide (OATP) 1B1 mediates the hepatic uptake of many drugs including lipid-lowering statins.
Investigation of Fluorescein Derivatives as Substrates of Organic Anion Transporting Polypeptide (OATP) 1B1 To Develop Sensitive Fluorescence-Based OATP1B1 Inhibition Assays.
New
Sugiyama et al., Tsukuba, Japan. In Mol Pharm, Feb 2016
UNASSIGNED: Organic anion transporting polypeptide (OATP) 1B1 plays an important role in the hepatic uptake of various drugs.
Primary-like Human Hepatocytes Genetically Engineered to Obtain Proliferation Competence Display Hepatic Differentiation Characteristics in Monolayer and Organotypical Spheroid Cultures.
New
Küpper et al., Senftenberg, Germany. In Cell Biol Int, Jan 2016
Additionally, transcripts for phase II liver enzymes and transporter proteins OATP-C, MRP2, Oct1 and BSEP were present in HepaFH3.
The non-metabolized β-blocker nadolol is a substrate of OCT1, OCT2, MATE1, MATE2-K and P-glycoprotein, but not of OATP1B1 and OATP1B3.
New
Fromm et al., In Mol Pharm, Jan 2016
UNASSIGNED: Nadolol is a non-metabolized β-adrenoceptor antagonist and is a substrate of OATP1A2, but not of OATP2B1.
Solitary Inhibition of the Breast Cancer Resistance Protein (BCRP) Efflux Transporter Results in a Clinically Significant Drug-Drug Interaction with Rosuvastatin by Causing Up To a Two-Fold Increase in Statin Exposure.
New
Fenner et al., In Drug Metab Dispos, Jan 2016
Of the transporters important to rosuvastatin disposition, fostamatinib inhibited BCRP (IC50=50nM), organic anion-transporting polypeptide (OATP)1B1 (IC50>10μM), but not organic anion transporter 3 in vitro, predicting a drug-drug interaction (DDI) in vivo through inhibition of BCRP only.
Influence of captopril on the cellular uptake and toxic potential of microcystin-LR in non-hepatic adhesive cell lines.
New
Dzhambazov et al., Plovdiv, Bulgaria. In Toxicon, Jan 2016
To penetrate through the plasma membrane, MC-LR needs specific transporters such the organic anion-transporting polypeptides (OATP) that are highly expressed on the hepatocytes.
The effect of statins on cancer cells--review.
Review
New
Sikorski et al., Wrocław, Poland. In Tumour Biol, Jul 2015
Moreover, statins may change the arrangement of transporter OATP1, the localization of HMGCR, and could induce conformational changes in GLUT proteins.
Drug Interactions With Direct-Acting Antivirals for Hepatitis C: Implications for HIV and Transplant Patients.
Review
New
Hussaini et al., Vancouver, Canada. In Ann Pharmacother, Jun 2015
Simeprevir is also prone to drug interactions because of cytochrome P450(CYP) 3A4, CYP1A2, P-glycoprotein, and OATP1 involvement and is not recommended for use in combination with several HIV antiretrovirals (ARVs).
[Regulation of organic anion transporting polypeptides expression and activity].
Review
New
Li et al., In Yao Xue Xue Bao, Apr 2015
Organic anion transporting polypeptides (OATP), a member of solute carrier (SLC) superfamily, is considered as an important transmembrane uptake transporters.
Montelukast Disposition: No Indication of Transporter-Mediated Uptake in OATP2B1 and OATP1B1 Expressing HEK293 Cells.
Grime et al., Mölndal, Sweden. In Pharmaceutics, 2014
Using OATP1B1-transfected HEK293 cells and primary human hepatocytes in the presence of OATP inhibitors we demonstrate for the first time that active OATP-dependent transport is unlikely to play a significant role in the human disposition of montelukast.
Genetic polymorphisms and function of the organic anion-transporting polypeptide 1A2 and its clinical relevance in drug disposition.
Review
Zhang et al., Zhengzhou, China. In Pharmacology, 2014
Human OATP1A2 is a drug uptake transporter known for its broad substrate specificity, including many drugs in clinical use.
[Determinants of the stereoselective pharmacokinetics of fexofenadine].
Review
Akamine, Okinawa, Japan. In Yakugaku Zasshi, 2014
The findings suggested that a combination of multiple transporters involving organic anion transporting polypeptide (OATP) 2B1, P-glycoprotein (P-gp), and multidrug resistance-associated protein 2 (MRP2) react to stereoselective fexofenadine exposure.
Targeted drug delivery to treat pain and cerebral hypoxia.
Review
Impact
Davis et al., Tucson, United States. In Pharmacol Rev, 2013
OATP/Oatp substrates include drugs that are efficacious in treatment of pain and/or cerebral hypoxia (i.e., opioid analgesic peptides, 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors).
The SLCO1A2 gene, encoding human organic anion-transporting polypeptide 1A2, is transactivated by the vitamin D receptor.
GeneRIF
Kullak-Ublick et al., Zürich, Switzerland. In Mol Pharmacol, 2012
SLCO1A2 promoter variant 1 was strongly induced by vitamin D receptor.
Gene expression of ATP-binding cassette transporters during liver regeneration after 90% hepatectomy in rats.
GeneRIF
Sasaki et al., Hirosaki, Japan. In Int J Mol Med, 2012
persistent elevation of serum bilirubin during regeneration of small liver was suggested to be due to sustained low uptake from the sinusoids by repressed OATP1 and low export from hepatocytes to bile duct by repressed MRP2 on the canalicular membrane.
Alteration in placental expression of bile acids transporters OATP1A2, OATP1B1, OATP1B3 in intrahepatic cholestasis of pregnancy.
GeneRIF
Wang et al., Hangzhou, China. In Arch Gynecol Obstet, 2012
The expression of OATP1A2 and OATP1B3 in placenta decreased in, and may be involved in the pathophysiology of, intrahepatic cholestasis of pregnancy. OATP1A2 was localized to the vasculo-syncytial membrane and apical surface of syncytiotrophoblasts.
Intestinal OATP1A2 inhibition as a potential mechanism for the effect of grapefruit juice on aliskiren pharmacokinetics in healthy subjects.
GeneRIF
Jarugula et al., United States. In Eur J Clin Pharmacol, 2012
Data suggest that inhibition of OATP1A2 in intestinal mucosa at least partially explains effects of grapefruit juice (or grapefruit juice components such as the flavonoid naringin) on pharmacokinetics of aliskiren, an antihypertensive agent.
The expression and function of organic anion transporting polypeptides in normal tissues and in cancer.
Review
Impact
Hagenbuch et al., Kansas City, United States. In Annu Rev Pharmacol Toxicol, 2011
Members of the OATP1 and OATP2 families are functionally the best-characterized OATPs.
Digoxin is not a substrate for organic anion-transporting polypeptide transporters OATP1A2, OATP1B1, OATP1B3, and OATP2B1 but is a substrate for a sodium-dependent transporter expressed in HEK293 cells.
GeneRIF
Lee et al., United States. In Drug Metab Dispos, 2011
Digoxin inhibited the uptake of probe substrates of OATP1B1 (IC(50) of 47 muM), OATP1B3 (IC(50) > 8.1 muM), and OATP2B1 (IC(50) > 300 muM), but not OATP1A2 in transfected cell lines.
Evaluation of drug-drug interaction in the hepatobiliary and renal transport of drugs.
Review
Impact
Sugiyama et al., Tokyo, Japan. In Annu Rev Pharmacol Toxicol, 2004
Among them, cephalosporins and probenecid have the potential to produce clinically relevant OAT-mediated drug-drug interactions, whereas cyclosporin A and rifampicin may trigger OATP-mediated ones.
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