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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

2'-5' oligoadenylate synthetase-like 1

Oasl1
Top mentioned proteins: IRF-7, OASL, OAS2, SET, Ubiquitin
Papers on Oasl1
OASL1 deficiency promotes antiviral protection against genital herpes simplex virus type 2 infection by enhancing type I interferon production.
New
Lee et al., Taejŏn, South Korea. In Sci Rep, Dec 2015
Recently, we reported that 2'-5' oligoadenylate synthetase-like 1 (OASL1) negatively regulates type I IFN production by inhibiting the translation of the type I IFN-regulating master transcription factor, IRF7.
Comparative proteomic approach in rat model of absence epilepsy.
New
Karson et al., Sakarya, Turkey. In J Mol Neurosci, Mar 2015
Another set of six proteins (Protein FAM89A and Oasl1, Gemin2, NuDEL1, Pur-beta, 3-alpha HSD) were found to be differentially expressed in the thalamus of WAG/Rij and Wistar rats.
Secondary structure of the Irf7 5'-UTR, analyzed using SHAPE (selective 2'-hydroxyl acylation analyzed by primer extension).
Kim et al., Seoul, South Korea. In Bmb Rep, 2014
OASL1 is a member of the 2'-5'-oligoadenylate synthetase (OAS) family and promotes viral clearance by activating RNase L. OASL1 interacts with the 5'-untranslated region (UTR) of interferon regulatory factor 7 (Irf7) and inhibits its translation.
STAT1-dependent signal integration between IFNγ and TLR4 in vascular cells reflect pro-atherogenic responses in human atherosclerosis.
Bluyssen et al., München, Germany. In Plos One, 2013
These included the chemokines Cxcl9, Ccl12, Ccl8, Ccrl2, Cxcl10 and Ccl5, adhesion molecules Cd40, Cd74, and antiviral and antibacterial genes Rsad2, Mx1, Oasl1, Gbp5, Nos2, Batf2 and Tnfrsf11a.
Global gene expression changes in BV2 microglial cell line during rabies virus infection.
Xia et al., Changchun, China. In Infect Genet Evol, 2013
Genes in BV2 were significantly regulated (P<0.01) in response to RABV infection and they were found to be interferon stimulated genes (Isg15, Isg20, Oasl1, Oasl2, Ifit2, Irf7 and Ifi203), chemokine genes (Ccl5, Cxcl10 and Ccrl2) and the proinflammatory factor gene (Interleukin 6).
OASL1 inhibits translation of the type I interferon-regulating transcription factor IRF7.
Impact
Kim et al., Seoul, South Korea. In Nat Immunol, 2013
Here we found that OASL1 inhibited translation of IRF7, the master transcription factor for type I interferon, and thus negatively regulated the robust production of type I interferon during viral infection.
Negative regulation of type I IFN expression by OASL1 permits chronic viral infection and CD8⁺ T-cell exhaustion.
Ha et al., Seoul, South Korea. In Plos Pathog, 2012
Herein, we explored whether 2'-5' oligoadenylate synthetase-like 1 (OASL1), a recently defined IFN-I negative regulator, plays a key role in the virus-specific T-cell response and viral defense against chronic LCMV.
Acetaminophen modulates the transcriptional response to recombinant interferon-beta.
Li et al., Ottawa, Canada. In Plos One, 2009
Additionally, we observed a large decrease in the expression of several IFN-induced genes including Ifit-3, Isg-15, Oasl1, Zbp1 and predicted gene EG634650 at both early and late time points.
The mammalian 2'-5' oligoadenylate synthetase gene family: evidence for concerted evolution of paralogous Oas1 genes in Rodentia and Artiodactyla.
Brinton et al., Atlanta, United States. In J Mol Evol, 2006
Twelve 2'-5' oligoadenylate synthetase (Oas) genes were identified in the rat genome, including eight Oas1 genes, two Oas1 pseudogenes, single copies of Oas2 and Oas3, and two Oas-like genes, Oasl1 and Oasl2.
Characterization of the 2'-5'-oligoadenylate synthetase ubiquitin-like family.
Hartmann et al., Århus, Denmark. In Nucleic Acids Res, 2003
The human and murine OAS gene families each contain four genes: OAS1, OAS2, OAS3 and OASL, all having one or more conserved OAS units composed of five translated exons.
Gene structure of the murine 2'-5'-oligoadenylate synthetase family.
Justesen et al., Århus, Denmark. In Cell Mol Life Sci, 2002
Compared to the single OASL gene found in humans, two genes of OAS-like proteins, Oasl1 and Oasl2, were identified.
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