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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

2'-5'-oligoadenylate synthetase-like

OASL, Oasl2, 2'-5' oligoadenylate synthetase-like protein
Top mentioned proteins: OAS2, MxA, CAN, ACID, ISG15
Papers on OASL
Alleviation of selenium toxicity in Brassica juncea L.: salicylic acid-mediated modulation in toxicity indicators, stress modulators, and sulfur-related gene transcripts.
Gupta et al., New Delhi, India. In Protoplasma, Dec 2015
Increasing Se concentrations inhibited growth and, caused lipid peroxidation, concomitantly increased stress modulators (proline, cysteine, SOD, CAT) along with sulfur-related gene transcripts (LAST, APS, APR, GR, OASL, MT-2, PCS) in Brassica seedlings.
Porcine 2', 5'-oligoadenylate synthetases inhibit Japanese encephalitis virus replication in vitro.
Chen et al., Nanjing, China. In J Med Virol, Nov 2015
The expression kinetics and antiviral functions of porcine OAS family (OAS1, OAS2, and OASL) in PK-15 cells following infection by Japanese encephalitis virus (JEV) were evaluated in the present study.
2'-5'-Oligoadenylate Synthetase-Like Protein Inhibits Respiratory Syncytial Virus Replication and Is Targeted by the Viral Nonstructural Protein 1.
Barik et al., Cleveland, United States. In J Virol, Oct 2015
2'-5'-Oligoadenylate synthetase-like protein (OASL) is an interferon-inducible antiviral protein.
The metabolomics of asthma control: a promising link between genetics and disease.
Lasky-Su et al., Boston, United States. In Immun Inflamm Dis, Sep 2015
Integrative ORA identified 17 significantly enriched pathways related to cellular immune response, interferon signaling, and cytokine-related signaling, for which arachidonic acid, PGE2 and S1P, in addition to six genes (CHN1, PRKCE, GNA12, OASL, OAS1, and IFIT3) appeared to drive the pathway results.
OASL-a new player in controlling antiviral innate immunity.
Sarkar et al., Pittsburgh, United States. In Curr Opin Virol, Jun 2015
Here we discuss a recently described mechanism of boosting the innate immunity by oligoadenylate synthetase-like (OASL) protein, which can potentially be used to overcome viral evasion and enhance innate immunity.
Sperm mRNAs and microRNAs as candidate markers for the impact of toxicants on human spermatogenesis: an application to tobacco smoking.
Nguyen et al., Marseille, France. In Syst Biol Reprod Med, Jun 2015
Moreover, we observed an inverse relationship between the levels of microRNAs and six potential target mRNAs (B3GAT3, HNRNPL, OASL, ODZ3, CNGB1, and PKD2).
Structural and functional analysis reveals that human OASL binds dsRNA to enhance RIG-I signaling.
Hartmann et al., Århus, Denmark. In Nucleic Acids Res, Jun 2015
The human OAS-like (OASL) protein, however, does not harbor the catalytic activity required for synthesizing 2-5As and differs from the other human OAS family members by having two C-terminal ubiquitin-like domains.
Overlapping Patterns of Rapid Evolution in the Nucleic Acid Sensors cGAS and OAS1 Suggest a Common Mechanism of Pathogen Antagonism and Escape.
Elde et al., Pittsburgh, United States. In Plos Genet, May 2015
Further analysis of selection on the OAS family in primates, which comprises OAS1, OAS2, OAS3 and OASL, suggests a hypothesis where gene duplications and domain fusion events result in paralogs that provide another means of escaping pathogen inhibitors.
Comparative analysis of selected innate immune-related genes following infection of immortal DF-1 cells with highly pathogenic (H5N1) and low pathogenic (H9N2) avian influenza viruses.
Song et al., Jinan, China. In Virus Genes, Apr 2015
To address this hypothesis, expression of a panel of innate immune-related genes including IFN-α, IFN-β, Mx1, OASL, ISG12, IFIT5, IRF7, USP18, SST, and KHSRP in immortal DF-1 cells following H5N1 and H9N2 infection was analyzed and compared by real-time quantitative RT-PCR.
Identification of interferon-inducible genes as diagnostic biomarker for systemic lupus erythematosus.
Sun et al., Nanjing, China. In Clin Rheumatol, 2015
In this study, we assessed the values of expression levels of five type I interferon (IFN)-inducible genes (LY6E, OAS1, OASL, MX1, and ISG15) and total IFN score for the diagnosis of SLE.
Oligoadenylate synthase-like (OASL) proteins: dual functions and associations with diseases.
Kim et al., Seoul, South Korea. In Exp Mol Med, 2014
In particular, we focus on OASL, a member of the OAS family that is relatively less well understood than the other members.
Oral administration of Lactococcus lactis subsp. lactis JCM5805 enhances lung immune response resulting in protection from murine parainfluenza virus infection.
Fujiwara et al., Sayama, Japan. In Plos One, 2014
Interestingly, nevertheless resident pDCs at lung were not activated and expressions levels of IFNs at whole lung tissue were not influenced, the expressions of anti-viral factors induced by IFNs, such as Isg15, Oasl2, and Viperin, at lung were up-regulated in JCM5805-fed mice compared to control mice.
Antiviral activity of human OASL protein is mediated by enhancing signaling of the RIG-I RNA sensor.
Sarkar et al., Pittsburgh, United States. In Immunity, 2014
Bone-marrow-derived macrophages from mice deficient for Oasl2 showed that among the two mouse orthologs of human OASL, Oasl2 is functionally similar to human OASL.
A diverse range of gene products are effectors of the type I interferon antiviral response.
Rice et al., New York City, United States. In Nature, 2011
Broadly acting effectors included IRF1, C6orf150 (also known as MB21D1), HPSE, RIG-I (also known as DDX58), MDA5 (also known as IFIH1) and IFITM3, whereas more targeted antiviral specificity was observed with DDX60, IFI44L, IFI6, IFITM2, MAP3K14, MOV10, NAMPT (also known as PBEF1), OASL, RTP4, TREX1 and UNC84B (also known as SUN2).
Genetic variants in LPL, OASL and TOMM40/APOE-C1-C2-C4 genes are associated with multiple cardiovascular-related traits.
Whitfield et al., Brisbane, Australia. In Bmc Med Genet, 2010
variants in LPL, OASL and TOMM40/APOE-C1-C2-C4 genes are associated with multiple cardiovascular-related traits
[Interferon-inducible genes 2', 5'-ollgoadenylate synthetase-like and tetratricopeptide repeats 2 are correlated with clinical features of patients with systemic lupus erythematosus].
Zhong et al., Chengdu, China. In Sichuan Da Xue Xue Bao Yi Xue Ban, 2010
The expression of OASL and IFIT2 was significantly higher in SLE patients than in controls.
2',5'-Oligoadenylate synthetase-like gene highly induced by hepatitis C virus infection in human liver is inhibitory to viral replication in vitro.
Esumi et al., Tokyo, Japan. In Biochem Biophys Res Commun, 2010
OASLa, a major isoform of OASL induced in human liver, may mediate anti-HCV activity through two different domains.
Differential regulation of the OASL and OAS1 genes in response to viral infections.
Hartmann et al., Århus, Denmark. In J Interferon Cytokine Res, 2009
The pronounced difference in gene regulation between the OASL gene agrees with a functional difference between these genes, which must exist as a consequence of the lack of the 2-5A synthetase activity of the OASL protein.
The p59 oligoadenylate synthetase-like protein possesses antiviral activity that requires the C-terminal ubiquitin-like domain.
Hartmann et al., Cleveland, United States. In J Gen Virol, 2008
Proof that OASL is an antiviral protein that works through a novel mechanism distinct from other OASL proteins in other vertebrate species.
The human 2'-5'oligoadenylate synthetase family: unique interferon-inducible enzymes catalyzing 2'-5' instead of 3'-5' phosphodiester bond formation.
Justesen et al., Paris, France. In Biochimie, 2007
OASL is an OAS like IFN-induced protein encoded by a gene located about 8 Mb telomeric from the 2'-5'OAS locus.
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