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Nuclear RNA export factor 3

This gene is one member of a family of nuclear RNA export factor genes. Common domain features of this family are a noncanonical RNP-type RNA-binding domain (RBD), 4 leucine-rich repeats (LRRs), a nuclear transport factor 2 (NTF2)-like domain that allows heterodimerization with NTF2-related export protein-1 (NXT1), and a ubiquitin-associated domain that mediates interactions with nucleoporins. The LRRs and NTF2-like domains are required for export activity. Alternative splicing seems to be a common mechanism in this gene family. The encoded protein of this gene has shortened LRR and ubiquitin-associated domains and its RDB is unable to bind RNA. It is located in the nucleoplasm but is not associated with either the nuclear envelope or the nucleolus. [provided by RefSeq, Jul 2008] (from NCBI)
Papers on NXF3
Nxf3 is expressed in Sertoli cells, but is dispensable for spermatogenesis.
Wang et al., Philadelphia, United States. In Mol Reprod Dev, 2011
The Nxf3 is expressed exclusively in Sertoli cells of the postnatal testis, in a developmentally regulated manner.
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