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Nuclear VCP-like

This gene encodes a member of the AAA (ATPases associated with diverse cellular activities) superfamily. Multiple transcript variants encoding different isoforms have been found for this gene. Two encoded proteins, described as major and minor isoforms, have been localized to distinct regions of the nucleus. The largest encoded protein (major isoform) has been localized to the nucleolus and shown to participate in ribosome biosynthesis (PMID: 15469983, 16782053), while the minor isoform has been localized to the nucleoplasmin. [provided by RefSeq, Aug 2011] (from NCBI)
Top mentioned proteins: VILIP-3, Arylamine N-Acetyltransferase, ATPase, Insulin, AGE
Papers on NVL
The landscape of prognostic outlier genes in high-risk prostate cancer.
Feng et al., Ad Dānā, Syria. In Clin Cancer Res, Jan 2016
Three top prognostic outlier genes were novel prostate cancer genes; NVL, SMC4, or SQLE knockdown reduced migration and/or invasion and outlier expression was significantly associated with poor prognosis.
The NVL gene confers risk for both major depressive disorder and schizophrenia in the Han Chinese population.
Shi et al., Shanghai, China. In Prog Neuropsychopharmacol Biol Psychiatry, Nov 2015
NVL (nuclear VCP (valosin containing protein)/p97-Like), a member of the AAA-ATPase (ATPases associated with various cellular activities) family, encodes a novel hTERT (human telomerase reverse transcriptase)-interacting protein NVL2 which is a telomerase component essential for holoenzyme assembly.
[Treatment of chronic back pain: current standards].
Braun et al., Wiesbaden, Germany. In Internist (berl), 2014
The management of low back pain has been addressed by the German National Disease Management Guideline (NVL) low back pain published in 2010.
Inhibition of neovascularization and expression shift of pro-/anti-angiogenic vascular endothelial growth factor isoforms after intravitreal bevacizumab injection in oxygen-induced-retinopathy mouse model.
Li et al., Beijing, China. In Chin Med J (engl), 2013
The Evans blue perfused retina were used to test the retinal neovascularization-leakage (NVL) area and non-perfusion (NP) area.
Role of xanthophylls in light harvesting in green plants: a spectroscopic investigation of mutant LHCII and Lhcb pigment-protein complexes.
Frank et al., United States. In J Phys Chem B, 2012
The complexes were derived from mutants of plants denoted npq1 (NVL), npq2lut2 (Z), aba4npq1lut2 (V), aba4npq1 (VL), npq1lut2 (NV), and npq2 (LZ).
The AAA-ATPase NVL2 is a telomerase component essential for holoenzyme assembly.
Chung et al., Seoul, South Korea. In Biochem Biophys Res Commun, 2012
these findings suggest that NVL2 is essential for telomerase biogenesis and provides an alternative approach for inhibiting telomerase activity in cancer.
Structure and function of the N-terminal nucleolin binding domain of nuclear valosin-containing protein-like 2 (NVL2) harboring a nucleolar localization signal.
Hiroaki et al., Kōbe, Japan. In J Biol Chem, 2011
NVL2 might facilitate the dissociation and recycling of nucleolin, thereby promoting efficient ribosome biogenesis
Rapid identification of mutations in GJC2 in primary lymphoedema using whole exome sequencing combined with linkage analysis with delineation of the phenotype.
Jeffery et al., London, United Kingdom. In J Med Genet, 2011
This approach revealed two novel non-synonymous single nucleotide substitutions within the chromosome 1 locus, in NVL and GJC2.
The AAA-ATPase NVL2 is a component of pre-ribosomal particles that interacts with the DExD/H-box RNA helicase DOB1.
Tagaya et al., Hachiōji, Japan. In Biochem Biophys Res Commun, 2006
Nuclear VCP/p97-like protein 2 might regulate the association/dissociation reaction of DOB1 with pre-ribosomal particles by acting as a molecular chaperone.
NVL2 is a nucleolar AAA-ATPase that interacts with ribosomal protein L5 through its nucleolar localization sequence.
Tagaya et al., Hachiōji, Japan. In Mol Biol Cell, 2004
interaction of NVL2 with ribosomal protein L5 is ATP-dependent and likely contributes to the nucleolar translocation of NVL2
A prospective, randomized, sequential crossover trial of large-volume versus normal-volume leukapheresis procedures: effects on serum electrolytes, platelet counts, and other coagulation measures.
Köhler et al., Göttingen, Germany. In Transfusion, 2000
STUDY DESIGN AND METHODS: Patients were randomly assigned to start either with an LVL on Day 1 followed by a normal-volume leukapheresis (NVL) on Day 2 or vice versa.
NVL: a new member of the AAA family of ATPases localized to the nucleus.
Valle et al., Baltimore, United States. In Genomics, 1997
We report the cloning of NVL, a newly recognized human gene that encodes an approximately 110-kDa nuclear protein designated NVLp (nuclear VCP-like protein), which is a member of a rapidly growing family of ATP-binding proteins recently denoted the AAA family (ATPases associated with diverse cellular activities) (W.
Expression of VL30 vectors in human cells that are targets for gene therapy.
Hodgson et al., Omaha, United States. In Biochem Biophys Res Commun, 1995
The long terminal repeat (LTR) transcriptional promoter, derived from the retroelement NVL-3, expressed abundant mRNA containing the bacterial neomycin resistance gene (neo) in all cell types tested.
Oncogenic Ras activates c-Jun via a separate pathway from the activation of extracellular signal-regulated kinases.
Brenner et al., Chapel Hill, United States. In Proc Natl Acad Sci U S A, 1994
Coexpression of wild-type ERKs with oncogenic Ras proteins potentiated, while kinase-defective ERKs inhibited, Ras-induced transcriptional activation from the Ras-responsive element (Ets-1/AP-1) present in the NVL-3 enhancer and the serum-response element in the c-fos promoter.
Singlet oxygen: a primary effector in the ultraviolet A/near-visible light induction of the human heme oxygenase gene.
Tyrrell et al., Lausanne, Switzerland. In Cancer Res, 1993
We have modulated the cellular levels of these two reactive oxygen species in order to compare their involvement in the induction of the human heme oxygenase (HO) gene by broad spectrum UVA/near-visible light (UVA/NVL).
Independent regulation of mouse VL30 retrotransposon expression in response to serum and oncogenic cell transformation.
Norton et al., London, United Kingdom. In Nucleic Acids Res, 1990
The nucleotide sequence of the long terminal repeats (LTRs) of retrovirus-transmissible mouse VL30 cDNA clones, NVL-1 and NVL-2 were determined and compared with that of the prototype NVL-3.
Efficient packaging of a specific VL30 retroelement by psi 2 cells which produce MoMLV recombinant retroviruses.
Hanson et al., Cleveland, United States. In Hum Gene Ther, 1989
The restriction map analysis of the transferred VL30 provirus was identical to the mouse VL30s of the NVL subfamily which is known to be a significant fraction of the transcriptionally active VL30 subset.
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