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Nuclear receptor subfamily 4, group A, member 2

Nurr1, NR4A2
This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. The encoded protein may act as a transcription factor. Mutations in this gene have been associated with disorders related to dopaminergic dysfunction, including Parkinson disease, schizophernia, and manic depression. Misregulation of this gene may be associated with rheumatoid arthritis. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, hormone-receptor, Tec, V1a, HAD
Papers on Nurr1
Role of Nurr1 in the Generation and Differentiation of Dopaminergic Neurons from Stem Cells.
Vicario-Abejón et al., Madrid, Spain. In Neurotox Res, Jan 2016
UNASSIGNED: NURR1 is an essential transcription factor for the differentiation, maturation, and maintenance of midbrain dopaminergic neurons (DA neurons) as it has been demonstrated using knock-out mice.
Predicting functional regulatory SNPs in the human antimicrobial peptide genes DEFB1 and CAMP in tuberculosis and HIV/AIDS.
Prado Montes de Oca et al., Guadalajara, Mexico. In Comput Biol Chem, Dec 2015
However, most of these studies are very limited, as they only analyze SNPs in coding regions or when applied to promoters, and do not integrate essential biological data like TFBSs, expression profiles, pathway analysis, homotypic redundancy (number of TFBSs for the same TF in a region), chromatin accessibility and others, which could lead to a more accurate prediction.
Understanding gene expression in coronary artery disease through global profiling, network analysis and independent validation of key candidate genes.
Kakkar et al., Bengaluru, India. In J Genet, Dec 2015
Expression of EGR1/2/3, IL8, CXCL1, PTGS2, CD69, IFNG, FASLG, CCL4, CDC42, DDX58, NFKBID and NR4A2 genes were independently validated; EGR1/2/3 and IL8 showed >8-fold higher expression in cases relative to the controls implying their important role in CAD.
The Key Proteins of Dopaminergic Neurotransmission of Human Peripheral Blood Lymphocytes: Changed mRNA Level in Alcohol Dependence Syndrome.
Schwartzman et al., Saint Petersburg, Russia. In Bull Exp Biol Med, Dec 2015
The expression of dopamine receptor (DRD), Nurr1 transcription factor (NR4A2), and α-sinucleine (SNCA) genes in peripheral blood lymphocytes is evaluated.
Optogenetic Inhibitor of the Transcription Factor CREB.
Woolley et al., Toronto, Canada. In Chem Biol, Dec 2015
Current approaches for optogenetic control of transcription do not mimic the activity of endogenous transcription factors, which act at numerous sites in the genome in a complex interplay with other factors.
Association between NR4A2 genetic variation and schizophrenia: A comprehensive systematic review and meta-analysis.
Li et al., Shanghai, China. In Neurosci Lett, Jul 2015
The homo sapiens nuclear receptor subfamily 4, group A (NR4A2) genetic variation has been implicated as a risk factor for schizophrenia (SZ).
Genomic landscape of human papillomavirus-associated cancers.
Hammerman et al., Århus, Denmark. In Clin Cancer Res, Jun 2015
Recurrent integrations in RAD51B, NR4A2, and TP63, leading to aberrant forms of these proteins, are observed in both HPV-positive head and neck squamous cell carcinoma (HNSCC) and cervical carcinoma.
The interplay of NR4A receptors and the oncogene-tumor suppressor networks in cancer.
Chen et al., Memphis, United States. In Cell Signal, Feb 2015
These NRs are reportedly dysregulated in multiple cancer types, with many studies demonstrating pro-oncogenic roles for NR4A1 (Nur77) and NR4A2 (Nurr1).
The nuclear orphan receptor NR4A1 and NR4A3 as tumor suppressors in hematologic neoplasms.
Deutsch et al., Graz, Austria. In Curr Drug Targets, 2014
NR4A1 (Nur77) belongs together with NR4A2 (Nurr1) and NR4A3 (NOR-1) to the nuclear orphan receptors of the NR4A-family.
Elevated α-synuclein caused by SNCA gene triplication impairs neuronal differentiation and maturation in Parkinson's patient-derived induced pluripotent stem cells.
Jovin et al., Göttingen, Germany. In Cell Death Dis, 2014
This delayed maturation phenotype was confirmed by gene expression profiling, which revealed a significant reduction in mRNA for genes implicated in neuronal differentiation such as delta-like homolog 1 (DLK1), gamma-aminobutyric acid type B receptor subunit 2 (GABABR2), nuclear receptor related 1 protein (NURR1), G-protein-regulated inward-rectifier potassium channel 2 (GIRK-2) and tyrosine hydroxylase (TH).
Orphan nuclear receptor NR4A2 inhibits hepatic stellate cell proliferation through MAPK pathway in liver fibrosis.
Guo et al., Shanghai, China. In Peerj, 2014
NR4A2 is a nuclear receptor belonging to the NR4A subfamily and vital in regulating cell growth, metabolism, inflammation and other biological functions.
Impact of circadian nuclear receptor REV-ERBα on midbrain dopamine production and mood regulation.
Kim et al., Seoul, South Korea. In Cell, 2014
Also, REV-ERBα repressed tyrosine hydroxylase (TH) gene transcription via competition with nuclear receptor-related 1 protein (NURR1), another nuclear receptor crucial for dopaminergic neuronal function, thereby driving circadian TH expression through a target-dependent antagonistic mechanism.
A melanocyte lineage program confers resistance to MAP kinase pathway inhibition.
Garraway et al., Cambridge, United States. In Nature, 2014
These studies revealed a cyclic-AMP-dependent melanocytic signalling network not previously associated with drug resistance, including G-protein-coupled receptors, adenyl cyclase, protein kinase A and cAMP response element binding protein (CREB).
Nuclear receptor-mediated regulation of lipid droplet-associated protein gene expression in adipose tissue.
Christian, Coventry, United Kingdom. In Horm Mol Biol Clin Investig, 2013
Gene expression profiling reveals that most NRs are present in adipose tissues, with some showing greater expression in brown compared with white fat, including peroxisome proliferator-activated receptor (PPAR) α, estrogen-related receptor α, and NURR1.
Dual function of Pin1 in NR4A nuclear receptor activation: enhanced activity of NR4As and increased Nur77 protein stability.
de Vries et al., Amsterdam, Netherlands. In Biochim Biophys Acta, 2012
Pin1 enhances the transcriptional activity of all three NR4A nuclear receptors and increases protein stability of Nur77 through inhibition of its ubiquitination.
Exogenous Nurr1 gene expression in electrically-stimulated human MSCs and the induction of neurogenesis.
Park et al., South Korea. In Biomaterials, 2012
analysis of Nurr1 gene expression in electrically-stimulated human MSCs and the induction of neurogenesis
Conditional expression of Parkinson's disease-related mutant α-synuclein in the midbrain dopaminergic neurons causes progressive neurodegeneration and degradation of transcription factor nuclear receptor related 1.
Cai et al., Bethesda, United States. In J Neurosci, 2012
alpha-Synuclein-mediated suppression of transgenic Nurr1 protein overexpression contributes to the vulnerability of midbrain dopaminergic neurons in a model of Parkinson's disease pathogenesis.
In vitro generation of mature dopamine neurons by decreasing and delaying the expression of exogenous Nurr1.
Lee et al., Seoul, South Korea. In Development, 2012
It was shown that manipulating exogenous Nurr1 expression patterns to match those of the developing ventral midgrain generates morphologically and phenotypically mature dopaminergic neurons that exhibit presynaptic dopamine functions in vitro.
The function and mechanisms of Nurr1 action in midbrain dopaminergic neurons, from development and maintenance to survival.
Luo, Cleveland, United States. In Int Rev Neurobiol, 2011
Nurr1 is critical for the development and maintenance of midbrain dopaminergic (DA) neurons in mouse.
Mutations in NR4A2 associated with familial Parkinson disease.
Vassilatis et al., Houston, United States. In Nat Genet, 2003
Mutations in NR4A2 associated with familial Parkinson disease
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