Acute Myeloid Leukemia With Myelodysplasia-Related Changes.
Rochester, United States. In Am J Clin Pathol, Jul 2015
RESULTS: Session 3 of the workshop cases displayed heterogeneity as expected within AML-MRC, yet several cases suggested that recently recognized entities may exist within this category, such as familial MDS/AML predisposition syndromes and rare cases of high-risk AML associated with the cryptic t(5;11)(q35;p15);NUP98-NSD1 that may masquerade as a del(5q).
Hox gene dysregulation in acute myeloid leukemia.
Brest, France. In Future Oncol, 2014
Changes in HOX gene expression can be associated with chromosomal rearrangements generating fusion genes, such as those involving MLL and NUP98, or molecular defects, such as mutations in NPM1 and CEBPA for example.
Functional analysis of the NUP98-CCDC28A fusion protein.
Villejuif, France. In Haematologica, 2012
the recurrent NUP98-CCDC28A is an oncogene that induces a rapid and transplantable myeloid neoplasm in recipient mice. They also provide additional evidence for an alternative leukemogenic mechanism for NUP98 oncogenes.
Regulation of myeloid leukaemia by the cell-fate determinant Musashi.
Durham, United States. In Nature, 2010
As a possible explanation for the decreased levels of Numb in the blast crisis phase, we show that NUP98-HOXA9, an oncogene associated with blast crisis CML, can trigger expression of the RNA-binding protein Musashi2 (Msi2), which in turn represses Numb.
Haematopoietic malignancies caused by dysregulation of a chromatin-binding PHD finger.
New York City, United States. In Nature, 2009
Here we report that fusing an H3K4-trimethylation (H3K4me3)-binding PHD finger, such as the carboxy-terminal PHD finger of PHF23 or JARID1A (also known as KDM5A or RBBP2), to a common fusion partner nucleoporin-98 (NUP98) as identified in human leukaemias, generated potent oncoproteins that arrested haematopoietic differentiation and induced acute myeloid leukaemia in murine models.
Imaging hematopoietic precursor division in real time.
Durham, United States. In Cell Stem Cell, 2007
Oncoproteins can also influence division pattern: although BCR-ABL predominantly alters the rate of division and death, NUP98-HOXA9 promotes symmetric division, suggesting that distinct oncogenes subvert different aspects of cellular function.