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NUP133 Nup133p

Nup133, Nup133p
The nuclear envelope creates distinct nuclear and cytoplasmic compartments in eukaryotic cells. It consists of two concentric membranes perforated by nuclear pores, large protein complexes that form aqueous channels to regulate the flow of macromolecules between the nucleus and the cytoplasm. These complexes are composed of at least 100 different polypeptide subunits, many of which belong to the nucleoporin family. The nucleoporin protein encoded by this gene displays evolutionarily conserved interactions with other nucleoporins. This protein, which localizes to both sides of the nuclear pore complex at interphase, remains associated with the complex during mitosis and is targeted at early stages to the reforming nuclear envelope. This protein also localizes to kinetochores of mitotic cells. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Nucleoporin, Nup85, NUP120, CAN, ACID
Papers using Nup133 antibodies
Cell-cycle-dependent dynamics of nuclear pores: pore-free islands and lamins.
Klymkowsky Michael, In PLoS ONE, 2005
... Antibody to NUP133 was purchased from Abnova (product number H00055746-M01) ...
Papers on Nup133
Gene amplification during myogenic differentiation.
Meese et al., Homburg, Germany. In Oncotarget, Feb 2016
After differentiation induction we found an increase in copy numbers of CDK4 gene at day 3, of NUP133 at days 4 and 7, and of MYO18B at day 4.
Biallelic Mutations in Nuclear Pore Complex Subunit NUP107 Cause Early-Childhood-Onset Steroid-Resistant Nephrotic Syndrome.
Matsumoto et al., Yokohama, Japan. In Am J Hum Genet, Nov 2015
Three of four NUP107 mutations detected in the affected individuals hamper NUP107 binding to NUP133 (nucleoporin 133 kDa) and NUP107 incorporation into NPCs in vitro.
Rhizobial infection does not require cortical expression of upstream common symbiosis genes responsible for the induction of Ca(2+) spiking.
Hayashi et al., Tsukuba, Japan. In Plant J, 2014
To analyze the symbiotic gene requirements of the infection process, we have developed an epidermis-specific expression system (pEpi expression system) and examined the symbiotic genes NFR1, NFR5, NUP85, NUP133, CASTOR, POLLUX, CCaMK, CYCLOPS, NSP1 and NSP2 for involvement in the infection process in the epidermis and cortex.
Analysis of the Lotus japonicus nuclear pore NUP107-160 subcomplex reveals pronounced structural plasticity and functional redundancy.
Parniske et al., Martinsried, Germany. In Front Plant Sci, 2012
Mutations in the Lotus japonicus nucleoporin genes, NUP85, NUP133, and NENA (SEH1), lead to defects in plant-microbe symbiotic signaling.
Dissection of the NUP107 nuclear pore subcomplex reveals a novel interaction with spindle assembly checkpoint protein MAD1 in Caenorhabditis elegans.
Askjaer et al., Sevilla, Spain. In Mol Biol Cell, 2012
In contrast, NPP-5 is essential for proper kinetochore localization of NUP133/NPP-15, another NUP107 complex member, whereas recruitment of NUP96/NPP-10C and ELYS/MEL-28 is NPP-5 independent.
Architectural nucleoporins Nup157/170 and Nup133 are structurally related and descend from a second ancestral element.
Schwartz et al., Cambridge, United States. In J Biol Chem, 2009
Data present crystal structures of yNup170(979-1502) and hNup107(658-925) x hNup133(517-1156), and conservation of domain arrangement and of tertiary structure suggests that Nup157/170 and Nup133 derived from a common ancestor.
Structural and functional analysis of Nup120 suggests ring formation of the Nup84 complex.
Hoelz et al., New York City, United States. In Proc Natl Acad Sci U S A, 2009
As mapping of the individual components in the Nup84 complex places Nup120 and Nup133 at opposite ends of the heptamer, findings indicate a head-to-tail arrangement of elongated Nup84 complexes into a ring structure.
ER membrane-bending proteins are necessary for de novo nuclear pore formation.
Wente et al., Nashville, United States. In J Cell Biol, 2009
Analysis of Saccharomyces cerevisiae prp20-G282S and nup133 Delta NPC assembly mutants revealed perturbations in Rtn1-green fluorescent protein (GFP) and Yop1-GFP ER distribution and colocalization to NPC clusters.
Structural and functional studies of Nup107/Nup133 interaction and its implications for the architecture of the nuclear pore complex.
Schwartz et al., Cambridge, United States. In Mol Cell, 2008
The significant topological differences between Nup107 and Nup133 suggest that helical nucleoporin domains of the nuclear pore complex scaffold fall in different classes and fulfill largely nonredundant functions.
Yeast screens identify the RNA polymerase II CTD and SPT5 as relevant targets of BRCA1 interaction.
Marks et al., Durham, United States. In Plos One, 2007
These genes delineate a metabolic mRNA pathway that temporally links transcription elongation (SPT4, SPT5, CTK1, DEF1) to nucleopore-mediated mRNA export (ASM4, MLP1, MLP2, NUP2, NUP53, NUP120, NUP133, NUP170, NUP188, POM34) and cytoplasmic mRNA decay at P-bodies (CCR4, DHH1).
Purification, crystallization and preliminary X-ray analysis of a Nup107-Nup133 heterodimeric nucleoporin complex.
Schwartz et al., Cambridge, United States. In Acta Crystallogr Sect F Struct Biol Cryst Commun, 2007
When complexed with NUP107, this complex will give the first insights into the protein-protein interactions within a core module of the nuclear pore complex.
NUCLEOPORIN85 is required for calcium spiking, fungal and bacterial symbioses, and seed production in Lotus japonicus.
Kawaguchi et al., Saitama, Japan. In Plant Cell, 2007
Together with symbiotic nucleoporin NUP133, L. japonicus NUP85 might be part of a specific nuclear pore subcomplex that is crucial for fungal and rhizobial colonization and seed production.
Analysis of Nod-factor-induced calcium signaling in root hairs of symbiotically defective mutants of Lotus japonicus.
Downie et al., Norwich, United Kingdom. In Mol Plant Microbe Interact, 2006
Two classes of mutants (nfr1 and nfr5) lacked both calcium influx and calcium spiking, whereas five classes of mutants (symRK, castor, pollux, nup133, and sym24) defective for calcium spiking retained a calcium flux.
Telomere tethering at the nuclear periphery is essential for efficient DNA double strand break repair in subtelomeric region.
Fabre et al., Paris, France. In J Cell Biol, 2006
Here, using fluorescence microscopy in living cells, we show that nuclear pore proteins of the Nup84 core complex, Nup84p, Nup145Cp, Nup120p, and Nup133p, serve to anchor telomere XI-L at the nuclear periphery.
A nucleoporin is required for induction of Ca2+ spiking in legume nodule development and essential for rhizobial and fungal symbiosis.
Stougaard et al., Århus, Denmark. In Proc Natl Acad Sci U S A, 2006
Here we present positional cloning of a plant nucleoporin gene, Nup133, essential for a symbiotic signal transduction pathway shared by Rhizobium bacteria and mycorrhizal fungi.
Structural and functional analysis of Nup133 domains reveals modular building blocks of the nuclear pore complex.
Schwartz et al., New York City, United States. In J Cell Biol, 2004
human Nup133 contains two domains: a COOH-terminal domain responsible for its interaction with its subcomplex through Nup107; and an NH2-terminal domain whose crystal structure reveals a seven-bladed beta-propeller.
Identification of genes encoding putative nucleoporins and transport factors in the fission yeast Schizosaccharomyces pombe: a deletion analysis.
Balasundaram et al., Singapore, Singapore. In Yeast, 2004
encode putative nucleoporins with low similarity to the S. cerevisiae nucleoporins NUP2p, NUP53p and NUP133p, respectively.
Nuclear accumulation of the small GTPase Gsp1p depends on nucleoporins Nup133p, Rat2p/Nup120p, Nup85p, Nic96p, and the acetyl-CoA carboxylase Acc1p.
Stochaj et al., Montréal, Canada. In J Biol Chem, 2003
We show that the nucleoporins Nup133p, Rat2p/Nup120p, Nup85p, Nic96p, and the enzyme acetyl-CoA carboxylase (MTR7) control the distribution and cellular concentration of Gsp1p.
Deciphering networks of protein interactions at the nuclear pore complex.
Rexach et al., Stanford, United States. In Mol Cell Proteomics, 2002
Also unexpected were the interactions of various FG Nups with the nucleoporins Nup2p and Nup133p, the Gsp1p-GTPase-activating protein Rna1p, and the mRNA-binding protein Pab1p.
Modular self-assembly of a Y-shaped multiprotein complex from seven nucleoporins.
Hurt et al., Heidelberg, Germany. In Embo J, 2002
Here, we report the reconstitution of seven proteins (Nup133p, Nup145p-C, Nup120p, Nup85p, Nup84p, Seh1p and Sec13p) into a heptameric 0.5 MDa nuclear pore subcomplex.
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