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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Numb homolog

The protein encoded by this gene plays a role in the determination of cell fates during development. The encoded protein, whose degradation is induced in a proteasome-dependent manner by MDM2, is a membrane-bound protein that has been shown to associate with EPS15, LNX1, and NOTCH1. Four transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: FATE, CAN, V1a, p300, Ubiquitin
Papers using Numb antibodies
Notch1 signaling stimulates proliferation of immature cardiomyocytes
Giacca Mauro et al., In The Journal of Cell Biology, 2007
... obtained from Cell Signaling Technology; antisarcomeric α-actinin (EA-53) and anti-p21Cip1 antibodies were obtained from AbCam; anti-Numb antibodies were obtained from Millipore; and FITC-coupled anti-BrdU antibodies were obtained from BD Biosciences.
Papers on Numb
Calpain restrains the stem cells compartment in breast cancer.
Demarchi et al., Trieste, Italy. In Cell Cycle, Feb 2016
The expansion of the cancer stem cell population in CAPNS1 depleted cells is coupled to a defective shift from symmetric to asymmetric division during mammosphere growth coupled to a decrease in NUMB protein level.
Cancer mediates effector T cell dysfunction by targeting microRNAs and EZH2 via glycolysis restriction.
Zou et al., Ann Arbor, United States. In Nat Immunol, Jan 2016
EZH2 activated the Notch pathway by suppressing Notch repressors Numb and Fbxw7 via trimethylation of histone H3 at Lys27 and, consequently, stimulated T cell polyfunctional cytokine expression and promoted their survival via Bcl-2 signaling.
Identification of important long non-coding RNAs and highly recurrent aberrant alternative splicing events in hepatocellular carcinoma through integrative analysis of multiple RNA-Seq datasets.
Chen et al., Beijing, China. In Mol Genet Genomics, Jan 2016
With regard to splicing alterations, we identified nine highly recurrent differential splicing events belonging to eight genes USO1, RPS24, CCDC50, THNSL2, NUMB, FN1 (two events), SLC39A14 and NR1I3.
Numb deficiency in cerebellar Purkinje cells impairs synaptic expression of metabotropic glutamate receptor and motor coordination.
Shen et al., Hangzhou, China. In Proc Natl Acad Sci U S A, Jan 2016
Protein Numb, first identified as a cell-fate determinant in Drosophila, has been shown to promote the development of neurites in mammals and to be cotransported with endocytic receptors in clathrin-coated vesicles in vitro.
Aberrant expression of Notch1, HES1, and DTX1 genes in glioblastoma formalin-fixed paraffin-embedded tissues.
Chand et al., Bengaluru, India. In Tumour Biol, Jan 2016
Using real-time PCR, we assessed the expression of Notch genes including receptors (Notch1, Notch2, Notch3, and Notch4), ligands (JAG1, JAG2, and DLL3), downstream targets (HES1 and HEY2), regulator Deltex1 (DTX1), inhibitor NUMB along with transcriptional co-activator MAML1, and a component of gamma-secretase complex APH1A in 15 formalin-fixed paraffin-embedded (FFPE) patient samples.
Differentiation therapy for hepatocellular carcinoma: Multifaceted effects of miR-148a on tumor growth and phenotype and liver fibrosis.
Beretta et al., Houston, United States. In Hepatology, Dec 2015
These effects were associated with an increased differentiated phenotype and were mediated by IKKα/NUMB/NOTCH signaling.
Numb family proteins: novel players in cardiac morphogenesis and cardiac progenitor cell differentiation.
Li et al., In Biomol Concepts, Apr 2015
Two of the genes that were recently discovered to be involved in cardiac morphogenesis are Numb and Numblike.
TLR4-dependent tumor-initiating stem cell-like cells (TICs) in alcohol-associated hepatocellular carcinogenesis.
Tsukamoto et al., Los Angeles, United States. In Adv Exp Med Biol, 2014
TLR4/NANOG activation causes p53 degradation via phosphorylation of the protective protein NUMB and its dissociation from p53 by the oncoprotein TBC1D15.
Notch activity in neural progenitors coordinates cytokinesis and asymmetric differentiation.
Desplan et al., Abu Dhabi, United Arab Emirates. In Sci Signal, 2014
Although it was known that Notch signaling acts postmitotically to orchestrate differentiation of daughter cells from asymmetrically dividing precursor cells, Bhat reported a previously uncharacterized role for Notch that occurs before cell division to promote the asymmetric localization of the protein Numb and the positioning of the cleavage furrow.
NUMB inhibition of NOTCH signalling as a therapeutic target in prostate cancer.
Marignol et al., New York City, United States. In Nat Rev Urol, 2014
NUMB (protein numb homologue), a key regulator of cell fate, represents an attractive, actionable target in prostate cancer.
MicroRNA-146a directs the symmetric division of Snail-dominant colorectal cancer stem cells.
Yang et al., In Nat Cell Biol, 2014
miR-146a targets Numb to stabilize β-catenin, which forms a feedback circuit to maintain Wnt activity and directs SCD.
A microRNA-operated switch of asymmetric-to-symmetric cancer stem cell divisions.
Petritsch et al., San Francisco, United States. In Nat Cell Biol, 2014
A signalling axis involving Snail, microRNA-146a and Numb is now shown to regulate the switch between symmetric and asymmetric cell division in colorectal cancer stem cells.
Adaptor proteins involved in polarized sorting.
Bonifacino, Bethesda, United States. In J Cell Biol, 2014
The clathrin-associated adaptor protein 1 (AP-1) complex plays a preeminent role in this process, although other adaptors and coat proteins, such as AP-4, ARH, Numb, exomer, and retromer, have also been implicated.
The clathrin adaptor Numb regulates intestinal cholesterol absorption through dynamic interaction with NPC1L1.
Song et al., Shanghai, China. In Nat Med, 2014
Cholesterol binding on the N-terminal domain of NPC1L1 released the YVNXXF-containing region of NPC1L1 from association with the plasma membrane and enabled Numb binding.
A microRNA miR-34a-regulated bimodal switch targets Notch in colon cancer stem cells.
Shen et al., Ithaca, United States. In Cell Stem Cell, 2013
In contrast, the canonical cell-fate determinant Numb regulates Notch levels in a continuously graded manner.
Distinct expression profiles of MSI2 and NUMB genes in myelodysplastic syndromes and acute myeloid leukemia patients.
Favaro et al., Campinas, Brazil. In Leuk Res, 2012
Down-modulation of NUMB is associated with myelodysplastic syndromes and acute myeloid leukemia.
Numb expression and asymmetric versus symmetric cell division in distal embryonic lung epithelium.
Warburton et al., Los Angeles, United States. In J Histochem Cytochem, 2012
The more perpendicular/asymmetric cell division is, the more likely it is to segregate Numb preferentially to one daughter cell in mitotic lung epithelial progenitors.
Numb regulates stability and localization of the mitotic kinase PLK1 and is required for transit through mitosis.
Ahmad et al., Madison, United States. In Cancer Res, 2012
Dysregulation of Numb expression results in mislocalized Plk1 and poor centrosomal gamma-tubulin recruitment, potentially contributing to mitotic errors, aneuploidy, and cancer development.
Numb regulates glioma stem cell fate and growth by altering epidermal growth factor receptor and Skp1-Cullin-F-box ubiquitin ligase activity.
Johnson et al., Boston, United States. In Stem Cells, 2012
Numb regulates glioma stem cell fate and growth by altering epidermal growth factor receptor and Skp1-Cullin-F-box ubiquitin ligase activity
Interaction of Notch signaling modulator Numb with α-Adaptin regulates endocytosis of Notch pathway components and cell fate determination of neural stem cells.
Lu et al., Stanford, United States. In J Biol Chem, 2012
Interaction of Notch signaling modulator Numb with alpha-Adaptin regulates endocytosis of Notch pathway components and cell fate determination of neural stem cells.
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