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Nuclear mitotic apparatus protein 1

NuMA, NuMA protein, Nuclear Mitotic Apparatus protein
Top mentioned proteins: CAN, ACID, dynactin, PML, RAR
Papers using NuMA antibodies
Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation
Supplier
Gruneberg Ulrike et al., In The Journal of Cell Biology, 1997
... A302-372A; Bethyl Laboratories, Inc.), CREST (human auto-antiserum; Europa Bioproducts Ltd.), KID (rabbit AKIN12-A; Cytoskeleton, Inc.), NuMa (mouse AB5673; Abcam), PP1-α (rabbit 2582; Cell ...
Papers on NuMA
NuMA-microtubule interactions are critical for spindle orientation and the morphogenesis of diverse epidermal structures.
New
Lechler et al., Nashville, United States. In Elife, Feb 2016
A complex of NuMA and dynein/dynactin is required for robust spindle orientation in a number of cell types.
Concomitant binding of Afadin to LGN and F-actin directs planar spindle orientation.
New
Mapelli et al., Milano, Italy. In Nat Struct Mol Biol, Feb 2016
To orient the mitotic spindle, cortical cues trigger the recruitment of NuMA-dynein-based motors, which pull on astral microtubules via the protein LGN.
SAPCD2 Controls Spindle Orientation and Asymmetric Divisions by Negatively Regulating the Gαi-LGN-NuMA Ternary Complex.
New
Angers et al., Toronto, Canada. In Dev Cell, Feb 2016
Proper spatiotemporal localization of the evolutionarily conserved Gαi-LGN-NuMA protein complex is critical for mitotic spindle orientation, but how this is achieved remains unclear.
Tug of War in Spindle Orientation.
New
Wang et al., Singapore, Singapore. In Dev Cell, Feb 2016
The evolutionarily conserved Gαi-LGN-NuMA protein complex is a key regulator of spindle orientation, but how its spatiotemporal localization is achieved remains elusive.
Ubiquitin in regulation of spindle apparatus and its positioning: implications in development and disease.
Review
New
Chakrabarti et al., Calcutta, India. In Biochem Cell Biol, Aug 2015
In this review we discuss how various E3 ligases modulate the cortical proteins such as dynein, LGN, NuMa, Gα, along with polymerization, stability, and integrity of spindles.
Tank binding kinase 1 is a centrosome-associated kinase necessary for microtubule dynamics and mitosis.
Chellappan et al., Tampa, United States. In Nat Commun, 2014
TBK1 binds to the centrosomal protein CEP170 and to the mitotic apparatus protein NuMA, and both CEP170 and NuMA are TBK1 substrates.
Mechanisms of spindle positioning: cortical force generators in the limelight.
Review
Gönczy et al., Lausanne, Switzerland. In Curr Opin Cell Biol, 2013
At the heart of this machinery lies a ternary complex (LIN-5/GPR-1/2/Gα in Caenorhabditis elegans and NuMA/LGN/Gαi in Homo sapiens) that promotes the presence of the motor protein dynein at the cell cortex.
Going vertical: functional role and working principles of the protein Inscuteable in asymmetric cell divisions.
Review
Mapelli et al., Milano, Italy. In Cell Mol Life Sci, 2013
To date, the molecular explanation to account for this phenotype envisioned Insc as an adaptor molecule bridging between the polarity proteins Par3:Par6:aPKC and the spindle pulling machines assembled on NuMA:LGN:Gαi.
On the inscrutable role of Inscuteable: structural basis and functional implications for the competitive binding of NuMA and Inscuteable to LGN.
Review
Gonzalez et al., Milano, Italy. In Open Biol, 2012
The protein network coordinating the spindle position with cortical polarity includes the molecular machinery pulling on astral microtubules, which is assembled on conserved NuMA:LGN:Gαi complexes, the polarity proteins Par3:Par6:aPKC and an adaptor molecule known as Inscuteable (Insc).
Error-prone mammalian female meiosis from silencing the spindle assembly checkpoint without normal interkinetochore tension.
GeneRIF
Verlhac et al., Paris, France. In Proc Natl Acad Sci U S A, 2012
Without functional NuMA, microtubules lose connection to meiosis I spindle poles, resulting in highly disorganized early spindle assembly.
Chromosome- and spindle-pole-derived signals generate an intrinsic code for spindle position and orientation.
Impact
Cheeseman et al., Cambridge, United States. In Nat Cell Biol, 2012
We find that this signal comprises the spindle-pole-localized polo-like kinase (Plk1), which regulates dynein localization by controlling the interaction between dynein-dynactin and its upstream cortical targeting factors NuMA and LGN.
Early apoptotic reorganization of spliceosomal proteins involves caspases, CAD and rearrangement of NuMA.
GeneRIF
Muller et al., Strasbourg, France. In Traffic, 2012
During apoptotic rearrangement of interchromatin granule clusters, the nuclear matrix (NuMa rearrangement) and chromatin are closely associated. This process occurs in defined stages and depends on the activity of protein phosphatases, caspases and CAD.
Centrosome dynamics during mammalian oocyte maturation with a focus on meiotic spindle formation.
Review
Sun et al., Columbia, United States. In Mol Reprod Dev, 2011
The present review is focused on cytoskeletal and centrosome remodeling during oocyte maturation, with specific attention to γ-tubulin, pericentrin, the Nuclear Mitotic Apparatus (NuMA) protein, and microtubule organization.
aPKC phosphorylates NuMA-related LIN-5 to position the mitotic spindle during asymmetric division.
Impact
van den Heuvel et al., Utrecht, Netherlands. In Nat Cell Biol, 2011
In animals, an evolutionarily conserved pathway of LIN-5 (homologues: Mud and NuMA), GPR-1/2 (homologues: Pins, LGN, AGS-3) and Gα mediates spindle positioning, and acts downstream of the conserved PAR-3-PAR-6-aPKC polarity complex.
The nuclear mitotic apparatus (NuMA) protein: localization and dynamics in human oocytes, fertilization and early embryos.
GeneRIF
Rawe et al., Buenos Aires, Argentina. In Mol Hum Reprod, 2011
Accurate distribution of NuMA is important for oocyte maturation, zygote and embryo development in humans. Proper assembly of NuMA is likely necessary for bipolar spindle organization and human oocyte developmental competence.
Correlation among nuclear localization of NuMA-RARα, deregulation of gene expression and leukemic phenotype of hCG-NuMA-RARα transgenic mice.
GeneRIF
Kamel-Reid et al., Toronto, Canada. In Leuk Res, 2011
Phenotype onset is correlated with NuMA-RARalpha copy number; mice with higher copy number developing disease later than those with lower copy number.
Dynamic distribution of NuMA and microtubules in human fetal fibroblasts, developing oocytes and somatic cell nuclear transferred embryos.
GeneRIF
Lu et al., Changsha, China. In Hum Reprod, 2011
NuMA is expressed in interphase nuclei of fibroblasts and oocytes.
Asymmetric cell divisions promote Notch-dependent epidermal differentiation.
Impact
Fuchs et al., New York City, United States. In Nature, 2011
Evidence from invertebrates shows that this process is regulated by proteins asymmetrically distributed at the cell cortex during mitosis: Par3-Par6-aPKC, which confer polarity, and Gα(i)-LGN/AGS3-NuMA-dynein/dynactin, which govern spindle positioning.
NuMA-related LIN-5, ASPM-1, calmodulin and dynein promote meiotic spindle rotation independently of cortical LIN-5/GPR/Galpha.
Impact
van den Heuvel et al., Utrecht, Netherlands. In Nat Cell Biol, 2009
Spindle positioning is controlled by an evolutionarily conserved pathway, which involves LIN-5/GPR-1/2/Galpha in Caenorhabditis elegans, Mud/Pins/Galpha in Drosophila and NuMA/LGN/Galpha in humans.
Drosophila Pins-binding protein Mud regulates spindle-polarity coupling and centrosome organization.
Impact
Matsuzaki et al., Kōbe, Japan. In Nat Cell Biol, 2006
We propose that Drosophila Mud, vertebrate NuMA and Caenorhabditis elegans Lin-5 (refs 5, 6) have conserved roles in the mechanism by which G-proteins regulate the mitotic spindle.
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