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Nuclear distribution gene C homolog

This gene encodes a nuclear distribution protein that plays an essential role in mitosis and cytokinesis. The encoded protein is involved in spindle formation during mitosis and in microtubule organization during cytokinesis. Pseudogenes of this gene are found on chromosome 2. [provided by RefSeq, Feb 2012] (from NCBI)
Top mentioned proteins: 1-Alkyl-2-acetylglycerophosphocholine Esterase, CAN, thrombopoietin, ACID, MPL
Papers on NudC
NudC regulates actin dynamics and ciliogenesis by stabilizing cofilin 1.
Zhou et al., Hangzhou, China. In Cell Res, Jan 2016
Here we find that nuclear distribution gene C (NudC), an Hsp90 co-chaperone, is required for actin organization and dynamics.
The Krüppel-Like Factor Dar1 Determines Multipolar Neuron Morphology.
Ye et al., Ann Arbor, United States. In J Neurosci, Nov 2015
Dar1 regulates the expression of several dynein genes and nuclear distribution protein C (nudC), which is an essential component of a specialized dynein complex that positions the nucleus in a cell.
NAD captureSeq indicates NAD as a bacterial cap for a subset of regulatory RNAs.
Jäschke et al., Heidelberg, Germany. In Nature, Apr 2015
Analogous to a eukaryotic cap, 5'-NAD modification is shown in vitro to stabilize RNA against 5'-processing by the RNA-pyrophosphohydrolase RppH and against endonucleolytic cleavage by ribonuclease (RNase) E. The nudix phosphohydrolase NudC decaps NAD-RNA and thereby triggers RNase-E-mediated RNA decay, while being inactive against triphosphate-RNA.
EML4 promotes the loading of NUDC to the spindle for mitotic progression.
Senga et al., Nagoya, Japan. In Cell Cycle, 2014
We searched for EML4-associating proteins by mass spectrometry analysis and found that the nuclear distribution gene C (NUDC) protein, which is a critical factor for the progression of mitosis, was associated with EML4.
NudC Nudix hydrolase from Pseudomonas syringae, but not its counterpart from Pseudomonas aeruginosa, is a novel regulator of intracellular redox balance required for growth, motility and biofilm formation.
Kraszewska et al., Warsaw, Poland. In Mol Microbiol, 2014
We have investigated NudC Nudix proteins from the plant pathogen Pseudomonas syringae pv.
A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways.
Lindquist et al., Cambridge, United States. In Cell, 2014
As a salient example of the power of such analysis, we establish that NUDC family cochaperones specifically associate with structurally related but evolutionarily distinct β-propeller folds.
Transcriptional profiling of erythroid progenitors from G-CSF mobilized and nonmobilized peripheral blood.
Jovcic et al., Belgrade, Serbia. In J Buon, 2014
Regarding G-CSF stimulation the G-CSF receptor CSF2RB (1.1-fold) was linked via STAT3 to erythroid-specific ALAS2 (2.9-fold) and GATA2 (1.3-fold) factors, all upregulated in mPB-derived erythroid progenitors, coupled to common upregulated NUDC gene involved in the proliferation of erythroid cells.
Overexpression of nuclear distribution protein (hNUDC) causes pro-apoptosis and differentiation in Dami megakaryocytes.
Zhang et al., Guangzhou, China. In Cell Prolif, 2013
OBJECTIVES: Overexpression of hNUDC, a member of the nuclear distribution protein family, reduces cell population growth in prostate cancer cell lines, concurrent with induced morphological change and enhanced polyploidization.
NudC deacetylation regulates mitotic progression.
Yu-Lee et al., Houston, United States. In Plos One, 2012
Nuclear distribution protein C (NudC), a conserved protein that regulates cell division, was previously shown to be acetylated.
A unique role of dynein and nud family proteins in corticogenesis.
Hirotsune et al., Ōsaka, Japan. In Neuropathology, 2012
In addition, we report that mNUDC (mammalian NUDC) interacts with kinesin-1 and is required for the anterograde transport of a cytoplasmic dynein complex by kinesin-1.
ASYMMETRIC-LEAVES2 and an ortholog of eukaryotic NudC domain proteins repress expression of AUXIN-RESPONSE-FACTOR and class 1 KNOX homeobox genes for development of flat symmetric leaves in Arabidopsis.
Machida et al., Nagoya, Japan. In Biol Open, 2012
EAL encodes BOBBER1 (BOB1), an Arabidopsis ortholog of eukaryotic NudC domain proteins.
Live-cell visualization of intracellular interaction between a nuclear migration protein (hNUDC) and the thrombopoietin receptor (Mpl).
Xu et al., Guangzhou, China. In Plos One, 2011
We previously demonstrated that endogenous hNUDC and Mpl co-localized in the perinuclear and cytoplasmic regions of megakaryocyte cells by indirect immunofluorescence.
[Expression and clinical significance of human nuclear distribution C in nasopharyngeal carcinoma].
Lu et al., Guangzhou, China. In Lin Chuang Er Bi Yan Hou Ke Za Zhi, 2011
Human nuclear distribution C is found to be closely associated with cell malignant hyperplasia in nasopharyngeal carcinoma.
The L279P mutation of nuclear distribution gene C (NudC) influences its chaperone activity and lissencephaly protein 1 (LIS1) stability.
Zhou et al., Hangzhou, China. In J Biol Chem, 2010
NudC may be involved in the regulation of LIS1 stability by its chaperone function.
Identification of the residues in the extracellular domain of thrombopoietin receptor involved in the binding of thrombopoietin and a nuclear distribution protein (human NUDC).
Xu et al., Guangzhou, China. In J Biol Chem, 2010
separate binding sites on the Mpl receptor for TPO and hNUDC identified
Cytokinesis and cancer: Polo loves ROCK'n' Rho(A).
Xu et al., Beijing, China. In J Genet Genomics, 2010
We review current understandings of the interplay between Plk1, RhoA proteins and other proteins (e.g., NudC, MKLP2, PRC1, CEP55) involved in cytokinesis, with particular emphasis of its clinical implications in cancer.
mNUDC is required for plus-end-directed transport of cytoplasmic dynein and dynactins by kinesin-1.
Hirotsune et al., Ōsaka, Japan. In Embo J, 2010
An essential role of mNUDC for anterograde transport of dynein and dynactin by kinesin-1.
Interference RNA (RNAi)-based silencing of endogenous thrombopoietin receptor (Mpl) in Dami cells resulted in decreased hNUDC-mediated megakaryocyte proliferation and differentiation.
Xu et al., Guangzhou, China. In Exp Cell Res, 2010
Mpl plays an important and specific role in mediating hNUDC-induced megakaryocyte proliferation and differentiation.
The mammalian NudC-like genes: a family with functions other than regulating nuclear distribution.
Lazo et al., Oviedo, Spain. In Cell Mol Life Sci, 2009
Nuclear distribution gene C homolog (NudC) is a highly conserved gene.
The nuclear migration gene NudC and human hematopoiesis.
Miller et al., United States. In Leuk Lymphoma, 2000
The filamentous fungus Aspergillus nidulans nudC (nuclear distribution C) gene is required for movement of nuclei following mitosis and for normal colony growth.
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