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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Uveal autoantigen with coiled-coil domains and ankyrin repeats

Nucling, UACA, betacap73, Uveal autoantigen with coiled coil domains and ankyrin repeats
Papers on Nucling
Down-regulated expression of apoptosis-associated genes APIP and UACA in non-small cell lung carcinoma.
Benkova et al., Praha, Czech Republic. In Int J Oncol, 2012
The down-regulation of APIP and UACA expression suggests that the threshold to activate the apoptosome apparatus may be decreased in non-small cell lung cancer cells.
NF-kappaB regulates the expression of Nucling, a novel apoptosis regulator, with involvement of proteasome and caspase for its degradation.
Fukui et al., Tokushima, Japan. In J Biochem, 2010
Nucling expression is induced by canonical NF-kappaB signalling pathway, whereas Nucling is undergoing proteasome degradation, as well as being cleaved by caspase system under stress conditions
Inflammatory disease and cancer with a decrease in Kupffer cell numbers in Nucling-knockout mice.
Fukui et al., Tokushima, Japan. In Int J Cancer, 2010
Nucling deficiency could be a powerful tool to reveal the NF-kappaB-related molecular networks leading to hepatitis and hepatocellular carcinoma development.
Nucling interacts with nuclear factor-kappaB, regulating its cellular distribution.
Fukui et al., Tokushima, Japan. In Febs J, 2009
a novel function of Nucling as a suppressor of nuclear factor-kappaB, mediated by its cytoplasmic retention through physical interaction
Attenuation of MPTP-induced neurotoxicity and locomotor dysfunction in Nucling-deficient mice via suppression of the apoptosome pathway.
Fukui et al., Tokushima, Japan. In J Neurochem, 2006
These results indicate an important role for Nucling in MPTP-induced neuronal degeneration and suggest that the suppression of Nucling would be of therapeutic benefit for the treatment of neurodegeneration in PD.
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