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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Non-metastatic cells 4, protein expressed in

nucleoside diphosphate kinase, NDK
The nucleoside diphosphate (NDP) kinases (EC 2.7.4.6) are ubiquitous enzymes that catalyze transfer of gamma-phosphates, via a phosphohistidine intermediate, between nucleoside and dioxynucleoside tri- and diphosphates. The enzymes are products of the nm23 gene family, which includes NME4 (Milon et al., 1997 [PubMed 9099850]).[supplied by OMIM, May 2008] (from NCBI)
Top mentioned proteins: nm23, ACID, CAN, fibrillin-1, H1
Papers on nucleoside diphosphate kinase
Extreme dNTP pool changes and hypermutability in dcd ndk strains.
New
Miller et al., Los Angeles, United States. In Mutat Res, Jan 2016
In the work presented here, we show that double mutants of Escherichia coli lacking both DCD and NDK (nucleoside diphosphate kinase) have even more extreme imbalances of dNTPs than mutants lacking only one or the other of these enzymes.
EliA is required for inducing the stearyl alcohol-mediated expression of secretory proteins and production of polyester in Ralstonia sp. NT80.
New
Ishizuka et al., In Microbiology, Jan 2016
Comparative proteomic analysis of extracellular proteins from NT80 cells, grown in the presence or absence of stearyl alcohol, revealed that stearyl alcohol induced expressions of several secretory proteins including lipase (LipA), hemolysin-coregulated protein (Hcp), and nucleoside diphosphate kinase (Ndk).
Identification of critical genes and gene interaction networks that mediate osteosarcoma metastasis to the lungs.
New
Han et al., Yantai, China. In Exp Ther Med, Nov 2015
The following DEGs were associated with metastasis: Homeobox only protein; lysosomal-associated membrane protein-3; chemokine (C-C motif) ligand-18; carcinoembryonic antigen-related cell adhesion molecule-6; keratin-19; prostaglandin-endoperoxide synthase-2; clusterin; and nucleoside diphosphate kinase-1.
Janus-faces of NME-oncoprotein interactions.
Review
New
Boyd et al., Liverpool, United Kingdom. In Naunyn Schmiedebergs Arch Pharmacol, Feb 2015
To date, there are ten identified members of this family of genes, and these can be dichotomized into groups both taxonomically and by the presence or absence of their nucleoside diphosphate kinase activity with NMEs 1-4 encoding nucleoside diphosphate kinases (NDPKs) and NMEs 5-9 plus RP2 displaying little if any NDPK activity.
Modulation of cytoskeletal dynamics by mammalian nucleoside diphosphate kinase (NDPK) proteins.
Review
New
Omary et al., Ann Arbor, United States. In Naunyn Schmiedebergs Arch Pharmacol, Feb 2015
Nucleoside diphosphate kinase (NDPK) proteins comprise a family of ten human isoforms that participate in the regulation of multiple cellular processes via enzymatic and nonenzymatic functions.
Clues to the functions of plant NDPK isoforms.
Review
New
Rivoal et al., Montréal, Canada. In Naunyn Schmiedebergs Arch Pharmacol, Feb 2015
This review describes the five nucleoside diphosphate kinase (NDPK) genes found in both model plants Arabidopsis thaliana (thale cress) and Oryza sativa L. (rice).
Senescence-Associated Changes in Proteome and O-GlcNAcylation Pattern in Human Peritoneal Mesothelial Cells.
Witowski et al., Vienna, Austria. In Biomed Res Int, 2014
Comparison of protein pattern of senescent and young HPMC revealed 29 differentially abundant protein spots, 11 of which were identified to be actin (cytoplasmic 1 and 2), cytokeratin-7, cofilin-2, transgelin-2, Hsp60, Hsc70, proteasome β-subunits (type-2 and type-3), nucleoside diphosphate kinase A, and cytosolic 5'(3')-deoxyribonucleotidase.
Alterations in reversible protein histidine phosphorylation as intracellular signals in cardiovascular disease.
Review
Attwood et al., Mannheim, Germany. In Front Pharmacol, 2014
More recently, it has become evident that the nucleoside diphosphate kinase isoform B (NDPK-B), an ubiquitously expressed enzyme involved in nucleotide metabolism, and a highly specific phosphohistidine phosphatase (PHP) form a regulatory histidine protein kinase/phosphatase system in mammals.
Cell Signaling and Differential Protein Expression in Neuronal Differentiation of Bone Marrow Mesenchymal Stem Cells with Hypermethylated Salvador/Warts/Hippo (SWH) Pathway Genes.
Wang et al., T'ai-chung-shih, Taiwan. In Plos One, 2014
Further, cellular levels of protein kinase C epsilon type (PKC-ε) and kinesin heavy chain (KIF5B) increased with time of induction, whereas the level of NME/NM23 nucleoside diphosphate kinase 1 (Nm23-H1) decreased during the time course of differentiation.
Enzymes involved in metabolism of extracellular nucleotides and nucleosides: functional implications and measurement of activities.
Review
Yegutkin, Turku, Finland. In Crit Rev Biochem Mol Biol, 2014
Along with "classical" inactivating ectoenzymes, recent data provide evidence for the co-existence of a counteracting ATP-regenerating pathway comprising the enzymes of the adenylate kinase (AK) and nucleoside diphosphate kinase (NDPK/NME/NM23) families and ATP synthase.
The Drosophila metastasis suppressor gene Nm23 homolog, awd, regulates epithelial integrity during oogenesis.
GeneRIF
Hsu et al., Charleston, United States. In Mol Cell Biol, 2009
Data show that awd modulates the level and localization of adherens junction components via endocytosis, and is involved in regulating morphogenesis.
YNK1, the yeast homolog of human metastasis suppressor NM23, is required for repair of UV radiation- and etoposide-induced DNA damage.
GeneRIF
Kaetzel et al., Lexington, United States. In Mutat Res, 2009
The study indicates a novel role for YNK1 in DNA repair in yeast, and suggests an anti-mutator function that may contribute to the metastasis suppressor function of NM23-H1 in humans.
Structure of Ynk1 from the yeast Saccharomyces cerevisiae.
GeneRIF
Chen et al., Shanghai, China. In Acta Crystallogr Sect F Struct Biol Cryst Commun, 2008
Crystal structure of Ynk1 provides further insights into the interface and interactions between the dimers and the conserved residues involved in quaternary-structure formation.
High expression of ERCC1, FLT1, NME4 and PCNA associated with poor prognosis and advanced stages in myelodysplastic syndrome.
GeneRIF
Bruchova et al., Praha, Czech Republic. In Leuk Lymphoma, 2008
High expression of ERCC1, FLT1, NME4 and PCNA in myelodysplastic syndrome was associated with poor prognosis and disease progression along the sequence of 5q-syndrome/RCMD/RAEB/de novo AML
Awd, the homolog of metastasis suppressor gene Nm23, regulates Drosophila epithelial cell invasion.
GeneRIF
Hsu et al., Charleston, United States. In Mol Cell Biol, 2008
Awd is a negative regulator of ovary border-cell migration. Down-regulation allows optimal spatial signaling via Pvr & JAK/STAT. Overexpression stalls migration & reverts the phenotype of overexpressing constitutive Pvr or dominant-negative dynamin.
A functional protein chip for pathway optimization and in vitro metabolic engineering.
Impact
Stephanopoulos et al., Cambridge, United States. In Science, 2004
We provide concept validation with the sequential reactions catalyzed by luciferase and nucleoside diphosphate kinase and further illustrate this method with the optimization of the five-step pathway for trehalose synthesis.
Tumor suppressor NM23-H1 is a granzyme A-activated DNase during CTL-mediated apoptosis, and the nucleosome assembly protein SET is its inhibitor.
Impact
Lieberman et al., Boston, United States. In Cell, 2003
We show that GAAD is NM23-H1, a nucleoside diphosphate kinase implicated in suppression of tumor metastasis, and its specific inhibitor (IGAAD) is SET.
Phytochrome signalling is mediated through nucleoside diphosphate kinase 2.
Impact
Song et al., Kwangju, South Korea. In Nature, 1999
Here we report that nucleoside diphosphate kinase 2 (NDPK2) is an upstream component in the phytochrome signalling pathway in the plant Arabidopsis thaliana.
Human c-myc transcription factor PuF identified as nm23-H2 nucleoside diphosphate kinase, a candidate suppressor of tumor metastasis.
Impact
Ferrone et al., Princeton, United States. In Science, 1993
DNA sequence analysis of recombinant PuF revealed perfect identity with the human nm23-H2 nucleoside diphosphate kinase gene, a potential negative regulator of cancer metastasis.
Drosophila awdK-pn, a homologue of the metastasis suppressor gene nm23, suppresses the Tum-1 haematopoietic oncogene.
Impact
Dearolf et al., Boston, United States. In Nat Genet, 1993
It is known that nm23 genes encode nucleoside diphosphate kinase polypeptides, but the regulatory pathways involving Nm23 are unclear.
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