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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 30 Oct 2014.

Nucleolin

nucleolin, NCL, C23, Nucl, CLN5
Nucleolin (NCL), a eukaryotic nucleolar phosphoprotein, is involved in the synthesis and maturation of ribosomes. It is located mainly in dense fibrillar regions of the nucleolus. Human NCL gene consists of 14 exons with 13 introns and spans approximately 11kb. The intron 11 of the NCL gene encodes a small nucleolar RNA, termed U20. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, V1a, ACID, HAD, fibrillin-1
Papers using nucleolin antibodies
A phase I trial of adeno-associated virus serotype 1-γ-Sarcoglycan gene therapy for limb girdle muscular dystrophy type 2C
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Danos Olivier et al., In Molecular Therapy. Nucleic Acids, 2011
... Dystrophin and α-actinin proteins were detected by probing the membrane with 1:100 dilution of NCL-DYS1 primary antibody (monoclonal antibody to dystrophin R8 repeat; NovoCastra) and 1:200 dilution of α-actinin primary antibody (Santa Cruz Biotechnology), respectively ...
Accurate quantification of dystrophin mRNA and exon skipping levels in duchenne muscular dystrophy
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Aartsma-Rus Annemieke et al., In Molecular Therapy. Nucleic Acids, 2009
... dried milk (Campina Melkunie, Maasdam, the Netherlands) in TBS followed by an overnight incubation with NCL-DYS1 (dilution 1:125; Novacastra, Leica Microsystems, Valkerswaard, the Netherlands) ...
Use of peptide synthesis to probe viral antigens for epitopes to a resolution of a single amino acid
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Brünner Nils et al., In Histopathology, 2008
... GmbH), and for ELISA and immunoblotting experiments the corresponding CB11 antibody concentrate was employed (Novocastra NCL-CB11; Leica Microsystems A/S, Ballerup, Denmark) ...
Tumorigenesis suppressor Pdcd4 down-regulates mitogen-activated protein kinase kinase kinase kinase 1 expression to suppress colon carcinoma cell invasion
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Arlt Alexander, In PLoS ONE, 2005
... Anti-luciferase antibody came from Promega, anti-nucleolin and anti-IκB antibody from Santa Cruz Biotechnology, anti-HIF-1α and anti-p21 antibody ...
Neurological disease in HIV-infected patients in the era of highly active antiretroviral treatment: a Brazilian experience
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Adad Sheila Jorge et al., In AIDS Research and Treatment, 2005
... reaction (polymer technique) was made in some cases using monoclonal antibodies for toxoplasma (Novocastra-NCL-TG-TP3), cytomegalovirus (Novocastra-NCL-CMV-pp65), herpes virus (Dako HSV-I and II), JC ...
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Papers on nucleolin
Cell surface nucleolin interacts with CXCR4 receptor via the 212 C-terminal portion.
New
Wang et al., Jinan, China. In Tumour Biol, 19 Nov 2014
UNLABELLED: Previously, we reported that CXCR4 receptor interacted with cell surface nucleolin, and the synergy of CXCR4 and nucleolin plays an essential role in malignant transformation.
Neuronal Ceroid Lipofuscinosis: The Increasing Spectrum of an Old Disease.
New
Santorelli et al., Verona, Italy. In Curr Mol Med, 10 Nov 2014
UNLABELLED: Neuronal Ceroid Lipofuscinoses (NCL) are genetically heterogeneous heritable neurodegenerative disorders with worldwide distribution.
Nucleolin: dual roles in rDNA chromatin transcription.
Review
New
Sáez-Vásquez et al., Perpignan, France. In Gene, 12 Oct 2014
UNLABELLED: Nucleolin is a major nucleolar protein conserved in all eukaryotic organisms.
C9orf72 nucleotide repeat structures initiate molecular cascades of disease.
New
Impact
Wang et al., Baltimore, United States. In Nature, Apr 2014
Specifically, nucleolin, an essential nucleolar protein, preferentially binds the HRE G-quadruplex, and patient cells show evidence of nucleolar stress.
Induced expression of nucleolin phosphorylation-deficient mutant confers dominant-negative effect on cell proliferation.
New
Saxena et al., New York City, United States. In Plos One, Dec 2013
Nucleolin (NCL) is a major nucleolar phosphoprotein that has pleiotropic effects on cell proliferation and is elevated in a variety of tumors.
Tombusvirus-yeast interactions identify conserved cell-intrinsic viral restriction factors.
Review
New
Nagy et al., Lexington, United States. In Front Plant Sci, Dec 2013
We discuss the antiviral functions of selected CIRFs, such as the RNA binding nucleolin, ribonucleases, WW-domain proteins, single- and multi-domain cyclophilins, TPR-domain co-chaperones and cellular ion pumps.
DNA and RNA Quadruplex-Binding Proteins.
Review
New
Fojta et al., Brno, Czech Republic. In Int J Mol Sci, Dec 2013
The NHE III1 region of the c-MYC promoter has been shown to interact with nucleolin protein as well as other G-quadruplex-binding proteins.
Exome sequencing is an efficient tool for variant late-infantile neuronal ceroid lipofuscinosis molecular diagnosis.
New
Laissue et al., Bogotá, Colombia. In Plos One, Dec 2013
The neuronal ceroid-lipofuscinoses (NCL) is a group of neurodegenerative disorders characterized by epilepsy, visual failure, progressive mental and motor deterioration, myoclonus, dementia and reduced life expectancy.
Loss of Cln3 Function in the Social Amoeba Dictyostelium discoideum Causes Pleiotropic Effects That Are Rescued by Human CLN3.
New
Cotman et al., Boston, United States. In Plos One, Dec 2013
The neuronal ceroid lipofuscinoses (NCL) are a group of inherited, severe neurodegenerative disorders also known as Batten disease.
NCL Disorders: Frequent Causes of Childhood Dementia.
Review
Kohlschütter et al., Hamburg, Germany. In Iran J Child Neurol, 2012
Dementia in children or young adults is most frequently caused by neuronal ceroidlipofuscinoses (NCL), a group of incurable lysosomal storage disorders linked by the accumulation of a characteristic intracellular storage material and progressive clinical deterioration, usually in combination with visual loss, epilepsy, and motor decline.
Mechanisms of RNA-induced toxicity in CAG repeat disorders.
Review
Krauss et al., Bonn, Germany. In Cell Death Dis, 2012
These include the sequestration of MBNL1, leading to misregulated splicing; sequestration of nucleolin, leading to reduced cellular rRNA; and sequestration of proteins of the siRNA machinery, resulting in the production of short silencing RNAs that affect gene expression.
Heat shock cognate 70 regulates the translocation and angiogenic function of nucleolin.
GeneRIF
Luo et al., Beijing, China. In Arterioscler Thromb Vasc Biol, 2012
Hsc70 is a prerequisite for the surface translocation and angiogenic function of nucleolin, which suggests strategies to target both Hsc70 and NCL for more effective antiangiogenic therapies.
The maize b1 paramutation control region causes epigenetic silencing in Drosophila melanogaster.
GeneRIF
Lloyd et al., Halifax, Canada. In Mol Genet Genomics, 2012
Data show that maize B1 transgenic lines exhibit cis-silencing of white gene but epigenetic activation of white gene expression in trans.
H3S10 phosphorylation by the JIL-1 kinase regulates H3K9 dimethylation and gene expression at the white locus in Drosophila.
GeneRIF
Johansen et al., Ames, United States. In Fly (austin), 2012
H3K9me2 levels at the white gene directly correlate with its level of expression.
Nucleolin inhibits G4 oligonucleotide unwinding by Werner helicase.
GeneRIF
Bohr et al., Baltimore, United States. In Plos One, 2011
WRNp interacts with the RNA-binding protein, NCL.
Identification and characterization of nucleolin as a COUP-TFII coactivator of retinoic acid receptor β transcription in breast cancer cells.
GeneRIF
Klinge et al., Louisville, United States. In Plos One, 2011
nucleolin plays a coregulatory role in transcriptional regulation of the tumor suppressor RARB2 by COUP-TFII
Chemoselectivity in chemical biology: acyl transfer reactions with sulfur and selenium.
Impact
Raines et al., Madison, United States. In Acc Chem Res, 2011
One focus of our research is furthering the chemistry of native chemical ligation (NCL) and expressed protein ligation (EPL), two related processes that enable the synthesis and semisynthesis of proteins.
Identification of nucleolin as a cellular receptor for human respiratory syncytial virus.
Impact
GeneRIF
Hegele et al., Vancouver, Canada. In Nat Med, 2011
Nucleolin is a cellular receptor for human respiratory syncytial virus.
Mei-P26 regulates microRNAs and cell growth in the Drosophila ovarian stem cell lineage.
Impact
Knoblich et al., Vienna, Austria. In Nature, 2008
Whereas neuroblasts segregate the Trim-NHL (tripartite motif and Ncl-1, HT2A and Lin-41 domain)-containing protein Brain tumour (Brat) into one of the two daughter cells, ovarian stem cells are regulated by an extracellular signal from the surrounding stem cell niche.
Regulation of p53 translation and induction after DNA damage by ribosomal protein L26 and nucleolin.
Impact
GeneRIF
Kastan et al., Memphis, United States. In Cell, 2005
These findings demonstrate the importance of increased translation of p53 in DNA-damage responses and suggest critical roles for RPL26 and nucleolin in affecting p53 induction.
More papers using nucleolin antibodies
Hsp90 restrains ErbB-2/HER2 signalling by limiting heterodimer formation.
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Koch Karl-Wilhelm, In PLoS ONE, 2003
... ErbB1, ErbB2, ErbB3, ErbB4 antibodies, monoclonal mouse anti-phosphotyrosine (PY20), mouse anti-GFP (B-2) and mouse anti-nucleolin (C23) were purchased from Santa Cruz Biotechnology (Santa Cruz, CA, USA) ...
Identification of heparin affin regulatory peptide domains with potential role on angiogenesis
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Delbé Jean et al., In BMC Cancer, 2003
... Monoclonal antibody to human nucleolin was from Santa Cruz biotechnology (Montrouge, France), goat anti-mouse ...
Insulin-like growth factor-I inhibits transcriptional responses of transforming growth factor-beta by phosphatidylinositol 3-kinase/Akt-dependent suppression of the activation of Smad3 but not Smad2.
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Nurminsky Dmitry I., In PLoS ONE, 2002
... P-PKC-zeta (Abcam, ab76129), Syntaxin 4 (Abcam, ab57841), Vamp2 (Abcam, ab3347), Vimentin (Santacruz, sc73259, Actin (Santacruz, sc-1615), Nucleolin (Santacruz, sc13057), Lamin A (Santacruz, sc-20680), MEF2C (Abcam, ab65252), HDAC4 (Cell Signaling, ...
The biological action of saponins in animal systems: a review.
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Means Robert E., In PLoS ONE, 2001
... Antibodies against ERK, JNK, Akt, NF-κB (p65), C23 and phosphorylated proteins were purchased from Santa Cruz Biotechnology (Santa Cruz, CA) ...
WRN helicase accelerates the transcription of ribosomal RNA as a component of an RNA polymerase I-associated complex.
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Borgmann Kerstin, In PLoS ONE, 2001
... Marek Rusin, Maria Sklodowska-Curie Memorial Institute, Gliwice, Poland; GFP-NCL constructs are described below.The following antibodies were purchased from Santa Cruz Biotechnology (Santa Cruz, CA): Rabbit ...
Functional interaction between BLM helicase and 53BP1 in a Chk1-mediated pathway during S-phase arrest
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Harris Curtis C. et al., In The Journal of Cell Biology, 2001
... Anti-Nucleolin (C23): monoclonal MS-3 (Santa Cruz Biotechnology, Inc.) ...
Making ribosomes.
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Takahashi Nobuhiro et al., In Molecular & Cellular Proteomics : MCP, 1999
... Antibodies against B23, fibrillarin, and nucleolin were obtained from Santa Cruz Biotechnology (Santa Cruz, CA).
Transduction by adeno-associated virus vectors in the rabbit airway: efficiency, persistence, and readministration
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Gabellini Davide et al., In Molecular Therapy, 1996
... serum, the sections were incubated O/N with a mix of two anti-mouse Dystrophin antibodies (NCL-Dys1 and NCL-Dys2; Novacastra, Leica Microsystem, Wetzlar, Germany) diluted ...
Temperature-dependent physiological stability of rat skeletal muscle in vitro.
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Vina Jose, In PLoS ONE, 1984
... Dystrophin antibody (NCL-DYS2) was from Novocastra Vector Laboratories (Burlingame, CA) ...
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