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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 06 Jul 2015.

Nucleolin

nucleolin, NCL, C23, Nucl, CLN5
Nucleolin (NCL), a eukaryotic nucleolar phosphoprotein, is involved in the synthesis and maturation of ribosomes. It is located mainly in dense fibrillar regions of the nucleolus. Human NCL gene consists of 14 exons with 13 introns and spans approximately 11kb. The intron 11 of the NCL gene encodes a small nucleolar RNA, termed U20. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, V1a, HAD, ACID, fibrillin-1
Papers using nucleolin antibodies
A phase I trial of adeno-associated virus serotype 1-γ-Sarcoglycan gene therapy for limb girdle muscular dystrophy type 2C
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Danos Olivier et al., In Molecular Therapy. Nucleic Acids, 2011
... Dystrophin and α-actinin proteins were detected by probing the membrane with 1:100 dilution of NCL-DYS1 primary antibody (monoclonal antibody to dystrophin R8 repeat; NovoCastra) and 1:200 dilution of α-actinin primary antibody (Santa Cruz Biotechnology), respectively ...
Accurate quantification of dystrophin mRNA and exon skipping levels in duchenne muscular dystrophy
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Aartsma-Rus Annemieke et al., In Molecular Therapy. Nucleic Acids, 2009
... dried milk (Campina Melkunie, Maasdam, the Netherlands) in TBS followed by an overnight incubation with NCL-DYS1 (dilution 1:125; Novacastra, Leica Microsystems, Valkerswaard, the Netherlands) ...
Use of peptide synthesis to probe viral antigens for epitopes to a resolution of a single amino acid
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Brünner Nils et al., In Histopathology, 2008
... GmbH), and for ELISA and immunoblotting experiments the corresponding CB11 antibody concentrate was employed (Novocastra NCL-CB11; Leica Microsystems A/S, Ballerup, Denmark) ...
Tumorigenesis suppressor Pdcd4 down-regulates mitogen-activated protein kinase kinase kinase kinase 1 expression to suppress colon carcinoma cell invasion
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Arlt Alexander, In PLoS ONE, 2005
... Anti-luciferase antibody came from Promega, anti-nucleolin and anti-IκB antibody from Santa Cruz Biotechnology, anti-HIF-1α and anti-p21 antibody ...
Neurological disease in HIV-infected patients in the era of highly active antiretroviral treatment: a Brazilian experience
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Adad Sheila Jorge et al., In AIDS Research and Treatment, 2005
... reaction (polymer technique) was made in some cases using monoclonal antibodies for toxoplasma (Novocastra-NCL-TG-TP3), cytomegalovirus (Novocastra-NCL-CMV-pp65), herpes virus (Dako HSV-I and II), JC ...
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Papers on nucleolin
Aptamer-functionalized hydrogel as effective anti-cancer drugs delivery agents.
New
Xia et al., Qingdao, China. In Colloids Surf B Biointerfaces, 22 Jul 2015
Specially, the AS1411 initiates the hybridization of acrydite-modified oligonucleotides to form the hydrogels and the presence of the target protein nucleolin leads the gel to dissolve as a result of reducing the cross-linking density by competitive target-aptamer binding.
Recent studies of ovine neuronal ceroid lipofuscinoses from BARN, the Batten Animal Research Network.
Review
New
Mitchell et al., New Zealand. In Biochim Biophys Acta, 11 Jul 2015
Themes include CLN5 and CLN6 neuronal cell culture studies, studies on tissues from affected and control animals and whole animal in vivo studies.
Genetics of the Neuronal Ceroid Lipofuscinoses (Batten disease).
Review
New
Cotman et al., London, United Kingdom. In Biochim Biophys Acta, 27 Jun 2015
These genes encode lysosomal enzymes (CLN1, CLN2, CLN10, CLN13), a soluble lysosomal protein (CLN5), a protein in the secretory pathway (CLN11), two cytoplasmic proteins that also peripherally associate with membranes (CLN4, CLN14), and many transmembrane proteins with different subcellular locations (CLN3, CLN6, CLN7, CLN8, CLN12).
Towards a new understanding of NCL pathogenesis.
Review
New
Nelvagal et al., London, United Kingdom. In Biochim Biophys Acta, 27 Jun 2015
However, as the number of genes that appear to cause new forms of NCL continues to grow, it is timely to reassess our understanding of the pathogenesis of these disorders and what groups them together.
The Neuronal Ceroid Lipofuscinoses Program: A Translational Research Experience in Argentina.
Review
New
de Halac et al., Córdoba, Argentina. In Biochim Biophys Acta, 11 Jun 2015
Phenotypic studies comprised epileptic seizures and movement disorders, ophthalmology, neurophysiology, image analysis, rating scales, enzyme testing, and electron microscopy, carried out under a consensus algorithm; 2) DNA screening and validation of mutations in genes PPT1 (CLN1), TPP1 (CLN2), CLN3, CLN5, CLN6, MFSD8 (CLN7), and CLN8: characterization of variant types, novel/known mutations and polymorphisms; 3) Progress of the epidemiological picture in Latin America; 4) NCL-like pathology studies in progress.
Cell biology of the NCL proteins: What they do and don't do.
Review
New
Pearce et al., Sioux Falls, United States. In Biochim Biophys Acta, 08 Jun 2015
NCL-associated proteins have been localized mostly in lysosomes (CLN1, CLN2, CLN3, CLN5, CLN7, CLN10, CLN12 and CLN13) but also in the Endoplasmic Reticulum (CLN6 and CLN8), or in the cytosol associated to vesicular membranes (CLN4 and CLN14).
Quantitative proteomic analysis shows differentially expressed HSPB1 in glioblastoma as a discriminating short from long survival factor and NOVA1 as a differentiation factor between low-grade astrocytoma and oligodendroglioma.
New
Rosa et al., São Paulo, Brazil. In Bmc Cancer, Dec 2014
RESULTS: We found that expression of nucleophosmin (NPM1), glucose regulated protein 78 kDa (GRP78), nucleolin (NCL) and heat shock protein 90 kDa (HSP90B1) were increased, Raf kinase inhibitor protein (RKIP/PEBP1) was decreased in glioblastoma and they were associated with a network related to tumor progression.
CX3CR1 Is Expressed in Differentiated Human Ciliated Airway Cells and Co-Localizes with Respiratory Syncytial Virus on Cilia in a G Protein-Dependent Manner.
New
Parrington et al., Framingham, United States. In Plos One, Dec 2014
The RSV Glycoprotein (G) mediates attachment of the virus to the cell membrane, which facilitates interaction of the RSV Fusion (F) protein with nucleolin, thereby triggering fusion of the viral and cellular membranes.
Genetic Polymorphisms Associated with Hearing Threshold Shift in Subjects during First Encounter with Occupational Impulse Noise.
New
Rogers et al., San Diego, United States. In Plos One, Dec 2014
We report a significant association of SNP rs7598759 (p < 5 x 10-7; p = 0.01 after permutation and correction; Odds Ratio = 12.75) in the gene coding for nucleolin, a multifunctional phosphoprotein involved in the control of senescence and protection against apoptosis.
Development of a Bioluminescent Nitroreductase Probe for Preclinical Imaging.
New
Dubikovskaya et al., Lausanne, Switzerland. In Plos One, Dec 2014
We therefore developed a "NTR caged luciferin" (NCL) probe that is selectively reduced by NTR, producing light proportional to the NTR activity.
C9orf72 nucleotide repeat structures initiate molecular cascades of disease.
New
Impact
Wang et al., Baltimore, United States. In Nature, Apr 2014
Specifically, nucleolin, an essential nucleolar protein, preferentially binds the HRE G-quadruplex, and patient cells show evidence of nucleolar stress.
Heat shock cognate 70 regulates the translocation and angiogenic function of nucleolin.
GeneRIF
Luo et al., Beijing, China. In Arterioscler Thromb Vasc Biol, 2012
Hsc70 is a prerequisite for the surface translocation and angiogenic function of nucleolin, which suggests strategies to target both Hsc70 and NCL for more effective antiangiogenic therapies.
The maize b1 paramutation control region causes epigenetic silencing in Drosophila melanogaster.
GeneRIF
Lloyd et al., Halifax, Canada. In Mol Genet Genomics, 2012
Data show that maize B1 transgenic lines exhibit cis-silencing of white gene but epigenetic activation of white gene expression in trans.
H3S10 phosphorylation by the JIL-1 kinase regulates H3K9 dimethylation and gene expression at the white locus in Drosophila.
GeneRIF
Johansen et al., Ames, United States. In Fly (austin), 2012
H3K9me2 levels at the white gene directly correlate with its level of expression.
Nucleolin inhibits G4 oligonucleotide unwinding by Werner helicase.
GeneRIF
Bohr et al., Baltimore, United States. In Plos One, 2011
WRNp interacts with the RNA-binding protein, NCL.
Identification and characterization of nucleolin as a COUP-TFII coactivator of retinoic acid receptor β transcription in breast cancer cells.
GeneRIF
Klinge et al., Louisville, United States. In Plos One, 2011
nucleolin plays a coregulatory role in transcriptional regulation of the tumor suppressor RARB2 by COUP-TFII
Chemoselectivity in chemical biology: acyl transfer reactions with sulfur and selenium.
Impact
Raines et al., Madison, United States. In Acc Chem Res, 2011
One focus of our research is furthering the chemistry of native chemical ligation (NCL) and expressed protein ligation (EPL), two related processes that enable the synthesis and semisynthesis of proteins.
Identification of nucleolin as a cellular receptor for human respiratory syncytial virus.
Impact
GeneRIF
Hegele et al., Vancouver, Canada. In Nat Med, 2011
Nucleolin is a cellular receptor for human respiratory syncytial virus.
Mei-P26 regulates microRNAs and cell growth in the Drosophila ovarian stem cell lineage.
Impact
Knoblich et al., Vienna, Austria. In Nature, 2008
Whereas neuroblasts segregate the Trim-NHL (tripartite motif and Ncl-1, HT2A and Lin-41 domain)-containing protein Brain tumour (Brat) into one of the two daughter cells, ovarian stem cells are regulated by an extracellular signal from the surrounding stem cell niche.
Regulation of p53 translation and induction after DNA damage by ribosomal protein L26 and nucleolin.
Impact
GeneRIF
Kastan et al., Memphis, United States. In Cell, 2005
These findings demonstrate the importance of increased translation of p53 in DNA-damage responses and suggest critical roles for RPL26 and nucleolin in affecting p53 induction.
More papers using nucleolin antibodies
Hsp90 restrains ErbB-2/HER2 signalling by limiting heterodimer formation.
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Koch Karl-Wilhelm, In PLoS ONE, 2003
... ErbB1, ErbB2, ErbB3, ErbB4 antibodies, monoclonal mouse anti-phosphotyrosine (PY20), mouse anti-GFP (B-2) and mouse anti-nucleolin (C23) were purchased from Santa Cruz Biotechnology (Santa Cruz, CA, USA) ...
Identification of heparin affin regulatory peptide domains with potential role on angiogenesis
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Delbé Jean et al., In BMC Cancer, 2003
... Monoclonal antibody to human nucleolin was from Santa Cruz biotechnology (Montrouge, France), goat anti-mouse ...
Insulin-like growth factor-I inhibits transcriptional responses of transforming growth factor-beta by phosphatidylinositol 3-kinase/Akt-dependent suppression of the activation of Smad3 but not Smad2.
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Nurminsky Dmitry I., In PLoS ONE, 2002
... P-PKC-zeta (Abcam, ab76129), Syntaxin 4 (Abcam, ab57841), Vamp2 (Abcam, ab3347), Vimentin (Santacruz, sc73259, Actin (Santacruz, sc-1615), Nucleolin (Santacruz, sc13057), Lamin A (Santacruz, sc-20680), MEF2C (Abcam, ab65252), HDAC4 (Cell Signaling, ...
The biological action of saponins in animal systems: a review.
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Means Robert E., In PLoS ONE, 2001
... Antibodies against ERK, JNK, Akt, NF-κB (p65), C23 and phosphorylated proteins were purchased from Santa Cruz Biotechnology (Santa Cruz, CA) ...
WRN helicase accelerates the transcription of ribosomal RNA as a component of an RNA polymerase I-associated complex.
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Borgmann Kerstin, In PLoS ONE, 2001
... Marek Rusin, Maria Sklodowska-Curie Memorial Institute, Gliwice, Poland; GFP-NCL constructs are described below.The following antibodies were purchased from Santa Cruz Biotechnology (Santa Cruz, CA): Rabbit ...
Functional interaction between BLM helicase and 53BP1 in a Chk1-mediated pathway during S-phase arrest
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Harris Curtis C. et al., In The Journal of Cell Biology, 2001
... Anti-Nucleolin (C23): monoclonal MS-3 (Santa Cruz Biotechnology, Inc.) ...
Making ribosomes.
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Takahashi Nobuhiro et al., In Molecular & Cellular Proteomics : MCP, 1999
... Antibodies against B23, fibrillarin, and nucleolin were obtained from Santa Cruz Biotechnology (Santa Cruz, CA).
Transduction by adeno-associated virus vectors in the rabbit airway: efficiency, persistence, and readministration
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Gabellini Davide et al., In Molecular Therapy, 1996
... serum, the sections were incubated O/N with a mix of two anti-mouse Dystrophin antibodies (NCL-Dys1 and NCL-Dys2; Novacastra, Leica Microsystem, Wetzlar, Germany) diluted ...
Temperature-dependent physiological stability of rat skeletal muscle in vitro.
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Vina Jose, In PLoS ONE, 1984
... Dystrophin antibody (NCL-DYS2) was from Novocastra Vector Laboratories (Burlingame, CA) ...
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