GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 14 Mar 2013.
Nucleolin
nucleolin, NCL, C23, Nucl, CLN5
Nucleolin (NCL), a eukaryotic nucleolar phosphoprotein, is involved in the synthesis and maturation of ribosomes. It is located mainly in dense fibrillar regions of the nucleolus. Human NCL gene consists of 14 exons with 13 introns and spans approximately 11kb. The intron 11 of the NCL gene encodes a small nucleolar RNA, termed U20. [provided by RefSeq, Jul 2008] (from
NCBI)
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Papers using
nucleolin
antibodies
A phase I trial of adeno-associated virus serotype 1-γ-Sarcoglycan gene therapy for limb girdle muscular dystrophy type 2C
Supplier
In Molecular Therapy. Nucleic Acids, 2011
... Dystrophin and α-actinin proteins were detected by probing the membrane with 1:100 dilution of NCL-DYS1 primary antibody (monoclonal antibody to dystrophin R8 repeat; NovoCastra) and 1:200 dilution of α-actinin primary antibody (Santa Cruz Biotechnology), respectively ...
Accurate quantification of dystrophin mRNA and exon skipping levels in duchenne muscular dystrophy
Supplier
In Molecular Therapy. Nucleic Acids, 2009
... dried milk (Campina Melkunie, Maasdam, the Netherlands) in TBS followed by an overnight incubation with NCL-DYS1 (dilution 1:125; Novacastra, Leica Microsystems, Valkerswaard, the Netherlands) ...
Use of peptide synthesis to probe viral antigens for epitopes to a resolution of a single amino acid
Supplier
In Histopathology, 2008
... GmbH), and for ELISA and immunoblotting experiments the corresponding CB11 antibody concentrate was employed (Novocastra NCL-CB11; Leica Microsystems A/S, Ballerup, Denmark) ...
Tumorigenesis suppressor Pdcd4 down-regulates mitogen-activated protein kinase kinase kinase kinase 1 expression to suppress colon carcinoma cell invasion
Supplier
In PLoS ONE, 2005
... Anti-luciferase antibody came from Promega, anti-nucleolin and anti-IκB antibody from Santa Cruz Biotechnology, anti-HIF-1α and anti-p21 antibody ...
Neurological disease in HIV-infected patients in the era of highly active antiretroviral treatment: a Brazilian experience
more suppliersSupplier
In AIDS Research and Treatment, 2005
... reaction (polymer technique) was made in some cases using monoclonal antibodies for toxoplasma (Novocastra-NCL-TG-TP3), cytomegalovirus (Novocastra-NCL-CMV-pp65), herpes virus (Dako HSV-I and II), JC ...
Papers on
nucleolin
Nucleolin mediates microRNA-directed CSF-1 mRNA deadenylation, but increases translation of CSF-1 mRNA.
New
United States. In Mol Cell Proteomics, 07 Apr 2013
We find that nucleolin, which binds both G quadruplex and AREs, enhances deadenylation of CSF1 mRNA, promoting CSF-1 mRNA decay, while having the capacity to increase translation of CSF1 mRNA.
Drafting the CLN3 protein interactome in SH-SY5Y human neuroblastoma cells: a label-free quantitative proteomics approach.
New
In J Proteome Res, 07 Apr 2013
Moreover, 31 IP of ceroid-lipofuscinosis neuronal protein 5 (CLN5), were identified (18 of which were in common with the CLN3 bait).
Admixture Mapping in Lupus Identifies Multiple Functional Variants within IFIH1 Associated with Apoptosis, Inflammation, and Autoantibody Production.
New
Oklahoma City, United States. In Plos Genet, 28 Feb 2013
DNA carrying the intronic risk allele rs13023380 showed reduced binding efficiency to a cellular protein complex including nucleolin and lupus autoantigen Ku70/80, and showed reduced transcriptional activity in vivo.
A universal quantum dots-aptamer probe for efficient cancer detection and targeted imaging.
New
Shenzhen, China. In J Nanosci Nanotechnol, Oct 2012
The as-prepared QDs were then conjugated with the AS1411 aptamer recognizing the nucleolin overexpressed on cancer cell surface.
Human gastric cancer development with TNF-α-inducing protein secreted from Helicobacter pylori.
Review
New
Saitama, Japan. In Cancer Lett, Oct 2012
Tipα protein specifically binds to cell-surface nucleolin and then enters the gastric cancer cells, where TNF-α and chemokine gene expressions are induced by NF-κB activation.
RNA-binding protein nucleolin in disease.
Review
New
Baltimore, United States. In Rna Biol, Jun 2012
Nucleolin is a multifunctional protein localized primarily in the nucleolus, but also found in the nucleoplasm, cytoplasm and cell membrane.
Mouse models of neuronal ceroid lipofuscinoses: useful pre-clinical tools to delineate disease pathophysiology and validate therapeutics.
Review
New
Birmingham, United States. In Brain Res Bull, Jun 2012
Specific gene mutations are now known for each subclass of NCL in humans that now largely define the disease: cathepsin D (CTSD) for congenital (CLN10 form); palmitoyl protein thioesterase 1 (PPT1) for infantile (CLN1 form); tripeptidyl peptidase 1 (TPP1) for classic late infantile (CLN2 form); variant late infantile-CLN5, CLN6 or CLN8 for variant late infantile forms; and CLN3 for juvenile (CLN3 form).
Update of the mutation spectrum and clinical correlations of over 360 mutations in eight genes that underlie the neuronal ceroid lipofuscinoses.
Review
Helsinki, Finland. In Hum Mutat, 2012
For example, mutations in CLN5, CLN6, MFSD8, or CLN8 can underlie the clinically similar late infantile variant NCL disease.
Chimeric aptamers in cancer cell-targeted drug delivery.
Review
Geelong, Australia. In Crit Rev Biochem Mol Biol, 2011
We developed LNA-aptamer (anti-nucleolin and EpCAM) complexes which were loaded in iron-saturated bovine lactofeerin (Fe-blf)-coated dopamine modified surface of superparamagnetic iron oxide (Fe(3)O(4)) nanoparticles (SPIONs).
A retrospective study of outcome of percutaneous endoscopic gastrostomy in older adults with advanced cognitive impairment and severely reduced activities of daily living.
In Nihon Ronen Igakkai Zasshi, 2011
Evaluation included activities of daily living (ADL), nursing care level (NCL) based on assessment of care requirement, pre-existing disease, blood test data, swallowing function before PEG, and outcome.
Competitive regulation of nucleolin expression by HuR and miR-494.
GeneRIF
Baltimore, United States. In Mol Cell Biol, 2011
HUR was found to interact with the nucleolin (NCL) 3'UTR and specifically promoted nucleolin translation without affecting nucleolin mRNA levels.
Chemoselectivity in chemical biology: acyl transfer reactions with sulfur and selenium.
Impact
Madison, United States. In Acc Chem Res, 2011
One focus of our research is furthering the chemistry of native chemical ligation (NCL) and expressed protein ligation (EPL), two related processes that enable the synthesis and semisynthesis of proteins.
Identification of nucleolin as a cellular receptor for human respiratory syncytial virus.
Impact
GeneRIF
Vancouver, Canada. In Nat Med, 2011
Nucleolin is a cellular receptor for human respiratory syncytial virus.
Insulators form gene loops by interacting with promoters in Drosophila.
GeneRIF
Moscow, Russia. In Development, 2011
Both insulators support basal activity of the yellow and white promoters in eyes.
Identification of a putative Crimean-Congo hemorrhagic fever virus entry factor.
GeneRIF
Frederick, United States. In Biochem Biophys Res Commun, 2011
the human cell surface nucleolin as a putative Crimean-Congo hemorrhagic fever virus entry factor was indentified.
Targeting surface nucleolin with multivalent HB-19 and related Nucant pseudopeptides results in distinct inhibitory mechanisms depending on the malignant tumor cell type.
GeneRIF
Paris, France. In Bmc Cancer, 2010
Results suggest that targeting surface nucleolin could change the organization of the 500-kDa complex to interfere with the proper functioning of surface nucleolin and the associated proteins, and thus lead to distinct inhibitory mechanisms.
Mei-P26 regulates microRNAs and cell growth in the Drosophila ovarian stem cell lineage.
Impact
Vienna, Austria. In Nature, 2008
Whereas neuroblasts segregate the Trim-NHL (tripartite motif and Ncl-1, HT2A and Lin-41 domain)-containing protein Brain tumour (Brat) into one of the two daughter cells, ovarian stem cells are regulated by an extracellular signal from the surrounding stem cell niche.
Regulation of p53 translation and induction after DNA damage by ribosomal protein L26 and nucleolin.
Impact
GeneRIF
Memphis, United States. In Cell, 2005
These findings demonstrate the importance of increased translation of p53 in DNA-damage responses and suggest critical roles for RPL26 and nucleolin in affecting p53 induction.
Inappropriate gene activation in FSHD: a repressor complex binds a chromosomal repeat deleted in dystrophic muscle.
More papers using
nucleolin
antibodies
Impact
Worcester, United States. In Cell, 2002
We show that an element within D4Z4 specifically binds a multiprotein complex consisting of YY1, a known transcriptional repressor, HMGB2, an architectural protein, and nucleolin.
Identification of heparin affin regulatory peptide domains with potential role on angiogenesis
Supplier
In BMC Cancer, 2003
... Monoclonal antibody to human nucleolin was from Santa Cruz biotechnology (Montrouge, France), goat anti-mouse ...
Hsp90 restrains ErbB-2/HER2 signalling by limiting heterodimer formation.
Supplier
In PLoS ONE, 2003
... ErbB1, ErbB2, ErbB3, ErbB4 antibodies, monoclonal mouse anti-phosphotyrosine (PY20), mouse anti-GFP (B-2) and mouse anti-nucleolin (C23) were purchased from Santa Cruz Biotechnology (Santa Cruz, CA, USA) ...
Insulin-like growth factor-I inhibits transcriptional responses of transforming growth factor-beta by phosphatidylinositol 3-kinase/Akt-dependent suppression of the activation of Smad3 but not Smad2.
Supplier
In PLoS ONE, 2002
... P-PKC-zeta (Abcam, ab76129), Syntaxin 4 (Abcam, ab57841), Vamp2 (Abcam, ab3347), Vimentin (Santacruz, sc73259, Actin (Santacruz, sc-1615), Nucleolin (Santacruz, sc13057), Lamin A (Santacruz, sc-20680), MEF2C (Abcam, ab65252), HDAC4 (Cell Signaling, ...
The biological action of saponins in animal systems: a review.
Supplier
In PLoS ONE, 2001
... Antibodies against ERK, JNK, Akt, NF-κB (p65), C23 and phosphorylated proteins were purchased from Santa Cruz Biotechnology (Santa Cruz, CA) ...
Functional interaction between BLM helicase and 53BP1 in a Chk1-mediated pathway during S-phase arrest
Supplier
In The Journal of Cell Biology, 2001
... Anti-Nucleolin (C23): monoclonal MS-3 (Santa Cruz Biotechnology, Inc.) ...
WRN helicase accelerates the transcription of ribosomal RNA as a component of an RNA polymerase I-associated complex.
Supplier
In PLoS ONE, 2001
... Marek Rusin, Maria Sklodowska-Curie Memorial Institute, Gliwice, Poland; GFP-NCL constructs are described below.The following antibodies were purchased from Santa Cruz Biotechnology (Santa Cruz, CA): Rabbit ...
Making ribosomes.
Supplier
In Molecular & Cellular Proteomics : MCP, 1999
... Antibodies against B23, fibrillarin, and nucleolin were obtained from Santa Cruz Biotechnology (Santa Cruz, CA).
Transduction by adeno-associated virus vectors in the rabbit airway: efficiency, persistence, and readministration
Supplier
In Molecular Therapy, 1996
... serum, the sections were incubated O/N with a mix of two anti-mouse Dystrophin antibodies (NCL-Dys1 and NCL-Dys2; Novacastra, Leica Microsystem, Wetzlar, Germany) diluted ...
Temperature-dependent physiological stability of rat skeletal muscle in vitro.
Supplier
In PLoS ONE, 1984
... Dystrophin antibody (NCL-DYS2) was from Novocastra Vector Laboratories (Burlingame, CA) ...
