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Nuclear respiratory factor 1

Nuclear Respiratory Factor 1, NRF-1
This gene encodes a protein that homodimerizes and functions as a transcription factor which activates the expression of some key metabolic genes regulating cellular growth and nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication. The protein has also been associated with the regulation of neurite outgrowth. Alternate transcriptional splice variants, which encode the same protein, have been characterized. Additional variants encoding different protein isoforms have been described but they have not been fully characterized. Confusion has occurred in bibliographic databases due to the shared symbol of NRF1 for this gene and for "nuclear factor (erythroid-derived 2)-like 1" which has an official symbol of NFE2L1. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: NRF, PGC, TFAM, Nrf2, PGC-1alpha
Papers on Nuclear Respiratory Factor 1
The emerging role of Nrf2 in mitochondrial function.
Abramov et al., Dundee, United Kingdom. In Free Radic Biol Med, 30 Nov 2015
Under conditions of stress or growth factor stimulation, activation of Nrf2 counteracts the increased reactive oxygen species production in mitochondria via transcriptional upregulation of uncoupling protein 3 and influences mitochondrial biogenesis by maintaining the levels of nuclear respiratory factor 1 and peroxisome proliferator-activated receptor γ coactivator 1α, as well as by promoting purine nucleotide biosynthesis.
The Plasticizer BBP Selectively Inhibits Epigenetic Regulator Sirtuins.
Choudhury et al., Kingsville, United States. In Toxicology, 28 Nov 2015
In addition, mitochondrial biogenesis regulators PGC-1α, NRF-1, and NRF-2, were decreased (p<0.05).
EglN2 associates with the NRF1-PGC1α complex and controls mitochondrial function in breast cancer.
Zhang et al., Chapel Hill, United States. In Embo J, 22 Nov 2015
Integrative analyses of gene expression profile and genomewide binding of EglN2 under hypoxic conditions reveal nuclear respiratory factor 1 (NRF1) motif enrichment in EglN2-activated genes, suggesting NRF1 as an EglN2 binding partner.
Quercetin protects against aluminium induced oxidative stress and promotes mitochondrial biogenesis via activation of the PGC-1α signaling pathway.
Gill et al., Chandīgarh, India. In Neurotoxicology, 19 Nov 2015
NRF-1, NRF-2 and Tfam in mitochondrial biogenesis.
Acute Carnosine Administration Increases Respiratory Chain Complexes and Citric Acid Cycle Enzyme Activities in Cerebral Cortex of Young Rats.
Ferreira et al., Criciúma, Brazil. In Mol Neurobiol, 17 Nov 2015
However, quantitative real-time RT-PCR (RT-qPCR) data on mRNA levels of mitochondrial biogenesis-related proteins (nuclear respiratory factor 1 (Nrf1), peroxisome proliferator-activated receptor-γ coactivator 1-α (Ppargc1α), and mitochondrial transcription factor A (Tfam)) were not altered significantly and therefore suggest that short-term carnosine administration does not affect mitochondrial biogenesis.
Vitamin E enriched diet reduces adaptive responses to training determining respiratory capacity and redox homeostasis of rat heart.
Di Meo et al., Napoli, Italy. In Free Radic Res, 15 Nov 2015
On homogenates and/or mitochondria from rat hearts we determined aerobic capacity, tissue level of mitochondrial proteins and expression of cytochrome c and factors (PGC-1, NRF-1, and NRF-2) involved in mitochondrial biogenesis.
Regulation and function of the NFE2 transcription factor in hematopoietic and non-hematopoietic cells.
Blank et al., Montréal, Canada. In Cell Mol Life Sci, Jun 2015
In contrast to other CNC transcription family members including NFE2L1 (NRF1), NFE2L2 (NRF2) and NFE2L3 (NRF3), which are widely expressed, earlier studies had suggested that the major sites of NFE2 expression are hematopoietic cells.
Stem cell aging. A mitochondrial UPR-mediated metabolic checkpoint regulates hematopoietic stem cell aging.
Chen et al., Berkeley, United States. In Science, Apr 2015
Here, we identified a regulatory branch of the mitochondrial unfolded protein response (UPR(mt)), which is mediated by the interplay of SIRT7 and NRF1 and is coupled to cellular energy metabolism and proliferation.
Coordinated regulation of protein synthesis and degradation by mTORC1.
Manning et al., Boston, United States. In Nature, Oct 2014
The increase in proteasome gene expression, cellular proteasome content, and rates of protein turnover downstream of mTORC1 were all dependent on induction of the transcription factor nuclear factor erythroid-derived 2-related factor 1 (NRF1; also known as NFE2L1).
Mitochondrial adaptations evoked with exercise are associated with a reduction in age-induced testicular atrophy in Fischer-344 rats.
Adhihetty et al., Gainesville, United States. In Biogerontology, 2013
However, relative mitochondrial content was not reduced with age and this was consistent with the lack of change in the mitochondrial biogenesis regulator protein, peroxisome proliferator-activated receptor gamma coactivator 1-alpha and its downstream targets nuclear respiratory factor-1 and mitochondrial transcription factor A. No effect was observed in the pro- or anti-apoptotic proteins, Bax and Bcl-2, respectively, but age increased apoptosis inducing factor levels.
DNA methylation analysis in nonalcoholic fatty liver disease suggests distinct disease-specific and remodeling signatures after bariatric surgery.
Hampe et al., Kiel, Germany. In Cell Metab, 2013
Postbariatric and NAFLD-specific methylation signatures were clearly distinct both in gene ontology and transcription factor binding site analyses, with >400-fold enrichment of NRF1, HSF1, and ESRRA sites.
Thioredoxin-mediated redox regulation of resistance to endocrine therapy in breast cancer.
Roy et al., Miami, United States. In Biochim Biophys Acta, 2013
This, in turn, may lead to the disruption of reversible redox signaling that involves redox-sensitive phosphatases, protein kinases, such as, ERK and AKT, and transcription factors, such as, AP-1, NRF-1 and NF-κB.
Role of PGC-1α signaling in skeletal muscle health and disease.
Li Ji et al., Minneapolis, United States. In Ann N Y Acad Sci, 2012
PGC-1α is the master transcription regulator that stimulates mitochondrial biogenesis, by upregulating nuclear respiratory factors (NRF-1, 2) and mitochondrial transcription factor A (Tfam), which leads to increased mitochondrial DNA replication and gene transcription.
NF-E2-related factor 1 (Nrf1) serves as a novel regulator of hepatic lipid metabolism through regulation of the Lipin1 and PGC-1β genes.
Yamamoto et al., Sendai, Japan. In Mol Cell Biol, 2012
Nrf1 binds to the antioxidant response elements (AREs) in regulatory regions of the Lipin1 and PGC-1beta genes and the binding of Nrf1 to the AREs activates reporter gene transcription.
Nrf1 CNC-bZIP protein promotes cell survival and nucleotide excision repair through maintaining glutathione homeostasis.
He et al., Chicago, United States. In J Biol Chem, 2012
results indicate a novel role of Nrf1 in UVB-induced DNA damage repair and suggest Nrf1 as a tumor suppressor in the skin
Diesel exhaust particulate extracts inhibit transcription of nuclear respiratory factor-1 and cell viability in human umbilical vein endothelial cells.
Klinge et al., Louisville, United States. In Arch Toxicol, 2012
Given that NRF-1 is a key nuclear transcription factor regulating genes involved in mitochondrial activity and biogenesis, these data suggest that diesel exhaust particulate extracts may adversely affect mitochondrial function.
The Fbw7 tumor suppressor regulates nuclear factor E2-related factor 1 transcription factor turnover through proteasome-mediated proteolysis.
Chan et al., Irvine, United States. In J Biol Chem, 2011
Fbw7 as a regulator of Nrf1 expression and reveal a novel function of Fbw7 in cellular stress response.
PARIS (ZNF746) repression of PGC-1α contributes to neurodegeneration in Parkinson's disease.
Dawson et al., Baltimore, United States. In Cell, 2011
PARIS represses the expression of the transcriptional coactivator, PGC-1α and the PGC-1α target gene, NRF-1 by binding to insulin response sequences in the PGC-1α promoter.
The Nrf1 CNC-bZIP protein is regulated by the proteasome and activated by hypoxia.
Willmore et al., Ottawa, Canada. In Plos One, 2010
data suggests that Nrf1 is controlled by several post-translational mechanisms, including ubiquitination, proteolytic processing and proteasomal-mediated degradation as well as by its phosphorylation status
Hepatic-specific disruption of SIRT6 in mice results in fatty liver formation due to enhanced glycolysis and triglyceride synthesis.
Deng et al., Bethesda, United States. In Cell Metab, 2010
Here, we show that SIRT1 forms a complex with FOXO3a and NRF1 on the SIRT6 promoter and positively regulates expression of SIRT6, which, in turn, negatively regulates glycolysis, triglyceride synthesis, and fat metabolism by deacetylating histone H3 lysine 9 in the promoter of many genes involved in these processes.
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