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Nuclear respiratory factor 1

Nuclear Respiratory Factor 1, NRF-1
This gene encodes a protein that homodimerizes and functions as a transcription factor which activates the expression of some key metabolic genes regulating cellular growth and nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication. The protein has also been associated with the regulation of neurite outgrowth. Alternate transcriptional splice variants, which encode the same protein, have been characterized. Additional variants encoding different protein isoforms have been described but they have not been fully characterized. Confusion has occurred in bibliographic databases due to the shared symbol of NRF1 for this gene and for "nuclear factor (erythroid-derived 2)-like 1" which has an official symbol of NFE2L1. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: NRF, PGC, TFAM, Nrf2, PGC-1alpha
Papers on Nuclear Respiratory Factor 1
FNDC5 relates to skeletal muscle IGF-I and mitochondrial function and gene expression in obese men with reduced growth hormone.
New
Makimura et al., Boston, United States. In Growth Horm Igf Res, Feb 2016
P=0.03), NRF1 (ρ=0.66,
A PGC-1α-Mediated Transcriptional Network Maintains Mitochondrial Redox and Bioenergetic Homeostasis against Doxorubicin-Induced Toxicity in Human Cardiomyocytes: Implementation of TT21C.
New
Peng et al., Beijing, China. In Toxicol Sci, Feb 2016
Our in vitro study revealed a well-defined POD concentration of DOX below which adaptive induction of PGC-1α-mediated mitochondrial genes, including NRF-1, MnSOD, UCP2, and COX1, concurred with negligible changes in mitochondrial superoxide and cytotoxicity.
Chronic Arsenic Exposure-Induced Oxidative Stress is Mediated by Decreased Mitochondrial Biogenesis in Rat Liver.
New
Kumar et al., Rohtak, India. In Biol Trace Elem Res, Feb 2016
The entire phenomenon was associated with decrease in mitochondrial biogenesis as evident by decreased protein and mRNA expression of nuclear respiratory factor 1 (NRF-1), nuclear respiratory factor 2 (NRF-2), peroxisome proliferator activator receptor gamma-coactivator 1α (PGC-1α), and mitochondrial transcription factor A (Tfam) in arsenic-treated rat liver.
Chlorogenic acid ameliorates endotoxin-induced liver injury by promoting mitochondrial oxidative phosphorylation.
New
Yin et al., Nanchang, China. In Biochem Biophys Res Commun, Jan 2016
Moreover, phosphorylated AMP-activated protein kinase (AMPK), and mRNA levels of AMPK-α, peroxisome proliferator-activated receptor-gamma coactivator 1α (PGC-1α), nuclear respiratory factor 1, and mitochondrial DNA transcription factor A were increased after CGA supplementation.
Competition between DNA methylation and transcription factors determines binding of NRF1.
New
Impact
Schübeler et al., Basel, Switzerland. In Nature, Jan 2016
Methylation-restricted sites are enriched for TF motifs containing CpGs, especially for those of NRF1.
Mitochondrial DNA copy number and biogenesis in different tissues of early- and late-lactating dairy cows.
New
Häussler et al., Bonn, Germany. In J Dairy Sci, Jan 2016
German Holstein cows (n = 21) were fed according to their requirements, and biopsies from scAT, liver, mammary gland, and blood were collected in early and late lactation and assayed for relative mtDNA copy numbers and the mRNA abundance of genes regulating mitochondrial biogenesis, such as nuclear-respiratory factor 1 and 2 (NRF-1, NRF-2), mitochondrial transcription factor A (TFAM), and peroxisome proliferator-activated receptor-gamma coactivator 1-α (PGC-1α).
The emerging role of Nrf2 in mitochondrial function.
Review
New
Abramov et al., Dundee, United Kingdom. In Free Radic Biol Med, Nov 2015
Under conditions of stress or growth factor stimulation, activation of Nrf2 counteracts the increased reactive oxygen species production in mitochondria via transcriptional upregulation of uncoupling protein 3 and influences mitochondrial biogenesis by maintaining the levels of nuclear respiratory factor 1 and peroxisome proliferator-activated receptor γ coactivator 1α, as well as by promoting purine nucleotide biosynthesis.
Regulation and function of the NFE2 transcription factor in hematopoietic and non-hematopoietic cells.
Review
New
Blank et al., Montréal, Canada. In Cell Mol Life Sci, Jun 2015
In contrast to other CNC transcription family members including NFE2L1 (NRF1), NFE2L2 (NRF2) and NFE2L3 (NRF3), which are widely expressed, earlier studies had suggested that the major sites of NFE2 expression are hematopoietic cells.
Regulation of mitochondrial biogenesis and its intersection with inflammatory responses.
Review
New
Piantadosi et al., Durham, United States. In Antioxid Redox Signal, May 2015
RECENT ADVANCES: Early-phase inflammatory mediator proteins interact with PRRs to activate NF-κB-, MAPK-, and PKB/Akt-dependent pathways, resulting in increased expression or activity of coactivators and transcription factors (e.g., PGC-1α, NRF-1, NRF-2, and Nfe2l2) that regulate mitochondrial biogenesis.
Stem cell aging. A mitochondrial UPR-mediated metabolic checkpoint regulates hematopoietic stem cell aging.
New
Impact
Chen et al., Berkeley, United States. In Science, Apr 2015
Here, we identified a regulatory branch of the mitochondrial unfolded protein response (UPR(mt)), which is mediated by the interplay of SIRT7 and NRF1 and is coupled to cellular energy metabolism and proliferation.
Redox mechanisms of cardiomyocyte mitochondrial protection.
Review
Piantadosi et al., Durham, United States. In Front Physiol, 2014
Simultaneously, a number of other DNA binding transcription factors are expressed and/or activated under redox control, such as Nuclear Respiratory Factor-1 (NRF-1), and lead to the induction of genes involved in both intracellular and mitochondria-specific repair mechanisms.
Coordinated regulation of protein synthesis and degradation by mTORC1.
Impact
Manning et al., Boston, United States. In Nature, 2014
The increase in proteasome gene expression, cellular proteasome content, and rates of protein turnover downstream of mTORC1 were all dependent on induction of the transcription factor nuclear factor erythroid-derived 2-related factor 1 (NRF1; also known as NFE2L1).
Mitochondrial adaptations evoked with exercise are associated with a reduction in age-induced testicular atrophy in Fischer-344 rats.
Review
Adhihetty et al., Gainesville, United States. In Biogerontology, 2013
However, relative mitochondrial content was not reduced with age and this was consistent with the lack of change in the mitochondrial biogenesis regulator protein, peroxisome proliferator-activated receptor gamma coactivator 1-alpha and its downstream targets nuclear respiratory factor-1 and mitochondrial transcription factor A. No effect was observed in the pro- or anti-apoptotic proteins, Bax and Bcl-2, respectively, but age increased apoptosis inducing factor levels.
DNA methylation analysis in nonalcoholic fatty liver disease suggests distinct disease-specific and remodeling signatures after bariatric surgery.
Impact
Hampe et al., Kiel, Germany. In Cell Metab, 2013
Postbariatric and NAFLD-specific methylation signatures were clearly distinct both in gene ontology and transcription factor binding site analyses, with >400-fold enrichment of NRF1, HSF1, and ESRRA sites.
NF-E2-related factor 1 (Nrf1) serves as a novel regulator of hepatic lipid metabolism through regulation of the Lipin1 and PGC-1β genes.
GeneRIF
Yamamoto et al., Sendai, Japan. In Mol Cell Biol, 2012
Nrf1 binds to the antioxidant response elements (AREs) in regulatory regions of the Lipin1 and PGC-1beta genes and the binding of Nrf1 to the AREs activates reporter gene transcription.
Nrf1 CNC-bZIP protein promotes cell survival and nucleotide excision repair through maintaining glutathione homeostasis.
GeneRIF
He et al., Chicago, United States. In J Biol Chem, 2012
results indicate a novel role of Nrf1 in UVB-induced DNA damage repair and suggest Nrf1 as a tumor suppressor in the skin
Diesel exhaust particulate extracts inhibit transcription of nuclear respiratory factor-1 and cell viability in human umbilical vein endothelial cells.
GeneRIF
Klinge et al., Louisville, United States. In Arch Toxicol, 2012
Given that NRF-1 is a key nuclear transcription factor regulating genes involved in mitochondrial activity and biogenesis, these data suggest that diesel exhaust particulate extracts may adversely affect mitochondrial function.
The Fbw7 tumor suppressor regulates nuclear factor E2-related factor 1 transcription factor turnover through proteasome-mediated proteolysis.
GeneRIF
Chan et al., Irvine, United States. In J Biol Chem, 2011
Fbw7 as a regulator of Nrf1 expression and reveal a novel function of Fbw7 in cellular stress response.
PARIS (ZNF746) repression of PGC-1α contributes to neurodegeneration in Parkinson's disease.
Impact
Dawson et al., Baltimore, United States. In Cell, 2011
PARIS represses the expression of the transcriptional coactivator, PGC-1α and the PGC-1α target gene, NRF-1 by binding to insulin response sequences in the PGC-1α promoter.
The Nrf1 CNC-bZIP protein is regulated by the proteasome and activated by hypoxia.
GeneRIF
Willmore et al., Ottawa, Canada. In Plos One, 2010
data suggests that Nrf1 is controlled by several post-translational mechanisms, including ubiquitination, proteolytic processing and proteasomal-mediated degradation as well as by its phosphorylation status
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