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Nuclear respiratory factor 1
Nuclear Respiratory Factor 1, NRF-1
This gene encodes a protein that homodimerizes and functions as a transcription factor which activates the expression of some key metabolic genes regulating cellular growth and nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication. The protein has also been associated with the regulation of neurite outgrowth. Alternate transcriptional splice variants, which encode the same protein, have been characterized. Additional variants encoding different protein isoforms have been described but they have not been fully characterized. Confusion has occurred in bibliographic databases due to the shared symbol of NRF1 for this gene and for "nuclear factor (erythroid-derived 2)-like 1" which has an official symbol of NFE2L1. [provided by RefSeq, Jul 2008] (from
NCBI)
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Papers on
Nuclear Respiratory Factor 1
Thioredoxin-mediated redox regulation of resistance to endocrine therapy in breast cancer.
New
Miami, United States. In Biochim Biophys Acta, 04 Apr 2013
This, in turn, may lead to the disruption of reversible redox signaling that involves redox-sensitive phosphatases, protein kinases, such as, ERK and AKT, and transcription factors, such as, AP-1, NRF-1 and NF-κB.
Ropinirole protects against 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)-induced neurotoxicity in mice via anti-apoptotic mechanism.
New
Seoul, South Korea. In Pharmacol Biochem Behav, 31 Mar 2013
Ropinirole increased the Bcl-2/Bax ratio, transcription factor A, and nuclear respiratory factor 1 and inhibited cytosolic cytochrome c release and caspase-3 activity, indicating that ropinirole inhibited the apoptotic cascade.
Effect of nonpersistent pesticides on estrogen receptor, androgen receptor, and aryl hydrocarbon receptor.
New
Vienna, Austria. In Environ Toxicol, 23 Mar 2013
Fludioxonil and fenhexamid were ERα agonists (EC(50) -values of 3.7 and 9.0 μM, respectively) and had time-dependent effects on endogenous ERα-target gene expression (cyclin D1, progesterone receptor, and nuclear respiratory factor 1) in MCF-7 human breast cancer cells.
Effects of post-exercise recovery in a cold environment on muscle glycogen, PGC-1α, and downstream transcription factors.
New
Omaha, United States. In Cryobiology, 21 Mar 2013
There were no differences in NRF1 (p=.173) or TFAM (p=0.694).
Reactive Oxygen Species via Redox Signaling to PI3K/AKT Pathway Contribute to the Malignant Growth of 4-Hydroxy Estradiol-Transformed Mammary Epithelial Cells.
New
Miami, United States. In Plos One, Dec 2012
The expression of cell cycle genes, cdc2, PRC1 and PCNA and one of transcription factors that control the expression of these genes - nuclear respiratory factor-1 (NRF-1) was significantly up-regulated during the 4-OH-E2-mediated malignant transformation process.
Role of PGC-1α signaling in skeletal muscle health and disease.
Review
New
Minneapolis, United States. In Ann N Y Acad Sci, Oct 2012
PGC-1α is the master transcription regulator that stimulates mitochondrial biogenesis, by upregulating nuclear respiratory factors (NRF-1, 2) and mitochondrial transcription factor A (Tfam), which leads to increased mitochondrial DNA replication and gene transcription.
Bigenomic regulation of cytochrome c oxidase in neurons and the tight coupling between neuronal activity and energy metabolism.
Review
Milwaukee, United States. In Adv Exp Med Biol, 2011
Bigenomic regulation of all 13 transcripts is mediated by nuclear respiratory factors 1 and 2 (NRF-1 and NRF-2).
The Fbw7 tumor suppressor regulates nuclear factor E2-related factor 1 transcription factor turnover through proteasome-mediated proteolysis.
GeneRIF
Irvine, United States. In J Biol Chem, 2011
Fbw7 as a regulator of Nrf1 expression and reveal a novel function of Fbw7 in cellular stress response.
Dual regulation of the transcriptional activity of Nrf1 by β-TrCP- and Hrd1-dependent degradation mechanisms.
GeneRIF
Japan. In Mol Cell Biol, 2011
these results clearly suggest that both beta-TrCP- and Hrd1-dependent degradation mechanisms regulate the transcriptional activity of Nrf1 to maintain cellular homeostasis.
Coordination of mitochondrial biogenesis by thyroid hormone.
Review
Germany. In Mol Cell Endocrinol, 2011
Intermediate factors are transcription factors (such as NRF-1, NRF-2 and PPARγ) and transcriptional coactivators (such as PGC-1α and PGC-1β).
Central nervous system-specific deletion of transcription factor Nrf1 causes progressive motor neuronal dysfunction.
GeneRIF
Japan. In Genes Cells, 2011
These results show that Nrf1 sustains the CNS homeostasis through regulating target genes distinct from those regulated by Nrf2.
Airway remodeling in asthma: new mechanisms and potential for pharmacological intervention.
Review
Bordeaux, France. In Pharmacol Ther, 2011
ASM cell proliferation in severe asthma implicates a gallopamil-sensitive calcium influx and the activation of calcium-calmodulin kinase IV leading to enhanced mitochondrial biogenesis through the activation of various transcription factors (PGC-1α, NRF-1 and mt-TFA).
Contractile activity-induced gene expression in fast- and slow-twitch muscle.
GeneRIF
Toronto, Canada. In Appl Physiol Nutr Metab, 2011
NRF-1 has been identified as a mediator of the expression of nuclear genes encoding mitochondrial proteins.
PARIS (ZNF746) repression of PGC-1α contributes to neurodegeneration in Parkinson's disease.
Impact
Baltimore, United States. In Cell, 2011
PARIS represses the expression of the transcriptional coactivator, PGC-1α and the PGC-1α target gene, NRF-1 by binding to insulin response sequences in the PGC-1α promoter.
Estrogen-induced reactive oxygen species-mediated signalings contribute to breast cancer.
Review
Miami, United States. In Biochim Biophys Acta, 2011
Recent data implicated that these ROS induced DNA synthesis, increased phosphorylation of kinases, and activated transcription factors, e.g., AP-1, NRF1, E2F, NF-kB and CREB of non-genomic pathways which are responsive to both oxidants and estrogen.
Decreased expression of BRCA1 in SK-BR-3 cells is the result of aberrant activation of the GABP Beta promoter by an NRF-1-containing complex.
GeneRIF
Kingston, Canada. In Mol Cancer, 2010
Both NRF-1 and GABP have been linked to the regulation of nuclear-encoded mitochondrial proteins, and the results of this study suggest their expression is coordinated by NRF-1's activation of the GABPbeta promoter.
Hepatic-specific disruption of SIRT6 in mice results in fatty liver formation due to enhanced glycolysis and triglyceride synthesis.
Impact
Bethesda, United States. In Cell Metab, 2010
Here, we show that SIRT1 forms a complex with FOXO3a and NRF1 on the SIRT6 promoter and positively regulates expression of SIRT6, which, in turn, negatively regulates glycolysis, triglyceride synthesis, and fat metabolism by deacetylating histone H3 lysine 9 in the promoter of many genes involved in these processes.
Transcriptional paradigms in mammalian mitochondrial biogenesis and function.
Review
Impact
Chicago, United States. In Physiol Rev, 2008
Nucleomitochondrial interactions depend on the interplay between transcription factors (NRF-1, NRF-2, PPARalpha, ERRalpha, Sp1, and others) and members of the PGC-1 family of regulated coactivators (PGC-1alpha, PGC-1beta, and PRC).
Genome-wide orchestration of cardiac functions by the orphan nuclear receptors ERRalpha and gamma.
Impact
Montréal, Canada. In Cell Metab, 2007
Motif-finding algorithms assisted by functional studies indicated that ERR target promoters are enriched for NRF-1, CREB, and STAT3 binding sites.
Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1.
Impact
Boston, United States. In Cell, 1999
PGC-1 stimulates a powerful induction of NRF-1 and NRF-2 gene expression; in addition, PGC-1 binds to and coactivates the transcriptional function of NRF-1 on the promoter for mitochondrial transcription factor A (mtTFA), a direct regulator of mitochondrial DNA replication/transcription.
