Nuclear Respiratory Factor 1
Characterization of the metabolic effects of Irisin on skeletal muscle in vitro.
Albuquerque, United States. In Diabetes Obes Metab, 01 Mar 2014
Lastly, treatment with irisin also significantly elevated metabolic gene expression including peroxisome proliferator-activated receptor γ coactivator 1 alpha (PGC-1α), nuclear respiratory factor 1 (NRF1), mitochondrial transcription factor A (TFAM), irisin, glucose transporter 4 (GLUT4), and mitochondrial uncoupling protein 3 (UCP3) leading to increased mitochondrial biogenesis.
Thioredoxin-mediated redox regulation of resistance to endocrine therapy in breast cancer.
Miami, United States. In Biochim Biophys Acta, Aug 2013
This, in turn, may lead to the disruption of reversible redox signaling that involves redox-sensitive phosphatases, protein kinases, such as, ERK and AKT, and transcription factors, such as, AP-1, NRF-1 and NF-κB.
Role of PGC-1α signaling in skeletal muscle health and disease.
Minneapolis, United States. In Ann N Y Acad Sci, 2012
PGC-1α is the master transcription regulator that stimulates mitochondrial biogenesis, by upregulating nuclear respiratory factors (NRF-1, 2) and mitochondrial transcription factor A (Tfam), which leads to increased mitochondrial DNA replication and gene transcription.