Nuclear Respiratory Factor 1
Mitochondrial DNA copy number and biogenesis in different tissues of early- and late-lactating dairy cows.
Bonn, Germany. In J Dairy Sci, Jan 2016
German Holstein cows (n = 21) were fed according to their requirements, and biopsies from scAT, liver, mammary gland, and blood were collected in early and late lactation and assayed for relative mtDNA copy numbers and the mRNA abundance of genes regulating mitochondrial biogenesis, such as nuclear-respiratory factor 1 and 2 (NRF-1, NRF-2), mitochondrial transcription factor A (TFAM), and peroxisome proliferator-activated receptor-gamma coactivator 1-α (PGC-1α).
The emerging role of Nrf2 in mitochondrial function.
Dundee, United Kingdom. In Free Radic Biol Med, Nov 2015
Under conditions of stress or growth factor stimulation, activation of Nrf2 counteracts the increased reactive oxygen species production in mitochondria via transcriptional upregulation of uncoupling protein 3 and influences mitochondrial biogenesis by maintaining the levels of nuclear respiratory factor 1 and peroxisome proliferator-activated receptor γ coactivator 1α, as well as by promoting purine nucleotide biosynthesis.
Regulation of mitochondrial biogenesis and its intersection with inflammatory responses.
Durham, United States. In Antioxid Redox Signal, May 2015
RECENT ADVANCES: Early-phase inflammatory mediator proteins interact with PRRs to activate NF-κB-, MAPK-, and PKB/Akt-dependent pathways, resulting in increased expression or activity of coactivators and transcription factors (e.g., PGC-1α, NRF-1, NRF-2, and Nfe2l2) that regulate mitochondrial biogenesis.
mTORC1 signaling activates NRF1 to increase cellular proteasome levels.
Boston, United States. In Cell Cycle, 2014
Activation of mTORC1 genetically, through loss of the tuberous sclerosis complex (TSC) tumor suppressors, or physiologically, through growth factors or feeding, stimulates a transcriptional program involving the sterol-regulatory element binding protein 1 (SREBP1) and nuclear factor erythroid-derived 2-related factor 1 (NRF1; also known as NFE2L1) transcription factors leading to an increase in cellular proteasome content.
Redox mechanisms of cardiomyocyte mitochondrial protection.
Durham, United States. In Front Physiol, 2014
Simultaneously, a number of other DNA binding transcription factors are expressed and/or activated under redox control, such as Nuclear Respiratory Factor-1 (NRF-1), and lead to the induction of genes involved in both intracellular and mitochondria-specific repair mechanisms.
Coordinated regulation of protein synthesis and degradation by mTORC1.
Boston, United States. In Nature, 2014
The increase in proteasome gene expression, cellular proteasome content, and rates of protein turnover downstream of mTORC1 were all dependent on induction of the transcription factor nuclear factor erythroid-derived 2-related factor 1 (NRF1; also known as NFE2L1).