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Nuclear respiratory factor 1

Nuclear Respiratory Factor 1, NRF-1
This gene encodes a protein that homodimerizes and functions as a transcription factor which activates the expression of some key metabolic genes regulating cellular growth and nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication. The protein has also been associated with the regulation of neurite outgrowth. Alternate transcriptional splice variants, which encode the same protein, have been characterized. Additional variants encoding different protein isoforms have been described but they have not been fully characterized. Confusion has occurred in bibliographic databases due to the shared symbol of NRF1 for this gene and for "nuclear factor (erythroid-derived 2)-like 1" which has an official symbol of NFE2L1. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: NRF, PGC, TFAM, Nrf2, PGC-1alpha
Papers on Nuclear Respiratory Factor 1
Chronic oxidative stress causes estrogen-independent aggressive phenotype, and epigenetic inactivation of estrogen receptor alpha in MCF-7 breast cancer cells.
New
Singh et al., Lubbock, United States. In Breast Cancer Res Treat, 26 Aug 2015
Increases in mtTFA and NRF1 in these cells further suggested the role of mitochondria-dependent redox-sensitive growth signaling as an alternative pathway to estrogen-dependent growth.
Distinct profiles of human embryonic stem cell metabolism and mitochondria identified by oxygen.
New
Harvey et al., Melbourne, Australia. In Reproduction, 09 Aug 2015
In response to extended physiological oxygen culture MEL2 hES cells displayed reduced mtDNA content, mitochondrial mass and expression of metabolic genes TFAM, NRF1, PPARa and MT-ND4.
miR-504 mediated down-regulation of nuclear respiratory factor 1 leads to radio-resistance in nasopharyngeal carcinoma.
New
Cao et al., Changsha, China. In Oncotarget, 30 Jul 2015
In contrast, the expression of nuclear respiratory factor 1 (NRF1) and other mitochondrial metabolism factors, including mitochondrial transcription factor A (TFAM) and oxidative phosphorylation (OXPHOS) complex III were down-regulated in these cell lines.
Selenium supplementation induces mitochondrial biogenesis in trophoblasts.
New
Perkins et al., Gold Coast, Australia. In Placenta, 23 Jul 2015
The levels of the mitochondrial biogenesis markers selenoprotein H, PGC-1α and NRF-1 was examined by western blotting.
The emerging role of Nrf2 in mitochondrial function.
Review
New
Abramov et al., Dundee, United Kingdom. In Free Radic Biol Med, Jun 2015
Under conditions of stress or growth factor stimulation, activation of Nrf2 counteracts the increased ROS production in mitochondria by transcriptional upregulation of uncoupling protein 3 and influences mitochondrial biogenesis by maintaining the levels of nuclear respiratory factor 1 and peroxisome proliferator-activated receptor γ coactivator 1α, as well as by promoting purine nucleotide biosynthesis.
Stem cell aging. A mitochondrial UPR-mediated metabolic checkpoint regulates hematopoietic stem cell aging.
New
Impact
Chen et al., Berkeley, United States. In Science, Apr 2015
Here, we identified a regulatory branch of the mitochondrial unfolded protein response (UPR(mt)), which is mediated by the interplay of SIRT7 and NRF1 and is coupled to cellular energy metabolism and proliferation.
The Protective Effects of Salidroside from Exhaustive Exercise-Induced Heart Injury by Enhancing the PGC-1 α -NRF1/NRF2 Pathway and Mitochondrial Respiratory Function in Rats.
New
Cao et al., Baoding, China. In Oxid Med Cell Longev, Dec 2014
Compared to C group, the EE group showed marked myocardium ultrastructure injury and decrease of mitochondrial respiratory function (P < 0.05) and protein levels of PGC-1α, NRF1, and NRF2 (P < 0.05) but a significant increase of PGC-1α, NRF1, and NRF2 genes levels (P < 0.05); compared to EE group, SAL ameliorated myocardium injury, increased mitochondrial respiratory function (P < 0.05), and elevated both gene and protein levels of PGC-1α, NRF-1, and NRF-2.
Coordinated regulation of protein synthesis and degradation by mTORC1.
New
Impact
Manning et al., Boston, United States. In Nature, Oct 2014
The increase in proteasome gene expression, cellular proteasome content, and rates of protein turnover downstream of mTORC1 were all dependent on induction of the transcription factor nuclear factor erythroid-derived 2-related factor 1 (NRF1; also known as NFE2L1).
Mitochondrial adaptations evoked with exercise are associated with a reduction in age-induced testicular atrophy in Fischer-344 rats.
Review
Adhihetty et al., Gainesville, United States. In Biogerontology, 2013
However, relative mitochondrial content was not reduced with age and this was consistent with the lack of change in the mitochondrial biogenesis regulator protein, peroxisome proliferator-activated receptor gamma coactivator 1-alpha and its downstream targets nuclear respiratory factor-1 and mitochondrial transcription factor A. No effect was observed in the pro- or anti-apoptotic proteins, Bax and Bcl-2, respectively, but age increased apoptosis inducing factor levels.
DNA methylation analysis in nonalcoholic fatty liver disease suggests distinct disease-specific and remodeling signatures after bariatric surgery.
Impact
Hampe et al., Kiel, Germany. In Cell Metab, 2013
Postbariatric and NAFLD-specific methylation signatures were clearly distinct both in gene ontology and transcription factor binding site analyses, with >400-fold enrichment of NRF1, HSF1, and ESRRA sites.
Thioredoxin-mediated redox regulation of resistance to endocrine therapy in breast cancer.
Review
Roy et al., Miami, United States. In Biochim Biophys Acta, 2013
This, in turn, may lead to the disruption of reversible redox signaling that involves redox-sensitive phosphatases, protein kinases, such as, ERK and AKT, and transcription factors, such as, AP-1, NRF-1 and NF-κB.
Role of PGC-1α signaling in skeletal muscle health and disease.
Review
Li Ji et al., Minneapolis, United States. In Ann N Y Acad Sci, 2012
PGC-1α is the master transcription regulator that stimulates mitochondrial biogenesis, by upregulating nuclear respiratory factors (NRF-1, 2) and mitochondrial transcription factor A (Tfam), which leads to increased mitochondrial DNA replication and gene transcription.
NF-E2-related factor 1 (Nrf1) serves as a novel regulator of hepatic lipid metabolism through regulation of the Lipin1 and PGC-1β genes.
GeneRIF
Yamamoto et al., Sendai, Japan. In Mol Cell Biol, 2012
Nrf1 binds to the antioxidant response elements (AREs) in regulatory regions of the Lipin1 and PGC-1beta genes and the binding of Nrf1 to the AREs activates reporter gene transcription.
Nrf1 CNC-bZIP protein promotes cell survival and nucleotide excision repair through maintaining glutathione homeostasis.
GeneRIF
He et al., Chicago, United States. In J Biol Chem, 2012
results indicate a novel role of Nrf1 in UVB-induced DNA damage repair and suggest Nrf1 as a tumor suppressor in the skin
Diesel exhaust particulate extracts inhibit transcription of nuclear respiratory factor-1 and cell viability in human umbilical vein endothelial cells.
GeneRIF
Klinge et al., Louisville, United States. In Arch Toxicol, 2012
Given that NRF-1 is a key nuclear transcription factor regulating genes involved in mitochondrial activity and biogenesis, these data suggest that diesel exhaust particulate extracts may adversely affect mitochondrial function.
Bigenomic regulation of cytochrome c oxidase in neurons and the tight coupling between neuronal activity and energy metabolism.
Review
Wong-Riley, Milwaukee, United States. In Adv Exp Med Biol, 2011
Bigenomic regulation of all 13 transcripts is mediated by nuclear respiratory factors 1 and 2 (NRF-1 and NRF-2).
The Fbw7 tumor suppressor regulates nuclear factor E2-related factor 1 transcription factor turnover through proteasome-mediated proteolysis.
GeneRIF
Chan et al., Irvine, United States. In J Biol Chem, 2011
Fbw7 as a regulator of Nrf1 expression and reveal a novel function of Fbw7 in cellular stress response.
PARIS (ZNF746) repression of PGC-1α contributes to neurodegeneration in Parkinson's disease.
Impact
Dawson et al., Baltimore, United States. In Cell, 2011
PARIS represses the expression of the transcriptional coactivator, PGC-1α and the PGC-1α target gene, NRF-1 by binding to insulin response sequences in the PGC-1α promoter.
The Nrf1 CNC-bZIP protein is regulated by the proteasome and activated by hypoxia.
GeneRIF
Willmore et al., Ottawa, Canada. In Plos One, 2010
data suggests that Nrf1 is controlled by several post-translational mechanisms, including ubiquitination, proteolytic processing and proteasomal-mediated degradation as well as by its phosphorylation status
Hepatic-specific disruption of SIRT6 in mice results in fatty liver formation due to enhanced glycolysis and triglyceride synthesis.
Impact
Deng et al., Bethesda, United States. In Cell Metab, 2010
Here, we show that SIRT1 forms a complex with FOXO3a and NRF1 on the SIRT6 promoter and positively regulates expression of SIRT6, which, in turn, negatively regulates glycolysis, triglyceride synthesis, and fat metabolism by deacetylating histone H3 lysine 9 in the promoter of many genes involved in these processes.
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