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Nuclear respiratory factor 1

Nuclear Respiratory Factor 1, NRF-1
This gene encodes a protein that homodimerizes and functions as a transcription factor which activates the expression of some key metabolic genes regulating cellular growth and nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication. The protein has also been associated with the regulation of neurite outgrowth. Alternate transcriptional splice variants, which encode the same protein, have been characterized. Additional variants encoding different protein isoforms have been described but they have not been fully characterized. Confusion has occurred in bibliographic databases due to the shared symbol of NRF1 for this gene and for "nuclear factor (erythroid-derived 2)-like 1" which has an official symbol of NFE2L1. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: NRF, PGC, TFAM, Nrf2, PGC-1alpha
Papers on Nuclear Respiratory Factor 1
Cryptotanshinone protects against adriamycin-induced mitochondrial dysfunction in cardiomyocytes.
New
Ying et al., China. In Pharm Biol, 10 May 2015
Mitochondrial biogenesis-relative factors PGC-1α, NRF-1, and TFAM were also promoted.
Adaptive expression of uncoupling protein 1 in the carp liver and kidney in response to changes in ambient temperature.
New
Funaba et al., Sagamihara, Japan. In Comp Biochem Physiol A Mol Integr Physiol, 09 May 2015
Cold exposure increased the expressions of PPARβ/δ and NRF1 both in the liver and kidney, as well as renal PGC-1α expression, and subsequent increases in the water temperature from 8°C to 28°C decreased these expression levels.
Impaired Muscle Mitochondrial Biogenesis and Myogenesis in Spinal Muscular Atrophy.
New
Moggio et al., Milano, Italy. In Jama Neurol, 06 May 2015
We linked these alterations to downregulation of peroxisome proliferator-activated receptor coactivator 1α, the transcriptional activators nuclear respiratory factor 1 and nuclear respiratory factor 2, mitochondrial transcription factor A, and their downstream targets, implying depression of the entire mitochondrial biogenesis.
Extensive temporal transcriptome and microRNA analyses identify molecular mechanisms underlying mitochondrial dysfunction induced by multi-walled carbon nanotubes in human lung cells.
New
Briedé et al., Maastricht, Netherlands. In Nanotoxicology, 01 May 2015
Forty-nine of the MMP↓-associated genes showed highly similar expression patterns over time (six time points) and the majority was found to be regulated by two transcription factors strongly involved in mitochondrial homeostasis, APP and NRF1.
Liver delipidating effect of a combination of resveratrol and quercetin in rats fed an obesogenic diet.
New
Portillo et al., Vitoria-Gasteiz, Spain. In J Physiol Biochem, 01 May 2015
No significant changes were observed in the expression of peroxisome proliferator-activated receptor α (PPARα), nuclear respiratory factor 1 (NRF-1) and transcription factor A mitochondrial (TFAM).
Stem cell aging. A mitochondrial UPR-mediated metabolic checkpoint regulates hematopoietic stem cell aging.
New
Impact
Chen et al., Berkeley, United States. In Science, 20 Apr 2015
Here, we identified a regulatory branch of the mitochondrial unfolded protein response (UPR(mt)), which is mediated by the interplay of SIRT7 and NRF1 and is coupled to cellular energy metabolism and proliferation.
Coordinated regulation of protein synthesis and degradation by mTORC1.
New
Impact
Manning et al., Boston, United States. In Nature, Oct 2014
The increase in proteasome gene expression, cellular proteasome content, and rates of protein turnover downstream of mTORC1 were all dependent on induction of the transcription factor nuclear factor erythroid-derived 2-related factor 1 (NRF1; also known as NFE2L1).
DNA methylation analysis in nonalcoholic fatty liver disease suggests distinct disease-specific and remodeling signatures after bariatric surgery.
Impact
Hampe et al., Kiel, Germany. In Cell Metab, 2013
Postbariatric and NAFLD-specific methylation signatures were clearly distinct both in gene ontology and transcription factor binding site analyses, with >400-fold enrichment of NRF1, HSF1, and ESRRA sites.
Thioredoxin-mediated redox regulation of resistance to endocrine therapy in breast cancer.
Review
Roy et al., Miami, United States. In Biochim Biophys Acta, 2013
This, in turn, may lead to the disruption of reversible redox signaling that involves redox-sensitive phosphatases, protein kinases, such as, ERK and AKT, and transcription factors, such as, AP-1, NRF-1 and NF-κB.
Role of PGC-1α signaling in skeletal muscle health and disease.
Review
Li Ji et al., Minneapolis, United States. In Ann N Y Acad Sci, 2012
PGC-1α is the master transcription regulator that stimulates mitochondrial biogenesis, by upregulating nuclear respiratory factors (NRF-1, 2) and mitochondrial transcription factor A (Tfam), which leads to increased mitochondrial DNA replication and gene transcription.
NF-E2-related factor 1 (Nrf1) serves as a novel regulator of hepatic lipid metabolism through regulation of the Lipin1 and PGC-1β genes.
GeneRIF
Yamamoto et al., Sendai, Japan. In Mol Cell Biol, 2012
Nrf1 binds to the antioxidant response elements (AREs) in regulatory regions of the Lipin1 and PGC-1beta genes and the binding of Nrf1 to the AREs activates reporter gene transcription.
Nrf1 CNC-bZIP protein promotes cell survival and nucleotide excision repair through maintaining glutathione homeostasis.
GeneRIF
He et al., Chicago, United States. In J Biol Chem, 2012
results indicate a novel role of Nrf1 in UVB-induced DNA damage repair and suggest Nrf1 as a tumor suppressor in the skin
Diesel exhaust particulate extracts inhibit transcription of nuclear respiratory factor-1 and cell viability in human umbilical vein endothelial cells.
GeneRIF
Klinge et al., Louisville, United States. In Arch Toxicol, 2012
Given that NRF-1 is a key nuclear transcription factor regulating genes involved in mitochondrial activity and biogenesis, these data suggest that diesel exhaust particulate extracts may adversely affect mitochondrial function.
Bigenomic regulation of cytochrome c oxidase in neurons and the tight coupling between neuronal activity and energy metabolism.
Review
Wong-Riley, Milwaukee, United States. In Adv Exp Med Biol, 2011
Bigenomic regulation of all 13 transcripts is mediated by nuclear respiratory factors 1 and 2 (NRF-1 and NRF-2).
The Fbw7 tumor suppressor regulates nuclear factor E2-related factor 1 transcription factor turnover through proteasome-mediated proteolysis.
GeneRIF
Chan et al., Irvine, United States. In J Biol Chem, 2011
Fbw7 as a regulator of Nrf1 expression and reveal a novel function of Fbw7 in cellular stress response.
Coordination of mitochondrial biogenesis by thyroid hormone.
Review
Iwen et al., Germany. In Mol Cell Endocrinol, 2011
Intermediate factors are transcription factors (such as NRF-1, NRF-2 and PPARγ) and transcriptional coactivators (such as PGC-1α and PGC-1β).
Airway remodeling in asthma: new mechanisms and potential for pharmacological intervention.
Review
Berger et al., Bordeaux, France. In Pharmacol Ther, 2011
ASM cell proliferation in severe asthma implicates a gallopamil-sensitive calcium influx and the activation of calcium-calmodulin kinase IV leading to enhanced mitochondrial biogenesis through the activation of various transcription factors (PGC-1α, NRF-1 and mt-TFA).
PARIS (ZNF746) repression of PGC-1α contributes to neurodegeneration in Parkinson's disease.
Impact
Dawson et al., Baltimore, United States. In Cell, 2011
PARIS represses the expression of the transcriptional coactivator, PGC-1α and the PGC-1α target gene, NRF-1 by binding to insulin response sequences in the PGC-1α promoter.
The Nrf1 CNC-bZIP protein is regulated by the proteasome and activated by hypoxia.
GeneRIF
Willmore et al., Ottawa, Canada. In Plos One, 2010
data suggests that Nrf1 is controlled by several post-translational mechanisms, including ubiquitination, proteolytic processing and proteasomal-mediated degradation as well as by its phosphorylation status
Hepatic-specific disruption of SIRT6 in mice results in fatty liver formation due to enhanced glycolysis and triglyceride synthesis.
Impact
Deng et al., Bethesda, United States. In Cell Metab, 2010
Here, we show that SIRT1 forms a complex with FOXO3a and NRF1 on the SIRT6 promoter and positively regulates expression of SIRT6, which, in turn, negatively regulates glycolysis, triglyceride synthesis, and fat metabolism by deacetylating histone H3 lysine 9 in the promoter of many genes involved in these processes.
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