Nuclear Respiratory Factor 1
The emerging role of Nrf2 in mitochondrial function.
Dundee, United Kingdom. In Free Radic Biol Med, 11 Jun 2015
Under conditions of stress or growth factor stimulation, activation of Nrf2 counteracts the increased ROS production in mitochondria by transcriptional upregulation of uncoupling protein 3 and influences mitochondrial biogenesis by maintaining the levels of nuclear respiratory factor 1 and peroxisome proliferator-activated receptor γ coactivator 1α, as well as by promoting purine nucleotide biosynthesis.
Coordinated regulation of protein synthesis and degradation by mTORC1.
Boston, United States. In Nature, Oct 2014
The increase in proteasome gene expression, cellular proteasome content, and rates of protein turnover downstream of mTORC1 were all dependent on induction of the transcription factor nuclear factor erythroid-derived 2-related factor 1 (NRF1; also known as NFE2L1).
Thioredoxin-mediated redox regulation of resistance to endocrine therapy in breast cancer.
Miami, United States. In Biochim Biophys Acta, 2013
This, in turn, may lead to the disruption of reversible redox signaling that involves redox-sensitive phosphatases, protein kinases, such as, ERK and AKT, and transcription factors, such as, AP-1, NRF-1 and NF-κB.
Role of PGC-1α signaling in skeletal muscle health and disease.
Minneapolis, United States. In Ann N Y Acad Sci, 2012
PGC-1α is the master transcription regulator that stimulates mitochondrial biogenesis, by upregulating nuclear respiratory factors (NRF-1, 2) and mitochondrial transcription factor A (Tfam), which leads to increased mitochondrial DNA replication and gene transcription.