Hypothalamic NUCKS regulates peripheral glucose homoeostasis.
Singapore, Singapore. In Biochem J, Sep 2015
Nuclear ubiquitous casein and cyclin-dependent kinase substrate (NUCKS) is highly expressed in the brain and peripheral metabolic organs, and regulates transcription of a number of genes involved in insulin signalling.
NUCKS: a potential biomarker in cancer and metabolic disease.
Singapore, Singapore. In Clin Sci (lond), Jun 2015
Nuclear, casein kinase and cyclin-dependent kinase substrate (NUCKS), a protein similar to the HMG (high-mobility group) protein family, is one of the most modified proteins in the mammalian proteome.
Identification of species-specific and cross-reactive epitopes in human polyomavirus capsids using monoclonal antibodies.
Pittsburgh, United States. In J Gen Virol, 2009
Most antibodies recognized conformational species-specific epitopes, but several exceptions were found: (i) BKV mAb BK-F11 cross-reacted with a linear buried epitope common to both JCV and SV40 pseudocapsids, (ii) two of six JCV antibodies (JC-6.7 and JC-7.9) and two of 13 SV40 antibodies (VP1-H2 and VP1-I2) recognized linear buried epitopes common to all three viruses and (iii) SV40 antibody VP1-E5 recognized a linear surface epitope on JCV pseudocapsids.
NUCKS overexpression in breast cancer.
Athens, Greece. In Cancer Cell Int, 2008
The results show overexpression of the NUCKS protein and RNA in a number of non malignant breast lesions and cancerous tissues. In particular, the NUCKS overexpression in ADH and DCIS indicates a significant role of this protein in neoplastic progression.