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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Nuclear casein kinase and cyclin-dependent kinase substrate 1

NUCKS, Nuclear ubiquitous casein and cyclin-dependent kinases substrate, JC-7
This gene encodes a nuclear protein that is highly conserved in vertebrates. The conserved regions of the protein contain several consensus phosphorylation sites for casein kinase II and cyclin-dependent kinases, two putative nuclear localization signals, and a basic DNA-binding domain. It is phosphorylated in vivo by Cdk1 during mitosis of the cell cycle. [provided by RefSeq, Aug 2010] (from NCBI)
Papers on NUCKS
Prefrontal cortex shotgun proteome analysis reveals altered calcium homeostasis and immune system imbalance in schizophrenia.
Turck et al., São Paulo, Brazil. In Eur Arch Psychiatry Clin Neurosci, 2009
Using shotgun mass spectrometry, we found this protein differentially expressed in the dorsolateral prefrontal cortex from patients with schizophrenia.
Immunohistochemical and proteomic evaluation of nuclear ubiquitous casein and cyclin-dependent kinases substrate in invasive ductal carcinoma of the breast.
Wiśniewski et al., Wrocław, Poland. In J Biomed Biotechnol, 2008
Overexpression of NUCKS can play significant role in breast cancer biology.
NUCKS overexpression in breast cancer.
Aleporou-Marinou et al., Athens, Greece. In Cancer Cell Int, 2008
The results show overexpression of the NUCKS protein and RNA in a number of non malignant breast lesions and cancerous tissues. In particular, the NUCKS overexpression in ADH and DCIS indicates a significant role of this protein in neoplastic progression.
Constitutive and dynamic phosphorylation and acetylation sites on NUCKS, a hypermodified nuclear protein, studied by quantitative proteomics.
Mann et al., Martinsried, Germany. In Proteins, 2008
NUCKS appears to have the highest ratio of modified to unmodified residues of any protein so far described.
Identification and characterization of two putative nuclear localization signals (NLS) in the DNA-binding protein NUCKS.
Ostvold et al., Oslo, Norway. In Biochim Biophys Acta, 2007
Two putative nuclear localization signals have been identified and characterized in NUCKS.
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