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Nuclear casein kinase and cyclin-dependent kinase substrate 1
NUCKS, Nuclear ubiquitous casein and cyclin-dependent kinases substrate, JC-7
This gene encodes a nuclear protein that is highly conserved in vertebrates. The conserved regions of the protein contain several consensus phosphorylation sites for casein kinase II and cyclin-dependent kinases, two putative nuclear localization signals, and a basic DNA-binding domain. It is phosphorylated in vivo by Cdk1 during mitosis of the cell cycle. [provided by RefSeq, Aug 2010] (from
Aleporou-Marinou et al., Athens, Greece. In Cancer Cell Int, 2008
The results show overexpression of the NUCKS protein and RNA in a number of non malignant breast lesions and cancerous tissues. In particular, the NUCKS overexpression in ADH and DCIS indicates a significant role of this protein in neoplastic progression.