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Nuclear casein kinase and cyclin-dependent kinase substrate 1

NUCKS, Nuclear ubiquitous casein and cyclin-dependent kinases substrate, JC-7
This gene encodes a nuclear protein that is highly conserved in vertebrates. The conserved regions of the protein contain several consensus phosphorylation sites for casein kinase II and cyclin-dependent kinases, two putative nuclear localization signals, and a basic DNA-binding domain. It is phosphorylated in vivo by Cdk1 during mitosis of the cell cycle. [provided by RefSeq, Aug 2010] (from NCBI)
Top mentioned proteins: PCNA, ACID, fibrillin-1, CAN, CDC2
Papers on NUCKS
Hypothalamic NUCKS regulates peripheral glucose homoeostasis.
New
Tergaonkar et al., Singapore, Singapore. In Biochem J, Sep 2015
Nuclear ubiquitous casein and cyclin-dependent kinase substrate (NUCKS) is highly expressed in the brain and peripheral metabolic organs, and regulates transcription of a number of genes involved in insulin signalling.
NUCKS: a potential biomarker in cancer and metabolic disease.
Review
New
Tergaonkar et al., Singapore, Singapore. In Clin Sci (lond), Jun 2015
Nuclear, casein kinase and cyclin-dependent kinase substrate (NUCKS), a protein similar to the HMG (high-mobility group) protein family, is one of the most modified proteins in the mammalian proteome.
Combined evaluation of the expression of NUCKS and Ki-67 proteins as independent prognostic factors for patients with gastric adenocarcinoma.
Zhang et al., Harbin, China. In Tumour Biol, 2014
Nuclear ubiquitous casein and cyclin-dependent kinases substrate (NUCKS) has been recently documented in various malignancies.
NUCKS is a positive transcriptional regulator of insulin signaling.
Tergaonkar et al., Singapore, Singapore. In Cell Rep, 2014
We now find that NUCKS is a transcriptional regulator of the insulin signaling components, including the insulin receptor (IR).
The comparison of nuclear ubiquitous casein and cyclin-dependent kinases substrate (NUCKS) with Ki67 proliferation marker expression in common skin tumors.
Ziółkowski et al., Wrocław, Poland. In Pol J Pathol, 2014
Nuclear ubiquitous casein and cyclin-dependent kinases substrate (NUCKS) is a chromosomal protein of unknown function.
Dynamic expression of the vertebrate-specific protein Nucks during rodent embryonic development.
Aleporou-Marinou et al., Athens, Greece. In Gene Expr Patterns, 2014
The nuclear casein kinase and cyclin-dependent kinase substrate 1 (NUCKS) is a highly phosphorylated nuclear protein that is overexpressed in many types of cancer.
Effect of NUCKS-1 overexpression on cytokine profiling in obese women with breast cancer.
El-Khadrawy et al., Ţanţā, Egypt. In Asian Pac J Cancer Prev, 2013
The nuclear, casein kinase and cyclin-dependent kinase substrate-1 (NUCKS-1), is a nuclear DNA-binding protein that has been implicated in several human cancers, including breast cancer.
Immunocytochemical studies on the nuclear ubiquitous casein and cyclin-dependent kinases substrate following 5-aminolevulinicacid-mediated photodynamic therapy on MCF-7 cells.
Ziółkowski et al., Wrocław, Poland. In Photodiagnosis Photodyn Ther, 2013
BACKGROUND: Recent data indicates that nuclear ubiquitous casein and cyclin-dependent kinases substrate (NUCKS) may play role in tumor growth.
Prefrontal cortex shotgun proteome analysis reveals altered calcium homeostasis and immune system imbalance in schizophrenia.
GeneRIF
Turck et al., São Paulo, Brazil. In Eur Arch Psychiatry Clin Neurosci, 2009
Using shotgun mass spectrometry, we found this protein differentially expressed in the dorsolateral prefrontal cortex from patients with schizophrenia.
Identification of species-specific and cross-reactive epitopes in human polyomavirus capsids using monoclonal antibodies.
Christensen et al., Pittsburgh, United States. In J Gen Virol, 2009
Most antibodies recognized conformational species-specific epitopes, but several exceptions were found: (i) BKV mAb BK-F11 cross-reacted with a linear buried epitope common to both JCV and SV40 pseudocapsids, (ii) two of six JCV antibodies (JC-6.7 and JC-7.9) and two of 13 SV40 antibodies (VP1-H2 and VP1-I2) recognized linear buried epitopes common to all three viruses and (iii) SV40 antibody VP1-E5 recognized a linear surface epitope on JCV pseudocapsids.
Immunohistochemical and proteomic evaluation of nuclear ubiquitous casein and cyclin-dependent kinases substrate in invasive ductal carcinoma of the breast.
GeneRIF
Wiśniewski et al., Wrocław, Poland. In J Biomed Biotechnol, 2008
Overexpression of NUCKS can play significant role in breast cancer biology.
NUCKS overexpression in breast cancer.
GeneRIF
Aleporou-Marinou et al., Athens, Greece. In Cancer Cell Int, 2008
The results show overexpression of the NUCKS protein and RNA in a number of non malignant breast lesions and cancerous tissues. In particular, the NUCKS overexpression in ADH and DCIS indicates a significant role of this protein in neoplastic progression.
Chromosomal changes in high- and low-invasive mouse lung adenocarcinoma cell strains derived from early passage mouse lung adenocarcinoma cell strains.
Reynolds et al., Morgantown, United States. In Toxicol Appl Pharmacol, 2008
Expression array analysis and confirmation by real time PCR demonstrated increased expression of COX-2, Translin (TB-RBP), DYRK3, NUCKS and Tubulin-alpha4 genes in the high-invasive cell strains.
Constitutive and dynamic phosphorylation and acetylation sites on NUCKS, a hypermodified nuclear protein, studied by quantitative proteomics.
GeneRIF
Mann et al., Martinsried, Germany. In Proteins, 2008
NUCKS appears to have the highest ratio of modified to unmodified residues of any protein so far described.
Identification and characterization of two putative nuclear localization signals (NLS) in the DNA-binding protein NUCKS.
GeneRIF
Ostvold et al., Oslo, Norway. In Biochim Biophys Acta, 2007
Two putative nuclear localization signals have been identified and characterized in NUCKS.
Characterisation of the NUCKS gene on human chromosome 1q32.1 and the presence of a homologous gene in different species.
Østvold et al., Oslo, Norway. In Biochem Biophys Res Commun, 2004
The NUCKS gene is located on human chromosome 1q32.1 and consists of seven exons and six introns.
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