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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Neuronal growth regulator 1

ntrA, NEGR1, neurotractin
Top mentioned proteins: FTO, fibrillin-1, SH2-B, MC4R, KCTD15
Papers on ntrA
A long non-coding RNA, BC048612 and a microRNA, miR-203 coordinate the gene expression of neuronal growth regulator 1 (NEGR1) adhesion protein.
Jeyaseelan et al., Singapore, Singapore. In Biochim Biophys Acta, Jan 2016
Neuronal growth regulator 1 (NEGR1) is a cell adhesion molecule that has been shown to play an important role in neurite outgrowth during neuronal development.
[Long non-coding RNA Gm15577 is involved in mouse cerebellar neurogenesis].
Tong et al., Beijing, China. In Zhonghua Bing Li Xue Za Zhi, Jul 2015
Expression profiles of lncRNA Gm15577 and coding gene Negr1 in mice, primary cerebellar culture and cell lines were measured using RT-qPCR.
Obesity-Related Genetic Variants and their Associations with Physical Activity.
Pescatello et al., Providence, United States. In Sports Med Open, 2014
Due to the pleiotropic effects of related phenotypes, we tested six of these obesity-related genetic variants for their association with physical activity: fat mass and obesity-associated (FTO)(rs9939609)T>A, potassium channel tetramerization domain containing (KCTD15) (rs11084753)G>A, melanocortin receptor4 (MC4R)(rs17782313)T>C, neuronal growth regulator 1 (NEGR1)(rs2815752)A>G, SH2B adapter protein 1 (SH2B1)(rs7498665)A>G, and transmembrane protein18 (TMEM18)(rs6548238)C>T.
Clinical and Molecular Cytogenetic Characterization of a de novo Interstitial 1p31.1p31.3 Deletion in a Boy with Moderate Intellectual Disability and Severe Language Impairment.
Gimelli et al., Genova, Italy. In Cytogenet Genome Res, 2014
The deleted region contains 20 OMIM genes, but we focused on GADD45A (MIM 126335; growth arrest- and DNA damage-inducible gene), LRRC7 (MIM 614453; leucine-rich repeat-containing protein 7), and NEGR1 (MIM 613173; neuronal growth regulator 1).
Stress defense mechanisms of NADPH-dependent thioredoxin reductases (NTRs) in plants.
Kim et al., Chinju, South Korea. In Plant Signal Behav, 2014
However, due to functional redundancy between cytosolic and mitochondrial NTRs (NTRA and NTRB, respectively), their functional involvements under stress conditions have not been well characterized.
Characterizing gene-gene interactions in a statistical epistasis network of twelve candidate genes for obesity.
Gilbert-Diamond et al., United States. In Biodata Min, 2014
In this study, we aimed to analyze pairwise interactions that are associated with Body Mass Index (BMI) between SNPs from twelve genes robustly associated with obesity (BDNF, ETV5, FAIM2, FTO, GNPDA2, KCTD15, MC4R, MTCH2, NEGR1, SEC16B, SH2B1, and TMEM18).
Proteomic Analysis of Urine to Identify Breast Cancer Biomarker Candidates Using a Label-Free LC-MS/MS Approach.
Li et al., Kogarah, Australia. In Plos One, 2014
These include stage specific markers associated with pre-invasive breast cancer in the ductal carcinoma in-situ (DCIS) samples (Leucine LRC36, MAST4 and Uncharacterized protein CI131), early invasive breast cancer (DYH8, HBA, PEPA, uncharacterized protein C4orf14 (CD014), filaggrin and MMRN2) and metastatic breast cancer (AGRIN, NEGR1, FIBA and Keratin KIC10).
Genome-wide SNP and CNV analysis identifies common and low-frequency variants associated with severe early-onset obesity.
Farooqi et al., Cambridge, United Kingdom. In Nat Genet, 2013
A previously reported 43-kb deletion at the NEGR1 locus was significantly associated with severe obesity (P = 6.6 × 10(-7)).
Functional analysis of seven genes linked to body mass index and adiposity by genome-wide association studies: a review.
Speakman, Beijing, China. In Hum Hered, 2012
The remaining 7 SNPs are adjacent to, or within, the genes NEGR1, TMEM18, ETV5, FLJ35779, LINGO2, SH2B1 and GIPR, most of which are less well studied than FTO, particularly in the context of obesity.
Genetic determinants of obesity and related vascular diseases.
Back et al., Marburg an der Lahn, Germany. In Vitam Horm, 2012
In addition to common variants, FTO and MC4R, new loci, such as TMEM18, KCTD15, GNPDA2, SH2B1, MTCH2, and NEGR1 have been detected.
What model organisms and interactomics can reveal about the genetics of human obesity.
Schiöth et al., Uppsala, Sweden. In Cell Mol Life Sci, 2012
Here, we searched biological databases and discovered 33 additional genes associated with human obesity (CADM2, GIPR, GPCR5B, LRP1B, NEGR1, NRXN3, SH2B1, FANCL, GNPDA2, HMGCR, MAP2K5, NUDT3, PRKD1, QPCTL, TNNI3K, MTCH2, DNAJC27, SLC39A8, MTIF3, RPL27A, SEC16B, ETV5, HMGA1, TFAP2B, TUB, ZNF608, FAIM2, KCTD15, LINGO2, POC5, PTBP2, TMEM18, TMEM160).
The role of obesity-related genetic loci in insulin sensitivity.
Ingelsson et al., Stockholm, Sweden. In Diabet Med, 2012
Our study supports earlier reports of SH2B1 to be of importance in insulin sensitivity and, in addition, suggests potential roles of NEGR1 and MTCH2.
Proteomic analysis identifies dysfunction in cellular transport, energy, and protein metabolism in different brain regions of atypical frontotemporal lobar degeneration.
Bahn et al., Cambridge, United Kingdom. In J Proteome Res, 2012
A protein encoded by this locus was found to be differentially expressed in postmortem brains from patients with atypical frontotemporal lobar degeneration.
Implication of European-derived adiposity loci in African Americans.
Ng et al., Winston-Salem, United States. In Int J Obes (lond), 2012
Meta-analysis of 4992 subjects revealed seven SNPs near four loci, including NEGR1, TMEM18, SH2B1 /ATP2A1 and MC4R, showing significant association at 0.005
Genetic predictors of weight loss and weight regain after intensive lifestyle modification, metformin treatment, or standard care in the Diabetes Prevention Program.
Diabetes Prevention Program Research Group et al., Boston, United States. In Diabetes Care, 2012
Gene-treatment interactions were observed for long-term (NEGR1 rs2815752, Pmetformin*SNP = 0.028; FTO rs9939609, Plifestyle*SNP = 0.044) weight loss.
Aberrations of NEGR1 on 1p31 and MYEOV on 11q13 in neuroblastoma.
Ogawa et al., Tokyo, Japan. In Cancer Sci, 2011
The results of these studies provide supporting evidence for MYEOV and NEGR1 as gene targets of 11q13 gains and 1p31 deletions in a neuroblastoma subset.
Six new loci associated with body mass index highlight a neuronal influence on body weight regulation.
Genetic Investigation of ANthropometric Traits Consortium et al., In Nat Genet, 2009
We strongly confirm FTO and MC4R and identify six additional loci (P < 5 x 10(-8)): TMEM18, KCTD15, GNPDA2, SH2B1, MTCH2 and NEGR1 (where a 45-kb deletion polymorphism is a candidate causal variant).
Sigma factors in Pseudomonas aeruginosa.
Levesque et al., Québec, Canada. In Fems Microbiol Rev, 2008
Summarized data are obtained from in silico analysis of P. aeruginosasigma and ECF including rpoD (sigma(70)), RpoH (sigma(32)), RpoF (FliA or sigma(28)), RpoS (sigma(S) or sigma(38)), RpoN (NtrA, sigma(54) or sigma(N)), ECF including AlgU (RpoE or sigma(22)), PvdS, SigX and a collection of uncharacterized sigma ECF, some of which are implicated in iron transport.
Function of a bacterial activator protein that binds to transcriptional enhancers.
Kustu et al., United States. In Science, 1989
The nitrogen regulatory (NtrC) protein of enteric bacteria, which binds to sites that have the properties of transcriptional enhancers, is known to activate transcription by a form of RNA polymerase that contains the NtrA protein (sigma 54) as sigma factor (referred to as sigma 54-holoenzyme).
Transcription of glnA in E. coli is stimulated by activator bound to sites far from the promoter.
Magasanik et al., In Cell, 1986
Initiation of transcription at the nitrogen-regulated promoter glnAp2 requires sigma 60, the product of rpoN (glnF, ntrA), and NRI, the product of glnG (ntrC).
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