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Neurotensin receptor 2

NTR2, Ntsr2, NTRL, neurotensin receptor 2
The protein encoded by this gene belongs to the G protein-coupled receptor family that activate a phosphatidylinositol-calcium second messenger system. Binding and pharmacological studies demonstrate that this receptor binds neurotensin as well as several other ligands already described for neurotensin NT1 receptor. However, unlike NT1 receptor, this gene recognizes, with high affinity, levocabastine, a histamine H1 receptor antagonist previously shown to compete with neurotensin for low-affinity binding sites in brain. These activities suggest that this receptor may be of physiological importance and that a natural agonist for the receptor may exist. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Neurotensin, NTR, CAN, V1a, Neuropeptide
Papers on NTR2
Differential expression and tumorigenic function of neurotensin receptor 1 in neuroendocrine tumor cells.
Evers et al., Lexington, United States. In Oncotarget, Oct 2015
Through RT-PCR analysis, we found that the expression of NTSR1 and NTSR2 was either variable (NTSR1) or absent (NTSR2) in human NET cell lines.
The Internalization of Neurotensin by the Low-Affinity Neurotensin Receptors (NTSR2 and vNTSR2) Activates ERK 1/2 in Glioma Cells and Allows Neurotensin-Polyplex Transfection of tGAS1.
Segovia et al., Mexico. In Cell Mol Neurobiol, Aug 2015
RT-PCR assays showed that healthy (non-tumor) astroglial cells and C6 glioma cells express NTSR2 and its isoform (vNTSR2) rather than NTSR1.
Improved radiosynthesis and preliminary in vivo evaluation of a (18)F-labeled glycopeptide-peptoid hybrid for PET imaging of neurotensin receptor 2.
Prante et al., Erlangen, Germany. In Bioorg Med Chem, Aug 2015
The neurotensin receptor 2 (NTS2) is an attractive target for cancer imaging, as it is overexpressed in a variety of tumor types including prostate, pancreas and breast carcinoma.
Reduction of Nfia gene expression and subsequent target genes by binge alcohol in the fetal brain.
Chai et al., Ansan, South Korea. In Neurosci Lett, Jul 2015
Some of the Nfia-target gene (Aldh1a, Folh1, Gjb6, Fgf1, Neurod1, Sept4, and Ntsr2) expressions were also altered as expected.
The actions of neurotensin in rat bladder detrusor contractility.
Li et al., Chongqing, China. In Sci Rep, 2014
This study assessed the expression, distribution and function of neurotensin (NTs) and two main neurotensin receptors (NTSR), NTSR1 and NTSR2 in normal rat urinary bladders.
Neurotensin enhances sperm capacitation and acrosome reaction in mice.
Tanemura et al., Sendai, Japan. In Biol Reprod, 2014
In addition, the acrosome reaction was promoted in capacitated spermatozoa, and addition of a selective antagonist of NTR1 and NTR2 blocked the induction.
Endogenous CNS expression of neurotensin and neurotensin receptors is altered during the postpartum period in outbred mice.
Gammie et al., Madison, United States. In Plos One, 2013
Neurotensin receptor 2 (Ntsr2) expression was not altered in any brain region tested.
Morphological evidence for a neurotensinergic periaqueductal gray-rostral ventromedial medulla-spinal dorsal horn descending pathway in rat.
Li et al., Xi'an, China. In Front Neuroanat, 2013
Neurotensin (NT) is an endogenous neuropeptide that exerts potent opioid-independent analgesic effects, most likely via the type 2 NT receptor (NTR2).
Maternal separation enhances conditioned fear and decreases the mRNA levels of the neurotensin receptor 1 gene with hypermethylation of this gene in the rat amygdala.
Kusumi et al., Tokorozawa, Japan. In Plos One, 2013
The results showed that MS enhanced freezing behaviors in fear-conditioned stress and reduced the gene expression of NTS receptor (NTSR) 1 but not of NTS or NTSR2 in the amygdalas of adult rats.
Discovery of ML314, a Brain Penetrant Non-Peptidic β-Arrestin Biased Agonist of the Neurotensin NTR1 Receptor.
Pinkerton et al., Orlando, United States. In Acs Med Chem Lett, 2013
The lead compound, 2-cyclopropyl-6,7-dimethoxy-4-(4-(2-methoxyphenyl)- piperazin-1-yl)quinazoline, 32 (ML314), exhibits full agonist behavior against NTR1 (EC50 = 2.0 μM) in the primary assay and selectivity against NTR2.
Small Molecule Agonists for the Neurotensin 1 Receptor (NTR1 Agonists)
Barak et al., Bethesda, United States. In Unknown Journal, 2012
This probe satisfied our secondary assay requirements; namely, the Ca(2+) mobilization Fluorescence Imaging Plate Reader (FLIPR) assay (93% efficacy at 298 nM) and good selectivity relative to NTR2 and G protein-coupled receptor (GPR)35.
Increased ethanol consumption and preference in mice lacking neurotensin receptor type 2.
Choi et al., Rochester, United States. In Alcohol Clin Exp Res, 2011
findings suggest that NTS2 regulates ethanol-induced hypnosis and ethanol consumption
Effects of neurotensin-2 receptor deletion on sensorimotor gating and locomotor activity.
Button et al., San Diego, United States. In Behav Brain Res, 2010
These data support the regulation of baseline prepulse inhibition, acoustic startle response and locomotor activity by endogenous neurotensin acting at the NT2 receptor.
Hyperactivity of the dopaminergic system in NTS1 and NTS2 null mice.
Richelson et al., Jacksonville, United States. In Neuropharmacology, 2010
Ntsr2 receptor subtype is necessary for normal dopaminergic function.
Involvement of NTS2 receptors in stress-induced analgesia.
Sarret et al., Sherbrooke, Canada. In Neuroscience, 2010
NTS2 receptors localized at the lumbar spinal cord participate to the disinhibition of descending pain control pathways.
Altered expression of neurotensin receptors is associated with the differentiation state of prostate cancer.
Maitland et al., York, United Kingdom. In Cancer Res, 2010
NTR2 and NTR3 were upregulated in prostate cancer cells with luminal phenotype (cytokeratin 18+)
Emerging evidence for neurotensin receptor 1 antagonists as novel pharmaceutics in neurodegenerative disorders.
Antonelli et al., Ferrara, Italy. In Mini Rev Med Chem, 2009
NT exerts its effects through the activation of different receptor subtypes, NTR1, NTR2 and NTR3.
Leung, Bethesda, United States. In Unknown Journal, 2009
There are three NTR subtypes, namely NTR1, NTR2, and NTR3.
Cancer, chemistry, and the cell: molecules that interact with the neurotensin receptors.
Ley et al., Cambridge, United Kingdom. In Acs Chem Biol, 2009
This Review aims to summarize the isolation, cloning, localization, and binding properties of the accepted receptor subtypes (NTR1, NTR2, and NTR3) and the molecules known to bind at these receptors.
Carbon and nitrogen nutrient balance signaling in plants.
Zheng, New York City, United States. In Plant Signal Behav, 2009
Three genetic studies involving distinct bioassays have demonstrated that a putative nitrate transporter (NTR2.1), a putative glutamate receptor (GLR1.1) and a putative methyltransferase (OSU1) have important functions in the C/N balance response.
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