Synapsins Are Downstream Players of the BDNF-Mediated Axonal Growth.
Genova, Italy. In Mol Neurobiol, Feb 2016
The expression analysis of BDNF receptors in Syn KO neurons revealed a significant decrease of the full length TrkB receptor and an increase in the levels of the truncated TrkB.t1 isoform and p75(NTR) associated with a marked reduction of the BDNF-induced MAPK/Erk activation.
Neurotrophins and B-cell malignancies.
Galway, Ireland. In Cell Mol Life Sci, Jan 2016
The p75(NTR) and Trk receptors can elicit signalling in response to the presence or absence of their corresponding neurotrophin ligands.
Structure of a yeast spliceosome at 3.6-angstrom resolution.
Beijing, China. In Science, Oct 2015
Splicing of precursor messenger RNA (pre-mRNA) in yeast is executed by the spliceosome, which consists of five small nuclear ribonucleoproteins (snRNPs), NTC (nineteen complex), NTC-related proteins (NTR), and a number of associated enzymes and cofactors.
The p75 neurotrophin receptor: at the crossroad of neural repair and death.
Chapel Hill, United States. In Neural Regen Res, May 2015
Recently, the p75 neurotrophin receptor (p75(NTR)) has emerged as a potential target for pharmacological control of neurotrophin activity, supported in part by studies demonstrating 1) regulation of neural plasticity in the mature nervous system, 2) promotion of adult neurogenesis and 3) increased expression in neurons, macrophages, microglia, astrocytes and/or Schwann cells in response to injury and neurodegenerative diseases.
Cardiovascular actions of neurotrophins.
Bristol, United Kingdom. In Physiol Rev, 2009
Conversely, the neurotrophin low-affinity p75(NTR) receptor induces apoptosis of endothelial cells and vascular smooth muscle cells and impairs angiogenesis.