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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Neurotensin receptor 1

NTR, NTR1
Neurotensin receptor 1 belongs to the large superfamily of G-protein coupled receptors. NTSR1 mediates the multiple functions of neurotensin, such as hypotension, hyperglycemia, hypothermia, antinociception, and regulation of intestinal motility and secretion. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: p75, CAN, trkA, NGF, V1a
Papers on NTR
p75 Neurotrophin Receptor Regulates Energy Balance in Obesity.
New
Akassoglou et al., San Francisco, United States. In Cell Rep, Feb 2016
Here, we show that the p75 neurotrophin receptor (p75(NTR)) controls energy expenditure in obese mice on a high-fat diet (HFD).
Synapsins Are Downstream Players of the BDNF-Mediated Axonal Growth.
New
Onofri et al., Genova, Italy. In Mol Neurobiol, Feb 2016
The expression analysis of BDNF receptors in Syn KO neurons revealed a significant decrease of the full length TrkB receptor and an increase in the levels of the truncated TrkB.t1 isoform and p75(NTR) associated with a marked reduction of the BDNF-induced MAPK/Erk activation.
Neurotrophins and B-cell malignancies.
Review
New
Gorman et al., Galway, Ireland. In Cell Mol Life Sci, Jan 2016
The p75(NTR) and Trk receptors can elicit signalling in response to the presence or absence of their corresponding neurotrophin ligands.
Good and bad protons: genetic aspects of acidity stress responses in plants.
Review
New
Hirai et al., Okayama, Japan. In J Exp Bot, Jan 2016
A range of transporter genes including those for nitrate (NTR1), malate (ALMT1), and heavy metals are often up-regulated by H(+) rhizotoxicity.
Chronic mild stress influences nerve growth factor through a matrix metalloproteinase-dependent mechanism.
New
Budziszewska et al., Kraków, Poland. In Psychoneuroendocrinology, Jan 2016
Additionally, the decreased level of m-NGF together with the increased level of pro-NGF can decrease TrkA-mediated neuronal survival signalling and enhance the action of pro-NGF on the p75(NTR) receptor, respectively, to evoke pro-apoptotic signalling.
A ptsP deficiency in PGPR Pseudomonas fluorescens SF39a affects bacteriocin production and bacterial fitness in the wheat rhizosphere.
New
Fischer et al., Río Cuarto, Argentina. In Res Microbiol, Jan 2016
This phenotype was caused by inactivation of the ptsP gene which encodes a phosphoenolpyruvate phosphotransferase (EI(Ntr)) of the nitrogen-related phosphotransferase system (PTS(Ntr)).
Plasticity of an Ultrafast Interaction between Nucleoporins and Nuclear Transport Receptors.
New
Impact
Lemke et al., Heidelberg, Germany. In Cell, Nov 2015
This is achieved using multiple, minimalistic, low-affinity binding motifs that are in rapid exchange when engaging with the NTR, allowing the FG-Nup to maintain an unexpectedly high plasticity in its bound state.
Structure of a yeast spliceosome at 3.6-angstrom resolution.
New
Impact
Shi et al., Beijing, China. In Science, Oct 2015
Splicing of precursor messenger RNA (pre-mRNA) in yeast is executed by the spliceosome, which consists of five small nuclear ribonucleoproteins (snRNPs), NTC (nineteen complex), NTC-related proteins (NTR), and a number of associated enzymes and cofactors.
The p75 neurotrophin receptor: at the crossroad of neural repair and death.
Review
New
Williams et al., Chapel Hill, United States. In Neural Regen Res, May 2015
Recently, the p75 neurotrophin receptor (p75(NTR)) has emerged as a potential target for pharmacological control of neurotrophin activity, supported in part by studies demonstrating 1) regulation of neural plasticity in the mature nervous system, 2) promotion of adult neurogenesis and 3) increased expression in neurons, macrophages, microglia, astrocytes and/or Schwann cells in response to injury and neurodegenerative diseases.
Phytochemicals that regulate neurodegenerative disease by targeting neurotrophins: a comprehensive review.
Review
Kim et al., Inch'ŏn, South Korea. In Biomed Res Int, 2014
Here, we review the phytochemicals that mediate the signaling pathways involved in neuroprotection specifically neurotrophin-mediated activation of Trk receptors and members of p75(NTR) superfamily.
Cerebellar Expression of the Neurotrophin Receptor p75 in Naked-Ataxia Mutant Mouse.
Marzban et al., Winnipeg, Canada. In Int J Mol Sci, 2014
Studies have suggested that the p75 neurotrophin receptor (NTR) plays a role in Pc degeneration; thus, in this study, we investigated the p75NTR pattern and protein expression in the cerebellum of the nax mutant mouse.
Death Receptors in the Selective Degeneration of Motoneurons in Amyotrophic Lateral Sclerosis.
Review
Raoul et al., Marseille, France. In J Neurodegener Dis, 2012
Hallmarks of Fas, TNFR, LT-βR, and p75(NTR) signaling have been observed in both animal models and ALS patients.
Vasopressin/oxytocin-related signaling regulates gustatory associative learning in C. elegans.
Impact
Schoofs et al., Leuven, Belgium. In Science, 2012
Through activation of its receptor NTR-1, a vasopressin/oxytocin-related neuropeptide, designated nematocin, facilitates the experience-driven modulation of salt chemotaxis, a type of gustatory associative learning in C. elegans.
Neurotensin-induced proinflammatory signaling in human colonocytes is regulated by β-arrestins and endothelin-converting enzyme-1-dependent endocytosis and resensitization of neurotensin receptor 1.
GeneRIF
Pothoulakis et al., Los Angeles, United States. In J Biol Chem, 2012
Endothelin-converting enzyme-1 (ECE-1) degrades NT in acidic conditions, and its activity is crucial for NTR1 recycling.
Prostate cancer targeting motifs: expression of αν β3, neurotensin receptor 1, prostate specific membrane antigen, and prostate stem cell antigen in human prostate cancer cell lines and xenografts.
GeneRIF
Sillerud et al., Albuquerque, United States. In Prostate, 2012
Integrin alpha(nu) beta(3), NTRS1 and PSCA mRNA expression increased with tumorigenic potential, but mRNA expression levels for these proteins do not translate directly to equivalent expression levels of membrane bound protein.
Neurotensin receptor-1 inducible palmitoylation is required for efficient receptor-mediated mitogenic-signaling within structured membrane microdomains.
GeneRIF
Kester et al., United States. In Cancer Biol Ther, 2011
Our studies demonstrate that NTSR-1 plamitoylation is required for NTSR-1-mediated MAPK signaling and cellular proliferation in breast cancer cells.
Adjuvant tamoxifen and exemestane in early breast cancer (TEAM): a randomised phase 3 trial.
Impact
Jones et al., Leiden, Netherlands. In Lancet, 2011
NCT00279448, NCT00032136, and NCT00036270; NTR 267; Ethics Commission Trial27/2001; and UMIN, C000000057.
Neurotensin receptor 1 gene (NTSR1) polymorphism is associated with working memory.
GeneRIF
Dong et al., Beijing, China. In Plos One, 2010
NTSR1 single nucleotide polymorphisms were significantly associated with variance in working memory performance among healthy adults.
Cardiovascular actions of neurotrophins.
Review
Impact
Emanueli et al., Bristol, United Kingdom. In Physiol Rev, 2009
Conversely, the neurotrophin low-affinity p75(NTR) receptor induces apoptosis of endothelial cells and vascular smooth muscle cells and impairs angiogenesis.
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