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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Nucleoside-triphosphatase, cancer-related

NTPase, nucleoside triphosphate phosphohydrolase
Top mentioned proteins: ATPase, ACID, CAN, POLYMERASE, HAD
Papers on NTPase
Geometry-induced protein pattern formation.
Frey et al., München, Germany. In Proc Natl Acad Sci U S A, Feb 2016
The key component is an NTPase protein that cycles between nucleotide-dependent membrane-bound and cytosolic states.
Obg-like ATPase 1 regulates global protein serine/threonine phosphorylation in cancer cells by suppressing the GSK3β-inhibitor 2-PP1 positive feedback loop.
Shi et al., Hangzhou, China. In Oncotarget, Jan 2016
UNASSIGNED: OLA1 is an Obg family P-loop NTPase that possesses both GTP- and ATP-hydrolyzing activities.
Ritchie et al., United States. In Pac Symp Biocomput, Dec 2015
We identified several significant pathways such as toll-like receptor signaling pathway and hepatitis C pathway, gene ontologies (GOs) of nucleoside triphosphatase activity (NTPase) and response to virus, and protein families such as cell morphogenesis that are associated with the total cholesterol phenotype based on CNV profiles (permutation p-value < 0.01).
In situ structures of the segmented genome and RNA polymerase complex inside a dsRNA virus.
Zhou et al., Los Angeles, United States. In Nature, Dec 2015
The TEC consists of two extensively interacting subunits: an RNA-dependent RNA polymerase (RdRP) and an NTPase VP4.
Current Drug Discovery for Anti-hepatitis C Virus Targeting NS4B.
Liu et al., Zhengzhou, China. In Curr Top Med Chem, Dec 2015
A variety of functions have been recognized for NS4B, such as the ability to induce the membranous web replication platform, RNA binding and NTPase activity.
Acquisition of Full-Length Viral Helicase Domains by Insect Retrotransposon-Encoded Polypeptides.
Morozov et al., Moscow, Russia. In Front Microbiol, 2014
Here we describe a new example of this kind, insect R1 LINEs with an additional C-terminal domain in their open reading frame 2. This domain is similar to NTPase/helicase (SF1H) domains, which are found in replicative proteins encoded by plant viruses of the genus Tobamovirus.
[The specific enzyme inhibitors for potential therapeutic use].
Bretner, In Postepy Biochem, 2014
Appropriate was to find effective inhibitors of viral replication e.g. by inhibition of a viral enzyme, NTPase/helicase required in the process of translation and RNA replication of the HCV.
Functional interplay among the flavivirus NS3 protease, helicase, and cofactors.
Luo et al., Singapore, Singapore. In Virol Sin, 2014
The N-terminal region of NS3, and its cofactor NS2B fold into a protease that is responsible for viral polyprotein processing, and the C-terminal domain of NS3 possesses NTPase/RNA helicase activities and is involved in viral RNA replication and virus particle formation.
Coordination and control inside simple biomolecular machines.
Yu, Beijing, China. In Adv Exp Med Biol, 2013
The other type belongs to ring-shaped NTPase motors that also move or transport nucleic acid or protein substrate in a directional manner, such as for genome packaging or protein degradation.
Fifty years of nuclear pores and nucleocytoplasmic transport studies: multiple tools revealing complex rules.
Doye et al., Paris, France. In Methods Cell Biol, 2013
The outcome of investigations on nucleocytoplasmic trafficking will then be detailed, showing how it involves a limited number of molecular factors and common mechanisms, namely (i) indirect association of cargos with nuclear pores through receptors in the donor compartment, (ii) progression within the channel through dynamic hydrophobic interactions with FG-Nups, and (iii) NTPase-driven remodeling of transport complexes in the target compartment.
Hepatitis C virus proteins: from structure to function.
Penin et al., Lausanne, Switzerland. In Curr Top Microbiol Immunol, 2012
The nonstructural proteins include the p7 viroporin, the NS2 protease, the NS3-4A complex harboring protease and NTPase/RNA helicase activities, the NS4B and NS5A proteins, and the NS5B RNA-dependent RNA polymerase.
Packaging in dsRNA viruses.
Mindich, Newark, United States. In Adv Exp Med Biol, 2011
The particles have complexes of a hexameric NTPase that serve as motors to bring the transcripts into the particle, and they have polymerase molecules in the interior that synthesize minus and plus strand copies of the genomic segments.
The ER UDPase ENTPD5 promotes protein N-glycosylation, the Warburg effect, and proliferation in the PTEN pathway.
Wang et al., Dallas, United States. In Cell, 2010
During a study using the embryonic fibroblasts from the PTEN null mice ENTPD5, is found to be upregulated by AKT activation; this enzyme seems to mediate many of the observed cancer-related phenotypes associated with AKT activation.
Ectonucleoside triphosphate diphosphohydrolase type 5 (Entpd5)-deficient mice develop progressive hepatopathy, hepatocellular tumors, and spermatogenic arrest.
Vogel et al., The Woodlands, United States. In Vet Pathol, 2009
The effect of Entpd5 deletion on the development of hepatocellualr neoplasia in mice is reported.
Structure and function of hexameric helicases.
Picha et al., United States. In Annu Rev Biochem, 1999
Helicases are motor proteins that couple the hydrolysis of nucleoside triphosphate (NTPase) to nucleic acid unwinding.
RNA unwinding activity of SV40 large T antigen.
Stahl et al., Konstanz, Germany. In Cell, 1989
Accordingly, T antigen has both an intrinsic non-ATP NTPase activity that is stimulated by single-stranded RNA and an ATPase activity stimulated by single-stranded DNA.
Transcription termination factor rho is an RNA-DNA helicase.
Platt et al., In Cell, 1987
Release of trp t' RNA from the duplex requires nucleoside triphosphate hydrolysis by rho's NTPase activity and is dependent on rho recognition of the RNA that is 5' to the RNA-DNA duplex region.
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