Structural Biology and Regulation of Protein Import into the Nucleus.
Australia. In J Mol Biol, Nov 2015
The pathways involve transport factors that are members of the β-karyopherin family, which can bind cargo directly (e.g., importin-β, transportin-1, transportin-3, importin-13) or through adaptor proteins (e.g., importin-α, snurportin-1, symportin-1), as well as unrelated transport factors such as Hikeshi, involved in the transport of heat-shock proteins, and NTF2, involved in the transport of RanGDP.
Alternaria alternata and its allergens: a comprehensive review.
Wrocław, Poland. In Clin Rev Allergy Immunol, 2014
Others have structural and regulatory functions: Alt a 5 and Alt a 12 comprise the structure of large ribosomal subunits and mediate translation, Alt a 3 is a molecular chaperone, Alt a 7 regulates transcription, Alt a NTF2 facilitates protein import into the nucleus, and Alt a TCTP acts like a cytokine.
Nuclear size is regulated by importin α and Ntf2 in Xenopus.
Berkeley, United States. In Cell, 2010
Nuclear import rates correlated with nuclear size, and varying the concentrations of two transport factors, importin alpha and Ntf2, was sufficient to account for nuclear scaling between the two species, X. laevis and X. tropicalis.
Nucleocytoplasmic transport: cargo trafficking across the border.
Berkeley, United States. In Curr Opin Cell Biol, 2002
Transport of macromolecules between the cytoplasm and the nucleus is mediated by at least three different classes of soluble transport receptors, members of the importin-beta protein family, the Mex67/Tap family and the small nuclear transport factor 2 (NFT2).
Regulation of nuclear import and export by the GTPase Ran.
Charlottesville, United States. In Int Rev Cytol, 2001
We describe the identification and characterization of the RanGTPase and its binding partners: the guanine nucleotide exchange factor, RanGEF; the GTPase activating protein, RanGAP; the soluble import and export receptors; Ran-binding domain-(RBD) containing proteins; and NTF2 and related factors.