gopubmed logo
 
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Polycomb group ring finger 1

NSPc1, Nervous system polycomb 1
PCGF1 is a mammalian homolog of the Drosophila polycomb group genes, which act as transcriptional repressors to regulate anterior-posterior patterning in early embryonic development (Nunes et al., 2001 [PubMed 11287196]). See also PCGF2 (MIM 600346).[supplied by OMIM, Aug 2008] (from NCBI)
Papers on NSPc1
Polycomb group ring finger 1 cooperates with Runx1 in regulating differentiation and self-renewal of hematopoietic cells.
GeneRIF
Buchholz et al., Dresden, Germany. In Blood, 2012
Pcgf1 is an epigenetic regulator of hematopoietic cell differentiation. Simultaneous depletion of Runx1 and Pcgf1 allows sustained self-renewal while blocking differentiation of lineage marker-negative cells in vitro.
[Expression pattern of polycomb gene Nspc1 at the early developmental stage in zebrafish].
GeneRIF
Peng et al., Beijing, China. In Zhongguo Yi Xue Ke Xue Yuan Xue Bao, 2008
Nspc1 was expressed globally at the early stage.
Stem cells and cancer; the polycomb connection.
Impact
GeneRIF
van Lohuizen et al., Amsterdam, Netherlands. In Cell, 2004
polycomb has a role in stem cell fate and development of cancer (review)
share on facebooktweetadd +1mail to friends