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Polycomb group ring finger 1

NSPc1, Nervous system polycomb 1
PCGF1 is a mammalian homolog of the Drosophila polycomb group genes, which act as transcriptional repressors to regulate anterior-posterior patterning in early embryonic development (Nunes et al., 2001 [PubMed 11287196]). See also PCGF2 (MIM 600346).[supplied by OMIM, Aug 2008] (from NCBI)
Top mentioned proteins: Polycomb, Bmi-1, BC or, H2A, bcl-6
Papers on NSPc1
Nspc1 regulates the key pluripotent Oct4-Nanog-Sox2 axis in P19 embryonal carcinoma cells via directly activating Oct4.
Gong et al., Tianjin, China. In Biochem Biophys Res Commun, 2013
Nspc1 is an identified transcription repressor.
Fusion of the ZC3H7B and BCOR genes in endometrial stromal sarcomas carrying an X;22-translocation.
Micci et al., Oslo, Norway. In Genes Chromosomes Cancer, 2013
The putative ZC3H7B-BCOR protein would contain the tetratricopeptide repeats and LD motif from ZC3H7B and the AF9 binding site (1093-1233aa), the 3 ankyrin repeats (1410-1509 aa), and the NSPC1 binding site of BCOR.
Structure of the polycomb group protein PCGF1 in complex with BCOR reveals basis for binding selectivity of PCGF homologs.
Kim et al., San Antonio, United States. In Structure, 2013
Here, we identify a protein interaction domain in BCL6 corepressor, BCOR, which binds the RING finger- and WD40-associated ubiquitin-like (RAWUL) domain of PCGF1 (NSPC1) and PCGF3 but not of PCGF2 (MEL18) or PCGF4 (BMI1).
Fbxl10/Kdm2b recruits polycomb repressive complex 1 to CpG islands and regulates H2A ubiquitylation.
Helin et al., Copenhagen, Denmark. In Mol Cell, 2013
Here, we show that Fbxl10 interacts with Ring1B and Nspc1, forming a noncanonical PRC1 that is required for H2AK119ub1 in mouse ESCs.
Polycomb group ring finger 1 cooperates with Runx1 in regulating differentiation and self-renewal of hematopoietic cells.
Buchholz et al., Dresden, Germany. In Blood, 2012
Pcgf1 is an epigenetic regulator of hematopoietic cell differentiation. Simultaneous depletion of Runx1 and Pcgf1 allows sustained self-renewal while blocking differentiation of lineage marker-negative cells in vitro.
Side population in oral squamous cell carcinoma possesses tumor stem cell phenotypes.
Chen et al., Shanghai, China. In Cancer Lett, 2009
The SP cells expressed higher levels of ABCG2, ABCB1, CD44, Oct-4, Bmi-1, NSPc1 and CK19.
[Expression pattern of polycomb gene Nspc1 at the early developmental stage in zebrafish].
Peng et al., Beijing, China. In Zhongguo Yi Xue Ke Xue Yuan Xue Bao, 2008
Nspc1 was expressed globally at the early stage.
Cooperation between EZH2, NSPc1-mediated histone H2A ubiquitination and Dnmt1 in HOX gene silencing.
Peng et al., Beijing, China. In Nucleic Acids Res, 2008
Here we provided evidence that Nervous System Polycomb 1 (NSPc1), a BMI1 homologous polycomb protein, plays important roles in promoting H2A ubiquitination and cooperates with DNA methylation in HOX gene silencing.
Proteomics analysis of Ring1B/Rnf2 interactors identifies a novel complex with the Fbxl10/Jhdm1B histone demethylase and the Bcl6 interacting corepressor.
Vidal et al., Madrid, Spain. In Mol Cell Proteomics, 2007
In this way we identified a novel Ring1B-Fbxl10 complex that also includes Bcl6 corepressor (BcoR), CK2alpha, Skp1, and Nspc1/Pcgf1.
Polycomb group and SCF ubiquitin ligases are found in a novel BCOR complex that is recruited to BCL6 targets.
Bardwell et al., Minneapolis, United States. In Mol Cell Biol, 2006
The PcG proteins include RING1, RYBP, NSPC1, a Posterior Sex Combs homolog, and RNF2, an E3 ligase for the mono-ubiquitylation of H2A.
NSPc1 is a cell growth regulator that acts as a transcriptional repressor of p21Waf1/Cip1 via the RARE element.
Yuan et al., Beijing, China. In Nucleic Acids Res, 2005
Nervous system polycomb 1 (NSPc1) is a newly identified transcription repressor, highly homologous with PcG protein Bmi-1.
NSPc1, a mainly nuclear localized protein of novel PcG family members, has a transcription repression activity related to its PKC phosphorylation site at S183.
Yuan et al., Beijing, China. In Febs Lett, 2005
Nervous system polycomb 1 (NSPc1) shares high homology with vertebrate PcG proteins Mel-18 and Bmi-1.
Stem cells and cancer; the polycomb connection.
van Lohuizen et al., Amsterdam, Netherlands. In Cell, 2004
polycomb has a role in stem cell fate and development of cancer (review)
NSPc1, a novel mammalian Polycomb gene, is expressed in neural crest-derived structures of the peripheral nervous system.
McElreavey et al., Paris, France. In Mech Dev, 2001
We describe the isolation and characterization of a novel mammalian PcG gene, termed Nervous System Polycomb-1 (NSPc1).
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