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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Breast cancer anti-estrogen resistance 3

Breast tumors are initially dependent on estrogens for growth and progression and can be inhibited by anti-estrogens such as tamoxifen. However, breast cancers progress to become anti-estrogen resistant. Breast cancer anti-estrogen resistance gene 3 was identified in the search for genes involved in the development of estrogen resistance. The gene encodes a component of intracellular signal transduction that causes estrogen-independent proliferation in human breast cancer cells. The protein contains a putative src homology 2 (SH2) domain, a hall mark of cellular tyrosine kinase signaling molecules, and is partly homologous to the cell division cycle protein CDC48. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, HAD, CAN, Nogo, POLYMERASE
Papers on NSP2
Analysis of genetic variation of porcine reproductive and respiratory syndrome virus (PRRSV) isolates in Central China.
Dong-Dong et al., China. In J Vet Med Sci, Feb 2016
Moreover, comparative analysis of amino acid (AA) sequences of NSP2, GP3, GP5 and ORF5a revealed the main evolution trend of PRRSVs in Central China from 1998 to 2014, which was from C-PRRSV to HP-PRRSV, accompanied by different evolving directions to S-PRRSV.
Characterization of the interactome of the porcine reproductive and respiratory syndrome virus (PRRSV) NSP2 protein reveals the hyper variable region as a binding platform for association with 14-3-3 proteins.
Hiscox et al., In J Proteome Res, Jan 2016
PRRSV non-structural protein 2 (nsp2) is a multifunctional polypeptide with strain-dependent influences on pathogenicity.
Nucleotide sequence analysis of Vietnamese highly pathogenic porcine reproductive and respiratory syndrome virus from 2013 to 2014 based on the NSP2 and ORF5 coding regions.
Chae et al., Seoul, South Korea. In Arch Virol, Dec 2015
A partial sequence of ORF1a corresponding to the nonstructural protein 2 (Nsp2) coding region and the full sequence of open reading frame 5 (ORF5) gene was used for the analysis.
Expression pattern of bcar3, a downstream target of Gata2, and its binding partner, bcar1, during Xenopus development.
Christian et al., Salt Lake City, United States. In Gene Expr Patterns, Dec 2015
Here we have identified Breast Cancer Antiestrogen Resistance 3 (bcar3) as a gene that is induced in ectodermal cells downstream of Gata2.
Full genome characterization of the first G3P[24] rotavirus strain detected in humans provides evidence of interspecies reassortment and mutational saturation in the VP7 gene.
Bowen et al., Rochester, United States. In J Gen Virol, Dec 2015
In addition, this strain carries an AU-1-like NSP2 and NSP4 genes.
Immunological features of the non-structural proteins of porcine reproductive and respiratory syndrome virus.
Hernández et al., Hermosillo, Mexico. In Viruses, Mar 2015
nsps have been involved in the host innate immune response, specifically, nsp1α/β, nsp2, nsp4 and nsp11 have been associated with the immunomodulation capability of the virus.
Engineering the PRRS virus genome: updates and perspectives.
Yoo et al., Urbana, United States. In Vet Microbiol, 2015
Foreign sequences have successfully been inserted into the nsp2 and N regions and in the space between ORF1b and ORF2a.
Connecting SNPs in Diabetes: A Spatial Analysis of Meta-GWAS Loci.
O'Sullivan et al., Auckland, New Zealand. In Front Endocrinol (lausanne), 2014
Our findings include a three-way functional-spatial connection between the TM6SF2, CTRB1-BCAR1, and CELSR2-PSRC1 loci (rs201189528, rs7202844, and rs7202844, respectively) connected through the KCNIP3 and BCAR1/BCAR3 loci, respectively.
Immune Response of Multiparous Hyper-Immunized Sows against Peptides from Non-Structural and Structural Proteins of PRRSV.
Hernández et al., Hermosillo, Mexico. In Vaccines (basel), 2014
The analysis of the cellular response revealed that the number of immunizations did not affect the frequency of IFNγ-SC and that the response was stronger against peptides from structural proteins (M protein) than against nsp (nsp2).
Breast cancer anti-estrogen resistance 3 (BCAR3) protein augments binding of the c-Src SH3 domain to Crk-associated substrate (p130cas).
Lerner et al., Boston, United States. In J Biol Chem, 2012
BCAR3 expression may regulate Src signaling in a BCAR3-p130(cas) complex-dependent fashion by altering the ability of the Src SH3 domain to bind the p130(cas) SBD
Mutations in the ER-shaping protein reticulon 2 cause the axon-degenerative disorder hereditary spastic paraplegia type 12.
Züchner et al., Miami, United States. In J Clin Invest, 2012
Results implicate reticulon 2 in axonopathy, show that this protein participates in a network of interactions among hereditary spastic paraplegia proteins involved in endoplasmic reticulum shaping.
BCAR3/AND-34 can signal independent of complex formation with CAS family members or the presence of p130Cas.
Lerner et al., Boston, United States. In Cell Signal, 2011
many BCAR3-mediated signaling events in epithelial and mesenchymal cells are independent of p130Cas association
Bcar3 is expressed in sertoli cells and germ cells of the developing testis in mice.
Dworniczak et al., Münster, Germany. In Sex Dev, 2010
data presented here suggest that Bcar3 could play a role in testis development
The PRRSV replicase: exploring the multifunctionality of an intriguing set of nonstructural proteins.
Snijder et al., Brookings, United States. In Virus Res, 2010
In addition, progress has been made on nsp functions relating to the regulation of subgenomic mRNAs synthesis (nsp1), the induction of replication-associated membrane rearrangements (nsp2 and nsp3), and an intriguing replicative endoribonuclease (nsp11) for which the natural substrate remains to be identified.
In vivo growth of porcine reproductive and respiratory syndrome virus engineered nsp2 deletion mutants.
Han et al., Ames, United States. In Virus Res, 2010
Prior studies on PRRSV strain VR-2332 non-structural protein 2 (nsp2) had shown that as much as 403 amino acids could be removed from the hypervariable region without losing virus viability in vitro.
BCAR3 regulates Src/p130 Cas association, Src kinase activity, and breast cancer adhesion signaling.
Bouton et al., Charlottesville, United States. In J Biol Chem, 2010
the c-Src/Cas/BCAR3 signaling axis is a prominent regulator of c-Src activity, which in turn controls cell behaviors that lead to aggressive and invasive breast tumor phenotypes
Relevance of breast cancer antiestrogen resistance genes in human breast cancer progression and tamoxifen resistance.
Dorssers et al., Rotterdam, Netherlands. In J Clin Oncol, 2009
PATIENTS AND METHODS: mRNA levels of 10 BCAR genes (AKT1, AKT2, BCAR1, BCAR3, EGFR, ERBB2, GRB7, SRC, TLE3, and TRERF1) were measured in estrogen receptor-positive breast tumors using quantitative reverse-transcriptase polymerase chain reaction.
Nodulation signaling in legumes requires NSP2, a member of the GRAS family of transcriptional regulators.
Oldroyd et al., Norwich, United Kingdom. In Science, 2005
Here, we show that NSP2 from Medicago truncatula encodes a GRAS protein essential for Nod-factor signaling.
Reticulon family members modulate BACE1 activity and amyloid-beta peptide generation.
Yan et al., Cleveland, United States. In Nat Med, 2004
The reticulon family of proteins has four members, RTN1, RTN2, RTN3 and RTN4 (also known as Nogo), the last of which is well known for its role in inhibiting neuritic outgrowth after injury.
Rotavirus protein involved in genome replication and packaging exhibits a HIT-like fold.
Prasad et al., Houston, United States. In Nature, 2002
The non-structural protein NSP2 of rotavirus, which exhibits nucleoside triphosphatase, single-stranded RNA binding, and nucleic-acid helix-destabilizing activities, is a major component of viral replicase complexes.
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