gopubmed logo
 
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Wolf-Hirschhorn syndrome candidate 1-like 1

NSD3, WHISTLE, WHSC1L1
This gene is related to the Wolf-Hirschhorn syndrome candidate-1 gene and encodes a protein with PWWP (proline-tryptophan-tryptophan-proline) domains. The function of the protein has not been determined. Two alternatively spliced variants have been described. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Histone, SET, STO, WHS, HAD
Papers on NSD3
The Short Isoform of NSD3 Couples BRD4 and CHD8 to Drive Transcription.
New
In Cancer Discov, Jan 2016
BRD4-mediated transactivation activity in AML depends upon its interaction with NSD3-short.
NSD3-Short Is an Adaptor Protein that Couples BRD4 to the CHD8 Chromatin Remodeler.
New
Vakoc et al., United States. In Mol Cell, Jan 2016
Here, we demonstrate that the AML maintenance function of BRD4 requires its interaction with NSD3, which belongs to a subfamily of H3K36 methyltransferases.
NUT carcinoma of the thorax: Case report and review of the literature.
Review
New
Warth et al., Heidelberg, Germany. In Lung Cancer, Nov 2015
Pathological assessment of the biopsy specimens revealed a NUT carcinoma with typical morphological characteristics and an uncommon NUT translocation variant with a NSD3-NUT fusion.
Mutation spectra of histone methyltransferases with canonical SET domains and EZH2-targeted therapy.
New
Katoh, Tokyo, Japan. In Epigenomics, Oct 2015
UNASSIGNED: Germline mutations in canonical SET-methyltransferases have been identified in autism and intellectual disability syndromes and gain-of-function somatic alterations in EZH2, MLL3, NSD1, WHSC1 (NSD2) and WHSC1L1 (NSD3) in cancer.
Identification of miR-2400 gene as a novel regulator in skeletal muscle satellite cells proliferation by targeting MYOG gene.
New
Li et al., Harbin, China. In Biochem Biophys Res Commun, Sep 2015
Furthermore, we found that miR-2400, which was located within the eighth intron of the Wolf-Hirschhorn syndrome candidate 1-like 1 (WHSC1L1) gene, was down-regulated in MDSCs in a direct correlation with the WHSC1L1 transcript by Clustered regularly interspaced palindromic repeats interference (CRISPRi).
The NSD family of protein methyltransferases in human cancer.
Review
New
Saloura et al., Chicago, United States. In Epigenomics, Aug 2015
The NSD family of protein lysine methyltransferases consists of NSD1, NSD2/WHSC1/MMSET and NSD3/WHSC1L1.
NSD3-NUT-expressing midline carcinoma of the lung: first characterization of primary cancer tissue.
New
Sugimura et al., Iwata, Japan. In Pathol Res Pract, May 2015
A 5'- rapid amplification of the cDNA end (RACE) procedure successfully identified the partner of the NUT translocation as NSD3, a recently discovered partner.
TET3 is recruited by REST for context-specific hydroxymethylation and induction of gene expression.
New
Michalakis et al., München, Germany. In Cell Rep, May 2015
Moreover, we found that TET3 also interacts with NSD3 and two other H3K36 methyltransferases and is able to induce H3K36 trimethylation.
Genetic alterations of histone lysine methyltransferases and their significance in breast cancer.
New
Yang et al., Detroit, United States. In Oncotarget, Mar 2015
Integrative analysis identified 8 HMTs (SETDB1, SMYD3, ASH1L, SMYD2, WHSC1L1, SUV420H1, SETDB2, and KMT2C) that are dysregulated by genetic alterations, classifying them as candidate therapeutic targets.
Exome-wide mutation profile in benzo[a]pyrene-derived post-stasis and immortal human mammary epithelial cells.
Futscher et al., Tucson, United States. In Mutat Res Genet Toxicol Environ Mutagen, 2014
Mutations predicted to impact protein function occurred in several known and putative cancer drivers including p16, PLCG1, MED12, TAF1 in 184Aa; PIK3CG, HSP90AB1, WHSC1L1, LCP1 in 184Be and FANCA, LPP in 184Ce.
Cytological Features of a Variant NUT Midline Carcinoma of the Lung Harboring the NSD3-NUT Fusion Gene: A Case Report and Literature Review.
Sugimura et al., Iwata, Japan. In Case Report Pathol, 2014
We recently reported this patient as the first case of a variant NMC of the lung harboring an NSD3-NUT fusion, based on immunohistochemical and genetic analyses.
In vitro histone lysine methylation by NSD1, NSD2/MMSET/WHSC1 and NSD3/WHSC1L.
di Luccio et al., Taegu, South Korea. In Bmc Struct Biol, 2013
The NSD family of HMTases comprised of three members (NSD1, NSD2/MMSET/WHSC1, and NSD3/WHSC1L) are oncogenes aberrantly expressed in several cancers, suggesting their potential to serve as novel therapeutic targets.
Cancers and the NSD family of histone lysine methyltransferases.
Review
di Luccio et al., Taegu, South Korea. In Biochim Biophys Acta, 2011
The nuclear receptor binding SET domain (NSD) protein is a family of three HMTases, NSD1, NSD2/MMSET/WHSC1, and NSD3/WHSC1L1, and plays a critical part in chromatin integrity as evidenced by a growing number of conditions linked to the alterations and/or amplification of NSD1, NSD2, and/or NSD3.
The Brd4 extraterminal domain confers transcription activation independent of pTEFb by recruiting multiple proteins, including NSD3.
GeneRIF
Howley et al., Boston, United States. In Mol Cell Biol, 2011
Functional studies with Brd4 indicate that the ET domain mediates pTEFb-independent transcriptional activation through a subset of these associated factors, including NSD3.
Transforming properties of 8p11-12 amplified genes in human breast cancer.
GeneRIF
Ethier et al., Detroit, United States. In Cancer Res, 2010
Overexpression of WHSC1L1 gene is associated with breast cancer.
The NSD3L histone methyltransferase regulates cell cycle and cell invasion in breast cancer cells.
GeneRIF
Nielsen et al., Århus, Denmark. In Biochem Biophys Res Commun, 2010
NSD3L depletion increased the invasiveness of MDA-MB-231 breast cancer cells indicating that NSD3L normally restrain cellular metastatic potential. Together the presented data indicates that NSD3L is a candidate tumor suppressor.
NUP98-NSD1 links H3K36 methylation to Hox-A gene activation and leukaemogenesis.
Impact
Kamps et al., San Diego, United States. In Nat Cell Biol, 2007
Nuclear receptor-binding SET domain protein 1 (NSD1) prototype is a family of mammalian histone methyltransferases (NSD1, NSD2/MMSET/WHSC1, NSD3/WHSC1L1) that are essential in development and are mutated in human acute myeloid leukemia (AML), overgrowth syndromes, multiple myeloma and lung cancers.
Fusion of the NUP98 gene and the homeobox gene HOXC13 in acute myeloid leukemia with t(11;12)(p15;q13).
Review
Johansson et al., Lund, Sweden. In Genes Chromosomes Cancer, 2003
The NUP98 gene at 11p15 is known to be fused to DDX10, HOXA9, HOXA11, HOXA13, HOXD11, HOXD13, LEDGF, NSD1, NSD3, PMX1, RAP1GDS1, and TOP1 in various hematologic malignancies.
share on facebooktweetadd +1mail to friends