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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

High-mobility group nucleosome binding domain 5

NSBP1, nucleosomal binding protein 1, Nucleosome Binding Protein, NBP-45, nucleosomal binding protein NSBP1, HMGN5
This gene encodes a nuclear protein with similarities to the high mobility group proteins, HMG14 and HMG17, which suggests that this protein may function as a nucleosomal binding and transcriptional activating protein. [provided by RefSeq, Sep 2009] (from NCBI)
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Top mentioned proteins: PCNA, HMG-14, CAN, bcl-2, Histone
Papers on NSBP1
Suppression of nucleosome-binding protein 1 by miR-326 impedes cell proliferation and invasion in non-small cell lung cancer cells.
New
Li et al., Xi'an, China. In Oncol Rep, Feb 2016
Nucleosome-binding protein 1 (NSBP1) has been suggested as an oncogene in various types of human cancers.
microRNA-340 Suppresses Tumorigenic Potential of Prostate Cancer Cells by Targeting High-Mobility Group Nucleosome-Binding Domain 5.
New
Sun et al., Zhengzhou, China. In Dna Cell Biol, Jan 2016
Intriguingly, on the basis of bioinformatics analysis and luciferase reporter assay, we found that miR-340 directly targeted the 3'-untranslated region of the high-mobility group nucleosome-binding domain 5 (HMGN5).
Research advances in HMGN5 and cancer.
Review
New
Sun et al., Xuzhou, China. In Tumour Biol, Jan 2016
UNASSIGNED: High-mobility group nucleosome-binding domain 5 (HMGN5) is a new member of the high-mobility group N (HMGN) protein family that is involved in nucleosomal binding and transcriptional activation.
HMGN5 blockade by siRNA enhances apoptosis, suppresses invasion and increases chemosensitivity to temozolomide in meningiomas.
New
Gao et al., Beijing, China. In Int J Oncol, Oct 2015
The high-mobility group nucleosome-binding protein-5 (HMGN5) is frequently overexpressed in various malignant cancers.
Growth Cone Localization of the mRNA Encoding the Chromatin Regulator HMGN5 Modulates Neurite Outgrowth.
New
Pertz et al., Basel, Switzerland. In Mol Cell Biol, Jul 2015
We report that the mRNA encoding the high-mobility group N5 (HMGN5) chromatin binding protein localizes to growth cones of both neuron-like cells and of hippocampal neurons, where it has the potential to be translated, and that HMGN5 can be retrogradely transported into the nucleus along neurites.
Knockdown of HMGN5 suppresses the viability and invasion of human urothelial bladder cancer 5637 cells in vitro and in vivo.
New
Tang et al., Changsha, China. In Med Oncol, Apr 2015
The high-mobility group nucleosome-binding domain 5 (HMGN5) is a new and typical member of HMGN protein family.
Expression of oncogenic HMGN5 increases the sensitivity of prostate cancer cells to gemcitabine.
New
Zhou et al., Beijing, China. In Oncol Rep, Mar 2015
In the present study, we showed that HMGN5, a nucleosome binding protein that can unfold chromatin by binding to histone (H1), is overexpressed in prostate cancer cells and plays an oncogenic role in prostate cancer tumorigenesis and development by activating the MAPK signaling pathway.
Nucleosome-binding protein HMGN2 exhibits antitumor activity in human SaO2 and U2-OS osteosarcoma cell lines.
New
Zhou et al., China. In Oncol Rep, Mar 2015
HMGN1 and HMGN5 were previously shown to be associated with the bioactivities of osteosarcoma.
The high-mobility group nucleosome-binding domain 5 is highly expressed in breast cancer and promotes the proliferation and invasion of breast cancer cells.
New
Xu et al., Shanghai, China. In Tumour Biol, Feb 2015
The high-mobility group nucleosome-binding domain 5 (HMGN5) is a member of the high-mobility group proteins family.
HMGN5 knockdown sensitizes prostate cancer cells to ionizing radiation.
Zhou et al., Beijing, China. In Prostate, 2015
HMGN5 is a novel and characteristic member of the HMGN protein family.
Evolution of high mobility group nucleosome-binding proteins and its implications for vertebrate chromatin specialization.
Ausió et al., Victoria, Canada. In Mol Biol Evol, 2015
Selection analyses on independent lineages suggest that their functional specialization was mediated by bursts of adaptive selection at specific evolutionary times, in a small subset of codons with functional relevance-most notably in HMGN1, and in the rapidly evolving HMGN5.
MiR-186 suppresses the growth and metastasis of bladder cancer by targeting NSBP1.
Tan et al., Changsha, China. In Diagn Pathol, 2014
Luciferase reporter assay showed that miR-186 targets NSBP1 3'-untranslated region (UTR) directly and suppresses NSBP1 (HMGN5) expression in human bladder cancer cells.
Chromatin decompaction by the nucleosomal binding protein HMGN5 impairs nuclear sturdiness.
Bustin et al., Bethesda, United States. In Nat Commun, 2014
We show that in cultured cells, chromatin decompaction by the nucleosome binding protein HMGN5 decreases the sturdiness, elasticity and rigidity of the nucleus.
Small interfering RNA targeting HMGN5 induces apoptosis via modulation of a mitochondrial pathway and Bcl-2 family proteins in prostate cancer cells.
GeneRIF
Zhou et al., Beijing, China. In Asian J Androl, 2012
HMGN5 may be a potential molecular target with therapeutic relevance for the treatment of prostate cancer.
Knockdown of the nucleosome binding protein 1 inhibits the growth and invasion of clear cell renal cell carcinoma cells in vitro and in vivo.
GeneRIF
Zhou et al., Beijing, China. In J Exp Clin Cancer Res, 2011
NSBP1 plays oncogenic role in clear cell renal cell carcinoma (ccRCC) by promoting cell proliferation and invasion.
The nucleosome binding protein NSBP1 is highly expressed in human bladder cancer and promotes the proliferation and invasion of bladder cancer cells.
GeneRIF
Zhou et al., Beijing, China. In Tumour Biol, 2011
these results suggest that NSBP1 promotes the viability of bladder cancer cells through increased cell proliferation
HMGN5: a potential oncogene in gliomas.
GeneRIF
Lu et al., Shanghai, China. In J Neurooncol, 2011
The data of study suggested that HMGN5 may play a critical role in the development of gliomas.
Distinct properties of human HMGN5 reveal a rapidly evolving but functionally conserved nucleosome binding protein.
GeneRIF
Bustin et al., Bethesda, United States. In Mol Cell Biol, 2011
HMGN5 has a highly disordered structure, binds dynamically to nucleosome core particles, modulates the binding of H1 to chromatin, reduces the compaction of the chromatin fiber, and affects transcription.
HMGN5/NSBP1: a new member of the HMGN protein family that affects chromatin structure and function.
Review
GeneRIF
Bustin et al., Bethesda, United States. In Biochim Biophys Acta, 2010
The structure of the HMGN5 gene and the known properties of the HMGN5 protein, are described.
HMGNs, DNA repair and cancer.
Review
Gerlitz, Bethesda, United States. In Biochim Biophys Acta, 2010
In addition, emerging roles for HMGN5 in cancer progression and for HMGN2 as a potential tool in cancer therapy will be discussed.
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