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Neuregulin 3

NRG3, Neuregulin 3
This gene is a member of the neuregulin gene family. This gene family encodes ligands for the transmembrane tyrosine kinase receptors ERBB3 and ERBB4 - members of the epidermal growth factor receptor family. Ligand binding activates intracellular signaling cascades and the induction of cellular responses including proliferation, migration, differentiation, and survival or apoptosis. This gene encodes neuregulin 3 (NRG3). NRG3 has been shown to activate the tyrosine phosphorylation of its cognate receptor, ERBB4, and is thought to influence neuroblast proliferation, migration and differentiation by signalling through ERBB4. NRG3 also promotes mammary differentiation during embryogenesis. Linkage studies have implicated this gene as a susceptibility locus for schizophrenia and schizoaffective disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described but their biological validity has not been verified.[provided by RefSeq, Sep 2009] (from NCBI)
Top mentioned proteins: ErbB4, Epidermal Growth Factor, NRG2, erbB-3, erbB-2
Papers on NRG3
Integrative Review of Genetic Factors Influencing Neurodevelopmental Outcomes in Preterm Infants.
Anderson et al., Columbus, United States. In Biol Res Nurs, Oct 2015
However, several avenues of investigation offer promise, including large (>100 kb) copy number variants and the candidate genes MET, NRG3, and SLC6A4, each of which were reported to have associations with neurodevelopmental outcomes in multiple, high-quality studies.
Identification and functional studies of regulatory variants responsible for the association of NRG3 with a delusion phenotype in schizophrenia.
Valle et al., Baltimore, United States. In Mol Neuropsychiatry, May 2015
In follow up fine mapping we found strong evidence of association between three intronic single nucleotide variants (SNVs) in the 5' end of Neuregulin 3 (NRG3) and the delusion factor score of our phenotypic principal component analysis.
PTPN21 exerts pro-neuronal survival and neuritic elongation via ErbB4/NRG3 signaling.
Song et al., Hong Kong, Hong Kong. In Int J Biochem Cell Biol, Apr 2015
Here we combined eQTL and molecular analyses to identify an association between two seemingly non-associated genes in brain expression data from BXD inbred mice, namely Ptpn21 and Nrg3.
Neuregulin-3 regulates epithelial progenitor cell positioning and specifies mammary phenotype.
Howard et al., London, United Kingdom. In Stem Cells Dev, 2014
Mutation of Neuregulin-3 (Nrg3) results in defective embryonic mammary gland development.
Neuregulin-3 in the mouse medial prefrontal cortex regulates impulsive action.
Spijker et al., Amsterdam, Netherlands. In Biol Psychiatry, 2014
METHODS: Using the widely used 5-choice serial reaction time task, we measured impulsive action in 1) a panel of 41 BXD recombinant inbred strains of mice (n = 13.7 ± .8 per strain; n = 654 total) to detect underlying genetic loci; 2) congenic mice (n = 23) to replicate the identified locus; 3) mice overexpressing the Nrg3 candidate gene in the medial prefrontal cortex (n = 21); and 4) a Nrg3 loss-of-function mutant (n = 59) to functionally implicate the Nrg3 candidate gene in impulsivity.
Polythelia: simple atavistic remnant or a suspicious clinical sign for investigation?
Stergidou et al., In Pediatr Endocrinol Rev, 2014
The fact that the Scaramanga (ska) mutant mice presented with ectopic breast tissue imply that misregulation of the neuregulin-3 signaling pathway may be critical in the occurrence of polythelia.
Effects of neuregulin 3 genotype on human prefrontal cortex physiology.
Law et al., Aurora, United States. In J Neurosci, 2014
The neuregulin 3 gene (NRG3) plays pleiotropic roles in neurodevelopment and is a putative susceptibility locus for schizophrenia.
Investigating the Role of Gene-Gene Interactions in TB Susceptibility.
Hoal et al., Cape Town, South Africa. In Plos One, 2013
A number of models were successfully validated, indicating that interplay between the NRG1 - NRG3, GRIK1 - GRIK3 and IL23R - ATG4C gene pairs may modify susceptibility to TB. Gene pairs involved in the NF-κB pathway were also identified in the discovery data set (SFTPD - NOD2, ISG15 - TLR8 and NLRC5 - IL12RB1), but could not be tested in the Gambian study group due to lack of overlapping data.
Impulsivity and comorbid traits: a multi-step approach for finding putative responsible microRNAs in the amygdala.
Spijker et al., New Brunswick, United States. In Front Neurosci, 2013
Previously, we discovered a locus for impulsivity (Impu1) containing the neuregulin 3 (Nrg3) gene, of which the level of expression determines levels of inhibitory control.
Transient overexposure of neuregulin 3 during early postnatal development impacts selective behaviors in adulthood.
Law et al., Aurora, United States. In Plos One, 2013
Neuregulin 3 (NRG3), a specific ligand for ErbB4 and a neuronal-enriched neurotrophin is implicated in the genetic predisposition to a broad spectrum of neurodevelopmental, neurocognitive and neuropsychiatric disorders, including Alzheimer's disease, autism and schizophrenia.
Cognitive outcome and gamma noise power unrelated to neuregulin 1 and 3 variation in schizophrenia.
Molina et al., Salamanca, Spain. In Ann Gen Psychiatry, 2013
Among them, Neuregulin 1 and Neuregulin 3 have been reported to contribute to an increased risk for developing schizophrenia.
Neuregulin 3 and erbb signalling networks in embryonic mammary gland development.
Howard et al., London, United Kingdom. In J Mammary Gland Biol Neoplasia, 2013
We review the role of Neuregulin 3 (Nrg3) and Erbb receptor signalling in embryonic mammary gland development.
Relationships between progesterone receptor isoforms and the HER/ErbB receptors and ligands network in 299 primary breast cancers.
Bonneterre et al., Lille, France. In Int J Biol Markers, 2012
The PR isoforms positively correlated with the mRNA levels of HER/ErbB receptors and ligands associated with a more differentiated phenotype (HER3, HER4, EGF, AREG, NRG3 and NRG4) while they correlated negatively with those associated with aggressiveness (EGFR, TGFa, HB-EGF, EREG, and NRG2).
Genome-wide copy number analysis uncovers a new HSCR gene: NRG3.
Garcia-Barceló et al., Hong Kong, Hong Kong. In Plos Genet, 2011
Our results suggest a role for NRG3 in HSCR etiology and provide insights into the relative contribution of structural variants in both syndromic and non-syndromic HSCR.
Neuregulin 3 does not confer risk for schizophrenia and smooth pursuit eye movement abnormality in a Korean population.
Woo et al., Seoul, South Korea. In Genes Brain Behav, 2011
NRG3 polymorphisms and haplotypes were similar between schizophrenia patients and healthy controls of Korean ethnicity
Platinum sensitivity-related germline polymorphism discovered via a cell-based approach and analysis of its association with outcome in ovarian cancer patients.
Dolan et al., Chicago, United States. In Clin Cancer Res, 2011
Data show that rs1649942, which is located in the intron region of NM_001165973.1. (NRG3 neuregulin 3), was associated with poorer overall survival in women with optimally debulked tumors.
[Neuregulin promotes spermatogonia proliferation in mice].
Jin et al., Yanji, China. In Zhonghua Nan Ke Xue, 2011
NRG1beta and NRG3 can promote the proliferation of mouse spermatogonia.
Common genetic variation in Neuregulin 3 (NRG3) influences risk for schizophrenia and impacts NRG3 expression in human brain.
Law et al., Bethesda, United States. In Proc Natl Acad Sci U S A, 2010
Data show that NRG3 is a schizophrenia susceptibility gene, provide quantitative insight into NRG3 transcription traits in the brain, and reveal a probable mechanistic basis for disease association.
The role of NRG3 in mammary development.
Howard, London, United Kingdom. In J Mammary Gland Biol Neoplasia, 2008
Neuregulin3 (NRG3), a ligand for ERBB4, promotes early mammary morphogenesis and acts during specification of the mammary placode, an aggregate of epithelial cells that forms during mid-embryogenesis.
The neuregulin-I/ErbB signaling system in development and disease.
Britsch, Berlin, Germany. In Adv Anat Embryol Cell Biol, 2006
The neuregulin family of ligands has four members: NRG1, NRG2, NRG3, and NRG4.
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