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Neuregulin 2

NRG2, neuregulin-2, NTAK
This gene encodes a novel member of the neuregulin family of growth and differentiation factors. Through interaction with the ERBB family of receptors, this protein induces the growth and differentiation of epithelial, neuronal, glial, and other types of cells. The gene consists of 12 exons and the genomic structure is similar to that of neuregulin 1, another member of the neuregulin family of ligands. The products of these genes mediate distinct biological processes by acting at different sites in tissues and eliciting different biological responses in cells. This gene is located close to the region for demyelinating Charcot-Marie-Tooth disease locus, but is not responsible for this disease. Alternative transcript variants encoding distinct isoforms have been described. [provided by RefSeq, May 2010] (from NCBI)
Top mentioned proteins: ErbB4, erbB-3, Epidermal Growth Factor, erbB-2, NRG3
Papers on NRG2
The Arabidopsis NRG2 protein mediates nitrate signaling and interacts with and regulates key nitrate regulators.
Wang et al., San Diego, United States. In Plant Cell, Feb 2016
UNASSIGNED: Here, we show that the Nitrate Regulatory Gene 2 (NRG2), a novel gene identified using forward genetics, mediates nitrate signaling in Arabidopsis.
Bidirectional Signaling of Neuregulin-2 Mediates Formation of GABAergic Synapses and Maturation of Glutamatergic Synapses in Newborn Granule Cells of Postnatal Hippocampus.
Lee et al., Seoul, South Korea. In J Neurosci, Jan 2016
UNLABELLED: Expression of neuregulin-2 (NRG2) is intense in a few regions of the adult brain where neurogenesis persists; however, little is understood about its role in developments of newborn neurons.
YAP forms autocrine loops with the ERBB pathway to regulate ovarian cancer initiation and progression.
Wang et al., Omaha, United States. In Oncogene, Jan 2016
YAP induces the expression of epidermal growth factor (EGF) receptors (EGFR, ERBB3) and production of EGF-like ligands (HBEGF, NRG1 and NRG2).
Detection and quantification of new psychoactive substances (NPSs) within the evolved "legal high" product, NRG-2, using high performance liquid chromatography-amperometric detection (HPLC-AD).
Sutcliffe et al., Manchester, United Kingdom. In Analyst, Oct 2015
The global increase in the production and abuse of cathinone-derived New Psychoactive Substances (NPSs) has developed the requirement for rapid, selective and sensitive protocols for their separation and detection.
A negative feedback loop controls NMDA receptor function in cortical interneurons via neuregulin 2/ErbB4 signalling.
Buonanno et al., Bethesda, United States. In Nat Commun, 2014
Here we demonstrate, in cultured neurons and in acute slices, that the NMDA receptor is both effector and target of neuregulin 2 (NRG2)/ErbB4 signalling in cortical interneurons.
Associations with growth factor genes (FGF1, FGF2, PDGFB, FGFR2, NRG2, EGF, ERBB2) with breast cancer risk and survival: the Breast Cancer Health Disparities Study.
Wolff et al., Salt Lake City, United States. In Breast Cancer Res Treat, 2013
We examined how genetic variation in epidermal growth factor (EGF), neuregulin 2 (NRG2), ERBB2 (HER2/neu), fibroblast growth factors 1 and 2 (FGF1 and FGF2) and its receptor 2 (FGFR2), and platelet-derived growth factor B (PDGFB) independently and collectively influence breast cancer risk and survival.
Recreational use of 1-(2-naphthyl)-2-(1-pyrrolidinyl)-1-pentanone hydrochloride (NRG-1), 6-(2-aminopropyl) benzofuran (benzofury/ 6-APB) and NRG-2 with review of available evidence-based literature.
Deluca et al., Swansea, United Kingdom. In Hum Psychopharmacol, 2013
Available evidence-based literature were reviewed along with a user's experimentation with mephedrone, NRG-1, NRG-2 and Benzofury.
Potential Impact of miR-137 and Its Targets in Schizophrenia.
Perrone-Bizzozero et al., Albuquerque, United States. In Front Genet, 2012
Using TargetScan and the schizophrenia gene resource (SZGR) database, we found that in addition to CSMD1, C10orf26, CACNA1C, TCF4, and ZNF804A, five schizophrenia risk genes whose transcripts are also validated miR-137 targets, there are other schizophrenia-associated genes that may be targets of miR-137, including ERBB4, GABRA1, GRIN2A, GRM5, GSK3B, NRG2, and HTR2C.
Relationships between progesterone receptor isoforms and the HER/ErbB receptors and ligands network in 299 primary breast cancers.
Bonneterre et al., Lille, France. In Int J Biol Markers, 2012
The PR isoforms positively correlated with the mRNA levels of HER/ErbB receptors and ligands associated with a more differentiated phenotype (HER3, HER4, EGF, AREG, NRG3 and NRG4) while they correlated negatively with those associated with aggressiveness (EGFR, TGFa, HB-EGF, EREG, and NRG2).
The Onecut transcription factor HNF-6 regulates in motor neurons the formation of the neuromuscular junctions.
Clotman et al., Brussels, Belgium. In Plos One, 2011
Furthermore, we show that the expression level of numerous regulators of neuromuscular junction formation, namely agrin, neuregulin-2 and TGF-ß receptor II, is downregulated in the spinal motor neurons of Hnf6 mutant newborn animals.
ErbB/HER ligands in human breast cancer, and relationships with their receptors, the bio-pathological features and prognosis.
Peyrat et al., Lille, France. In Ann Oncol, 2008
NRG2 was positive in almost all breast cancers studied. High expression is related to the biological aggressiveness of breast cancer.
Inter-conversion of neuregulin2 full and partial agonists for ErbB4.
Riese et al., West Lafayette, United States. In Biochem Biophys Res Commun, 2008
Gln43 of NRG2beta is both necessary and sufficient for NRG2 stimulation of ErbB4 coupling to IL3 independence.
Fine mapping of new glaucoma locus GLC1M and exclusion of neuregulin 2 as the causative gene.
Pang et al., Hong Kong, Hong Kong. In Mol Vis, 2006
Linkage interval for GLC1M was refined to a smaller region. The NRG2 gene was excluded as the causative gene for juvenile-onset primary open angle glaucoma.
The neuregulin-I/ErbB signaling system in development and disease.
Britsch, Berlin, Germany. In Adv Anat Embryol Cell Biol, 2006
The neuregulin family of ligands has four members: NRG1, NRG2, NRG3, and NRG4.
Schwann cell-derived neuregulin-2alpha can function as a cell-attached activator of muscle acetylcholine receptor expression.
Rimer et al., Austin, United States. In Glia, 2006
These results provide a potential role for the previously reported, paradoxical perisynaptic accumulation of Nrg-2alpha, the isoform with the least AChR-inducing activity when presented in a soluble form.
Repressors Nrg1 and Nrg2 regulate a set of stress-responsive genes in Saccharomyces cerevisiae.
Carlson et al., New York City, United States. In Eukaryot Cell, 2005
Results suggest that Nrg1/Nrg2 fine-tune the regulation of a set of stress-responsive genes.
Neuregulins: primary or secondary signals for the control of synapse-specific gene expression.
Rimer, Austin, United States. In J Neurocytol, 2003
In addition, I briefly present new evidence that raise the possibility that Nrgs encoded by the ngr-1 -related gene nrg-2 might have a role controlling AChR expression.
Neuregulins: functions, forms, and signaling strategies.
Falls, Atlanta, United States. In Exp Cell Res, 2003
The neuregulin family of genes has four members: NRG1, NRG2, NRG3, and NRG4.
Neuregulin-2, a new ligand of ErbB3/ErbB4-receptor tyrosine kinases.
Lai et al., Boston, United States. In Nature, 1997
We have now discovered a set of new neuregulin-like growth factors, which we call neuregulin-2 (NRG-2): these are encoded by their own gene and exhibit a distinct expression pattern in adult brain and developing heart.
Ligands for ErbB-family receptors encoded by a neuregulin-like gene.
McMahan et al., Stanford, United States. In Nature, 1997
Here we report the cloning of a second neuregulin-like gene, neuregulin-2.
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