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Nuclear factor

Nrf3, NF-E2-related factor 3
This gene encodes a member of the cap 'n' collar basic-region leucine zipper family of transcription factors. The encoded protein heterodimerizes with small musculoaponeurotic fibrosarcoma factors to bind antioxidant response elements in target genes. This protein is a membrane bound glycoprotein that is targeted to the endoplasmic reticulum and the nuclear envelope. Pseudogenes of this gene are found on chromosomes 16, 17, and 18. [provided by RefSeq, Mar 2009] (from NCBI)
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Top mentioned proteins: Nrf2, Nuclear Respiratory Factor 1, NF-E2, NRF, MAF
Papers on Nrf3
Nrf2 and Nrf2-related proteins in development and developmental toxicity: Insights from studies in zebrafish (Danio rerio).
Stegeman et al., Amherst Center, United States. In Free Radic Biol Med, Nov 2015
Vertebrate animals including zebrafish share Nfe2, Nrf1, Nrf2, and Nrf3 as well as a core set of genes that respond to oxidative stress, contributing to the value of zebrafish as a model system with which to investigate the mechanisms involved in regulation of redox signaling and the response to oxidative stress during embryolarval development.
SKN-1/Nrf, stress responses, and aging in Caenorhabditis elegans.
Isik et al., Boston, United States. In Free Radic Biol Med, Nov 2015
The mammalian Nrf/CNC proteins (Nrf1, Nrf2, Nrf3, p45 NF-E2) perform a wide range of cellular protective and maintenance functions.
Stringent Control of NFE2L3 (Nuclear Factor, Erythroid 2-Like 3; NRF3) Protein Degradation by FBW7 (F-box/WD Repeat-containing Protein 7) and Glycogen Synthase Kinase 3 (GSK3).
Blank et al., Montréal, Canada. In J Biol Chem, Nov 2015
UNLABELLED: The NFE2L3 transcription factor has been implicated in various cellular processes, including carcinogenesis, stress response, differentiation, and inflammation.
Bisphenol A increases BeWo trophoblast survival in stress-induced paradigms through regulation of oxidative stress and apoptosis.
De Girolamo et al., Nottingham, United Kingdom. In Chem Res Toxicol, Oct 2015
BPA was also able to reduce the activation of the antioxidant response element (ARE) through mediation of its activators, nuclear factor erythroid related factor family members (Nrf's).
Regulation and function of the NFE2 transcription factor in hematopoietic and non-hematopoietic cells.
Blank et al., Montréal, Canada. In Cell Mol Life Sci, Jun 2015
In contrast to other CNC transcription family members including NFE2L1 (NRF1), NFE2L2 (NRF2) and NFE2L3 (NRF3), which are widely expressed, earlier studies had suggested that the major sites of NFE2 expression are hematopoietic cells.
Natural antioxidants exhibit chemopreventive characteristics through the regulation of CNC b-Zip transcription factors in estrogen-induced breast carcinogenesis.
Bhat et al., Kansas City, United States. In J Biochem Mol Toxicol, 2014
mRNA and protein expression levels of CNC b-zip transcription factors nuclear factor erythroid 2-related factor 1 (Nrf1), nuclear factor erythroid 2 related factor 2 (Nrf2), nuclear factor erythroid 2 related factor 3 (Nrf3), and Nrf2-regulated antioxidant enzymes superoxide dismutase 3 (SOD3) and NAD(P)H: quinone oxidoreductase 1 (NQO1) were quantified.
[CNC proteins in physiology and pathology].
Skrzydlewska et al., Laizhou, China. In Postepy Hig Med Dosw (online), 2014
CNC proteins consist of Bach1, Bach2 and 4 homologous transcription factors: Nrf1, Nrf2, Nrf3 and p45NF-E2.
Developmental expression of the Nfe2-related factor (Nrf) transcription factor family in the zebrafish, Danio rerio.
Hahn et al., Lewiston, United States. In Plos One, 2012
Transcription factors in the CNC-bZIP family (NFE2, NRF1, NRF2 and NRF3) regulate genes with a wide range of functions in response to both physiological and exogenous signals, including those indicating changes in cellular redox status.
Nrf3-Pla2g7 interaction plays an essential role in smooth muscle differentiation from stem cells.
Xu et al., London, United Kingdom. In Arterioscler Thromb Vasc Biol, 2012
Pla2g7 plays a crucial physiological role in smooth muscle cell differentiation from stem cells, and interactions between Nrf3 and Pla2g7 are essential.
NFE2L3 (NRF3): the Cinderella of the Cap'n'Collar transcription factors.
Blank et al., Montréal, Canada. In Cell Mol Life Sci, 2011
NFE2L3 [Nuclear factor (erythroid-derived 2)-like 3] or NRF3, a member of the Cap'n'Collar (CNC) family, is a basic-region leucine zipper (bZIP) transcription factor that was first identified over 10 years ago.
Nfe2l3 (Nrf3) deficiency predisposes mice to T-cell lymphoblastic lymphoma.
Blank et al., Montréal, Canada. In Blood, 2011
Contrary to wild-type mice, Nrf3-null animals are highly susceptible to B[a]P, exhibiting significantly increased mortality. Pathology analysis revealed a high incidence of T-cell lymphoblastic lymphoma in B[a]P-treated Nrf3(-/-) mice.
Crucial role of nrf3 in smooth muscle cell differentiation from stem cells.
Xu et al., London, United Kingdom. In Circ Res, 2010
Demonstrate that Nrf3 has a crucial role in smooth muscle cell differentiation from embryonic stem cells.
Nrf3-deficient mice are not protected against acute lung and adipose tissue damages induced by butylated hydroxytoluene.
Blank et al., Montréal, Canada. In Febs Lett, 2010
We found that both wild type and Nrf3 (NF-E2-related factor 3) deficient mice are sensitive to BHT single administration exhibiting respiratory distress and considerably lose body weight following treatment.
Stress-activated cap'n'collar transcription factors in aging and human disease.
Bohmann et al., Rochester, United States. In Sci Signal, 2009
The vertebrate Nrf1, Nrf2, and Nrf3; the Caenorhabditis elegans SKN-1; and the Drosophila CncC comprise a subgroup of Cnc factors that mediate adaptive responses to cellular stress.
The Nrf3 transcription factor is a membrane-bound glycoprotein targeted to the endoplasmic reticulum through its N-terminal homology box 1 sequence.
Hayes et al., Dundee, United Kingdom. In J Biol Chem, 2009
data are presented suggesting that the NHB2 sequence in mouse Nrf3 may regulate the topology of the transcription factor within the ER membrane
Endoplasmic reticulum association and N-linked glycosylation of the human Nrf3 transcription factor.
Blank et al., Montréal, Canada. In Febs Lett, 2007
Nrf3 is an N-glycosylated protein associated with the endoplasmic reticulum
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