Regulation of Vascular Endothelium Inflammatory Signalling by Shear Stress.
Bristol, United Kingdom. In Curr Vasc Pharmacol, Jan 2016
In this review, we summarise the available evidence regarding the effect of shear stress on vascular EC and smooth muscle cells, the regulation of MAPK and NF-кB including the production of different negative regulators of inflammation such as MKP-1 and NRF2, and the production of microRNAs.
Variations in Antioxidant Genes and Male Infertility.
Guangzhou, China. In Biomed Res Int, 2014
Antioxidant genes, which include catalase (CAT), glutathione peroxidase (GPX), glutathione S-transferase (GST), nitric oxide synthase (NOS), nuclear factor erythroid 2-related factor 2 (NRF2), and superoxide dismutase (SOD), play important roles in spermatogenesis and normal sperm function.
Sulforaphane Protects against Cardiovascular Disease via Nrf2 Activation.
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Changchun, China. In Oxid Med Cell Longev, 2014
SFN activates NF-E2-related factor 2 (Nrf2), a basic leucine zipper transcription factor that serves as a defense mechanism against oxidative stress and electrophilic toxicants by inducing more than a hundred cytoprotective proteins, including antioxidants and phase II detoxifying enzymes.