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Nuclear factor, erythroid derived 2, like 2

Nrf2, NF-E2-related factor 2
This gene encodes a transcription factor which is a member of a small family of basic leucine zipper (bZIP) proteins. The encoded transcription factor regulates genes which contain antioxidant response elements (ARE) in their promoters; many of these genes encode proteins involved in response to injury and inflammation which includes the production of free radicals. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012] (from NCBI)
Top mentioned proteins: NF-E2, V1a, Keap1, CAN, Ros
Papers using Nrf2 antibodies
Fumarates improve psoriasis and multiple sclerosis by inducing type II dendritic cells
Methner Axel et al., In Journal of Neuroinflammation, 2010
... 8-12, 69126 Heidelberg, Germany; the anti-Nrf2 antibody was from Santa Cruz Biotechnology, Bergheimer Straße 89, 69115 ...
Uncaria rhynchophylla induces heme oxygenase-1 as a cytoprotective effect in RAW 264.7 macrophages.
Pal Soumitro, In PLoS ONE, 2009
... The following antibodies were used; anti-Nrf2 (Santa Cruz Biotechnology, Santa Cruz, CA), anti-Lamin ...
Overexpression of aldehyde dehydrogenase 1A1 reduces oxidation-induced toxicity in SH-SY5Y neuroblastoma cells
Bohmann Dirk et al., In Disease Models & Mechanisms, 2009
... Keap1/Nrf2 signaling regulates oxidative stress tolerance and lifespan in Drosophila ...
Genetic alteration of Keap1 confers constitutive Nrf2 activation and resistance to chemotherapy in gallbladder cancer
Hwang Sung Chul et al., In The Korean Journal of Internal Medicine, 2007
... Nrf2, anti-hemagglutinin (HA), and α-tubulin were obtained from Santa Cruz Biotechnology (Santa Cruz, CA, USA) ...
Specificity protein 1 and Smad-dependent regulation of human heme oxygenase-1 gene by transforming growth factor-beta1 in renal epithelial cells.
Jhaveri Ravi, In PLoS ONE, 2006
... Antibodies to Nrf2 (ab31163), Nqo1 (ab28947), HO-1 (ab13248), HCV protein E2 (ab20852-100), HCV protein E1 (ab21306-100), HRP-conjugated anti-rabbit and anti-mouse secondary antibodies were obtained from Abcam (Cambridge, UK), monoclonal antibodies ...
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Papers on Nrf2
Enhanced muscle nutrient content and flesh quality, resulting from tryptophan, is associated with anti-oxidative damage referred to the Nrf2 and TOR signalling factors in young grass carp (Ctenopharyngodon idella): Avoid tryptophan deficiency or excess.
Feng et al., Chengdu, China. In Food Chem, Jun 2016
The expression of signalling molecules [Kelch-like ECH-associated protein 1, target of rapamycin (TOR) and ribosomal S6 protein kinase 1] involved in the NF-E2-related factor 2 (Nrf2) pathway revealed a potential method of Trp-enhanced antioxidant defence.
Integrated data analysis reveals uterine leiomyoma subtypes with distinct driver pathways and biomarkers.
Aaltonen et al., Helsinki, Finland. In Proc Natl Acad Sci U S A, Feb 2016
FH-deficient leiomyomas were uniquely characterized by activation of nuclear factor erythroid 2-related factor 2 (NRF2) target genes, supporting the hypothesis that accumulation of fumarate leads to activation of the oncogenic transcription factor NRF2.
Comprehensive Molecular Characterization of Papillary Renal-Cell Carcinoma.
Zuna et al., In N Engl J Med, Feb 2016
Type 1 tumors were associated with MET alterations, whereas type 2 tumors were characterized by CDKN2A silencing, SETD2 mutations, TFE3 fusions, and increased expression of the NRF2-antioxidant response element (ARE) pathway.
The novel triterpenoid RTA 408 protects human retinal pigment epithelial cells against H2O2-induced cell injury via NF-E2-related factor 2 (Nrf2) activation.
Wu et al., Fort Worth, United States. In Redox Biol, Jan 2016
Previous studies have shown that RTA 408, a synthetic triterpenoid compound, potently activates Nrf2.
NRF2 regulates serine biosynthesis in non-small cell lung cancer.
Cantley et al., New York City, United States. In Nat Genet, Dec 2015
Here we show that the activity of this pathway is highly heterogeneous and is regulated by NRF2, a transcription factor frequently deregulated in NSCLC.
Redox Modulating NRF2: A Potential Mediator of Cancer Stem Cell Resistance.
Kwak et al., Puch'ŏn, South Korea. In Oxid Med Cell Longev, Dec 2015
Recent studies demonstrate that nuclear factor-erythroid 2-related factor 2 (NRF2), a master regulator of the cellular antioxidant defense system, is involved in the maintenance of quiescence, survival, and stress resistance of CSCs.
Protection against acetaminophen-induced acute liver failure by omentum adipose tissue derived stem cells through the mediation of Nrf2 and cytochrome P450 expression.
Wu et al., Taipei, Taiwan. In J Biomed Sci, Dec 2015
RESULT: ASC transplantation significantly improved the survival rate of mice with ALF and attenuated the severity of APAP-induced liver damage by suppressing cytochrome P450 activity to reduce the accumulation of toxic nitrotyrosine and the upregulation of NF-E2-related factor 2 (Nrf2) expression, resulting in an increase in the subsequent antioxidant activity.
NRF2 Is a Key Target for Prevention of Noise-Induced Hearing Loss by Reducing Oxidative Damage of Cochlea.
Motohashi et al., Sendai, Japan. In Sci Rep, Dec 2015
NRF2 is a transcriptional activator playing an essential role in the defense mechanism against oxidative stress.
Sustained NRF2 activation in hereditary leiomyomatosis and renal cell cancer (HLRCC) and in hereditary tyrosinemia type 1 (HT1).
Ooi et al., Tucson, United States. In Biochem Soc Trans, Sep 2015
The nuclear erythroid 2-like 2 transcription factor (NRF2), is a major regulator of cellular redox balance.
NRF2 and microRNAs: new but awaited relations.
Werner et al., Zürich, Switzerland. In Biochem Soc Trans, Sep 2015
The nuclear factor erythroid 2-related factor 2 (NRF2) transcription factor is a key player in the cellular antioxidant response and it also controls various other functions in a cell-type specific manner.
BMPR2 preserves mitochondrial function and DNA during reoxygenation to promote endothelial cell survival and reverse pulmonary hypertension.
Rabinovitch et al., Stanford, United States. In Cell Metab, May 2015
Decreasing PAEC BMPR2 by siRNA during reoxygenation represses p53, PGC1α, NRF2, TFAM, mitochondrial membrane potential, and ATP and induces mitochondrial DNA deletion and apoptosis.
TGF-β promotes heterogeneity and drug resistance in squamous cell carcinoma.
Fuchs et al., New York City, United States. In Cell, Mar 2015
Rather, TGF-β transcriptionally activates p21, which stabilizes NRF2, thereby markedly enhancing glutathione metabolism and diminishing effectiveness of anti-cancer therapeutics.
Targeting ABL1-mediated oxidative stress adaptation in fumarate hydratase-deficient cancer.
Linehan et al., Bethesda, United States. In Cancer Cell, 2015
ABL1 upregulates aerobic glycolysis via the mTOR/HIF1α pathway and neutralizes fumarate-induced proteotoxic stress by promoting nuclear localization of the antioxidant response transcription factor NRF2.
Variations in Antioxidant Genes and Male Infertility.
Huang et al., Guangzhou, China. In Biomed Res Int, 2014
Antioxidant genes, which include catalase (CAT), glutathione peroxidase (GPX), glutathione S-transferase (GST), nitric oxide synthase (NOS), nuclear factor erythroid 2-related factor 2 (NRF2), and superoxide dismutase (SOD), play important roles in spermatogenesis and normal sperm function.
Sulforaphane Protects against Cardiovascular Disease via Nrf2 Activation.
Zheng et al., Changchun, China. In Oxid Med Cell Longev, 2014
SFN activates NF-E2-related factor 2 (Nrf2), a basic leucine zipper transcription factor that serves as a defense mechanism against oxidative stress and electrophilic toxicants by inducing more than a hundred cytoprotective proteins, including antioxidants and phase II detoxifying enzymes.
Aldehyde oxidase 1 gene is regulated by Nrf2 pathway.
Sakai et al., Sapporo, Japan. In Gene, 2012
It was shown that show that Nrf2 binds to and strongly activates the rat AOX1 gene.
Structural and functional characterization of Nrf2 degradation by the glycogen synthase kinase 3/β-TrCP axis.
Cuadrado et al., Madrid, Spain. In Mol Cell Biol, 2012
Two-dimensional gel electrophoresis and site-directed mutagenesis were used to identify two serines of NRF2 that are phosphorylated by glycogen synthase kinase 3 beta (GSK-3 beta) in the sequence DSGISL.
Keap1 degradation by autophagy for the maintenance of redox homeostasis.
Yamamoto et al., Sendai, Japan. In Proc Natl Acad Sci U S A, 2012
The autophagy pathway maintains the integrity of the Keap1-Nrf2 system for the normal liver function by governing the Keap1 turnover
Beneficial effects of Nrf2 overexpression in a mouse model of Alexander disease.
Messing et al., Madison, United States. In J Neurosci, 2012
This study showed that astrocyte-specific overexpression of Nrf2 is sufficient to decrease GFAP transcripts, protein, and Rosenthal fibers in a mouse model of Alexander disease
Nrf2 redirects glucose and glutamine into anabolic pathways in metabolic reprogramming.
Motohashi et al., Sendai, Japan. In Cancer Cell, 2012
active PI3K-Akt pathway augments the nuclear accumulation of Nrf2 and enables Nrf2 to promote metabolic activities that support cell proliferation in addition to enhancing cytoprotection
More papers using Nrf2 antibodies
Anti-inflammatory effect of heme oxygenase 1: glycosylation and nitric oxide inhibition in macrophages
Pae Hyun-Ock et al., In Journal of Clinical Biochemistry and Nutrition, 2004
... Antibodies against iNOS, HO-1, Nrf2, lamin B and β-actin and small interfering RNA (siRNA) products against Nrf2 and HO-1 were obtained from Santa Cruz Biotechnology (Santa Cruz, CA) ...
Overexpression of copper zinc superoxide dismutase suppresses human glioma cell growth
Freeman Michael L. et al., In Oncogene, 2001
... Antibodies were obtained as follows: Nrf2 (Santa Cruz: Cat# sc-13032; Abcam: Cat #ab62352), GCLC (Neomarkers: ...
A new HPLC method for the simultaneous determination of oxidized and reduced plasma aminothiols using coulometric electrochemical detection.
Gendelman Howard E., In PLoS ONE, 1998
... using appropriate primary antibodies (anti-Nrf2, (1∶1000 Epitomics CA); anti-NQO1, anti-glutathione reductase ...
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