Nucleotides in neuroregeneration and neuroprotection.
Madrid, Spain. In Neuropharmacology, Oct 2015
Finally, general signaling pathways triggered by nucleotide receptors in neuronal populations converge on several intracellular kinases, such as PI3K/Akt, GSK3 and ERK1,2, as well as the Nrf-2/heme oxigenase-1 axis, which specifically link them to neuroprotection.
Redox mechanisms of cardiomyocyte mitochondrial protection.
Durham, United States. In Front Physiol, 2014
Simultaneously, a number of other DNA binding transcription factors are expressed and/or activated under redox control, such as Nuclear Respiratory Factor-1 (NRF-1), and lead to the induction of genes involved in both intracellular and mitochondria-specific repair mechanisms.