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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

NRD1 Nrd1p

Nrd1, N-arginine dibasic convertase, NRD convertase, NRDc, Nardilysin, Nrd1p
This gene encodes a zinc-dependent endopeptidase that cleaves peptide substrates at the N-terminus of arginine residues in dibasic moieties and is a member of the peptidase M16 family. This protein interacts with heparin-binding EGF-like growth factor and plays a role in cell migration and proliferation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011] (from NCBI)
Top mentioned proteins: POLYMERASE, ACID, V1a, CAN, Epidermal Growth Factor
Papers on Nrd1
Loss of Peripheral Protection in Pancreatic Islets by Proteolysis-Driven Impairment of VTCN1 (B7-H4) Presentation Is Associated with the Development of Autoimmune Diabetes.
New
Savinov et al., Sioux Falls, United States. In J Immunol, Feb 2016
Diminishment of functional islet cells' VTCN1 is caused by the active proteolysis by metalloproteinase N-arginine dibasic convertase 1 (NRD1) and leads to the significant induction of proliferation and cytokine production by diabetogenic T cells.
Regulation of ADAM10 and ADAM17 by Sorafenib Inhibits Epithelial-to-Mesenchymal Transition in Epstein-Barr Virus-Infected Retinal Pigment Epithelial Cells.
New
Hur et al., Pusan, South Korea. In Invest Ophthalmol Vis Sci, Aug 2015
The expression of mature ADAM10, ADAM17, and cleaved Notch 1 proteins in ARPE/EBV cells was downregulated after treatment with sorafenib through the regulatory activity of nardilysin (NRD-1).
Heparin-binding EGF-like growth factor and enteric neural stem cell transplantation in the prevention of experimental necrotizing enterocolitis in mice.
New
Besner et al., Columbus, United States. In Pediatr Res, Jul 2015
RESULTS: HB-EGF promoted NSC proliferation via ErbB-1 receptors and enhanced NSC migration via ErbB-1, ErbB-4, and Nardilysin receptors.
Regulation of anti-sense transcription by Mot1p and NC2 via removal of TATA-binding protein (TBP) from the 3'-end of genes.
Timmers et al., Utrecht, Netherlands. In Nucleic Acids Res, 2015
In this, Mot1p and NC2 collaborate with the Nrd1p-Nab3p-Sen1p (NNS) complex that terminates the synthesis of anti-sense ncRNAs.
Genome-wide association discoveries of alcohol dependence.
Review
Luo et al., New Haven, United States. In Am J Addict, 2014
The associations with the variants within NRD1, GPD1L-CMTM8 or MAP3K9-PCNX were suggestive (5 × 10(-8)  < p < 10(-5) ) in some samples, and nominally replicable in other samples.
Nardilysin-dependent proteolysis of cell-associated VTCN1 (B7-H4) marks type 1 diabetes development.
Savinov et al., Sioux Falls, United States. In Diabetes, 2014
Mechanistically, we demonstrate that the loss of membrane-tethered VTCN1 is linked to proteolytic cleavage mediated by the metalloproteinase nardilysin.
Ethanol treatment of lymphoblastoid cell lines from alcoholics and non-alcoholics causes many subtle changes in gene expression.
Edenberg et al., Indianapolis, United States. In Alcohol, 2014
Among the genes affected by ethanol were ANK3, EPHB1, SLC1A1, SLC9A9, NRD1, and SH3BP5, which were reported to be associated with alcoholism or related phenotypes in 2 genome-wide association studies.
Molecular basis for coordinating transcription termination with noncoding RNA degradation.
Libri et al., Gif-sur-Yvette, France. In Mol Cell, 2014
The Nrd1-Nab3-Sen1 (NNS) complex is essential for controlling pervasive transcription and generating sn/snoRNAs in S. cerevisiae.
Critical roles of nardilysin in the maintenance of body temperature homoeostasis.
Nishi et al., Kyoto, Japan. In Nat Commun, 2013
Here we identify nardilysin (Nrd1 and NRDc) as a critical regulator of body temperature homoeostasis.
Deletion of nardilysin prevents the development of steatohepatitis and liver fibrotic changes.
Chiba et al., Kyoto, Japan. In Plos One, 2013
Nardilysin (N-arginine dibasic convertase; Nrd1), a zinc metalloendopeptidase of the M16 family, enhances ectodomain shedding of TNF-α, resulting in the activation of inflammatory responses.
Nardilysin in human brain diseases: both friend and foe.
Review
Reiser et al., Magdeburg, Germany. In Amino Acids, 2013
Nardilysin is a metalloprotease that cleaves peptides, such as dynorphin-A, α-neoendorphin, and glucagon, at the N-terminus of arginine and lysine residues in dibasic moieties.
Serine phosphorylation and proline isomerization in RNAP II CTD control recruitment of Nrd1.
GeneRIF
Stefl et al., Brno, Czech Republic. In Genes Dev, 2012
structure reveals a direct recognition of pSer5 by Nrd1 that requires the cis conformation of the upstream pSer5-Pro6 peptidyl-prolyl bond of the CTD
Budding yeast telomerase RNA transcription termination is dictated by the Nrd1/Nab3 non-coding RNA termination pathway.
GeneRIF
Wellinger et al., Sherbrooke, Canada. In Nucleic Acids Res, 2012
The results demonstrate that the function of the Tlc1 terminator region depends on the Nrd1/Nab3 transcription termination pathway.
Mutant p53 interactome identifies nardilysin as a p53R273H-specific binding partner that promotes invasion.
GeneRIF
Gunaratne et al., Singapore, Singapore. In Embo Rep, 2012
NRD1 interacts with p53 mutant R273H
Nardilysin and ADAM proteases promote gastric cancer cell growth by activating intrinsic cytokine signalling via enhanced ectodomain shedding of TNF-α.
GeneRIF
Chiba et al., Kyoto, Japan. In Embo Mol Med, 2012
These results demonstrate that gastric cancer cell growth is maintained by autonomous TNF-alpha-NF-kappaB and IL-6-STAT3 signalling, and that NRDc and ADAM proteases turn on these signalling cascades by stimulating ectodomain shedding of TNF-alpha.
Identification and characterization of nardilysin as a novel dimethyl H3K4-binding protein involved in transcriptional regulation.
GeneRIF
Wong et al., Shanghai, China. In J Biol Chem, 2012
Identification and characterization of nardilysin as a novel dimethyl H3K4-binding protein involved in transcriptional regulation.
Antigen processing by nardilysin and thimet oligopeptidase generates cytotoxic T cell epitopes.
Impact
GeneRIF
Melief et al., Leiden, Netherlands. In Nat Immunol, 2011
mediates antigen processing that generates cytotoxic T cell epitopes
Pro-protein convertases in intermediary metabolism: islet hormones, brain/gut hormones and integrated physiology.
Review
Bataille, Montpellier, France. In J Mol Med (berl), 2007
The archetype of such a pluripotent prohormone in the field of intermediary metabolism is pro-glucagon that, when cut by PC1 in intestinal L cells, produces four different peptides with different specificities [glicentin, oxyntomodulin (OXM), glucagon-like peptide-1, and glucagon-like peptide-2], whereas, when cut by PC2 in the alpha cells of the endocrine pancreas, glucagon is produced and, through the supplementary action of NRD convertase, a fragment of glucagon (miniglucagon) with original properties.
Nardilysin, a basic residues specific metallopeptidase that mediates cell migration and proliferation.
Review
Prat et al., Paris, France. In Protein Pept Lett, 2004
Nardilysin (NRDc), a metallopeptidase of the M16 family, presents, in vitro, cleavage specificity for basic residues.
Precursor convertases in the secretory pathway, cytosol and extracellular milieu.
Review
Prat et al., Montréal, Canada. In Essays Biochem, 2001
Recently, it was recognized that the metalloendopeptidase N-arginine dibasic convertase (NRDc; nardilysin), which cleaves at the N-terminus side of basic residues in dibasic pairs, is localized both in the cytosol and at the cell surface or in the extracellular milieu.
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