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Nuclear receptor subfamily 2, group E, member 3

NR2E3, rd7
This protein is part of a large family of nuclear receptor transcription factors involved in signaling pathways. Nuclear receptors have been shown to regulate pathways involved in embryonic development, as well as in maintenance of proper cell function in adults. Members of this family are characterized by discrete domains that function in DNA and ligand binding. This gene encodes a retinal nuclear receptor that is a ligand-dependent transcription factor. Defects in this gene are a cause of enhanced S cone syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ROD, CAN, HAD, CRX, Rhodopsin
Papers on NR2E3
Downregulation of the Canonical WNT Signaling Pathway by TGFβ1 Inhibits Photoreceptor Differentiation of Adult Human Müller Glia with Stem Cell Characteristics.
Limb et al., London, United Kingdom. In Stem Cells Dev, Feb 2016
Furthermore, TGFβ1 not only decreased WNT2B expression, but also inhibited FTRI-induced photoreceptor differentiation of hMSC, as determined by expression of the photoreceptor markers NR2E3, RHODOPSIN, and RECOVERIN.
Transcriptome Dynamics of Developing Photoreceptors in Three-Dimensional Retina Cultures Recapitulates Temporal Sequence of Human Cone and Rod Differentiation Revealing Cell Surface Markers and Gene Networks.
Swaroop et al., Bethesda, United States. In Stem Cells, Dec 2015
At day 90, robust expression of NRL and its target nuclear receptor NR2E3 is evident in many CRX+ cells, while minimal S-opsin and no rhodopsin or L/M-opsin is present.
Inhibition of Bacillus cereus Growth and Toxin Production by Bacillus amyloliquefaciens RD7-7 in Fermented Soybean Products.
Choi et al., South Korea. In J Microbiol Biotechnol, Dec 2015
In this study, we investigated whether B. amyloliquefaciens RD7-7, isolated from rice doenjang, a traditional Korean fermented soybean food, shows antimicrobial activity against B. cereus and regulates its toxin gene expression.
Deregulation of NR2E3, an orphan nuclear receptor, by benzo(a)pyrene-induced oxidative stress is associated with histone modification status change of the estrogen receptor gene promoter.
Kim et al., Cincinnati, United States. In Toxicol Lett, Oct 2015
We previously reported that NR2E3, an orphan nuclear receptor, plays an important role in maintaining the basal expression of estrogen receptor α (ER) and that the NR2E3 level is highly correlated with the relapse-free survival of breast cancer patients.
Transcriptional regulation via nuclear receptor crosstalk required for the Drosophila circadian clock.
Nagoshi et al., Bern, Switzerland. In Curr Biol, Jul 2015
We show here that the nuclear receptor E75, the fly homolog of REV-ERB α and REV-ERB β, and the NR2E3 subfamily nuclear receptor UNF are components of the molecular clocks in the Drosophila pacemaker neurons.
Differential dimerization of variants linked to enhanced S-cone sensitivity syndrome (ESCS) located in the NR2E3 ligand-binding domain.
Escher et al., Sion, Switzerland. In Hum Mutat, Jun 2015
Recessive variants located in the ligand-binding domain (LBD) of NR2E3 cause enhanced short wavelength sensitive- (S-) cone syndrome (ESCS), a retinal degeneration characterized by an excess of S-cones and non-functional rods.
A cytotoxic analysis of a sardinian plant extract cream on human oral primary cell cultures: an in vitro study.
Caputi et al., Pescara, Italy. In J Biol Regul Homeost Agents, 2015
The aim of this work was to evaluate the effect of different concentration of a new Sardinian plant cream (RD7) on two human primary cultures: Periodontal Ligament Stem Cells (hPDLSCs) and Gingival Fibroblasts (hGFs) derived from oral tissues in terms of morphological changes, cell proliferation and wound healing properties.
New COL6A6 variant detected by whole-exome sequencing is linked to break points in intron 4 and 3'-UTR, deleting exon 5 of RHO, and causing adRP.
Carballo et al., Barcelona, Spain. In Mol Vis, 2014
We used a newly devised multiplex PCR assay capable of amplifying the genetic loci of RHO, PRPH2, RP1, PRPF3, PRPF8, PRPF31, IMPDH1, NRL, CRX, KLHL7, and NR2E3 to molecularly diagnose 18 index patients with adRP.
Minireview: role of orphan nuclear receptors in cancer and potential as drug targets.
Lee et al., Houston, United States. In Mol Endocrinol, 2014
The nuclear orphan receptors for which endogenous ligands have not been identified include nuclear receptor (NR)0B1 (adrenal hypoplasia congenita critical region on chromosome X gene), NR0B2 (small heterodimer partner), NR1D1/2 (Rev-Erbα/β), NR2C1 (testicular receptor 2), NR2C2 (testicular receptor 4), NR2E1 (tailless), NR2E3 (photoreceptor-specific NR [PNR]), NR2F1 chicken ovalbumin upstream promoter transcription factor 1 (COUP-TFI), NR2F2 (COUP-TFII), NR2F6 (v-erbA-related protein), NR4A1 (Nur77), NR4A2 (Nurr1), NR4A3 (Nor1), and NR6A1 (GCNF).
A hybrid dynamic Bayesian network approach for modelling temporal associations of gene expressions for hypertension diagnosis.
Seker et al., In Conf Proc Ieee Eng Med Biol Soc, 2013
Results show that cell regulation FOXQ1 may inhibit the expression of focusyltransferase-6 (FUT6) and that ABCG1 ATP-binding cassette sub-family G may also play inhibitory role against NR2E3 nuclear receptor sub-family 2 and CGB2 Chromatin Gonadotrophin.
Pathognomonic (diagnostic) ERGs. A review and update.
Holder et al., Toronto, Canada. In Retina, 2013
PURPOSE: To review three inherited retinal disorders associated with diagnostic or pathognomonic electroretinogram (ERG) abnormalities: cone dystrophy with supernormal rod ERG (KCNV2), enhanced S-cone syndrome (NR2E3), and bradyopsia (RGS9/R9AP).
Orphan nuclear receptor PNR/NR2E3 stimulates p53 functions by enhancing p53 acetylation.
Ahlquist et al., Madison, United States. In Mol Cell Biol, 2012
In HeLa cells, PNR stimulated tumor suppressor p53-responsive promoters in a tumor suppressor p53-dependent fashion and induced apoptosis in several cell types.
Reconstruction of nuclear receptor network reveals that NR2E3 is a novel upstream regulator of ESR1 in breast cancer.
Lee et al., Houston, United States. In Embo Mol Med, 2012
NR2E3 is essential for expression of ESR1 in ER-positive breast cancer cells by binding directly to the proximal region of the ESR1 promoter.
Double concentric autofluorescence ring in NR2E3-p.G56R-linked autosomal dominant retinitis pigmentosa.
Munier et al., Sion, Switzerland. In Invest Ophthalmol Vis Sci, 2011
The presence of a double concentric hyperautofluorescent ring of FAF may represent a highly penetrant early phenotypic marker of NR2E3-p.G56R-linked autosomal dominant retinitis pigmentosa
Excess cones in the retinal degeneration rd7 mouse, caused by the loss of function of orphan nuclear receptor Nr2e3, originate from early-born photoreceptor precursors.
Swaroop et al., Ann Arbor, United States. In Hum Mol Genet, 2011
These studies further support the 'transcriptional dominance' model of photoreceptor cell fate determination and provide insights into the pathogenesis of retinal disease phenotypes caused by NR2E3 mutations.
Macular cysts in retinal dystrophy.
Levin et al., Philadelphia, United States. In Curr Opin Ophthalmol, 2011
RECENT FINDINGS: Macular cysts in retinal dystrophy are seen in retinopathies caused by mutations in the NR2E3 gene, juvenile X-linked retinoschisis (XLRS), and some other retinal dystrophies.
Nuclear receptor Rev-erb alpha (Nr1d1) functions in concert with Nr2e3 to regulate transcriptional networks in the retina.
Haider et al., Omaha, United States. In Plos One, 2010
These studies reveal a novel role for Nr1d1, in conjunction with its cofactor Nr2e3, in regulating transcriptional networks critical for photoreceptor development and function.
Transcriptional regulation of photoreceptor development and homeostasis in the mammalian retina.
Forrest et al., Bethesda, United States. In Nat Rev Neurosci, 2010
Recent progress in mammalian photoreceptor development has identified a complex relationship between six key transcription-regulatory factors (RORbeta, OTX2, NRL, CRX, NR2E3 and TRbeta2) that determine rod versus M cone or S cone cell fate.
Mutation of a nuclear receptor gene, NR2E3, causes enhanced S cone syndrome, a disorder of retinal cell fate.
Sheffield et al., Iowa City, United States. In Nat Genet, 2000
In 94% of a cohort of ESCS probands we found mutations in NR2E3 (also known as PNR), which encodes a retinal nuclear receptor recently discovered to be a ligand-dependent transcription factor.
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