Changes in glutamate receptors in dyskinetic parkinsonian monkeys after unilateral subthalamotomy.
Québec, Canada. In J Neurosurg, 01 Jun 2015
Autoradiography of slices from postmortem brain tissues was used to visualize changes in the specific binding of striatal and pallidal ionotropic glutamate receptors (that is, of the α-amino-3-hydroxy 5-methyl-4-isoxazole propionate [AMPA] and N-methyl-d-aspartate [NMDA] NR1/NR2B subunit receptors) and of metabotropic glutamate (mGlu) receptors (that is, mGlu2/3 and mGlu5 receptors).
Effect of salinity changes on olfactory memory-related genes and hormones in adult chum salmon Oncorhynchus keta.
Pusan, South Korea. In Comp Biochem Physiol A Mol Integr Physiol, 28 May 2015
We examined changes in the expression of three NRs (NR1, NR2B, and NR2C), olfactory receptor (OR), and adrenocorticotropic hormone (ACTH) in chum salmon (Oncorhynchus keta) using quantitative polymerase chain reaction (QPCR) during salinity change (seawater→50% seawater→freshwater). NRs significantly detected in the diencephalon and telencephalon and OR significantly detected in the olfactory epithelium.
Prenatal exposure to ultrasound affects learning and memory in young rats.
Shanghai, China. In Ultrasound Med Biol, Mar 2015
Using real-time polymerase chain reaction and Western blot, we also determined that both the mRNA and protein expression levels of hippocampal N-methyl-D-aspartate (NMDA) receptor units 1 (NR1) and 2B (NR2B) and brain-derived neurotrophic factor (BDNF) were significantly lower in pups exposed to ultrasound for 20 min than in controls.
Mechanism of differential control of NMDA receptor activity by NR2 subunits.
Paris, France. In Nature, 2009
A fundamental difference between NMDAR subtypes is their channel maximal open probability (P(o)), which spans a 50-fold range from about 0.5 for NR2A-containing receptors to about 0.01 for receptors containing NR2C and NR2D; NR2B-containing receptors have an intermediate value (about 0.1).