GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 27 Nov 2013.
Glutamate receptor, ionotropic, N-methyl D-aspartate 2B
NR2B
subunit of the NMDA receptor glutamate gated ion channel; displays voltage dependent sensitivity to magnesium, calcium permeability, and glycine regulated activity; may facilitate learning and long term potentiation [RGD, Feb 2006] (from
NCBI)
Sponsored links
Papers using
NR2B
antibodies
Glutamate and neurotrophic factors in neuronal plasticity and disease
Supplier
In PLoS ONE, 2007
... (Milan, Italy), and anti-NMDA Receptor subunit 2B (NR2B; GluN2B) was from BD Biosciences (Milan, Italy), respectively ...
In vivo protein transduction: delivery of a biologically active protein into the mouse
Supplier
In Molecular Therapy, 1998
... Antibodies used were mouse anti-NR2B (1:500, 75–101; Neuromab, Davis, CA), rabbit anti-PSD-95 ...
Papers on
NR2B
Bisphenol A promotes dendritic morphogenesis of hippocampal neurons through estrogen receptor-mediated ERK1/2 signal pathway.
New
China. In Chemosphere, 28 Feb 2014
The previous study indicated that BPA rapidly increased motility and density of dendritic filopodia and enhanced the phosphorylation of N-methyl-d-aspartate (NMDA) receptor subunit NR2B in cultured hippocampal neurons within 30min.
Role of NMDA receptors in the trigeminal pathway, and the modulatory effect of magnesium in a model of rat temporomandibular joint arthritis.
New
Fortaleza, Brazil. In Eur J Oral Sci, 31 Dec 2013
MgCl2 inhibited expression of NR2B mRNA and phospho-NR1 immunostaining and increased expression of NR3 mRNA.
GRIN2B mutations in west syndrome and intellectual disability with focal epilepsy.
New
Bern, Switzerland. In Ann Neurol, 23 Dec 2013
Results: We revealed de novo mutations in GRIN2B encoding the NR2B subunit of the NMDA receptor in two individuals with West syndrome and severe developmental delay as well as one individual with ID and focal epilepsy.
Oxytocin via its receptor affects restraint stress-induced methamphetamine CPP reinstatement in mice: Involvement of the medial prefrontal cortex and dorsal hippocampus glutamatergic system.
New
Shenyang, China. In Pharmacol Biochem Behav, 21 Dec 2013
Western blotting results showed that the levels of GLT1, VGLUT2, NR2B, p-ERK1/2 and p-CREB expression in the mPFC were increased and CaMKII was decreased markedly after the stress-priming MAP-induced CPP reinstatement test.
Neuroprotective effect of estrogen: role of nonsynaptic NR2B-containing NMDA receptors.
Review
New
Xi'an, China. In Brain Res Bull, Apr 2013
Some studies reported that NR2A and NR2B play different roles in the central nervous system (CNS).
Neural basis of imprinting behavior in chicks.
Review
New
Sagamihara, Japan. In Dev Growth Differ, Jan 2013
Expression and modulation of NR2B subunit-containing N-methyl-D-aspartate (NMDA) receptors in the HDCo cells are crucial for plastic changes in this circuit as well as the process of visual imprinting.
A polyamine-deficient diet prevents oxaliplatin-induced acute cold and mechanical hypersensitivity in rats.
New
Clermont-Ferrand, France. In Plos One, Dec 2012
The pathophysiology of these neuropathies has not been yet fully elucidated, but may involve spinal N-methyl-D-aspartate (NMDA) receptors, particularly the NR2B subunit.
Targeting glutamate receptors to tackle the pathogenesis, clinical symptoms and levodopa-induced dyskinesia associated with Parkinson's disease.
Review
New
London, United Kingdom. In Cns Drugs, Dec 2012
In contrast, antagonists selective for NR2B-containing NMDA receptors were effective against LID in animal models and in small-scale clinical trials, though observed adverse cognitive effects need addressing.
Pharmacokinetic and pharmacodynamic considerations for NMDA receptor antagonists in the treatment of chronic neuropathic pain.
Review
New
Leiden, Netherlands. In Expert Opin Drug Metab Toxicol, Nov 2012
Possible future alternatives for ketamine are discussed aimed at blockade of the subunit of the NMDAR involved in spinal and supraspinal pain pathways (NR2B).
[Novel therapeutic approach for the treatment of post-traumatic stress disorder (PTSD): facilitating fear extinction].
Review
New
Hiroshima, Japan. In Nihon Shinkei Seishin Yakurigaku Zasshi, Aug 2012
The levels of acetylated histone and NR2B mRNA, but not NR1 or NR2A mRNA, were elevated in the hippocampus 2 h after administration of vorinostat.
A critical role for GluN2B-containing NMDA receptors in cortical development and function.
GeneRIF
New Orleans, United States. In Neuron, 2012
These experiments indicate that GluN2B-containing NMDARs activate unique cellular processes that cannot be rescued by replacement with GluN2A.
Association of GRIN1 and GRIN2A-D with schizophrenia and genetic interaction with maternal herpes simplex virus-2 infection affecting disease risk.
GeneRIF
Århus, Denmark. In Am J Med Genet B Neuropsychiatr Genet, 2011
results suggest that genetic variation in the 3' region of GRIN2B is associated with schizophrenia and that genetic variation in this region interacts with maternal HSV-2 seropositivity, affecting the risk of schizophrenia in the offspring later in life
Heroin relapse requires long-term potentiation-like plasticity mediated by NMDA2b-containing receptors.
GeneRIF
Charleston, United States. In Proc Natl Acad Sci U S A, 2011
Long term potentiation-like neuroplasticity in prefrontal-accumbens synapses is initiated by NMDA2b stimulation and strongly contributes to heroin relapse.
Distinct modes of AMPA receptor suppression at developing synapses by GluN2A and GluN2B: single-cell NMDA receptor subunit deletion in vivo.
GeneRIF
San Francisco, United States. In Neuron, 2011
Data show that both GluN2B and GluN2A suppress AMPA receptor expression, albeit by distinct means.
Kalirin binds the NR2B subunit of the NMDA receptor, altering its synaptic localization and function.
GeneRIF
Farmington, United States. In J Neurosci, 2011
This study demonstrated a novel and functionally important interaction between the NR2B subunit of the NMDA receptor and Kalirin, proteins known to be essential for normal synaptic plasticity.
Mutations in GRIN2A and GRIN2B encoding regulatory subunits of NMDA receptors cause variable neurodevelopmental phenotypes.
Impact
GeneRIF
Erlangen, Germany. In Nat Genet, 2010
Mutations cause mental neurodevvelopmental disordes such as epilepsy and mental retardation.
DAPK1 interaction with NMDA receptor NR2B subunits mediates brain damage in stroke.
Impact
GeneRIF
New Orleans, United States. In Cell, 2010
Study reports that cerebral ischemia recruits death-associated protein kinase 1 (DAPK1) into the NMDA receptor NR2B protein complex in the cortex of adult mice.
Mechanism of differential control of NMDA receptor activity by NR2 subunits.
Impact
Paris, France. In Nature, 2009
A fundamental difference between NMDAR subtypes is their channel maximal open probability (P(o)), which spans a 50-fold range from about 0.5 for NR2A-containing receptors to about 0.01 for receptors containing NR2C and NR2D; NR2B-containing receptors have an intermediate value (about 0.1).
A selective filter for cytoplasmic transport at the axon initial segment.
Impact
Shanghai, China. In Cell, 2009
Axonal entry was allowed for KIF5-driven carriers of synaptic vesicle protein VAMP2, but not for KIF17-driven carriers of dendrite-targeting NMDA receptor subunit NR2B.
NMDA receptors mediate calcium accumulation in myelin during chemical ischaemia.
Impact
Ottawa, Canada. In Nature, 2006
In contrast, the Ca2+ increase in myelin was abolished by broad-spectrum NMDA receptor antagonists (MK-801, 7-chlorokynurenic acid, d-AP5), but not by more selective blockers of NR2A and NR2B subunit-containing receptors (NVP-AAM077 and ifenprodil).
