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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 01 Mar 2015.

Glutamate receptor, ionotropic, N-methyl D-aspartate 2B

NR2B
subunit of the NMDA receptor glutamate gated ion channel; displays voltage dependent sensitivity to magnesium, calcium permeability, and glycine regulated activity; may facilitate learning and long term potentiation [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: NR2A, NMDA receptor, CAN, V1a, ACID
Papers using NR2B antibodies
Glutamate and neurotrophic factors in neuronal plasticity and disease
Supplier
Norris Christopher Mark, In PLoS ONE, 2007
... (Milan, Italy), and anti-NMDA Receptor subunit 2B (NR2B; GluN2B) was from BD Biosciences (Milan, Italy), respectively ...
In vivo protein transduction: delivery of a biologically active protein into the mouse
Supplier
Dickenson Anthony H et al., In Molecular Therapy, 1998
... Antibodies used were mouse anti-NR2B (1:500, 75–101; Neuromab, Davis, CA), rabbit anti-PSD-95 ...
Papers on NR2B
Fyn inhibition rescues established memory and synapse loss in Alzheimer mice.
New
Strittmatter et al., New Haven, United States. In Ann Neurol, 23 Mar 2015
Results: AZD0530 potently inhibits Fyn and prevents both Aßo-induced Fyn signaling and downstream phosphorylation of the AD risk gene product, Pyk2, and of NR2B Glu receptors in brain slices.
Long-term imipramine treatment increases N-methyl-D-aspartate receptor activity and expression via epigenetic mechanisms.
New
Kubota et al., Japan. In Eur J Pharmacol, 18 Mar 2015
Furthermore, long-term treatment increased NMDA receptor 2B (NR2B) subunit expression via epigenetic changes, including increased acetylation of histones H3K9 and H3K27 in the NR2B promoter and decreased activity of histone deacetylase 3 (HDAC3) and HDAC4.
The NR2B antagonist, ifenprodil, corrects the l-DOPA-induced deficit of bilateral movement and reduces c-Fos expression in the subthalamic nucleus of hemiparkinsonian rats.
New
Saji et al., Sagamihara, Japan. In Neurosci Res, 16 Mar 2015
UNASSIGNED: The use of NR2B antagonists in Parkinsonism is still controversial.
Involvement of NMDA receptor subtypes in cortical spreading depression in rats assessed by fMRI.
New
Gröhn et al., Kuopio, Finland. In Neuropharmacology, 14 Mar 2015
Rats were treated with a non-selective NMDA blocker (MK-801), NR2B antagonist (ifenprodil) or a NR2A selective antagonist (TCN-201).
Prenatal Exposure to Ultrasound Affects Learning and Memory in Young Rats.
Review
New
Zhang et al., Shanghai, China. In Ultrasound Med Biol, 28 Feb 2015
Using real-time polymerase chain reaction and Western blot, we also determined that both the mRNA and protein expression levels of hippocampal N-methyl-D-aspartate (NMDA) receptor units 1 (NR1) and 2B (NR2B) and brain-derived neurotrophic factor (BDNF) were significantly lower in pups exposed to ultrasound for 20 min than in controls.
Neurological effects of inorganic arsenic exposure: altered cysteine/glutamate transport, NMDA expression and spatial memory impairment.
New
Gonsebatt et al., Mexico. In Front Cell Neurosci, Dec 2014
Gestational exposure to iAs affected the expression of cysteine/glutamate transporters in cortex and hippocampus and induced a negative modulation of NMDAR NR2B subunit in the hippocampus.
Meta-analysis of the association between N-methyl-d-aspartate receptor antibodies and schizophrenia, schizoaffective disorder, bipolar disorder, and major depressive disorder.
Review
New
Najjar et al., New York City, United States. In Schizophr Res, Aug 2014
Seropositive participants in psychiatric groups had various combinations of IgG, IgM, and IgA class antibodies against NR1, NR1/NR2B, and NR2A/NR2B subunits.
[Synapse maturation and autism: learning from neuroligin model mice].
Review
New
Pramanik et al., In Nihon Shinkei Seishin Yakurigaku Zasshi, Feb 2014
Electrophysiology in the CA1 region of the hippocampus revealed that LTP, the NMDA/AMPA ratio, and NR2B function were enhanced, indicating that synaptic maturation was impaired in the knock-in mice.
Glycine site agonists of the N-methyl-D-aspartate receptor and Parkinson's disease: a hypothesis.
Review
Javitt et al., Jerusalem, Israel. In Mov Disord, 2013
More recent theories indicate that NMDAR target selectivity may be a cardinal prerequisite for efficacy, with present efforts being devoted primarily to development of NMDAR-NR2B subunit antagonists.
Neural basis of imprinting behavior in chicks.
Review
Ohki-Hamazaki et al., Sagamihara, Japan. In Dev Growth Differ, 2013
Expression and modulation of NR2B subunit-containing N-methyl-D-aspartate (NMDA) receptors in the HDCo cells are crucial for plastic changes in this circuit as well as the process of visual imprinting.
GluN2B-containing NMDA receptors promote wiring of adult-born neurons into olfactory bulb circuits.
GeneRIF
Monyer et al., Heidelberg, Germany. In J Neurosci, 2012
GluN2B-containing NMDA receptors promote synapse activation in adult-born granule cells of the olfactory bulb.
Creatine increases hippocampal Na(+),K(+)-ATPase activity via NMDA-calcineurin pathway.
GeneRIF
Royes et al., Santa Maria, Brazil. In Brain Res Bull, 2012
The incubation of hippocampal slices with NMDA Receptor 2B antagonists blunted the effect of creatine on Na(+),K(+)-ATPase activity.
The effects of exercise intensity on p-NR2B expression in cerebral ischemic rats.
GeneRIF
He et al., Shanghai, China. In Can J Neurol Sci, 2012
The current findings demonstrate that physical exercise can produce neuroprotective effects, in part by down-regulating p-NR2B expression.
Glutamate binding to the GluN2B subunit controls surface trafficking of N-methyl-D-aspartate (NMDA) receptors.
GeneRIF
Craig et al., Vancouver, Canada. In J Biol Chem, 2012
Glutamate binding to the GluN2B subunit controls surface trafficking of N-methyl-D-aspartate (NMDA) receptors.
NR2B-dependent plasticity of adult-born granule cells is necessary for context discrimination.
GeneRIF
Hen et al., New York City, United States. In J Neurosci, 2012
NR2B-dependent plasticity of adult-born granule cells is necessary for fine contextual discrimination and is consistent with their proposed role in pattern separation.
Mutations in GRIN2A and GRIN2B encoding regulatory subunits of NMDA receptors cause variable neurodevelopmental phenotypes.
Impact
GeneRIF
Kutsche et al., Erlangen, Germany. In Nat Genet, 2010
Mutations cause mental neurodevvelopmental disordes such as epilepsy and mental retardation.
DAPK1 interaction with NMDA receptor NR2B subunits mediates brain damage in stroke.
Impact
GeneRIF
Lu et al., New Orleans, United States. In Cell, 2010
Study reports that cerebral ischemia recruits death-associated protein kinase 1 (DAPK1) into the NMDA receptor NR2B protein complex in the cortex of adult mice.
Mechanism of differential control of NMDA receptor activity by NR2 subunits.
Impact
Paoletti et al., Paris, France. In Nature, 2009
A fundamental difference between NMDAR subtypes is their channel maximal open probability (P(o)), which spans a 50-fold range from about 0.5 for NR2A-containing receptors to about 0.01 for receptors containing NR2C and NR2D; NR2B-containing receptors have an intermediate value (about 0.1).
A selective filter for cytoplasmic transport at the axon initial segment.
Impact
Poo et al., Shanghai, China. In Cell, 2009
Axonal entry was allowed for KIF5-driven carriers of synaptic vesicle protein VAMP2, but not for KIF17-driven carriers of dendrite-targeting NMDA receptor subunit NR2B.
NMDA receptors mediate calcium accumulation in myelin during chemical ischaemia.
Impact
Stys et al., Ottawa, Canada. In Nature, 2006
In contrast, the Ca2+ increase in myelin was abolished by broad-spectrum NMDA receptor antagonists (MK-801, 7-chlorokynurenic acid, d-AP5), but not by more selective blockers of NR2A and NR2B subunit-containing receptors (NVP-AAM077 and ifenprodil).
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