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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 29 Mar 2014.

Glutamate receptor, ionotropic, N-methyl D-aspartate 2B

NR2B
subunit of the NMDA receptor glutamate gated ion channel; displays voltage dependent sensitivity to magnesium, calcium permeability, and glycine regulated activity; may facilitate learning and long term potentiation [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: NR2A, NMDA receptor, CAN, V1a, ACID
Papers using NR2B antibodies
Glutamate and neurotrophic factors in neuronal plasticity and disease
Supplier
Norris Christopher Mark, In PLoS ONE, 2007
... (Milan, Italy), and anti-NMDA Receptor subunit 2B (NR2B; GluN2B) was from BD Biosciences (Milan, Italy), respectively ...
In vivo protein transduction: delivery of a biologically active protein into the mouse
Supplier
Dickenson Anthony H et al., In Molecular Therapy, 1998
... Antibodies used were mouse anti-NR2B (1:500, 75–101; Neuromab, Davis, CA), rabbit anti-PSD-95 ...
Papers on NR2B
Intrathecal Injection of JWH015 Attenuates Remifentanil-Induced Postoperative Hyperalgesia by Inhibiting Activation of Spinal Glia in a Rat Model.
New
Gu et al., Nanjing, China. In Anesth Analg, 30 Apr 2014
We used immunohistochemistry and immunoblotting to investigate the effect of JWH015 on CB2 receptor, NR2B subunits, activated glial cells, and proinflammatory cytokine expression in rats after remifentanil-induced postoperative hyperalgesia.
Structural reorganization of pyramidal neurons in the medial prefrontal cortex of alcohol dependent rats is associated with altered glial plasticity.
New
Mandyam et al., Los Angeles, United States. In Brain Struct Funct, 26 Apr 2014
CIE concomitantly increased the expression of total NR2B subunits without affecting phosphorylation of NR2B at Tyr-1472 or levels of PSD-95.
Cdk5 inhibitor roscovitine alleviates neuropathic pain in the dorsal root ganglia by downregulating N-methyl-D-aspartate receptor subunit 2A.
New
Ma et al., Nanjing, China. In Neurol Sci, 23 Apr 2014
We injected intrathecally Cdk5 inhibitor roscovitine in rat model of chronic compression of dorsal root ganglion and examined pain behaviors and the expression of N-methyl-D-aspartate receptor subunit 2A (NR2A) but not NR2B or NR1 in DRG.
Low Dose ZD7288 Attenuates the Ischemia/Reperfusion-Induced Impairment of Long-Term Potentiation Induction at Hippocampal Schaffer Collateral-CA1 Synapses.
New
Guo et al., Wuhan, China. In Cell Mol Neurobiol, 23 Apr 2014
This impairment of hippocampal synaptic plasticity can be caused by excitotoxicity and subsequent perturbation of hippocampal LTP-relevant transmitter systems, which include NR2B and PSD-95.
NMDA receptors are involved in the regulation of BMP4-mediated survival in rat cochlear epithelial cells.
New
Ou et al., Guangzhou, China. In Neurosci Lett, 14 Apr 2014
Meanwhile, the number of NR2B-positive cells, as revealed by the NR2B mRNA and protein levels, was greater in the BMP4 group than in the control group.
Neuroprotective effect of estrogen: role of nonsynaptic NR2B-containing NMDA receptors.
Review
New
Zhao et al., Xi'an, China. In Brain Res Bull, Apr 2013
Some studies reported that NR2A and NR2B play different roles in the central nervous system (CNS).
Glycine site agonists of the N-methyl-D-aspartate receptor and Parkinson's disease: a hypothesis.
Review
New
Javitt et al., Jerusalem, Israel. In Mov Disord, Apr 2013
More recent theories indicate that NMDAR target selectivity may be a cardinal prerequisite for efficacy, with present efforts being devoted primarily to development of NMDAR-NR2B subunit antagonists.
Neural basis of imprinting behavior in chicks.
Review
Ohki-Hamazaki et al., Sagamihara, Japan. In Dev Growth Differ, 2013
Expression and modulation of NR2B subunit-containing N-methyl-D-aspartate (NMDA) receptors in the HDCo cells are crucial for plastic changes in this circuit as well as the process of visual imprinting.
Targeting glutamate receptors to tackle the pathogenesis, clinical symptoms and levodopa-induced dyskinesia associated with Parkinson's disease.
Review
Duty, London, United Kingdom. In Cns Drugs, 2012
In contrast, antagonists selective for NR2B-containing NMDA receptors were effective against LID in animal models and in small-scale clinical trials, though observed adverse cognitive effects need addressing.
GluN2B-containing NMDA receptors promote wiring of adult-born neurons into olfactory bulb circuits.
GeneRIF
Monyer et al., Heidelberg, Germany. In J Neurosci, 2012
GluN2B-containing NMDA receptors promote synapse activation in adult-born granule cells of the olfactory bulb.
Creatine increases hippocampal Na(+),K(+)-ATPase activity via NMDA-calcineurin pathway.
GeneRIF
Royes et al., Santa Maria, Brazil. In Brain Res Bull, 2012
The incubation of hippocampal slices with NMDA Receptor 2B antagonists blunted the effect of creatine on Na(+),K(+)-ATPase activity.
The effects of exercise intensity on p-NR2B expression in cerebral ischemic rats.
GeneRIF
He et al., Shanghai, China. In Can J Neurol Sci, 2012
The current findings demonstrate that physical exercise can produce neuroprotective effects, in part by down-regulating p-NR2B expression.
Glutamate binding to the GluN2B subunit controls surface trafficking of N-methyl-D-aspartate (NMDA) receptors.
GeneRIF
Craig et al., Vancouver, Canada. In J Biol Chem, 2012
Glutamate binding to the GluN2B subunit controls surface trafficking of N-methyl-D-aspartate (NMDA) receptors.
[Novel therapeutic approach for the treatment of post-traumatic stress disorder (PTSD): facilitating fear extinction].
Review
Morinobu et al., Hiroshima, Japan. In Nihon Shinkei Seishin Yakurigaku Zasshi, 2012
The levels of acetylated histone and NR2B mRNA, but not NR1 or NR2A mRNA, were elevated in the hippocampus 2 h after administration of vorinostat.
NR2B-dependent plasticity of adult-born granule cells is necessary for context discrimination.
GeneRIF
Hen et al., New York City, United States. In J Neurosci, 2012
NR2B-dependent plasticity of adult-born granule cells is necessary for fine contextual discrimination and is consistent with their proposed role in pattern separation.
Mutations in GRIN2A and GRIN2B encoding regulatory subunits of NMDA receptors cause variable neurodevelopmental phenotypes.
Impact
GeneRIF
Kutsche et al., Erlangen, Germany. In Nat Genet, 2010
Mutations cause mental neurodevvelopmental disordes such as epilepsy and mental retardation.
DAPK1 interaction with NMDA receptor NR2B subunits mediates brain damage in stroke.
Impact
GeneRIF
Lu et al., New Orleans, United States. In Cell, 2010
Study reports that cerebral ischemia recruits death-associated protein kinase 1 (DAPK1) into the NMDA receptor NR2B protein complex in the cortex of adult mice.
Mechanism of differential control of NMDA receptor activity by NR2 subunits.
Impact
Paoletti et al., Paris, France. In Nature, 2009
A fundamental difference between NMDAR subtypes is their channel maximal open probability (P(o)), which spans a 50-fold range from about 0.5 for NR2A-containing receptors to about 0.01 for receptors containing NR2C and NR2D; NR2B-containing receptors have an intermediate value (about 0.1).
A selective filter for cytoplasmic transport at the axon initial segment.
Impact
Poo et al., Shanghai, China. In Cell, 2009
Axonal entry was allowed for KIF5-driven carriers of synaptic vesicle protein VAMP2, but not for KIF17-driven carriers of dendrite-targeting NMDA receptor subunit NR2B.
NMDA receptors mediate calcium accumulation in myelin during chemical ischaemia.
Impact
Stys et al., Ottawa, Canada. In Nature, 2006
In contrast, the Ca2+ increase in myelin was abolished by broad-spectrum NMDA receptor antagonists (MK-801, 7-chlorokynurenic acid, d-AP5), but not by more selective blockers of NR2A and NR2B subunit-containing receptors (NVP-AAM077 and ifenprodil).
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