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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 12 Nov 2015.

Glutamate receptor, ionotropic, N-methyl D-aspartate 2B

subunit of the NMDA receptor glutamate gated ion channel; displays voltage dependent sensitivity to magnesium, calcium permeability, and glycine regulated activity; may facilitate learning and long term potentiation [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: NR2A, NMDA receptor, CAN, V1a, ACID
Papers using NR2B antibodies
Glutamate and neurotrophic factors in neuronal plasticity and disease
Norris Christopher Mark, In PLoS ONE, 2007
... (Milan, Italy), and anti-NMDA Receptor subunit 2B (NR2B; GluN2B) was from BD Biosciences (Milan, Italy), respectively ...
In vivo protein transduction: delivery of a biologically active protein into the mouse
Dickenson Anthony H et al., In Molecular Therapy, 1998
... Antibodies used were mouse anti-NR2B (1:500, 75–101; Neuromab, Davis, CA), rabbit anti-PSD-95 ...
Papers on NR2B
NMDA receptors promote neurogenesis in the neonatal rat subventricular zone following hypoxic‑ischemic injury.
Yin et al., Xuzhou, China. In Mol Med Report, 04 Dec 2015
By contrast, a significant increase in NR2B expression was observed at 24 h after hypoxic‑ischemic injury, induced by the clamping of the right common carotid artery.
Melatonin pretreatment prevents isoflurane-induced cognitive dysfunction by modulating sleep-wake rhythm in mice.
Gu et al., Nanjing, China. In Brain Res, 28 Nov 2015
Furthermore, we discussed whether NR2B (N-methyl-d-aspartate receptor 2B subunit)-CREB (cAMP-response element binding protein) signaling pathway was involved in this course.
Repetitive transcranial magnetic stimulation enhances spatial learning and synaptic plasticity via the VEGF and BDNF-NMDAR pathways in a rat model of vascular dementia.
Cheng et al., Tianjin, China. In Neuroscience, 27 Nov 2015
Hippocampal expression of vascular endothelial growth factor (VEGF), brain-derived neurotrophic factor (BDNF) and three subunits of the N-methyl-d-aspartic acid receptor (NMDAR), NR1, NR2A and NR2B, was analyzed by Western blotting.
NR2B subunit in the prefrontal cortex: A double-edged sword for working memory function and psychiatric disorders.
Gao et al., Philadelphia, United States. In Neurosci Biobehav Rev, Sep 2015
The PFC appears to be specialized for sustaining persistent firing, with N-methyl-d-aspartate (NMDA) receptors, especially slow-decay NR2B subunits, playing an essential role in the maintenance of sustained activity and normal working memory function.
[The developmental switch of visual cortex NMDA receptor NR2 subunits and its implications for visual plasticity].
Zhao et al., Tianjin, China. In Zhonghua Yan Ke Za Zhi, Jun 2015
These tetrameric receptors consist of two obligatory NR1 subunits and two regulatory subunits, usually a combination of NR2A and NR2B.
Prenatal exposure to ultrasound affects learning and memory in young rats.
Zhang et al., Shanghai, China. In Ultrasound Med Biol, Mar 2015
Using real-time polymerase chain reaction and Western blot, we also determined that both the mRNA and protein expression levels of hippocampal N-methyl-D-aspartate (NMDA) receptor units 1 (NR1) and 2B (NR2B) and brain-derived neurotrophic factor (BDNF) were significantly lower in pups exposed to ultrasound for 20 min than in controls.
Phosphorylation of NR2B NMDA subunits by protein kinase C in arcuate nucleus contributes to inflammatory pain in rats.
Jiang et al., Suzhou, China. In Sci Rep, Dec 2014
Interestingly, CFA injection also remarkably elevated the level of phosphorylated NR2B (Tyr1472) without affecting the expression of total NR2B.
Promising targets of cell death signaling of NR2B receptor subunit in stroke pathogenesis.
Lu et al., Wuhan, China. In Regen Med Res, Dec 2014
This review will provide the concept of NR2B downstream signaling in neuronal death after stroke and provide evidences for developing better NMDAR-based therapeutics by targeting downstream proteins.
Monosialotetrahexosylganglioside Inhibits the Expression of p-CREB and NR2B in the Auditory Cortex in Rats with Salicylate-Induced Tinnitus.
Lou et al., In Clin Lab, Dec 2014
BACKGROUND: This study investigated the effects of monosialotetrahexosylganglioside (GM1) on the expression of N-methyl-D-aspartate receptor subunit 2B (NR2B) and phosphorylated (p)-cyclic AMP response element-binding protein (CREB) in the auditory cortex of rats with tinnitus.
Targeting the NMDA receptor subunit NR2B for treating or preventing age-related memory decline.
Tsien et al., Taiwan. In Expert Opin Ther Targets, Oct 2014
It is known that endogenous NR2B subunits decrease as the brain ages, whereas transgenic upregulation of NR2B enhances synaptic plasticity and learning and memory in several animal species.
GluN2B-containing NMDA receptors promote wiring of adult-born neurons into olfactory bulb circuits.
Monyer et al., Heidelberg, Germany. In J Neurosci, 2012
GluN2B-containing NMDA receptors promote synapse activation in adult-born granule cells of the olfactory bulb.
Creatine increases hippocampal Na(+),K(+)-ATPase activity via NMDA-calcineurin pathway.
Royes et al., Santa Maria, Brazil. In Brain Res Bull, 2012
The incubation of hippocampal slices with NMDA Receptor 2B antagonists blunted the effect of creatine on Na(+),K(+)-ATPase activity.
The effects of exercise intensity on p-NR2B expression in cerebral ischemic rats.
He et al., Shanghai, China. In Can J Neurol Sci, 2012
The current findings demonstrate that physical exercise can produce neuroprotective effects, in part by down-regulating p-NR2B expression.
Glutamate binding to the GluN2B subunit controls surface trafficking of N-methyl-D-aspartate (NMDA) receptors.
Craig et al., Vancouver, Canada. In J Biol Chem, 2012
Glutamate binding to the GluN2B subunit controls surface trafficking of N-methyl-D-aspartate (NMDA) receptors.
NR2B-dependent plasticity of adult-born granule cells is necessary for context discrimination.
Hen et al., New York City, United States. In J Neurosci, 2012
NR2B-dependent plasticity of adult-born granule cells is necessary for fine contextual discrimination and is consistent with their proposed role in pattern separation.
Mutations in GRIN2A and GRIN2B encoding regulatory subunits of NMDA receptors cause variable neurodevelopmental phenotypes.
Kutsche et al., Erlangen, Germany. In Nat Genet, 2010
Mutations cause mental neurodevvelopmental disordes such as epilepsy and mental retardation.
DAPK1 interaction with NMDA receptor NR2B subunits mediates brain damage in stroke.
Lu et al., New Orleans, United States. In Cell, 2010
Study reports that cerebral ischemia recruits death-associated protein kinase 1 (DAPK1) into the NMDA receptor NR2B protein complex in the cortex of adult mice.
Mechanism of differential control of NMDA receptor activity by NR2 subunits.
Paoletti et al., Paris, France. In Nature, 2009
A fundamental difference between NMDAR subtypes is their channel maximal open probability (P(o)), which spans a 50-fold range from about 0.5 for NR2A-containing receptors to about 0.01 for receptors containing NR2C and NR2D; NR2B-containing receptors have an intermediate value (about 0.1).
A selective filter for cytoplasmic transport at the axon initial segment.
Poo et al., Shanghai, China. In Cell, 2009
Axonal entry was allowed for KIF5-driven carriers of synaptic vesicle protein VAMP2, but not for KIF17-driven carriers of dendrite-targeting NMDA receptor subunit NR2B.
NMDA receptors mediate calcium accumulation in myelin during chemical ischaemia.
Stys et al., Ottawa, Canada. In Nature, 2006
In contrast, the Ca2+ increase in myelin was abolished by broad-spectrum NMDA receptor antagonists (MK-801, 7-chlorokynurenic acid, d-AP5), but not by more selective blockers of NR2A and NR2B subunit-containing receptors (NVP-AAM077 and ifenprodil).
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