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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 23 Nov 2014.

Glutamate receptor, ionotropic, N-methyl D-aspartate 2B

NR2B
subunit of the NMDA receptor glutamate gated ion channel; displays voltage dependent sensitivity to magnesium, calcium permeability, and glycine regulated activity; may facilitate learning and long term potentiation [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: NR2A, NMDA receptor, CAN, V1a, ACID
Papers using NR2B antibodies
Glutamate and neurotrophic factors in neuronal plasticity and disease
Supplier
Norris Christopher Mark, In PLoS ONE, 2007
... (Milan, Italy), and anti-NMDA Receptor subunit 2B (NR2B; GluN2B) was from BD Biosciences (Milan, Italy), respectively ...
In vivo protein transduction: delivery of a biologically active protein into the mouse
Supplier
Dickenson Anthony H et al., In Molecular Therapy, 1998
... Antibodies used were mouse anti-NR2B (1:500, 75–101; Neuromab, Davis, CA), rabbit anti-PSD-95 ...
Papers on NR2B
Sensitivity of NMDA receptor-mediated EPSPs and synaptic plasticity to TCN 201 and TCN 213 in rat hippocampal slices.
New
Zorumski et al., Washington, D.C., United States. In J Pharmacol Exp Ther, 20 Dec 2014
UNLABELLED: Whereas ifenprodil has been used as a selective GluN1/GluN2B (NR1/NR2B, B-type) receptor antagonist to distinguish between GluN2B (NR2B) and GluN2A (NR2A)-containing NMDA receptors (NMDARs), TCN-201 and TCN-213 have been found to be selective GluN1/GluN2A (NR1/NR2A, A-type) antagonists.
TiO2 nanoparticle-induced neurotoxicity may be involved in dysfunction of glutamate metabolism and its receptor expression in mice.
New
Hong et al., Suzhou, China. In Environ Toxicol, 20 Dec 2014
Furthermore, TiO2 NPs significantly inhibited the expression of N-methyl-d-aspartate receptor subunits (including NR1, NR2A, and NR2B) and metabotropic glutamate receptor 2 in mouse hippocampus.
Activation of Transient Receptor Potential Vanilloid 4 is Involved in Neuronal Injury in Middle Cerebral Artery Occlusion in Mice.
New
Chen et al., Nanjing, China. In Mol Neurobiol, 18 Dec 2014
injection of GSK1016790A (a TRPV4 agonist), dose-dependently induced hippocampal neuronal death, accompanied by an increase in phosphorylation of the NR2B subunit of the N-methyl-D-aspartate receptor (NMDAR).
Perceptual Training Restores Impaired Cortical Temporal Processing Due to Lead Exposure.
New
Zhou et al., Shanghai, China. In Cereb Cortex, 07 Dec 2014
Cortical expressions of parvalbumin, brain-derived neurotrophic factor, and NMDA receptor subunits NR2a and NR2b, which are down-regulated in lead-exposed animals, are also partially reversed with training.
Girdin Phosphorylation Is Crucial for Synaptic Plasticity and Memory: A Potential Role in the Interaction of BDNF/TrkB/Akt Signaling with NMDA Receptor.
New
Yamada et al., Nagoya, Japan. In J Neurosci, 05 Dec 2014
Furthermore, Girdin interacted with Src kinase and NR2B subunit of NMDA receptor, leading to phosphorylation of the NR2B subunit and NMDA receptor activation.
[Synapse maturation and autism: learning from neuroligin model mice].
Review
New
Pramanik et al., In Nihon Shinkei Seishin Yakurigaku Zasshi, Feb 2014
Electrophysiology in the CA1 region of the hippocampus revealed that LTP, the NMDA/AMPA ratio, and NR2B function were enhanced, indicating that synaptic maturation was impaired in the knock-in mice.
Glycine site agonists of the N-methyl-D-aspartate receptor and Parkinson's disease: a hypothesis.
Review
New
Javitt et al., Jerusalem, Israel. In Mov Disord, Apr 2013
More recent theories indicate that NMDAR target selectivity may be a cardinal prerequisite for efficacy, with present efforts being devoted primarily to development of NMDAR-NR2B subunit antagonists.
Neuroprotective effect of estrogen: role of nonsynaptic NR2B-containing NMDA receptors.
Review
New
Zhao et al., Xi'an, China. In Brain Res Bull, Apr 2013
Some studies reported that NR2A and NR2B play different roles in the central nervous system (CNS).
Neural basis of imprinting behavior in chicks.
Review
Ohki-Hamazaki et al., Sagamihara, Japan. In Dev Growth Differ, 2013
Expression and modulation of NR2B subunit-containing N-methyl-D-aspartate (NMDA) receptors in the HDCo cells are crucial for plastic changes in this circuit as well as the process of visual imprinting.
Targeting glutamate receptors to tackle the pathogenesis, clinical symptoms and levodopa-induced dyskinesia associated with Parkinson's disease.
Review
Duty, London, United Kingdom. In Cns Drugs, 2012
In contrast, antagonists selective for NR2B-containing NMDA receptors were effective against LID in animal models and in small-scale clinical trials, though observed adverse cognitive effects need addressing.
GluN2B-containing NMDA receptors promote wiring of adult-born neurons into olfactory bulb circuits.
GeneRIF
Monyer et al., Heidelberg, Germany. In J Neurosci, 2012
GluN2B-containing NMDA receptors promote synapse activation in adult-born granule cells of the olfactory bulb.
Creatine increases hippocampal Na(+),K(+)-ATPase activity via NMDA-calcineurin pathway.
GeneRIF
Royes et al., Santa Maria, Brazil. In Brain Res Bull, 2012
The incubation of hippocampal slices with NMDA Receptor 2B antagonists blunted the effect of creatine on Na(+),K(+)-ATPase activity.
The effects of exercise intensity on p-NR2B expression in cerebral ischemic rats.
GeneRIF
He et al., Shanghai, China. In Can J Neurol Sci, 2012
The current findings demonstrate that physical exercise can produce neuroprotective effects, in part by down-regulating p-NR2B expression.
Glutamate binding to the GluN2B subunit controls surface trafficking of N-methyl-D-aspartate (NMDA) receptors.
GeneRIF
Craig et al., Vancouver, Canada. In J Biol Chem, 2012
Glutamate binding to the GluN2B subunit controls surface trafficking of N-methyl-D-aspartate (NMDA) receptors.
NR2B-dependent plasticity of adult-born granule cells is necessary for context discrimination.
GeneRIF
Hen et al., New York City, United States. In J Neurosci, 2012
NR2B-dependent plasticity of adult-born granule cells is necessary for fine contextual discrimination and is consistent with their proposed role in pattern separation.
Mutations in GRIN2A and GRIN2B encoding regulatory subunits of NMDA receptors cause variable neurodevelopmental phenotypes.
Impact
GeneRIF
Kutsche et al., Erlangen, Germany. In Nat Genet, 2010
Mutations cause mental neurodevvelopmental disordes such as epilepsy and mental retardation.
DAPK1 interaction with NMDA receptor NR2B subunits mediates brain damage in stroke.
Impact
GeneRIF
Lu et al., New Orleans, United States. In Cell, 2010
Study reports that cerebral ischemia recruits death-associated protein kinase 1 (DAPK1) into the NMDA receptor NR2B protein complex in the cortex of adult mice.
Mechanism of differential control of NMDA receptor activity by NR2 subunits.
Impact
Paoletti et al., Paris, France. In Nature, 2009
A fundamental difference between NMDAR subtypes is their channel maximal open probability (P(o)), which spans a 50-fold range from about 0.5 for NR2A-containing receptors to about 0.01 for receptors containing NR2C and NR2D; NR2B-containing receptors have an intermediate value (about 0.1).
A selective filter for cytoplasmic transport at the axon initial segment.
Impact
Poo et al., Shanghai, China. In Cell, 2009
Axonal entry was allowed for KIF5-driven carriers of synaptic vesicle protein VAMP2, but not for KIF17-driven carriers of dendrite-targeting NMDA receptor subunit NR2B.
NMDA receptors mediate calcium accumulation in myelin during chemical ischaemia.
Impact
Stys et al., Ottawa, Canada. In Nature, 2006
In contrast, the Ca2+ increase in myelin was abolished by broad-spectrum NMDA receptor antagonists (MK-801, 7-chlorokynurenic acid, d-AP5), but not by more selective blockers of NR2A and NR2B subunit-containing receptors (NVP-AAM077 and ifenprodil).
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