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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 06 Jul 2015.

Glutamate receptor, ionotropic, N-methyl D-aspartate 2B

NR2B
subunit of the NMDA receptor glutamate gated ion channel; displays voltage dependent sensitivity to magnesium, calcium permeability, and glycine regulated activity; may facilitate learning and long term potentiation [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: NR2A, NMDA receptor, CAN, V1a, ACID
Papers using NR2B antibodies
Glutamate and neurotrophic factors in neuronal plasticity and disease
Supplier
Norris Christopher Mark, In PLoS ONE, 2007
... (Milan, Italy), and anti-NMDA Receptor subunit 2B (NR2B; GluN2B) was from BD Biosciences (Milan, Italy), respectively ...
In vivo protein transduction: delivery of a biologically active protein into the mouse
Supplier
Dickenson Anthony H et al., In Molecular Therapy, 1998
... Antibodies used were mouse anti-NR2B (1:500, 75–101; Neuromab, Davis, CA), rabbit anti-PSD-95 ...
Papers on NR2B
NR2B subunit in the prefrontal cortex: A double-edged sword for working memory function and psychiatric disorders.
Review
New
Gao et al., Philadelphia, United States. In Neurosci Biobehav Rev, 01 Aug 2015
The PFC appears to be specialized for sustaining persistent firing, with N-methyl-D-aspartate (NMDA) receptors, especially slow-decay NR2B subunits, playing an essential role in the maintenance of sustained activity and normal working memory function.
Central nervous system-specific knockout of Brg1 causes growth retardation and neuronal degeneration.
New
Li et al., Chengdu, China. In Brain Res, 29 Jul 2015
Brg1, PSD-95, NR2A and NR2B protein expressions were assessed using western blotting.
Forebrain NR2B overexpression enhancing fear acquisition and long-term potentiation in the lateral amygdala.
New
Cao et al., Shanghai, China. In Eur J Neurosci, 27 Jul 2015
However, the role of the NMDA receptor NR2B subunit in synaptic plasticity at T-LA synapses remains speculative.
Negative Allosteric Modulators Selective for the NR2B Subtype of the NMDA Receptor Impair Cognition in Multiple Domains.
New
Bristow et al., Wallingford, United States. In Neuropsychopharmacology, 24 Jul 2015
However, studies with NR2B subtype-selective NAMs have reported mixed results in rodents including increased impulsivity, no effect on cognition, impairment or even improvement of some cognitive tasks.
Interleukin-6 reduces NMDAR-mediated cytosolic Ca(2+) overload and neuronal death via JAK/CaN signaling.
New
Qiu et al., Nantong, China. In Cell Calcium, 12 Jul 2015
The NMDAR subunits, NR1, NR2A, NR2B and NR2C, were expressed in CGNs.
Gabapentin prevents oxaliplatin-induced central sensitization in the dorsal horn neurons in rats.
New
Wei et al., Qingdao, China. In Iran J Basic Med Sci, May 2015
The expression of glutamate receptor subunits (NR2B and GluR1) and brain-derived neurotrophic factor (BDNF) was measured in the dorsal horn.
Prenatal exposure to ultrasound affects learning and memory in young rats.
Review
New
Zhang et al., Shanghai, China. In Ultrasound Med Biol, Mar 2015
Using real-time polymerase chain reaction and Western blot, we also determined that both the mRNA and protein expression levels of hippocampal N-methyl-D-aspartate (NMDA) receptor units 1 (NR1) and 2B (NR2B) and brain-derived neurotrophic factor (BDNF) were significantly lower in pups exposed to ultrasound for 20 min than in controls.
Promising targets of cell death signaling of NR2B receptor subunit in stroke pathogenesis.
Review
New
Lu et al., Wuhan, China. In Regen Med Res, Dec 2014
This review will provide the concept of NR2B downstream signaling in neuronal death after stroke and provide evidences for developing better NMDAR-based therapeutics by targeting downstream proteins.
Targeting the NMDA receptor subunit NR2B for treating or preventing age-related memory decline.
Review
New
Tsien et al., Taiwan. In Expert Opin Ther Targets, Oct 2014
It is known that endogenous NR2B subunits decrease as the brain ages, whereas transgenic upregulation of NR2B enhances synaptic plasticity and learning and memory in several animal species.
[Synapse maturation and autism: learning from neuroligin model mice].
Review
New
Pramanik et al., In Nihon Shinkei Seishin Yakurigaku Zasshi, Feb 2014
Electrophysiology in the CA1 region of the hippocampus revealed that LTP, the NMDA/AMPA ratio, and NR2B function were enhanced, indicating that synaptic maturation was impaired in the knock-in mice.
GluN2B-containing NMDA receptors promote wiring of adult-born neurons into olfactory bulb circuits.
GeneRIF
Monyer et al., Heidelberg, Germany. In J Neurosci, 2012
GluN2B-containing NMDA receptors promote synapse activation in adult-born granule cells of the olfactory bulb.
Creatine increases hippocampal Na(+),K(+)-ATPase activity via NMDA-calcineurin pathway.
GeneRIF
Royes et al., Santa Maria, Brazil. In Brain Res Bull, 2012
The incubation of hippocampal slices with NMDA Receptor 2B antagonists blunted the effect of creatine on Na(+),K(+)-ATPase activity.
The effects of exercise intensity on p-NR2B expression in cerebral ischemic rats.
GeneRIF
He et al., Shanghai, China. In Can J Neurol Sci, 2012
The current findings demonstrate that physical exercise can produce neuroprotective effects, in part by down-regulating p-NR2B expression.
Glutamate binding to the GluN2B subunit controls surface trafficking of N-methyl-D-aspartate (NMDA) receptors.
GeneRIF
Craig et al., Vancouver, Canada. In J Biol Chem, 2012
Glutamate binding to the GluN2B subunit controls surface trafficking of N-methyl-D-aspartate (NMDA) receptors.
NR2B-dependent plasticity of adult-born granule cells is necessary for context discrimination.
GeneRIF
Hen et al., New York City, United States. In J Neurosci, 2012
NR2B-dependent plasticity of adult-born granule cells is necessary for fine contextual discrimination and is consistent with their proposed role in pattern separation.
Mutations in GRIN2A and GRIN2B encoding regulatory subunits of NMDA receptors cause variable neurodevelopmental phenotypes.
Impact
GeneRIF
Kutsche et al., Erlangen, Germany. In Nat Genet, 2010
Mutations cause mental neurodevvelopmental disordes such as epilepsy and mental retardation.
DAPK1 interaction with NMDA receptor NR2B subunits mediates brain damage in stroke.
Impact
GeneRIF
Lu et al., New Orleans, United States. In Cell, 2010
Study reports that cerebral ischemia recruits death-associated protein kinase 1 (DAPK1) into the NMDA receptor NR2B protein complex in the cortex of adult mice.
Mechanism of differential control of NMDA receptor activity by NR2 subunits.
Impact
Paoletti et al., Paris, France. In Nature, 2009
A fundamental difference between NMDAR subtypes is their channel maximal open probability (P(o)), which spans a 50-fold range from about 0.5 for NR2A-containing receptors to about 0.01 for receptors containing NR2C and NR2D; NR2B-containing receptors have an intermediate value (about 0.1).
A selective filter for cytoplasmic transport at the axon initial segment.
Impact
Poo et al., Shanghai, China. In Cell, 2009
Axonal entry was allowed for KIF5-driven carriers of synaptic vesicle protein VAMP2, but not for KIF17-driven carriers of dendrite-targeting NMDA receptor subunit NR2B.
NMDA receptors mediate calcium accumulation in myelin during chemical ischaemia.
Impact
Stys et al., Ottawa, Canada. In Nature, 2006
In contrast, the Ca2+ increase in myelin was abolished by broad-spectrum NMDA receptor antagonists (MK-801, 7-chlorokynurenic acid, d-AP5), but not by more selective blockers of NR2A and NR2B subunit-containing receptors (NVP-AAM077 and ifenprodil).
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