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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Nuclear receptor subfamily 1, group D, member 1

NR1D1, Rev-ErbA alpha, ear-1
member of the steroid hormone receptor superfamily [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: erbA, CLOCK, ACID, ERbeta, CAN
Papers on NR1D1
Possible involvement of the circadian pathway in alcohol use disorder in a South African adolescent cohort.
New
Stein et al., Cape Town, South Africa. In Metab Brain Dis, Feb 2016
However, from the gene-based analysis it was found that the circadian rhythm genes NR1D1 and BHLHE41 are associated with AUD.
NR1D1 ameliorates Mycobacterium tuberculosis clearance through regulation of autophagy.
New
Gupta et al., Chandīgarh, India. In Autophagy, Dec 2015
UNASSIGNED: NR1D1 (nuclear receptor subfamily 1, group D, member 1), an adopted orphan nuclear receptor, is widely known to orchestrate the expression of genes involved in various biological processes such as adipogenesis, skeletal muscle differentiation, and lipid and glucose metabolism.
Sleep interruption associated with house staff work schedules alters circadian gene expression.
New
Zarbl et al., United States. In Sleep Med, Nov 2015
The plasma melatonin level and messenger RNA (mRNA) expression of PER2, nuclear receptor subfamily 1, group d, member 1 (NR1D1), and ERS2 were measured, and the changes in levels of melatonin and gene expression were evaluated with statistical analyses.
[Circadian markers and genes in bipolar disorder].
New
Belliviera et al., Paris, France. In Encephale, Sep 2015
Several genetic association studies have also showed associations between multiple circadian genes and bipolar disorder, such as CLOCK, ARTNL1, GSK3β, PER3, NPAS2, NR1D1, TIMELESS, RORA, RORB, and CSNK1ε.
Gene-Environment Interactions of Circadian-Related Genes for Cardiometabolic Traits.
New
CHARGE Nutrition Study Group et al., Murcia, Spain. In Diabetes Care, Aug 2015
However, little is known about whether diet and sleep could modify associations between circadian-related variants (CLOCK-rs1801260, CRY2-rs11605924, MTNR1B-rs1387153, MTNR1B-rs10830963, NR1D1-rs2314339) and cardiometabolic traits (fasting glucose [FG], HOMA-insulin resistance, BMI, waist circumference, and HDL-cholesterol) to facilitate personalized recommendations.
A glutamatergic network mediates lithium response in bipolar disorder as defined by epigenome pathway analysis.
Athey et al., Ann Arbor, United States. In Pharmacogenomics, 2014
They were located within noncoding regions of ten genes: ANK3, ARNTL, CACNA1C, CACNG2, CDKN1A, CREB1, GRIA2, GSK3B, NR1D1 and SLC1A2.
Interaction of ApoA-IV with NR4A1 and NR1D1 Represses G6Pase and PEPCK Transcription: Nuclear Receptor-Mediated Downregulation of Hepatic Gluconeogenesis in Mice and a Human Hepatocyte Cell Line.
Tso et al., Xi'an, China. In Plos One, 2014
We have previously shown that the nuclear receptor, NR1D1, is a cofactor in ApoA-IV-mediated downregulation of gluconeogenesis.
Genome-Wide Screening of mRNA Expression in Leprosy Patients.
Soares et al., São Paulo, Brazil. In Front Genet, 2014
Some of these genes were observed in all forms of the disease (CD2, CD27, chit1, FA2H, FAM26F, GZMB, MMP9, SLAMF7, UBD) and others were exclusive to reactional forms (Type "1" reaction: GPNMB, IL1B, MICAL2, FOXQ1; Type "2" reaction: AKR1B10, FAM180B, FOXQ1, NNMT, NR1D1, PTX3, TNFRSF25).
Minireview: role of orphan nuclear receptors in cancer and potential as drug targets.
Review
Lee et al., Houston, United States. In Mol Endocrinol, 2014
The nuclear orphan receptors for which endogenous ligands have not been identified include nuclear receptor (NR)0B1 (adrenal hypoplasia congenita critical region on chromosome X gene), NR0B2 (small heterodimer partner), NR1D1/2 (Rev-Erbα/β), NR2C1 (testicular receptor 2), NR2C2 (testicular receptor 4), NR2E1 (tailless), NR2E3 (photoreceptor-specific NR [PNR]), NR2F1 chicken ovalbumin upstream promoter transcription factor 1 (COUP-TFI), NR2F2 (COUP-TFII), NR2F6 (v-erbA-related protein), NR4A1 (Nur77), NR4A2 (Nurr1), NR4A3 (Nor1), and NR6A1 (GCNF).
Circadian abnormalities as markers of susceptibility in bipolar disorders.
Review
Etain et al., Créteil, France. In Front Biosci (schol Ed), 2013
Several circadian genes have been found to be associated with bipolar disorders: at least three studies have reported positive associations for each of CLOCK, NPAS2, ARNTL1, NR1D1, PER3, RORB and CSNK1epsilon.
Clock gene variants in mood and anxiety disorders.
Review
Partonen, Helsinki, Finland. In J Neural Transm, 2012
The findings that have gained support indicate that genetic variants of RORA (rs2028122) and CRY1 (rs2287161) associate with depressive disorder, those of RORB (rs7022435, rs3750420, rs1157358, rs3903529) and NR1D1 (rs2314339) with bipolar disorder, and those of NPAS2 (rs11541353) and CRY2 (rs10838524) with seasonal affective disorder or winter depression.
Rev-erbα regulates circadian rhythms and StAR expression in rat granulosa cells as identified by the agonist GSK4112.
GeneRIF
Hattori et al., Fukuoka, Japan. In Biochem Biophys Res Commun, 2012
these data are the first to show the Rev-erbalpha function in the steroid biosynthesis of rat granulosa cells, and to suggest that Rev-erbalpha may coordinate circadian rhythm and metabolism in rat ovaries.
A large-scale population-based analysis of common genetic variation in the thyroid hormone receptor alpha locus and bone.
GeneRIF
Peeters et al., In Thyroid, 2012
Thyroid hormone receptor-alpha/NR1D1 polymorphisms were not associated with baseline characteristics, including serum TSH and free thyroxine. None of the polymorphisms were associated with bone mineral density or osteoporotic fractures.
Expression of retinoic acid-related orphan receptor alpha and its responsive genes in human endometrium regulated by cholesterol sulfate.
GeneRIF
Taketani et al., Tokyo, Japan. In J Steroid Biochem Mol Biol, 2012
in situ hybridization revealed that RORA and NR1D1 were expressed in human endometrial stromal and epithelial cells
Restricted feeding regime affects clock gene expression profiles in the suprachiasmatic nucleus of rats exposed to constant light.
GeneRIF
Sumová et al., Praha, Czech Republic. In Neuroscience, 2012
Restricted feeding induced significant circadian rhythms in Rev-erbalpha and Bmal1 gene expressionin rats maintained under constant light
Genetics of circadian rhythms and mood spectrum disorders.
Review
Leboyer et al., Créteil, France. In Eur Neuropsychopharmacol, 2011
Such connections to circadian genes such as CLOCK, ARNTL1, NPAS2, PER3 and NR1D1 have been repeatedly demonstrated for bipolar disorders, and to a lesser extent for recurrent depressive disorders and seasonal affective disorders.
Direct regulation of CLOCK expression by REV-ERB.
GeneRIF
Burris et al., Jupiter, United States. In Plos One, 2010
REV-ERBalpha plays a dual role in regulation of the activity of the BMAL1/CLOCK heterodimer by regulation of expression of both the BMAL1 and CLOCK genes.
Nuclear receptor Rev-erbalpha: a heme receptor that coordinates circadian rhythm and metabolism.
Review
Lazar et al., Ann Arbor, United States. In Nucl Recept Signal, 2009
Nuclear receptor Rev-erbalpha (NR1D1), previously considered to be an orphan nuclear receptor, is a receptor for heme, which promotes transcriptional repression via recruitment of the NCoR-HDAC3 corepressor complex.
Genomic and transcriptional aberrations linked to breast cancer pathophysiologies.
Impact
Gray et al., San Francisco, United States. In Cancer Cell, 2006
Nine of these (FGFR1, IKBKB, ERBB2, PROCC, ADAM9, FNTA, ACACA, PNMT, and NR1D1) are considered druggable.
Two erbA homologs encoding proteins with different T3 binding capacities are transcribed from opposite DNA strands of the same genetic locus.
Impact
Yamamoto et al., Tokyo, Japan. In Cell, 1989
Two erbA homologs, termed ear-1 and ear-7, are present in the human genome on chromosome 17.
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