gopubmed logo
 
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Nitrogen permease regulator-like 2

NPRL2, NPR2L
Top mentioned proteins: HYAL2, CAN, ACID, Flu, FUS
Papers on NPRL2
Amino acid-dependent NPRL2 interaction with Raptor determines mTOR Complex 1 activation.
New
Joe et al., Taejŏn, South Korea. In Cell Signal, Feb 2016
We assign a new function to a tumor suppressor NPRL2 that activates the mTOR complex 1 (mTORC1) activity.
Functional mechanism of the enhancement of 5-fluorouracil sensitivity by TUSC4 in colon cancer cells.
New
Liu et al., Harbin, China. In Oncol Lett, Dec 2015
Tumor suppressor candidate 4 (TUSC4), also referred to as nitrogen permease regulator-like 2 (NPRL2), is located at chromosome 3p21.3
Mutations in the mTOR pathway regulators NPRL2 and NPRL3 cause focal epilepsy.
New
Dibbens et al., Adelaide, Australia. In Ann Neurol, Nov 2015
In this study we investigated whether mutations in the mTOR regulators NPRL2 and NPRL3 also contribute to cases of focal epilepsy.
Downregulation of nitrogen permease regulator like-2 activates PDK1-AKT1 and contributes to the malignant growth of glioma cells.
New
Cheng et al., Chongqing, China. In Mol Carcinog, Nov 2015
UNASSIGNED: Nitrogen permease regulator like-2(NPRL2) is a candidate tumor suppressor gene(TSG) located on chromosome 3p21.3
Functional characterization of the nitrogen permease regulator-like-2 candidate tumor suppressor gene in colorectal cancer cell lines.
New
Liu et al., Harbin, China. In Mol Med Report, Sep 2015
The nitrogen permease regulator‑like‑2 (NPRL2) gene is a candidate tumor suppressor gene, which has been identified in the 3p21.3
Regulation of Hematopoiesis and Methionine Homeostasis by mTORC1 Inhibitor NPRL2.
New
Tu et al., Dallas, United States. In Cell Rep, Aug 2015
Nitrogen permease regulator-like 2 (NPRL2) is a component of a conserved complex that inhibits mTORC1 (mammalian Target Of Rapamycin Complex 1) in response to amino acid insufficiency.
Nitrogen permease regulator-like 2 enhances sensitivity to oxaliplatin in colon cancer cells.
New
Liu et al., Harbin, China. In Mol Med Report, Jul 2015
The nitrogen permease regulator like-2 (NPRL2) gene is a candidate tumor suppressor gene that resides in a 120-kb homozygous deletion region on chromosome 3p21.3.
Quantitative analysis of mRNA expression levels and DNA methylation profiles of three neighboring genes: FUS1, NPRL2/G21 and RASSF1A in non-small cell lung cancer patients.
Brzeziańska-Lasota et al., Łódź, Poland. In Respir Res, 2014
FUS1, NPRL2/G21 and RASSF1A are TSGs from LUCA region at 3p21.3, a critical chromosomal region in lung cancer development.
Decreased expression of NPRL2 in renal cancer cells is associated with unfavourable pathological, proliferation and apoptotic features.
Tang et al., Chongqing, China. In Pathol Oncol Res, 2014
The tumor suppressor gene nitrogen permease regulator-like 2(NPRL2) NPRL2 expressed obviously in many normal human tissues, but reduced in expression in many human tumors significantly.
Reciprocal conversion of Gtr1 and Gtr2 nucleotide-binding states by Npr2-Npr3 inactivates TORC1 and induces autophagy.
Noda et al., Ōsaka, Japan. In Autophagy, 2014
To investigate the mechanisms that regulate autophagy, we performed a genome-wide screen using a yeast deletion-mutant collection, and found that Npr2 and Npr3 mutants were defective in autophagy.
Relationship between tumor and peripheral blood NPRL2 mRNA levels in patients with colorectal adenoma and colorectal cancer.
Chen et al., Harbin, China. In Cancer Biol Ther, 2014
NPRL2 is a tumor suppressor gene involved in the progression of human cancer.
[Effect of recombinant plasmid pEGFP-N1-NPRL2 on the biological characteristics of human gastric cancer cells].
Jiang et al., Chongqing, China. In Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi, 2012
AIM: To investigate the effect of eukaryotic expression vector pEGFP-N1-NPRL2 on the proliferation, cell cycle, apoptosis, invasion and migration of human gastric carcinoma SGC-7901 cells in vitro.
NPRL2 gene expression in the progression of colon tumors.
Buyru et al., İstanbul, Turkey. In Genet Mol Res, 2011
NPRL2 is a candidate tumor suppressor gene identified in the human chromosome 3p21.3
NPRL2 is an independent prognostic factor of osteosarcoma.
Fan et al., Jinzhou, China. In Cancer Biomark, 2011
NPRL2 is a tumor suppressor gene whose inactivation contributes to tumor development.
Npr2, yeast homolog of the human tumor suppressor NPRL2, is a target of Grr1 required for adaptation to growth on diverse nitrogen sources.
GeneRIF
Wittenberg et al., Los Angeles, United States. In Eukaryot Cell, 2010
Data indicate that Npr2, a homolog of human NPRL2, is a phosphorylation-dependent target of the SCF(Grr1) E3 ubiquitin ligase that plays a role in cell growth on some nitrogen sources.
Simultaneous down-regulation of tumor suppressor genes RBSP3/CTDSPL, NPRL2/G21 and RASSF1A in primary non-small cell lung cancer.
GeneRIF
Zabarovsky et al., Moscow, Russia. In Bmc Cancer, 2009
tumor suppressor genes RBSP3/CTDSPL, NPRL2/G21 and RASSF1A are downregulated in primary non-small cell lung cancer
The tumor suppressor NPRL2 in hepatocellular carcinoma plays an important role in progression and can be served as an independent prognostic factor.
GeneRIF
Nakao et al., Nagoya, Japan. In J Surg Oncol, 2009
Our results suggest that NPRL2 mRNA expression has prognostic significance for the survival of patients with HCC.
[Down-regulation of RBSP3/CTDSPL, NPRL2/G21, RASSF1A, ITGA9, HYAL1 and HYAL2 genes in non-small cell lung cancer].
GeneRIF
Senchenko et al., In Mol Biol (mosk), 2008
Down-regulation of RBSP3/CTDSPL, NPRL2/G21, RASSF1A, ITGA9, HYAL1 and HYAL2 genes in non-small cell lung cancer
TUSC4/NPRL2, a novel PDK1-interacting protein, inhibits PDK1 tyrosine phosphorylation and its downstream signaling.
GeneRIF
Fujita et al., Tokyo, Japan. In Cancer Sci, 2008
TUSC4/NPRL2, a novel PDK1-interacting protein, plays a role in regulating the Src/PDK1 signaling pathway and cell sensitivity to multiple cancer chemotherapeutic drugs.
Evaluation of the 3p21.3 tumour-suppressor gene cluster.
Review
Latif et al., Dundee, United Kingdom. In Oncogene, 2007
The candidate genes are HYAL2, FUS1, Ras-associated factor 1 (RASSF1), BLU/ZMYND10, NPR2L, 101F6, PL6 and CACNA2D2.
share on facebooktweetadd +1mail to friends