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NPR1 Regulatory protein NPR1

NPR1, nim1
This gene is a key regulator of the salicylic acid (SA)-mediated systemic acquired resistance (SAR) pathway. It is similar to the transcription factor inhibitor I kappa B, and contains ankyrin repeats. It confers resistance to the pathogens Pseudomonas syringae and Peronospora parasitica in a dosage-dependent fashion. Although transgenic Arabidopsis plants overexpressing NPR1 acquire enhanced sensitivity to SA and (benzothiadiazole) BTH, they display no obvious detrimental morphological changes and do not have elevated pathogenesis-related gene expression until activated by inducers or pathogens. (from NCBI)
Top mentioned proteins: ACID, CAN, SAR, prolactin receptor, V1a
Papers on NPR1
Characterization of the interaction between Oidium heveae and Arabidopsis thaliana.
Rong et al., Haikou, China. In Mol Plant Pathol, Feb 2016
However, SA-independent resistance also appears to limit O. heveae infection of Arabidopsis, because the pathogen does not produce conidiospores on npr1, sid2, and NahG plants, which have disruptions of SA signaling.
Analysis of salicylic acid-dependent pathways in Arabidopsis thaliana following infection with Plasmodiophora brassicae and the influence of salicylic acid on disease.
Cahill et al., Geelong, Australia. In Mol Plant Pathol, Jan 2016
In wt, sid2 (SA biosynthesis), NahG (SA-deficient) and npr1 (SA-signaling impaired) mutants SA treatment could not alter the gall score, however positively affected shoot weightThis suggests that SA alone is not sufficient for Arabidopsis resistance against P. brassicae.
Correction: Transgenic Citrus Expressing an Arabidopsis NPR1 Gene Exhibit Enhanced Resistance against Huanglongbing (HLB; Citrus Greening).
Grosser et al., In Plos One, Dec 2015
UNASSIGNED: [This corrects the article DOI: 10.1371/journal.pone.0137134.].
Rutin-Mediated Priming of Plant Resistance to Three Bacterial Pathogens Initiating the Early SA Signal Pathway.
Chu et al., China. In Plos One, Dec 2015
We also demonstrated that the rutin-mediated priming resistance was attenuated in npr1, eds1, eds5, pad4-1, ndr1 mutants, and NahG transgenic Arabidopsis plant, while not in either snc1-11, ein2-5 or jar1 mutants.
Redox rhythm reinforces the circadian clock to gate immune response.
Dong et al., Durham, United States. In Nature, Aug 2015
Here we report that the master immune regulator NPR1 (non-expressor of pathogenesis-related gene 1) of Arabidopsis is a sensor of the plant's redox state and regulates transcription of core circadian clock genes even in the absence of pathogen challenge.
Transcriptional Control of Glutaredoxin GRXC9 Expression by a Salicylic Acid-Dependent and NPR1-Independent Pathway in Arabidopsis.
Holuigue et al., Santiago, Chile. In Plant Mol Biol Rep, 2014
GRXC9, coding for a CC-type glutaredoxin from Arabidopsis, is an SA-responsive gene induced early and transiently by an NPR1-independent pathway.
Salicylic acid signaling in disease resistance.
Kumar, Johnson City, United States. In Plant Sci, 2014
Recent identification of NPR3, NPR4 and NPR1 as potential SA receptors and ╬▒-ketoglutarate dehydrogenase (KGDHE2), several glutathione S transferases (GSTF) such as SA binding proteins have generated more interest in this field.
Perception of the plant immune signal salicylic acid.
Dong et al., Durham, United States. In Curr Opin Plant Biol, 2014
Mutant screens revealed that NPR1 is a master regulator of SA-mediated responses.
The functions of WHIRLY1 and REDOX-RESPONSIVE TRANSCRIPTION FACTOR 1 in cross tolerance responses in plants: a hypothesis.
Krupinska et al., Leeds, United Kingdom. In Philos Trans R Soc Lond B Biol Sci, 2014
We propose that the redox state of the photosynthetic electron transport chain triggers the movement of WHIRLY1 from the chloroplasts to the nucleus, and draw parallels with the regulation of NONEXPRESSOR OF PATHOGENESIS-RELATED GENES 1 (NPR1).
BLADE-ON-PETIOLE genes: setting boundaries in development and defense.
Hepworth et al., Ottawa, Canada. In Plant Sci, 2014
BLADE-ON-PETIOLE (BOP) genes encode an ancient and conserved subclade of BTB-ankryin transcriptional co-activators, divergent in the NPR1 family of plant defense regulators.
Tell me more: roles of NPRs in plant immunity.
Mukhtar et al., Birmingham, United States. In Trends Plant Sci, 2013
Here, we review the mechanisms of NPR1 action in concert with its paralogues NPR3 and NPR4 and other SAR players.
Systemic acquired resistance: turning local infection into global defense.
Dong et al., Durham, United States. In Annu Rev Plant Biol, 2012
The Arabidopsis NPR1 (nonexpresser of PR genes 1) protein is a master regulator of SAR.
NPR3 and NPR4 are receptors for the immune signal salicylic acid in plants.
Dong et al., Durham, United States. In Nature, 2012
Systemic acquired resistance in Arabidopsis requires the transcription cofactor nonexpresser of PR genes 1 (NPR1), the degradation of which acts as a molecular switch.
UV-C-irradiated Arabidopsis and tobacco emit volatiles that trigger genomic instability in neighboring plants.
Kovalchuk et al., Lethbridge, Canada. In Plant Cell, 2011
The NONEXPRESSOR OF PATHOGENESIS-RELATED GENES1 (npr1) mutant, defective in cylic acid signaling, is impaired in both the production and the perception of the volatile signals, demonstrating a key role for NPR1 as a central regulator of genome stability.
Overexpression of Arabidopsis ACBP3 enhances NPR1-dependent plant resistance to Pseudomonas syringe pv tomato DC3000.
Chye et al., Hong Kong, Hong Kong. In Plant Physiol, 2011
The enhanced pathogenesis-related gene expression and P. syringae DC3000 resistance in the ACBP3-overexpressors are dependent on the NPR1-mediated, but not the COI1-mediated, signaling pathway.
Exchanging the as-1-like element of the PR-1 promoter by the as-1 element of the CaMV 35S promoter abolishes salicylic acid responsiveness and regulation by NPR1 and SNI1.
Gatz et al., G├Âttingen, Germany. In Plant Signal Behav, 2010
the configuration of two TGA binding sites within the PR-1 promoter determines whether NPR1 can induce and whether SNI1 can repress the promoter
Cytoplasmic H2O2 prevents translocation of NPR1 to the nucleus and inhibits the induction of PR genes in Arabidopsis.
Levine et al., Jerusalem, Israel. In Plant Signal Behav, 2010
These results show that the pathogen-triggered or salicylic acid-induced nuclear translocation is prevented by accumulation of hydrogen peroxide in the cytosol.
Functional analysis of the Theobroma cacao NPR1 gene in Arabidopsis.
Guiltinan et al., United States. In Bmc Plant Biol, 2009
Data show that the cacao TcNPR1 gene partially complemented the npr1 mutation in transgenic Arabidopsis plants, resulting in 100 fold less bacterial growth in a leaf infection assay.
NPR1 in Plant Defense: It's Not over 'til It's Turned over.
Dangl et al., Chapel Hill, United States. In Cell, 2009
NPR1 is a key transcriptional coregulator in plant defense responses.
Proteasome-mediated turnover of the transcription coactivator NPR1 plays dual roles in regulating plant immunity.
Dong et al., Durham, United States. In Cell, 2009
Study shows that turnover of nuclear NPR1 protein plays an important role in modulating transcription of its target genes.
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