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Natriuretic peptide receptor B/guanylate cyclase B

NPR-B, GC-B, natriuretic peptide receptor-B, NPR2
This gene encodes natriuretic peptide receptor B, one of two integral membrane receptors for natriuretic peptides. Both NPR1 and NPR2 contain five functional domains: an extracellular ligand-binding domain, a single membrane-spanning region, and intracellularly a protein kinase homology domain, a helical hinge region involved in oligomerization, and a carboxyl-terminal guanylyl cyclase catalytic domain. The protein is the primary receptor for C-type natriuretic peptide (CNP), which upon ligand binding exhibits greatly increased guanylyl cyclase activity. Mutations in this gene are the cause of acromesomelic dysplasia Maroteaux type. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CNP, NPR, ANP, BNP, Elongation Factor 2
Papers on NPR-B
Dephosphorylation of juxtamembrane serines and threonines of the NPR2 guanylyl cyclase is required for rapid resumption of oocyte meiosis in response to luteinizing hormone.
New
Jaffe et al., Farmington, United States. In Dev Biol, Feb 2016
An essential event in this process is a decrease in cyclic GMP in the granulosa cells, and part of the cGMP decrease results from dephosphorylation and inactivation of the natriuretic peptide receptor 2 (NPR2) guanylyl cyclase, also known as guanylyl cyclase B. However, it is unknown whether NPR2 dephosphorylation is essential for LH-induced meiotic resumption.
Genome-Wide Analysis of the TORC1 and Osmotic Stress Signaling Network in Saccharomyces cerevisiae.
New
Capaldi et al., United States. In G3 (bethesda), Jan 2016
Studies in yeast and human cells have shown that nitrogen/amino acid starvation signals act through Npr2/3 and the small GTPases Gtr1/2 (Rags in humans) to inhibit TORC1.
Electrophysiological effects of natriuretic peptides in the heart are mediated by multiple receptor subtypes.
New
Rose et al., Halifax, Canada. In Prog Biophys Mol Biol, Jan 2016
These peptides elicit their effects by binding to three distinct cell surface receptors called natriuretic peptide receptors A, B and C (NPR-A, NPR-B and NPR-C).
Modulation in Natriuretic Peptides System in Experimental Colitis in Rats.
New
Kim et al., Chŏnju, South Korea. In Dig Dis Sci, Jan 2016
The colonic natriuretic peptide receptor-A mRNA level and particulate guanylyl cyclase activity in response to ANP from colonic tissue membranes were higher, and the mRNA levels of ANP and natriuretic peptide receptor-B were lower in DSS-treated rats than in control rats.
Genetic Factors Influencing B-type Natriuretic Peptide-Mediated Production of Cyclic Guanosine Monophosphate and Blood Pressure Effects in Heart Failure Patients.
New
Chow et al., Detroit, United States. In J Cardiovasc Transl Res, Dec 2015
We tested the association of 119 single nucleotide polymorphisms (SNPs) in 4 candidate genes (NPR1, NPR2, NPR3, and membrane metallo-endopeptidase (MME)) with the change in cGMP and BP.
MECHANISMS IN ENDOCRINOLOGY: Novel genetic causes of short stature.
Review
New
Kant et al., Leiden, Netherlands. In Eur J Endocrinol, Dec 2015
Disorders of signalling of various paracrine factors (FGFs, BMPs, WNTs, PTHrP/IHH and CNP/NPR2) or genetic defects affecting cartilage extracellular matrix usually cause disproportionate short stature.
Acromesomelic dysplasia, type maroteaux caused by novel loss-of-function mutations of the NPR2 gene: Three case reports.
New
Cho et al., Suita, Japan. In Am J Med Genet A, Dec 2015
UNASSIGNED: The C-type natriuretic peptide (CNP)-natriuretic peptide receptor 2 (NPR2) signaling pathway plays an important role in chondrocyte development.
Selective Regulation of Oocyte Meiotic Events Enhances Progress in Fertility Preservation Methods.
Review
Aydin et al., Uşak, Turkey. In Biochem Insights, 2014
cGMP is produced in the somatic compartment, and natriuretic peptide precursor C (Nppc) and natriuretic peptide receptor 2 (Npr2) regulate its production.
Guanylyl cyclase/natriuretic peptide receptor-A signaling antagonizes phosphoinositide hydrolysis, Ca(2+) release, and activation of protein kinase C.
Review
Pandey, New Orleans, United States. In Front Mol Neurosci, 2013
Atrial and brain natriuretic peptides (ANP and BNP) specifically bind and activate guanylyl cyclase/natriuretic peptide receptor-A (GC-A/NPRA), and C-type natriuretic peptide (CNP) shows specificity to activate guanylyl cyclase/natriuretic peptide receptor-B (GC-B/NPRB).
Role of the natriuretic peptide system in normal growth and growth disorders.
Review
Jorge et al., São Paulo, Brazil. In Horm Res Paediatr, 2013
Animal models involving CNP or NPR-B genes (Nppc or Npr2) support the fundamental role of CNP/NPR-B for endochondral ossification.
C-type natriuretic peptide: a new cardiac mediator.
Review
Del Ry, Pisa, Italy. In Peptides, 2013
Taken together, these observations suggest that CNP and its specific receptor, NPR-B, can play a very important role in regulating cardiac hypertrophy and remodeling, indicating NPR-B as a new potential drug target for the treatment of cardiovascular disease.
Expression of guanylyl cyclase-B (GC-B/NPR2) receptors in normal human fetal pituitaries and human pituitary adenomas implicates a role for C-type natriuretic peptide.
GeneRIF
Fowkes et al., London, United Kingdom. In Endocr Relat Cancer, 2012
NPR2 expression in normal human fetal and adult pituitaries and adenomatous pituitary tissue suggests a role for these receptors in both pituitary development and oncogenesis.
C-type natriuretic peptide and its receptors in atherosclerotic plaques of the carotid artery of clinically asymptomatic patients.
GeneRIF
Eckstein et al., München, Germany. In Eur J Vasc Endovasc Surg, 2012
Report the presence of CNP and its receptors, NPR2/3 in atherosclerotic plaques of human carotid artery.
Guanylyl cyclase (GC)-A and GC-B activities in ventricles and cardiomyocytes from failed and non-failed human hearts: GC-A is inactive in the failed cardiomyocyte.
GeneRIF
Potter et al., Minneapolis, United States. In J Mol Cell Cardiol, 2012
GC-B activity is increased in non-myocytes from failing human ventricles, possibly as a result of increased fibrosis.
Selective regulation of autophagy by the Iml1-Npr2-Npr3 complex in the absence of nitrogen starvation.
GeneRIF
Tu et al., Dallas, United States. In Mol Biol Cell, 2011
A visual screen uncovered three regulators of autophagy-Iml1p, Npr2p, and Npr3p-which function in the same complex and are selectively required for non-nitrogen starvation-induced autophagy
Mendelian randomization study of B-type natriuretic peptide and type 2 diabetes: evidence of causal association from population studies.
GeneRIF
Wareham et al., Cambridge, United Kingdom. In Plos Med, 2011
results provide evidence for a potential causal role of the B-type natriuretic peptide system in the aetiology of type 2 diabetes
Granulosa cell ligand NPPC and its receptor NPR2 maintain meiotic arrest in mouse oocytes.
Impact
GeneRIF
Eppig et al., Beijing, China. In Science, 2010
findings show mural granulosa cells express Nppc mRNA; cumulus cells surrounding oocytes express mRNA of NPPC receptor NPR2; granulosa cell ligand NPPC and receptor NPR2 in cumulus cells prevent precocious meiotic maturation
Natriuretic peptides, their receptors, and cyclic guanosine monophosphate-dependent signaling functions.
Review
Impact
Dickey et al., Minneapolis, United States. In Endocr Rev, 2006
Two, NPR-A/GC-A/NPR1 and NPR-B/GC-B/NPR2, are transmembrane guanylyl cyclases, enzymes that catalyze the synthesis of cGMP.
Overexpression of CNP in chondrocytes rescues achondroplasia through a MAPK-dependent pathway.
Impact
Nakao et al., Kyoto, Japan. In Nat Med, 2004
C-type natriuretic peptide (CNP) is a newly identified molecule that regulates endochondral bone growth through GC-B, a subtype of particulate guanylyl cyclase.
The primary structure of a plasma membrane guanylate cyclase demonstrates diversity within this new receptor family.
Impact
Garbers et al., Nashville, United States. In Cell, 1989
We show that a second guanylate cyclase/receptor (GC-B) exists, with distinctly different specificities for various natriuretic peptides.
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