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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

NPL3 Npl3p

Npl3, Npl3p, TAF15, TAF12, RBP56, TAF2N
Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes a subunit of TFIID present in a subset of TFIID complexes. Translocations involving chromosome 17 and chromosome 9, where the gene for the nuclear receptor CSMF is located, result in a gene fusion product that is an RNA binding protein associated with a subset of extraskeletal myxoid chondrosarcomas. Two transcripts encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: EWS, FUS, CAN, POLYMERASE, TBP
Papers on Npl3
Yeast proteins Gar1p, Nop1p, Npl3p, Nsr1p, and Rps2p are natively methylated and are substrates of the arginine methyltransferase Hmt1p.
Wilkins et al., Sydney, Australia. In Proteomics, Sep 2015
Here we used peptide immunoaffinity enrichment, followed by LC-ETD-MS/MS, to discover 21 native sites of arginine methylation on five putative Hmt1 substrate proteins, namely Gar1p (H/ACA ribonucleoprotein complex subunit 1), Nop1p (rRNA 2'-O-methyltransferase fibrillarin), Npl3p (nucleolar protein 3), Nsr1p (nuclear localization sequence-binding protein), and Rps2p (40S ribosomal protein S2).
An autopsy case of frontotemporal lobar degeneration with the appearance of fused in sarcoma inclusions (basophilic inclusion body disease) clinically presenting corticobasal syndrome.
Hisanaga et al., Tokorozawa, Japan. In Neuropathology, Aug 2015
The inclusions were immunoreactive for FUS, p62, and TATA-binding protein-associated factor 15 (TAF15), but not for phosphorylated tau, transactive response DNA-binding protein of 43 kDa (TDP-43), neurofilament protein, or Ewing sarcoma (EWS).
Concurrent Gain of Oncogenes Drives Choroid Plexus Carcinoma.
In Cancer Discov, Jul 2015
TAF12, NFYC, and RAD54L are oncogenes required to initiate and maintain choroid plexus carcinoma (CPC).
A Systematic Analysis of Factors Localized to Damaged Chromatin Reveals PARP-Dependent Recruitment of Transcription Factors.
Elledge et al., Boston, United States. In Cell Rep, Jul 2015
These include the BAF tumor suppressor complex and the amyotrophic lateral sclerosis (ALS) candidate protein TAF15.
Cross-Species Genomics Identifies TAF12, NFYC, and RAD54L as Choroid Plexus Carcinoma Oncogenes.
Gilbertson et al., Memphis, United States. In Cancer Cell, Jun 2015
TAF12, NFYC, and RAD54L co-located on human chromosome 1p32-35.3
Biochemical Properties and Biological Functions of FET Proteins.
Parker et al., Boulder, United States. In Annu Rev Biochem, 2014
Members of the FET protein family, consisting of FUS, EWSR1, and TAF15, bind to RNA and contribute to the control of transcription, RNA processing, and the cytoplasmic fates of messenger RNAs in metazoa.
Engineering enhanced protein disaggregases for neurodegenerative disease.
Shorter et al., Philadelphia, United States. In Prion, 2014
Remarkably subtle modifications of Hsp104 primary sequence yielded large gains in protective activity against deleterious α-synuclein, TDP-43, FUS, and TAF15 misfolding.
SimiRa: A tool to identify coregulation between microRNAs and RNA-binding proteins.
Theis et al., München, Germany. In Rna Biol, 2014
SimiRa also predicts possible cooperation of microRNAs and RBPs beyond direct interaction on the target mRNA for the nuclear RBP TAF15.
Structural delineation of stem-loop RNA binding by human TAF15 protein.
Bhavesh et al., New Delhi, India. In Sci Rep, 2014
Human TATA binding protein associated factor 2 N (TAF15) and Fused in sarcoma (FUS) are nucleic acid binding proteins belonging to the conserved FET family of proteins.
Oxidative stress affects FET proteins localization and alternative pre-mRNA processing in cellular models of ALS.
Paronetto et al., Roma, Italy. In Free Radic Biol Med, 2014
FUS/TLS, EWS and TAF15 are members of the FET family of DNA and RNA binding proteins, involved in multiple steps of DNA and RNA processing and implicated in the regulation of gene expression and cell-signaling.
Phosphorylation-regulated binding of RNA polymerase II to fibrous polymers of low-complexity domains.
McKnight et al., Dallas, United States. In Cell, 2013
The low-complexity (LC) domains of the products of the fused in sarcoma (FUS), Ewings sarcoma (EWS), and TAF15 genes are translocated onto a variety of different DNA-binding domains and thereby assist in driving the formation of cancerous cells.
Amyotrophic lateral sclerosis: an update on recent genetic insights.
Sobue et al., Nagoya, Japan. In J Neurol, 2013
Above all, the RNA-binding protein, such as FUS, TAF15, EWSR1 and hnRNPA1, have structural and functional similarities to TDP-43, and physiological functions of some molecules, including VCP, UBQLN2, OPTN, FIG4 and SQSTM1, are involved in a protein degradation system.
Frontotemporal lobar degeneration and amyotrophic lateral sclerosis: molecular similarities and differences.
Neumann, Tübingen, Germany. In Rev Neurol (paris), 2013
All members of the FET family (FUS, EWS, TAF15) are co-accumulating with their nuclear import receptor Transportin in FTLD-FUS which is usually not associated with FUS mutations, whilst ALS-FUS is almost always associated with FUS mutations and reveals only FUS aggregates.
The architecture of human general transcription factor TFIID core complex.
Berger et al., Grenoble, France. In Nature, 2013
A functional core-TFIID subcomplex was revealed in Drosophila nuclei, consisting of a subset of TAFs (TAF4, TAF5, TAF6, TAF9 and TAF12).
Primary pulmonary myxoid sarcoma with EWSR1-CREB1 fusion, resembling extraskeletal myxoid chondrosarcoma: Case report with a review of Literature.
Hata et al., Tokyo, Japan. In Pathol Int, 2012
Our reverse transcription-polymerase chain reaction using the formalin-fixed, paraffin-embedded tumor tissues detected EWSR1-CREB1 fusion transcript, but could not demonstrate EWSR1-ATF1 fusion or EWSR1/TAF15/TFG-NR4A3 fusion.
Domains involved in TAF15 subcellular localisation: dependence on cell type and ongoing transcription.
Leichter et al., Athens, Greece. In Gene, 2012
TAF15 plays a role in RNA transport and/or local RNA translation
A yeast functional screen predicts new candidate ALS disease genes.
Gitler et al., Philadelphia, United States. In Proc Natl Acad Sci U S A, 2012
Missense mutations of TAF-15, an RNA-binding protein, were found in patients with amyotrophic lateral sclerosis, and gene conferred neurodegeneration when expressend in Drosophila.
FET proteins TAF15 and EWS are selective markers that distinguish FTLD with FUS pathology from amyotrophic lateral sclerosis with FUS mutations.
Mackenzie et al., Zürich, Switzerland. In Brain, 2011
REsults suggest the possibility that alterations of TAF15 and EWS might also be involved in the pathogenesis of FUS proteinopathies such as ALS and FTLD.
Mutational analysis reveals the FUS homolog TAF15 as a candidate gene for familial amyotrophic lateral sclerosis.
Landers et al., Worcester, United States. In Am J Med Genet B Neuropsychiatr Genet, 2011
These results suggest that additional studies are needed to determine whether mutations in the TAF15 gene represent a cause of familial amyotrophic lateral sclerosis.
Identification of the TAF15-ZNF384 fusion gene in two new cases of acute lymphoblastic leukemia with a t(12;17)(p13;q12).
Micci et al., Oslo, Norway. In Cancer Genet, 2011
Rare translocation t(12;17)(p13;q12), this translocation has been reported in 25 cases and its putative molecular consequence, the formation of a TAF15-ZNF384 fusion gene, in only six cases.
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