gopubmed logo
 
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Neuropeptide FF receptor 2

NPFF2, neuropeptide FF2, HLWAR77
This gene encodes a member of a subfamily of G-protein-coupled neuropeptide receptors. This protein is activated by the neuropeptides A-18-amide (NPAF) and F-8-amide (NPFF) and may function in pain modulation and regulation of the opioid system. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2009] (from NCBI)
Top mentioned proteins: Neuropeptide, neuropeptide FF, neuropeptide FF, Cho, Prolactin
Papers on NPFF2
Effects of neuropeptide FF and related peptides on the antinociceptive activities of VD-hemopressin(α) in naive and cannabinoid-tolerant mice.
New
Wang et al., Lanzhou, China. In Eur J Pharmacol, Dec 2015
In contrast, neuropeptide VF (NPVF) and D.NP(N-Me)AFLFQPQRF-NH2 (dNPA), two highly selective agonists for Neuropeptide FF1 and Neuropeptide FF2 receptors, enhanced VD-hemopressin(α)-induced antinociception in a dose-dependent manner.
The effect of neuropeptide FF in the amygdala kindling model.
New
Boon et al., Gent, Belgium. In Acta Neurol Scand, Nov 2015
OBJECTIVE: Neuropeptide FF (NPFF) and its receptors (NPFF1 R and NPFF2 R) are differentially distributed throughout the central nervous system.
Neuropeptide FF receptors as novel targets for limbic seizure attenuation.
New
Smolders et al., Brussels, Belgium. In Neuropharmacology, Aug 2015
Administration of the NPFF1/NPFF2 receptor antagonist RF9 also significantly attenuated limbic seizure activity.
Neuropeptide FF attenuates RANKL-induced differentiation of macrophage-like cells into osteoclast-like cells.
New
Qian et al., Xi'an, China. In Arch Oral Biol, Feb 2015
The mRNA expression of NPFF2 receptor (NPFFR2) and osteoclast genes was evaluated by using real-time quantitative PCR which includes TRAP, RANK (receptor activator of NF-κB), Cathepsin K, MMP-9 (matrix metallopeptidase 9), Intβ3 (integrin β3) and NFATc1 (nuclear factor of activated T cells cytoplasmic 1).
Identification and functional characterization of the phosphorylation sites of the neuropeptide FF2 receptor.
Moulédous et al., Toulouse, France. In J Biol Chem, 2015
The neuropeptide FF2 (NPFF2) receptor belongs to the rhodopsin family of G protein-coupled receptors and mediates the effects of several related RFamide neuropeptides.
Nonpeptide small molecule agonist and antagonist original leads for neuropeptide FF1 and FF2 receptors.
McCurdy et al., United States. In J Med Chem, 2014
Neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R), and their endogenous ligand NPFF, are one of only several systems responsible for mediating opioid-induced hyperalgesia, tolerance, and dependence.
Heterologous regulation of Mu-opioid (MOP) receptor mobility in the membrane of SH-SY5Y cells.
Mollereau et al., Toulouse, France. In J Biol Chem, 2014
Here we investigate the regulation of MOP receptor diffusion by heterologous activation of other G protein-coupled receptors and characterize the dynamic properties of the MOP receptor within the heterodimer MOP/neuropeptide FF (NPFF2) receptor.
Intraamygdaloid microinjection of RFamide-related peptide-3 decreases food intake in rats.
Lénárd et al., Pécs, Hungary. In Brain Res Bull, 2014
RFRP analogs bind with relatively high affinity to the NPFF1 and NPFF2 receptors (NPFF-R).
A high-affinity, radioiodinatable neuropeptide FF analogue incorporating a photolabile p-(4-hydroxybenzoyl)phenylalanine.
Zajac et al., Toulouse, France. In Anal Biochem, 2014
A new radioiodinated photoaffinity compound, [(125)I]YE(Bpa)WSLAAPQRFNH2, derived from a peptide present in the rat neuropeptide FF (NPFF) precursor was synthesized, and its binding characteristics were investigated on a neuroblastoma clone, SH-SY5Y, stably expressing rat NPFF2 receptors tagged with the T7 epitope.
NPFF2 receptor is involved in the modulatory effects of neuropeptide FF for macrophage cell line.
Wang et al., Lanzhou, China. In Protein Pept Lett, 2014
Here, we report that NPFF2 receptors may be functionally expressed in two immune cell models, the primary peritoneal macrophage and RAW 264.7 macrophage.
Endogenous mammalian RF-amide peptides, including PrRP, kisspeptin and 26RFa, modulate nociception and morphine analgesia via NPFF receptors.
Simonin et al., Illkirch-Graffenstaden, France. In Neuropharmacology, 2013
RF-amide-related peptides-1 and -3, neuropeptides AF and FF, Prolactin releasing peptides, Kisspeptins and RFa peptides are currently considered endogenous peptides for NPFF1, NPFF2, GPR10, GPR54 and GPR103 receptors, respectively.
Opposite effects of neuropeptide FF on central antinociception induced by endomorphin-1 and endomorphin-2 in mice.
Wang et al., Lanzhou, China. In Plos One, 2013
The results using the selective NPFF1 and NPFF2 receptor agonists indicated that the EM-1-modulating action of NPFF was mainly mediated by NPFF2 receptor, while NPFF potentiated EM-2-induecd antinociception via both NPFF1 and NPFF2 receptors.
From gonadotropin-inhibitory hormone to SIFamides: are echinoderm SALMFamides the "missing link" in a bilaterian family of neuropeptides that regulate reproductive processes?
Elphick, London, United Kingdom. In Gen Comp Endocrinol, 2013
Gonadotropin-inhibitory hormone (GnIH) belongs to a family of vertebrate neuropeptides with a C-terminal PxRFamide motif, which exert effects by activating the G-protein coupled receptors NPFF1 and/or NPFF2.
Role of neuropeptide FF in central cardiovascular and neuroendocrine regulation.
Goncharuk et al., Edmonton, Canada. In Front Endocrinol (lausanne), 2012
The effects of these peptides are mediated via NPFF1 and NPFF2 receptors that are abundantly expressed in the rat and human brain.
RFamide-related peptide-3 receptor gene expression in GnRH and kisspeptin neurons and GnRH-dependent mechanism of action.
GeneRIF
Anderson et al., Dunedin, New Zealand. In Endocrinology, 2012
Data showed that 33% of GnRH neurons and 9-16% of rostral periventricular kisspeptin neurons expressed Gpr147, whereas Gpr74 was not expressed in either population.
GRK2 protein-mediated transphosphorylation contributes to loss of function of μ-opioid receptors induced by neuropeptide FF (NPFF2) receptors.
GeneRIF
Mollereau et al., Toulouse, France. In J Biol Chem, 2012
These data show that NPFF-induced heterologous desensitization of MOP receptor signaling is mediated by GRK2 and could involve transphosphorylation within the heteromeric receptor complex.
Polymorphisms in the NPY2R gene show significant associations with BMI that are additive to FTO, MC4R, and NPFFR2 gene effects.
GeneRIF
Adams et al., Salt Lake City, United States. In Obesity (silver Spring), 2011
Four genetic loci were strongly and independently associated with obesity, NPY2R, NPFFR2, MC4R, and FTO.
Opposite control of body temperature by NPFF1 and NPFF2 receptors in mice.
GeneRIF
Zajac et al., Toulouse, France. In Neuropeptides, 2010
central NPFF1 and NPFF2 receptors control in an opposite manner the body temperature in mice.
Human kisspeptins activate neuropeptide FF2 receptor.
GeneRIF
Panula et al., Helsinki, Finland. In Neuroscience, 2010
Mouse kisspeptin-8 and kisspeptin-13 produce very small currents in NPFF2 receptor-injected Xenopus oocytes, compared to human kisspeptin.
Structure-activity relationships of neuropeptide FF and related peptidic and non-peptidic derivatives.
Review
McCurdy et al., United States. In Peptides, 2006
To date however, little information has been obtained as to the exact pharmacological roles of the individual NPFF1 and NPFF2 receptors.
share on facebooktweetadd +1mail to friends