Optogenetic Control of Mouse Outer Hair Cells.
Ann Arbor, United States. In Biophys J, Feb 2016
Three approaches were compared: 1) adeno-associated virus-mediated in utero transfer of the ChR-2 gene into the developing murine otocyst, 2) expression of ChR-2(H134R) in an auditory cell line (HEI-OC1), and 3) expression of ChR-2 in the OHCs of a mouse line carrying a ChR-2 conditional allele.
Arylpiperidines as a new class of oxidosqualene cyclase inhibitors.
München, Germany. In Eur J Med Chem, Jan 2016
UNASSIGNED: The cyclization of oxidosqualene to lanosterol, catalyzed by the enzyme oxidosqualene cyclase (OSC), goes through a number of carbocationic high energy intermediates (HEI), and mimicking these intermediates is a promising approach for the development of OSC inhibitors.
[Research advances in diagnosis and therapy of Niemann-Pick disease type C].
Beijing, China. In Zhongguo Dang Dai Er Ke Za Zhi, May 2015
Impaired cholesterol trafficking and unesterified cholesterol accumulation in the late endosomes and lysosomals, as a results of mutations in NPC1 or NPC2 genes, are initial for the disease, and defective cellular autophagy, defective lysosomal calcium homeostasis and oxidative stress may all play roles in the physiological processes.
Transfer of cholesterol by the NPC team.
Edmonton, Canada. In Cell Metab, 2010
In this issue of Cell Metabolism, Wang et al. (2010) identify amino acid residues on the lumenal lysosomal protein Niemann-Pick C2 (NPC2) that are required for intralysosomal transfer of endocytosed cholesterol to membrane-bound NPC1 via a process that avoids movement of hydrophobic cholesterol through the aqueous phase.
Getting a "Hold" on NPC2.
Saint Louis, United States. In Cell Metab, 2009
Lipoprotein cholesterol is mobilized from lysosomes by actions of the NPC1 and NPC2 proteins.