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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

NPC1-like 1

NPC1L1
The protein encoded by this gene is a multi-pass membrane protein. It contains a conserved N-terminal Niemann-Pick C1 (NPC1) domain and a putative sterol-sensing domain (SSD) which includes a YQRL motif functioning as a plasma membrane to trans-Golgi network transport signal in other proteins. This protein takes up free cholesterol into cells through vesicular endocytosis and plays a critical role in the absorption of intestinal cholesterol. It also has the ability to transport alpha-tocopherol (vitamin E). The drug ezetimibe targets this protein and inhibits the absorption of intestinal cholesterol and alpha-tocopherol. In addition, this protein may play a critical role in regulating lipid metabolism. Polymorphic variations in this gene are associated with plasma total cholesterol and low-density lipoprotein cholesterol (LDL-C) levels and coronary heart disease (CHD) risk. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009] (from NCBI)
Top mentioned proteins: ACID, ABCG8, V1a, CAN, HAD
Papers on NPC1L1
Synthesis and Characterization of Fatty Acid Conjugates of Niacin and Salicylic Acid.
New
Jirousek et al., In J Med Chem, Feb 2016
The fatty acid niacin conjugate 5 has been shown to be an inhibitor of the sterol regulatory element binding protein (SREBP), a key regulator of cholesterol metabolism proteins such as PCSK9, HMG-CoA reductase, ATP citrate lyase and NPC1L1.
Characterization of the NPC1L1 gene and proteome from an exceptional responder to ezetimibe.
New
Chalifour et al., Montréal, Canada. In Atherosclerosis, Jan 2016
Niemann-Pick C 1-like 1 (NPC1L1) is the molecular target of ezetimibe.
Isoflavones and phytosterols contained in Xuezhikang capsules modulate cholesterol homeostasis in high-fat diet mice.
New
Wang et al., Nanjing, China. In Acta Pharmacol Sin, Dec 2015
Administration of F3 decreased serum TC, TG and LDL-C levels by 33%, 29% and 39%, respectively, and increased serum HDL-C by 28%, sig¬nificantly reduced intestinal absorption of cholesterol by inhibiting the transcription of NPC1L1, and elevated excretion of TC, FC and CE by 96%, 72% and 101%, respectively.
Role of Ezetimibe in Lipid-Lowering and Cardiovascular Disease Prevention.
Review
New
Davidson et al., Chicago, United States. In Curr Atheroscler Rep, Dec 2015
Ezetimibe, a cholesterol absorption blocker that inhibits the Niemann-Pick C1-Like 1 (NPC1L1) receptor, has been the focus of recent trials that support its use in cardiovascular risk reduction.
Pravastatin Modulate Niemann-Pick C1-Like 1 and ATP-Binding Cassette G5 and G8 to Influence Intestinal Cholesterol Absorption.
New
Iwaki et al., Ōsaka, Japan. In J Pharm Pharm Sci, Dec 2015
PURPOSE: Niemann-Pick C1-like 1 (NPC1L1), ATP-binding cassette (ABC)G5, and ABCG8 mediate intestinal cholesterol absorption.
Genetics of coronary heart disease: towards causal mechanisms, novel drug targets and more personalized prevention.
Review
New
Orho-Melander, Malmö, Sweden. In J Intern Med, Nov 2015
Furthermore, identification of rare loss-of-function variants in genes such as PCSK9, NPC1L1, APOC3 and APOA5, which cause a markedly decreased risk of CHD and no adverse side effects, illustrates the power of translating genetic findings into novel mechanistic information and provides some optimism for the future of developing novel drugs, given the many genes associated with CHD in GWASs.
[Study on anti-hyperlipidemia mechanism of high frequency herb pairs by molecular docking method].
New
Zhang et al., In Zhongguo Zhong Yao Za Zhi, Jun 2015
The 20 main ingredients were selected from the herb pairs and docked with 3 key hyperlipidemia targets, namely 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMG-CoA reductase), peroxisome proliferator activated receptor-α (PPAR-α ) and niemann-pick C1 like 1 (NPC1L1) to further discuss the molecular mechanism of the high frequency herb pairs, by using the docking program, LibDock.
Inactivating mutations in NPC1L1 and protection from coronary heart disease.
Impact
Kathiresan et al., In N Engl J Med, 2014
BACKGROUND: Ezetimibe lowers plasma levels of low-density lipoprotein (LDL) cholesterol by inhibiting the activity of the Niemann-Pick C1-like 1 (NPC1L1) protein.
Resistance and intolerance to statins.
Review
Reiner, Zagreb, Croatia. In Nutr Metab Cardiovasc Dis, 2014
RESULTS: The resistance to statins has been associated with polymorphisms in the 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMG-CoA-R), P-glycoprotein (Pg-P/ABCB1), breast cancer resistance protein (BCRP/ABCG2), multidrug resistance-associated proteins (MRP1/ABCC1 and MRP2/ABCC2), organic anion transporting polypeptides (OATP), RHOA, Nieman-Pick C1-like1 protein (NPC1L1), farnesoid X receptor (FXR), cholesterol 7alpha-hydroxylase (CYP7A1), Apolipoprotein E (ApoE), proprotein convertase subtilisin/kexin type 9 (PCSK9), low density lipoprotein receptor (LDLR), lipoprotein (a) (LPA), cholesteryl ester transfer protein (CETP), and tumor necrosis factor α (TNF-α) genes.
Intestinal and hepatic Niemann-Pick C1L1 proteins: future therapeutic targets for cholesterol gallstones disease?
Review
Martínez-Vázquez et al., Mexico. In Eur J Pharmacol, 2014
The search for a therapeutic target is oriented towards decreasing bile secretion and intestinal absorption of cholesterol, in which Niemann-Pick C1L1 (NPC1L1) proteins play an important role.
The clathrin adaptor Numb regulates intestinal cholesterol absorption through dynamic interaction with NPC1L1.
Impact
Song et al., Shanghai, China. In Nat Med, 2014
Although it has been shown that intestinal cholesterol absorption is mediated by vesicular endocytosis of the Niemann-Pick C1-like 1 (NPC1L1) protein, the mechanism of sterol-stimulated NPC1L1 internalization is still mysterious.
Virtual screening for cholesterol absorption inhibitors.
Review
Huang et al., Nanjing, China. In Med Chem, 2013
Statins can reduce endogenous sterol synthesis by inhibiting HMG-CoA reductase, whereas cholesterol absorption inhibitors, such as ezetimibe, can block cholesterol uptake from dietary sources by blocking Niemann- Pick C1-like 1 (NPC1L1).
Role of the gut in lipid homeostasis.
Review
Impact
Davidson et al., Saint Louis, United States. In Physiol Rev, 2012
We discuss the regulation and functions of CD36 in fatty acid absorption, NPC1L1 in cholesterol absorption, as well as other lipid transporters including FATP4 and SRB1.
Novel function of Niemann-Pick C1-like 1 as a negative regulator of Niemann-Pick C2 protein.
GeneRIF
Suzuki et al., Tokyo, Japan. In Hepatology, 2012
NPC1L1 down-regulates the expression and secretion of NPC2 by inhibiting its maturation and accelerating its degradation. Hepatic NPC1L1 may control cholesterol homeostasis via the down-regulation of NPC2.
Identification of the Niemann-Pick C1-like 1 cholesterol absorption receptor as a new hepatitis C virus entry factor.
Impact
GeneRIF
Uprichard et al., Chicago, United States. In Nat Med, 2012
hepatitis c virus entry factor
Involvement of cholesterol membrane transporter Niemann-Pick C1-like 1 in the intestinal absorption of lutein.
GeneRIF
Iseki et al., Sapporo, Japan. In J Pharm Pharm Sci, 2011
Lutein absorption is, at least in part, mediated by influx transporters NPC1L1 and SR-B1 rather than mediated by efflux transporters such as ABC (ATP-binding cassette) transporters
Association of rs2072183 SNP and serum lipid levels in the Mulao and Han populations.
GeneRIF
Lin et al., Nanning, China. In Lipids Health Dis, 2011
The present study suggests that the rs2072183 SNP in NPC1L1 gene and its association with serum lipid profiles are different between the Mulao and Han populations.
The small GTPase Cdc42 interacts with Niemann-Pick C1-like 1 (NPC1L1) and controls its movement from endocytic recycling compartment to plasma membrane in a cholesterol-dependent manner.
GeneRIF
Song et al., Shanghai, China. In J Biol Chem, 2011
Cdc42 controls the cholesterol-regulated transport and localization of NPC1L1, and plays a role in cholesterol absorption.
Biological, clinical and population relevance of 95 loci for blood lipids.
Impact
Kathiresan et al., Ann Arbor, United States. In Nature, 2010
The newly reported associations include single nucleotide polymorphisms (SNPs) near known lipid regulators (for example, CYP7A1, NPC1L1 and SCARB1) as well as in scores of loci not previously implicated in lipoprotein metabolism.
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