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Neuronal PAS domain protein 3

NPAS3, neuronal PAS domain protein 3, basic helix-loop-helix-PAS protein
This gene encodes a member of the basic helix-loop-helix and PAS domain-containing family of transcription factors. The encoded protein is localized to the nucleus and may regulate genes involved in neurogenesis. Chromosomal abnormalities that affect the coding potential of this gene are associated with schizophrenia and mental retardation. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009] (from NCBI)
Top mentioned proteins: HIF-1alpha, Sim, HAD, OUT, NPAS1
Papers on NPAS3
Cumulative role of rare and common putative functional genetic variants at NPAS3 in schizophrenia susceptibility.
New
Costas et al., Santiago de Compostela, Spain. In Am J Med Genet B Neuropsychiatr Genet, Oct 2015
NPAS3, a transcription factor involved in central nervous system development and neurogenesis, seems to be implicated in the evolution of human brain, as it is the human gene with most human-specific accelerated elements (HAEs), i.e., .mammalian
Lower NPAS3 expression during the later stages of abnormal lung development in rat congenital diaphragmatic hernia.
New
Keijzer et al., Winnipeg, Canada. In Pediatr Surg Int, Jul 2015
NPAS3 is a PAS domain transcription factor regulating Drosophila tracheogenesis.
NPAS1 represses the generation of specific subtypes of cortical interneurons.
Rubenstein et al., San Francisco, United States. In Neuron, 2015
We show that NPAS1 and NPAS3 transcription factors (TFs) are expressed in progenitor domains of the mouse basal ganglia (subpallium, MGE, and CGE).
Genetic markers of white matter integrity in schizophrenia revealed by parallel ICA.
Calhoun et al., Albuquerque, United States. In Front Hum Neurosci, 2014
The SNP component was overrepresented in genes whose products are involved in corpus callosum morphology (e.g., CNTNAP2, NPAS3, and NFIB) as well as canonical pathways of synaptic long term depression and protein kinase A signaling.
Identification of pathways for bipolar disorder: a meta-analysis.
Psychiatric Genomics Consortium Bipolar Group et al., San Diego, United States. In Jama Psychiatry, 2014
Among the 226 genes, 9 differed in expression in the dorsolateral prefrontal cortex in patients with BP: CACNA1C, DTNA, FOXP1, GNG2, ITPR2, LSAMP, NPAS3, NCOA2, and NTRK3.
A fast-evolving human NPAS3 enhancer gained reporter expression in the developing forebrain of transgenic mice.
Franchini et al., Buenos Aires, Argentina. In Philos Trans R Soc Lond B Biol Sci, 2014
The developmental brain gene NPAS3 stands out as a hot spot in human evolution because it contains the largest number of human-specific, fast-evolving, conserved, non-coding elements.
NPAS3 variants in schizophrenia: a neuroimaging study.
Tibbo et al., Halifax, Canada. In Bmc Med Genet, 2013
Studies support a role for the neuronal Per-Arnt-Sim 3 (NPAS3) gene in processes that are essential for normal brain development.
Novel alternative splice variants of chicken NPAS3 are expressed in the developing central nervous system.
Kim et al., Seoul, South Korea. In Gene, 2013
Newly identified cNPAS3 splice variants feature N-terminus coding sequences with high degrees of homology to human NPAS3 (hNAPS3).
Rank-based genome-wide analysis reveals the association of ryanodine receptor-2 gene variants with childhood asthma among human populations.
Mersha et al., Cincinnati, United States. In Hum Genomics, 2012
Although the top 1,000 SNPs were not shared, 11 genes (RYR2, PDE4D, CSMD1, CDH13, ROBO2, RBFOX1, PTPRD, NPAS3, PDE1C, SEMA5A, and CTNNA2) mapped by these SNPs were shared across populations.
Characterizing the Genetic Basis for Nicotine Induced Cancer Development: A Transcriptome Sequencing Study.
Garner et al., Blacksburg, United States. In Plos One, 2012
We discovered the greatest nicotine stress response by HPCAL4 (up-regulated by 4.71 fold) and NPAS3 (down-regulated by -2.73 fold); both are genes that have not been previously implicated in nicotine exposure but are linked to cancer.
Transcriptional regulation of neurodevelopmental and metabolic pathways by NPAS3.
GeneRIF
Pickard et al., Edinburgh, United Kingdom. In Mol Psychiatry, 2012
Most NPAS3 immunofluorescence originated in the subgranular zone of the dentate gyrus with immunopositive processes radiating into the granule cell layer proper. Npas3 acts during neuronal maturation/differentiation.
NPAS3 demonstrates features of a tumor suppressive role in driving the progression of Astrocytomas.
GeneRIF
Kamnasaran et al., Québec, Canada. In Am J Pathol, 2011
Loss of NPAS3 is associated with the progression of Astrocytomas.
Immunohistochemical analyses of NPAS3 expression in the developing human fetal brain.
GeneRIF
Kamnasaran et al., Canada. In Anat Histol Embryol, 2011
report of immunohistochemical findings on NPAS3 protein expression in the developing human fetal brain during the three trimesters (10-41 weeks) of gestational development
Discovery of a proneurogenic, neuroprotective chemical.
Impact
McKnight et al., Dallas, United States. In Cell, 2010
Mice missing the gene encoding neuronal PAS domain protein 3 (NPAS3) are devoid of hippocampal neurogenesis and display malformation and electrophysiological dysfunction of the dentate gyrus.
Association of NPAS3 exonic variation with schizophrenia.
GeneRIF
Cox et al., Edmonton, Canada. In Schizophr Res, 2010
This study identification of potentially defective NPAS3 variants supports recent studies that implicate perturbations in NPAS3 pathways in impaired neurogenesis and psychosis.
NPAS3 is a trachealess homolog critical for lung development and homeostasis.
GeneRIF
Sunday et al., Durham, United States. In Proc Natl Acad Sci U S A, 2009
NPAS3 is a trachealess homolog critical for lung development and homeostasis.
Schizopsychotic symptom-profiles and biomarkers: beacons in diagnostic labyrinths.
Review
Archer et al., Madrid, Spain. In Neurotox Res, 2008
The associations between adolescent-adult use of cannabis, on the one hand, and, alternatively, the prevalence of chromosomal abnormalities, e.g., GRIK4 and NPAS3, and mental retardation, on the other hand, with the symptom-profiles of schizopsychosis provide further evidence of emerging biomarkers of biological inheritance factors.
Chromosome abnormalities, mental retardation and the search for genes in bipolar disorder and schizophrenia.
Review
Muir et al., Edinburgh, United Kingdom. In Neurotox Res, 2008
The genes GRIK4 and NPAS3, each associated with psychosis in patients with mental retardation are discussed to illustrate the value of rare cytogenetic events as a means to signpost neurobiological pathways of general importance for illness in the wider population.
Neurogenesis and schizophrenia: dividing neurons in a divided mind?
Review
Lesch et al., Würzburg, Germany. In Eur Arch Psychiatry Clin Neurosci, 2007
reelin and NPAS3 knockout mice.
The NPAS3 gene--emerging evidence for a role in psychiatric illness.
Review
Muir et al., Edinburgh, United Kingdom. In Ann Med, 2005
NPAS3 is a member of the basic helix-loop-helix PAS domain class of transcription factors expressed in the brain.
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