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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 10 Nov 2014.

NADPH oxidase organizer 1

NOXO1, Nox organizer 1, NADPH oxidase organizer 1
NADPH oxidases (NOXs) catalyze the transfer of electrons from NADPH to molecular oxygen to generate reactive oxygen species (ROS). NOX organizers, such as NOXO1, target NOX activators (see NOXA1; MIM 611255) to NOX and also target NOX to different subcellular compartments (Opitz et al., 2007 [PubMed 17189823]).[supplied by OMIM, Mar 2008] (from NCBI)
Top mentioned proteins: Ros, Akt, p22, p67phox, p47phox
Papers on NOXO1
Nicotinamide adenine dinucleotide phosphate oxidase is differentially regulated in normal myometrium versus leiomyoma.
New
Saed et al., Detroit, United States. In Reprod Sci, Sep 2014
Hypoxia increased NOX4, DUOX1, and NOXO1 and decreased p22(phox) in myometrial and reduced DUOX1 in fibroid cells.
Nox4: a hydrogen peroxide-generating oxygen sensor.
New
Lambeth et al., Atlanta, United States. In Biochemistry, Sep 2014
All other Nox enzymes except for Nox4 require upstream activators, either calcium or organizer/activator subunits (p47(phox), NOXO1/p67(phox), and NOXA1).
Immunohistochemical localization of Nox1, Nox4 and Mn-SOD in mouse femur during endochondral ossification.
New
Nakagawa et al., Japan. In Tissue Cell, Sep 2014
Weakly positive reactions with Nox1, Noxa1, and Noxo1 were observed in the zones of proliferative and prehypertrophic chondrocytes at 3 weeks of age.
TNF-α/TNFR1 signaling promotes gastric tumorigenesis through induction of Noxo1 and Gna14 in tumor cells.
New
Oshima et al., Kanazawa, Japan. In Oncogene, Aug 2014
Moreover, the microarray analysis and colony formation assay indicated that NADPH oxidase organizer 1 (Noxo1) and Gna14 are induced in tumor epithelial cells in a TNF-α-dependent manner, and have an important role in tumorigenicity and tumor-initiating cell property of gastric cancer cells.
Nox1 activation by βPix and the role of Ser-340 phosphorylation.
New
Tamura et al., Japan. In Febs Lett, Jun 2014
We examined the effects of βPix and its phosphomimetic mutant on endogenous Nox1 in Caco-2 cells transfected with Noxo1 and Noxa1.
The role of NADPH oxidase in a mouse model of fetal alcohol syndrome.
New
Bytautiene et al., Galveston, United States. In Am J Obstet Gynecol, May 2014
Evaluation of messenger ribonucleic acid (mRNA) expression of NOX subunits (DUOX1, DUOX2, NOX1, NOX2, NOX3, NOX4, NOXA1, NOXO1, RAC1, p22phox, and p67phox) was performed using quantitative real-time polymerase chain reaction; alcohol vs placebo groups were compared using a Student t test or a Mann-Whitney test (P < .05).
N-Linked glycosylation of the superoxide-producing NADPH oxidase Nox1.
New
Sumimoto et al., Fukuoka, Japan. In Biochem Biophys Res Commun, Feb 2014
Superoxide production by unglycosylated Nox1 is largely dependent on p22(phox), which is abrogated by glutamine substitution for Pro-156 in p22(phox), a mutation leading to a defective interaction with the Nox1-activating protein Noxo1.
Expression of oxidative stress and antioxidant defense genes in the kidney of inbred mice after intestinal ischemia and reperfusion.
New
Fagundes et al., In Acta Cir Bras, Dec 2013
The genes that up regulated in the reactive oxygen species cluster (16 genes): Il19, Il22, Nos2, Nox1, Noxa1, Noxo1, Recql4 and Sod2.
C-terminal truncation of Noxa1 greatly enhances its ability to activate Nox2 in a pure reconstitution system.
New
Tamura et al., Japan. In Arch Biochem Biophys, Nov 2013
Noxa1 activates Nox2 together with Noxo1 and Rac in a pure reconstitution system, but the resulting activity is considerably lower than that induced by p67(phox) and p47(phox).
Phosphorylation of Noxo1 at threonine 341 regulates its interaction with Noxa1 and the superoxide-producing activity of Nox1.
New
Sumimoto et al., Fukuoka, Japan. In Febs J, Oct 2013
UNLABELLED: Superoxide production by Nox1, a member of the Nox family NAPDH oxidases, requires expression of its regulatory soluble proteins Noxo1 (Nox organizer 1) and Noxa1 (Nox activator 1) and is markedly enhanced upon cell stimulation with phorbol 12-myristate 13-acetate (PMA), a potent activator of protein kinase C (PKC).
The NOXO1β PX domain preferentially targets PtdIns(4,5)P2 and PtdIns(3,4,5)P3.
GeneRIF
Horita et al., Winston-Salem, United States. In J Mol Biol, 2012
Surface plasmon resonance experiments identify PtdIns(4,5)P(2) and PtdIns(3,4,5)P(3) as preferred targets of NOXO1beta PX.
Backbone 1H, 15N, and 13C resonance assignments for the NOXO1β PX domain.
GeneRIF
Horita et al., Winston-Salem, United States. In Biomol Nmr Assign, 2011
The backbone assignments of NOXO1beta PX are studied using NMR.
Receptor activation of NADPH oxidases.
Review
Görlach et al., München, Germany. In Antioxid Redox Signal, 2010
They mainly differ in containing one out of seven homologous catalytic core proteins termed NOX1 to NOX5 and DUOX1 or 2. NADPH oxidase activity is controlled by regulatory subunits, including the NOX regulators p47phox and p67phox, their homologs NOXO1 and NOXA1, or the DUOX1 or 2 regulators DUOXA1 and 2. In addition, the GTPase Rac modulates activity of several of these enzymes.
Regulation of NOXO1 activity through reversible interactions with p22 and NOXA1.
GeneRIF
Rittinger et al., London, United Kingdom. In Plos One, 2009
The first quantitative characterization of the interactions made between the cytosolic regulators NOXO1 and NOXA1 and membrane-bound p22(phox), is presented.
Targeting and regulation of reactive oxygen species generation by Nox family NADPH oxidases.
Review
Ueyama et al., Bethesda, United States. In Antioxid Redox Signal, 2009
Determinants of subcellular targeting include: (a) formation of Nox-p22(phox) heterodimeric complexes allowing plasma membrane translocation, (b) phospholipids-binding specificities of PX domain-containing organizer proteins (p47(phox) or Nox organizer 1 (Noxo1 and p40(phox)), and (c) variably splicing of Noxo1 PX domains directing them to nuclear or plasma membranes.
Signaling components of redox active endosomes: the redoxosomes.
Review
Engelhardt et al., Iowa City, United States. In Antioxid Redox Signal, 2009
Unique features of redox-active signaling endosomes can include NADPH oxidase complex components (Nox1, Noxo1, Noxa1, Nox2, p47phox, p67phox, and/or Rac1), ROS processing enzymes (SOD1 and/or peroxiredoxins), chloride channels capable of mediating superoxide transport and/or membrane gradients required for Nox activity, and novel redox-dependent sensors that control Nox activity.
Role of the small GTPase Rac in p22phox-dependent NADPH oxidases.
Review
Sumimoto et al., Fukuoka, Japan. In Biochimie, 2007
The p22(phox)-complexed Nox2 and Nox1 are dormant on their own, and their activation requires soluble supportive proteins such as a Nox organizer (p47(phox) or Noxo1) and a Nox activator (p67(phox) or Noxa1).
[Two breakthroughs in CGD studies].
Review
Nunoi, Miyazaki, Japan. In Nihon Rinsho Meneki Gakkai Kaishi, 2007
First, the discovery of 7 Nox/Duox family proteins, Noxo1 and Noxa1 (homologues of gp91(phox), p47(phox) and p67(phox)) may clarify novel physiological mechanisms for superoxide regulation in various organs, such as the regulation of blood pressure, mucosal defense system in respiratory/digestive tract and nephron.
Interaction between the SH3 domains and C-terminal proline-rich region in NADPH oxidase organizer 1 (Noxo1).
GeneRIF
Sumimoto et al., Fukuoka, Japan. In Biochem Biophys Res Commun, 2007
These findings suggest that Nox activation involves a conformational change leading to disruption of the bis-SH3-PRR interaction in Noxo1.
Expression and function of Noxo1gamma, an alternative splicing form of the NADPH oxidase organizer 1.
GeneRIF
Sumimoto et al., Fukuoka, Japan. In Febs J, 2006
This study shows the expression of alternatively spliced transcripts of the NOXO1 gene and the roles of the protein products in the activation of Nox oxidases.
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