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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 25 Jan 2016.

NADPH oxidase organizer 1

NOXO1, Nox organizer 1, NADPH oxidase organizer 1
NADPH oxidases (NOXs) catalyze the transfer of electrons from NADPH to molecular oxygen to generate reactive oxygen species (ROS). NOX organizers, such as NOXO1, target NOX activators (see NOXA1; MIM 611255) to NOX and also target NOX to different subcellular compartments (Opitz et al., 2007 [PubMed 17189823]).[supplied by OMIM, Mar 2008] (from NCBI)
Top mentioned proteins: Ros, Akt, p22, p67phox, p47phox
Papers on NOXO1
NADPH oxidase 1 activity and ROS generation are regulated by Grb2/Cbl-mediated proteasomal degradation of NoxO1 in colon cancer cells.
Bae et al., South Korea. In Cancer Res, 18 Feb 2016
In this study, we report a novel mechanism in which Nox1 activity is regulated through the proteasomal degradation of Nox organizer 1 (NoxO1).
Immunohistochemical localization of Nox in mouse circumvallate papillae.
Watanabe et al., Kōriyama, Japan. In Tissue Cell, 31 Dec 2015
In the epithelium of the circumvallate papilla, Nox 1, 2, 3, and 4, Noxo1, and Noxa1 were expressed.
Escherichia coli LF82 differentially regulates ROS production and mucin expression in intestinal epithelial T84 cells: implication of NOX1.
Marie et al., Paris, France. In Inflamm Bowel Dis, May 2015
Also, we observed an increased expression of NOX1 and NOXO1 in response to LF82 bacteria versus the mutant LF82ΔFimA.
NOX1 deficiency in apolipoprotein E-knockout mice is associated with elevated plasma lipids and enhanced atherosclerosis.
Drummond et al., Australia. In Free Radic Res, Feb 2015
Although NOX1 mRNA expression was unchanged in aortas from APOE(-/-) versus wild-type mice, expression of the NOX1-specific organizer, NOXO1, was diminished, consistent with an overall reduction in NOX1 activity in APOE(-/-) mice.
Immunohistochemical localization of Nox1, Nox4 and Mn-SOD in mouse femur during endochondral ossification.
Nakagawa et al., Japan. In Tissue Cell, 2014
Weakly positive reactions with Nox1, Noxa1, and Noxo1 were observed in the zones of proliferative and prehypertrophic chondrocytes at 3 weeks of age.
Nicotinamide adenine dinucleotide phosphate oxidase is differentially regulated in normal myometrium versus leiomyoma.
Saed et al., Detroit, United States. In Reprod Sci, 2014
Hypoxia increased NOX4, DUOX1, and NOXO1 and decreased p22(phox) in myometrial and reduced DUOX1 in fibroid cells.
Nox4: a hydrogen peroxide-generating oxygen sensor.
Lambeth et al., Atlanta, United States. In Biochemistry, 2014
All other Nox enzymes except for Nox4 require upstream activators, either calcium or organizer/activator subunits (p47(phox), NOXO1/p67(phox), and NOXA1).
TNF-α/TNFR1 signaling promotes gastric tumorigenesis through induction of Noxo1 and Gna14 in tumor cells.
Oshima et al., Kanazawa, Japan. In Oncogene, 2014
Moreover, the microarray analysis and colony formation assay indicated that NADPH oxidase organizer 1 (Noxo1) and Gna14 are induced in tumor epithelial cells in a TNF-α-dependent manner, and have an important role in tumorigenicity and tumor-initiating cell property of gastric cancer cells.
Nox1 activation by βPix and the role of Ser-340 phosphorylation.
Tamura et al., Japan. In Febs Lett, 2014
We examined the effects of βPix and its phosphomimetic mutant on endogenous Nox1 in Caco-2 cells transfected with Noxo1 and Noxa1.
The role of NADPH oxidase in a mouse model of fetal alcohol syndrome.
Bytautiene et al., Galveston, United States. In Am J Obstet Gynecol, 2014
Evaluation of messenger ribonucleic acid (mRNA) expression of NOX subunits (DUOX1, DUOX2, NOX1, NOX2, NOX3, NOX4, NOXA1, NOXO1, RAC1, p22phox, and p67phox) was performed using quantitative real-time polymerase chain reaction; alcohol vs placebo groups were compared using a Student t test or a Mann-Whitney test (P < .05).
N-Linked glycosylation of the superoxide-producing NADPH oxidase Nox1.
Sumimoto et al., Fukuoka, Japan. In Biochem Biophys Res Commun, 2014
Superoxide production by unglycosylated Nox1 is largely dependent on p22(phox), which is abrogated by glutamine substitution for Pro-156 in p22(phox), a mutation leading to a defective interaction with the Nox1-activating protein Noxo1.
Expression of oxidative stress and antioxidant defense genes in the kidney of inbred mice after intestinal ischemia and reperfusion.
Fagundes et al., In Acta Cir Bras, 2013
The genes that up regulated in the reactive oxygen species cluster (16 genes): Il19, Il22, Nos2, Nox1, Noxa1, Noxo1, Recql4 and Sod2.
C-terminal truncation of Noxa1 greatly enhances its ability to activate Nox2 in a pure reconstitution system.
Tamura et al., Japan. In Arch Biochem Biophys, 2013
Noxa1 activates Nox2 together with Noxo1 and Rac in a pure reconstitution system, but the resulting activity is considerably lower than that induced by p67(phox) and p47(phox).
Phosphorylation of Noxo1 at threonine 341 regulates its interaction with Noxa1 and the superoxide-producing activity of Nox1.
Sumimoto et al., Fukuoka, Japan. In Febs J, 2013
UNLABELLED: Superoxide production by Nox1, a member of the Nox family NAPDH oxidases, requires expression of its regulatory soluble proteins Noxo1 (Nox organizer 1) and Noxa1 (Nox activator 1) and is markedly enhanced upon cell stimulation with phorbol 12-myristate 13-acetate (PMA), a potent activator of protein kinase C (PKC).
Genetic resistance to liver fibrosis on A/J mouse chromosome 17.
Croniger et al., Cleveland, United States. In Alcohol Clin Exp Res, 2013
NADPH oxidase organizer 1 (Noxo1) and NLR family, CARD domain containing 4 (Nlrc4) showed altered hepatic gene expression in strains with the A/J allele at the end of the EtOH diet study and after CCl4 treatment.
The NOXO1β PX domain preferentially targets PtdIns(4,5)P2 and PtdIns(3,4,5)P3.
Horita et al., Winston-Salem, United States. In J Mol Biol, 2012
Surface plasmon resonance experiments identify PtdIns(4,5)P(2) and PtdIns(3,4,5)P(3) as preferred targets of NOXO1beta PX.
Backbone 1H, 15N, and 13C resonance assignments for the NOXO1β PX domain.
Horita et al., Winston-Salem, United States. In Biomol Nmr Assign, 2011
The backbone assignments of NOXO1beta PX are studied using NMR.
Regulation of NOXO1 activity through reversible interactions with p22 and NOXA1.
Rittinger et al., London, United Kingdom. In Plos One, 2009
The first quantitative characterization of the interactions made between the cytosolic regulators NOXO1 and NOXA1 and membrane-bound p22(phox), is presented.
Interaction between the SH3 domains and C-terminal proline-rich region in NADPH oxidase organizer 1 (Noxo1).
Sumimoto et al., Fukuoka, Japan. In Biochem Biophys Res Commun, 2007
These findings suggest that Nox activation involves a conformational change leading to disruption of the bis-SH3-PRR interaction in Noxo1.
Expression and function of Noxo1gamma, an alternative splicing form of the NADPH oxidase organizer 1.
Sumimoto et al., Fukuoka, Japan. In Febs J, 2006
This study shows the expression of alternatively spliced transcripts of the NOXO1 gene and the roles of the protein products in the activation of Nox oxidases.
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