The role of NADPH oxidase in a mouse model of fetal alcohol syndrome.
Galveston, United States. In Am J Obstet Gynecol, 2014
Evaluation of messenger ribonucleic acid (mRNA) expression of NOX subunits (DUOX1, DUOX2, NOX1, NOX2, NOX3, NOX4, NOXA1, NOXO1, RAC1, p22phox, and p67phox) was performed using quantitative real-time polymerase chain reaction; alcohol vs placebo groups were compared using a Student t test or a Mann-Whitney test (P < .05).
N-Linked glycosylation of the superoxide-producing NADPH oxidase Nox1.
Fukuoka, Japan. In Biochem Biophys Res Commun, 2014
Superoxide production by unglycosylated Nox1 is largely dependent on p22(phox), which is abrogated by glutamine substitution for Pro-156 in p22(phox), a mutation leading to a defective interaction with the Nox1-activating protein Noxo1.
Genetic resistance to liver fibrosis on A/J mouse chromosome 17.
Cleveland, United States. In Alcohol Clin Exp Res, 2013
NADPH oxidase organizer 1 (Noxo1) and NLR family, CARD domain containing 4 (Nlrc4) showed altered hepatic gene expression in strains with the A/J allele at the end of the EtOH diet study and after CCl4 treatment.