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NADPH oxidase 4

Nox4, Kox, NADPH oxidase 4
This gene encodes a member of the NOX-family of enzymes that functions as the catalytic subunit the NADPH oxidase complex. The encoded protein is localized to non-phagocytic cells where it acts as an oxygen sensor and catalyzes the reduction of molecular oxygen to various reactive oxygen species (ROS). The ROS generated by this protein have been implicated in numerous biological functions including signal transduction, cell differentiation and tumor cell growth. A pseudogene has been identified on the other arm of chromosome 11. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jan 2009] (from NCBI)
Top mentioned proteins: Ros, V1a, CAN, HAD, Angiotensin II
Papers using Nox4 antibodies
Nrf2 protects against maladaptive cardiac responses to hemodynamic stress
Supplier
Shah Ajay M. et al., In Free Radical Biology & Medicine, 2008
... Cardiomyocyte-targeted Nox4-transgenic mice have been described ...
Thiazolidinediones induce proliferation of human bronchial epithelial cells through the GPR40 receptor
Supplier
Li Jian-Mei et al., In Free Radical Biology & Medicine, 2008
... , Nox2, Nox4, and α-tubulin were from Santa Cruz Biotechnology; antibodies to phospho-ERK1/2, phospho-p38MAPK, ...
Poldip2, a novel regulator of Nox4 and cytoskeletal integrity in vascular smooth muscle cells
Supplier
Lambeth J. David et al., In Biochemistry, 2008
... The polyclonal antibody to a C-terminal peptide (residues 500−578) of Nox4 was from Novus Biologicals Inc., and the monoclonal ...
Hypoxia-inducible factor-dependent degeneration, failure, and malignant transformation of the heart in the absence of the von Hippel-Lindau protein
Supplier
Giordano Frank J et al., In Molecular Therapy, 2007
... Recombinant adenoviral vectors encoding 6439-Kox and Kox were generated using the Adeno-X Express System (Clontech, Mountain View, CA) ...
Inefficient replication of Listeria innocua in the cytosol of mammalian cells.
Supplier
Cossart Pascale, In PLoS Pathogens, 2003
... Nox4, Card12, Cias1, control siRNA,) were from Qiagen (Hilden, Germany), the ...
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Papers on Nox4
Role of mitochondria and NADPH oxidase derived reactive oxygen species in hyperoxaluria induced nephrolithiasis: Therapeutic intervention with combinatorial therapy of N-acetyl cysteine and apocynin.
New
Singla et al., Chandīgarh, India. In Mitochondrion, Feb 2016
Furthermore, NADPH Oxidase activity was significantly increased, with raised expression of NOX1, NOX2, NOX4, p38MAPK and MnSOD, in the renal tissue of hyperoxaluric rats compared to control.
miR214-regulated p53-NOX4/p66shc pathway plays a crucial role in the protective effect of Ginkgolide B against cisplatin-induced cytotoxicity in HEI-OC1 cells.
New
Xu et al., Xi'an, China. In Chem Biol Interact, Feb 2016
The results showed that, in HEI-OC1 auditory cells, both NOX4 and p66(shc) expression was increased by cisplatin.
Angiotensin-(1-7) improve liver fibrosis by regulating the NLRP3 inflammasome via redox balance modulation.
New
Li et al., Guangzhou, China. In Antioxid Redox Signal, Feb 2016
Results In vivo, Ang-(1-7) improved bile duct ligation (BDL) induced-hepatic fibrosis, reduced H2O2 content, protein levels of NOX4 and the NLRP3-inflammasome, whereas increased glutathione (GSH) and nuclear erythroid 2-related factor 2 (Nrf2)-antioxidant response element (ARE).
Excess TGF-β mediates muscle weakness associated with bone metastases in mice.
New
Impact
Guise et al., Indianapolis, United States. In Nat Med, Nov 2015
We found that transforming growth factor (TGF)-β, released from the bone surface as a result of metastasis-induced bone destruction, upregulated NADPH oxidase 4 (Nox4), resulting in elevated oxidization of skeletal muscle proteins, including the ryanodine receptor and calcium (Ca(2+)) release channel (RyR1).
[Effect of chrysin on expression of NOX4 and NF-κB in right ventricle of monocrotaline-induced pulmonary arterial hypertension of rats].
New
Yang et al., In Yao Xue Xue Bao, Sep 2015
The expressions of collagen I, collagen III, NADPH oxidase 4 (NOX4) and nuclear factor-kappa B (NF-κB) were analyzed by immunohistochemisty, qPCR and (or) Western blot.
NADPH oxidases and cancer.
Review
New
Doroshow et al., Bethesda, United States. In Clin Sci (lond), Jun 2015
NOX4 expression is increased in pre-malignant fibrotic states which may lead to carcinomas of the lung and liver.
The role of reactive oxygen species in mesenchymal stem cell adipogenic and osteogenic differentiation: a review.
Review
New
Pepper et al., Genève, Switzerland. In Stem Cells Dev, Jun 2015
Mitochondrial complexes I and III, and the NADPH oxidase isoform NOX4 are major sources of ROS production during MSC differentiation.
Cardiac-targeted NADPH oxidase 4 in the adaptive cardiac remodelling of the murine heart.
New
Impact
Shah et al., Tromsø, Norway. In Lancet, Mar 2015
NADPH oxidase (NOX) proteins produce reactive oxygen species (ROS) involved in redox signalling, and our recent studies have found that an increase in Nox4 during pressure overload protects the heart against failure.
Role of cellular senescence and NOX4-mediated oxidative stress in systemic sclerosis pathogenesis.
Review
Jimenez et al., Philadelphia, United States. In Curr Rheumatol Rep, 2015
Systemic sclerosis (SSc) is a systemic autoimmune disease characterized by progressive fibrosis of skin and numerous internal organs and a severe fibroproliferative vasculopathy resulting frequently in severe disability and high mortality.
NADPH oxidase 5 and renal disease.
Review
Kennedy et al., Ottawa, Canada. In Curr Opin Nephrol Hypertens, 2015
Although much emphasis has been placed on the role of NADPH oxidase 4 in this setting, a growing body of work continues to uncover the key roles for other Nox family members, not only in diabetic kidney disease, but also in a diverse array of renal pathological conditions.
miR-31 Overexpression Exacerbates Atherosclerosis by Targeting NOX4 in apoE(-/-) Mice.
Ping et al., In Clin Lab, 2014
In addition, the impact of NOX4 on cell apoptosis was tested with a specific siRNA targeting NADPH oxidase 4 (NOX4).
Transcript profile of cellular senescence-related genes in Fuchs endothelial corneal dystrophy.
Review
Jun et al., Baltimore, United States. In Exp Eye Res, 2014
Markedly elevated mRNA-levels of the constitutively active and reactive oxygen species-generating enzyme NOX4 were found in all evaluable FECD samples.
Activation of calcium signaling through Trpv1 by nNOS and peroxynitrite as a key trigger of skeletal muscle hypertrophy.
Impact
Takeda et al., Kodaira, Japan. In Nat Med, 2013
This activation promoted formation of peroxynitrite, a reaction product of nitric oxide with superoxide, which was derived from NADPH oxidase 4 (Nox4).
Transcriptional regulation of Nox4 by histone deacetylases in human endothelial cells.
GeneRIF
Li et al., Mainz, Germany. In Basic Res Cardiol, 2012
Knockdown of c-Jun with siRNA led to a down-regulation of Nox4 mRNA expression
NADPH oxidase-4 maintains neuropathic pain after peripheral nerve injury.
GeneRIF
Schmidtko et al., Frankfurt am Main, Germany. In J Neurosci, 2012
Our results suggest that Nox4 essentially contributes to nociceptive processing in neuropathic pain states.
Rosiglitazone attenuates NF-κB-mediated Nox4 upregulation in hyperglycemia-activated endothelial cells.
GeneRIF
Hart et al., Atlanta, United States. In Am J Physiol Cell Physiol, 2012
High glucose increases the expression and activity of NADPH oxidase catalytic subunit Nox4 in vascular endothelial cells.
[Caloric restriction suppresses endothelial cells senescence via down-regulation of NOX4 induced by HNF3γ].
GeneRIF
Wang et al., Hangzhou, China. In Yi Chuan, 2012
low caloric intake decreases the production of intracellular reactive oxygen species and suppresses endothelial cells senescence through promoting HNF3gamma binging to NOX4 promoter region and inhibiting NOX4 gene expression induced by up-regulated HNF3gamma
Nox4 inhibition enhances the cytotoxicity of cisplatin in human renal cancer cells.
GeneRIF
Maranchie et al., Pittsburgh, United States. In J Exp Ther Oncol, 2011
Nox4 contributes to renal cancer cells chemo-resistance through modulation of pro-apoptotic and anti-apoptotic signaling, suggesting that Nox4 inhibition might enhance the efficacy of conventional cytotoxic drugs against RCC.
NADPH oxidase-4 mediates myofibroblast activation and fibrogenic responses to lung injury.
Impact
GeneRIF
Thannickal et al., Ann Arbor, United States. In Nat Med, 2009
NOX-4 is upregulated in noninfectious lung injury and has a role in tissue repair functions of myofibroblasts and fibrogenesis.
The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology.
Review
Impact
Krause et al., Genève, Switzerland. In Physiol Rev, 2007
Over the last years, six homologs of the cytochrome subunit of the phagocyte NADPH oxidase were found: NOX1, NOX3, NOX4, NOX5, DUOX1, and DUOX2.
More papers using Nox4 antibodies
Paeoniflorin: an antihyperlipidemic agent from Paeonia lactiflora
Supplier
Yokozawa Takako et al., In Evidence-based Complementary and Alternative Medicine : eCAM, 2003
... Rabbit polyclonal anti-reduced nicotinamide adenine dinucleotide phosphate oxidase-4 (Nox-4) (LifeSpan BioSciences, Seattle, WA, USA) ...
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