Excess TGF-β mediates muscle weakness associated with bone metastases in mice.
Indianapolis, United States. In Nat Med, Nov 2015
We found that transforming growth factor (TGF)-β, released from the bone surface as a result of metastasis-induced bone destruction, upregulated NADPH oxidase 4 (Nox4), resulting in elevated oxidization of skeletal muscle proteins, including the ryanodine receptor and calcium (Ca(2+)) release channel (RyR1).
NADPH oxidases and cancer.
Bethesda, United States. In Clin Sci (lond), Jun 2015
NOX4 expression is increased in pre-malignant fibrotic states which may lead to carcinomas of the lung and liver.
NADPH oxidase 5 and renal disease.
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Ottawa, Canada. In Curr Opin Nephrol Hypertens, 2015
Although much emphasis has been placed on the role of NADPH oxidase 4 in this setting, a growing body of work continues to uncover the key roles for other Nox family members, not only in diabetic kidney disease, but also in a diverse array of renal pathological conditions.