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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Neuro-oncological ventral antigen 1

This gene encodes a neuron-specific RNA-binding protein, a member of the Nova family of paraneoplastic disease antigens, that is recognized and inhibited by paraneoplastic antibodies. These antibodies are found in the sera of patients with paraneoplastic opsoclonus-ataxia, breast cancer, and small cell lung cancer. Alternatively spliced transcripts encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, Anova, HuD, miR, HAD
Papers on Nova-1
NOVA1 inhibition by miR-146b-5p in the remnant tissue microenvironment defines occult residual disease after gastric cancer removal.
Yang et al., Seoul, South Korea. In Oncotarget, Jan 2016
NOVA1, a target gene of miR-146b-5p, was decreased in remnant tissues of patients with a poor prognosis.
MicroRNA-339, an epigenetic modulating target is involved in human gastric carcinogenesis through targeting NOVA1.
Feng et al., Nanjing, China. In Febs Lett, Nov 2015
Furthermore, NOVA1 was confirmed as a target of miR-339.
A large-scale functional screen identifies Nova1 and Ncoa3 as regulators of neuronal miRNA function.
Schratt et al., Marburg an der Lahn, Germany. In Embo J, Oct 2015
In a large-scale functional screen, we identified two novel regulators of neuronal miRNA function, Nova1 and Ncoa3.
LSD1 Neurospecific Alternative Splicing Controls Neuronal Excitability in Mouse Models of Epilepsy.
Battaglioli et al., Milano, Italy. In Cereb Cortex, Sep 2015
Here we show that the LSD1/neuroLSD1 ratio changes in response to neuronal activation and such effect is mediated by neurospecific splicing factors NOVA1 and nSR100/SRRM4 together with a novel cis-silencer.
Ethanol-related alterations in gene expression patterns in the developing murine hippocampus.
Chai et al., Ansan, South Korea. In Acta Biochim Biophys Sin (shanghai), Aug 2015
Microarray analysis revealed that Nova1, Ntng1, Gal, Neurog2, Neurod2, and Fezf2 gene expressions are altered in the fetal hippocampus.
Transcriptome-wide landscape of pre-mRNA alternative splicing associated with metastatic colonization.
Xing et al., Los Angeles, United States. In Mol Cancer Res, Feb 2015
These include splicing factors known to be differentially regulated in epithelial-mesenchymal transition (ESRP1, ESRP2, and RBFOX2), a cellular process critical for cancer metastasis, as well as novel findings (NOVA1 and MBNL3).
Embryonic Lethality Due to Arrested Cardiac Development in Psip1/Hdgfrp2 Double-Deficient Mice.
Engelman et al., Boston, United States. In Plos One, 2014
Among the dozen genes known to encode for LEDGF/p75 binding factors, only the expression of Nova1, which encodes an RNA splicing factor, was significantly deregulated by the knockouts.
Quantitative proteomic analysis shows differentially expressed HSPB1 in glioblastoma as a discriminating short from long survival factor and NOVA1 as a differentiation factor between low-grade astrocytoma and oligodendroglioma.
Rosa et al., São Paulo, Brazil. In Bmc Cancer, 2014
Expression level of RNA binding protein nova 1 (NOVA1) differentiated low-grade oligodendroglioma and astrocytoma grade II (p = 0.0082).
Genome-wide miR-155 and miR-802 target gene identification in the hippocampus of Ts65Dn Down syndrome mouse model by miRNA sponges.
Fillat et al., Barcelona, Spain. In Bmc Genomics, 2014
Significant associations were found in a subset of genes (Rufy2, Nova1, Nav1, Thoc1 and Sumo3) that could be experimentally validated.
Hsa-miR-195 targets PCMT1 in hepatocellular carcinoma that increases tumor life span.
Tawab et al., Cairo, Egypt. In Tumour Biol, 2014
FGF7, GHR, PCMT1, CITED2, PEX5, PEX13, NOVA1, AXIN2, and TSPYL2 were detected with high significant (P < 0.005).
Nova1 is a master regulator of alternative splicing in pancreatic beta cells.
Eizirik et al., Brussels, Belgium. In Nucleic Acids Res, 2014
Our recently published data indicated that the 'neuron-specific' Nova1 splicing factor is expressed in pancreatic beta cells.
RNA-binding proteins in neurological diseases.
Wu et al., In Sci China Life Sci, 2014
Here, we mainly focus on selected RNA-binding proteins including Nova-1/Nova-2, HuR/HuB/HuC/HuD, TDP-43, Fus, Rbfox1/Rbfox2, QKI and FMRP, discussing their function and roles in human diseases.
High expression of neuro-oncological ventral antigen 1 correlates with poor prognosis in hepatocellular carcinoma.
Liu et al., Shanghai, China. In Plos One, 2013
Neuro-oncological ventral antigen 1 (Nova1) is a neuron-specific RNA-binding protein in human paraneoplastic opsoclonus-myoclonus ataxia accompanying with malignant tumors, but its role in hepatocellular carcinoma (HCC) remains elusive.
MiR-181b-5p downregulates NOVA1 to suppress proliferation, migration and invasion and promote apoptosis in astrocytoma.
Yang et al., Changzhou, China. In Plos One, 2013
The NOVA1 (neuro-oncological ventral antigen 1) gene was further identified as a novel direct target of miR-181b-5p.
Regulatory roles of heterogeneous nuclear ribonucleoprotein M and Nova-1 protein in alternative splicing of dopamine D2 receptor pre-mRNA.
Kim et al., Seoul, South Korea. In J Biol Chem, 2011
identify Nova-1 and hnRNP M as D2R pre-mRNA-binding proteins and show their antagonistic role in the alternative splicing of D2R pre-mRNA.
Integrative modeling defines the Nova splicing-regulatory network and its combinatorial controls.
Darnell et al., New York City, United States. In Science, 2010
integrative network revealed combinatorial regulation by Nova and the neuronal splicing factor Fox, interplay between phosphorylation and splicing, and potential links to neurologic disease
Paraneoplastic antibody during follow-up of a patient with anti-Ri-associated paraneoplastic neurological syndrome.
Rauer et al., Freiburg, Germany. In Acta Neurol Scand, 2009
Semiquantitative estimation of circulating anti-Ri antibodies demonstrated a renewed increase in antibody levels preceding relapse of the cancer, as confirmed using F-fluorodeoxyglucose positron emission tomography (FDG-PET)
Rescuing Z+ agrin splicing in Nova null mice restores synapse formation and unmasks a physiologic defect in motor neuron firing.
Darnell et al., New York City, United States. In Proc Natl Acad Sci U S A, 2009
Nova1/Nova2 double knockout mice are paralyzed and fail to cluster AChRs at the neuromuscular junction, and breeding them with transgenic mice constitutively expressing Z(+) agrin in motor neurons rescued AChR clustering
Post-transcriptional regulation of neuro-oncological ventral antigen 1 by the neuronal RNA-binding proteins ELAV.
Silani et al., Milano, Italy. In J Biol Chem, 2008
Gene silencing and overexpression of the nELAV member HuD in motoneuronal NSC34 cells indicate that Nova1 mRNA stability and translation are positively and strongly controlled by the nELAV proteins
Role of HuD and other RNA-binding proteins in neural development and plasticity.
Bolognani et al., Albuquerque, United States. In J Neurosci Res, 2002
In addition, we will present recent findings on other neural RNA-binding proteins: the ribonucleoprotein K homology (KH)-domain proteins, Fragile X mental retardation protein (FMRP), quakinguiable protein (QKI), and Nova-1.
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