P8.07Novel mutational profiles in relapsed/refractory advanced cancer patients' pre- and post-targeted therapy.
Memphis, United States. In Ann Oncol, 31 Mar 2015
Of 250 unique mutations, TP53 was the most common followed by PIK3CA, KRAS, PMS2, PTEN, NOTCH2, CSMD3, ATM, MAP2K4, PRKDC, ARID1A, NOTCH1 and LRP1B.
Activation of NOTCH1 or NOTCH3 Signaling Skews Human Airway Basal Cell Differentiation toward a Secretory Pathway.
New York City, United States. In Plos One, Dec 2014
Sustained cell autonomous ligand independent Notch activation via lentivirus expression of the intracellular domain of each Notch receptor (NICD1-4) demonstrated that the NOTCH2 and 4 pathways have little effect on BC differentiation into secretory and ciliated cells, while activation of the NOTCH1 or 3 pathways has a major influence, with persistent expression of NICD1 or 3 resulting in a skewing toward secretory cell differentiation with a parallel decrease in ciliated cell differentiation.
[Mantle cell lymphoma: Towards a personalized therapeutic strategy?]
Madrid, Spain. In Med Clin (barc), Aug 2014
Advances in the biology and pathogenesis of MCL have unveiled several genes involved in deregulation of cell cycle checkpoints and the finding of subclonal populations with specific recurrent mutations (p53, ATM, NOTCH2) with an impact on disease progression and refractoriness to treatment.
Therapy of advanced squamous cell carcinoma of the skin.
Paris, France. In Curr Treat Options Oncol, Jun 2014
Moreover, there are several new molecular candidate treatment targets for unresectable SCCS including somatic NOTCH1 or NOTCH2 inactivating mutations, ALK1, which could be a good candidate for antiangiogenic therapy and matrix metallopeptidase 7, which enhances proliferation, migration, and invasion of cancer cells.
Clinical risk factors, DNA variants, and the development of type 2 diabetes.
Malmö, Sweden. In N Engl J Med, 2008
Variants in 11 genes (TCF7L2, PPARG, FTO, KCNJ11, NOTCH2, WFS1, CDKAL1, IGF2BP2, SLC30A8, JAZF1, and HHEX) were significantly associated with the risk of type 2 diabetes independently of clinical risk factors; variants in 8 of these genes were associated with impaired beta-cell function.