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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Nodal homolog

NODAL
The protein encoded by this gene is a member of the TGF-beta superfamily. Studies of the mouse counterpart suggested that this gene may be essential for mesoderm formation and subsequent organization of axial structures in early embryonic development. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, SFRP1, Nanog, V1a, Smad2
Papers on NODAL
Conserved and divergent expression patterns of markers of axial development in eutherian mammals.
New
Aizawa et al., Kōbe, Japan. In Dev Dyn, Jan 2016
RESULTS: All embryos examined expressed Nodal initially throughout epiblast and visceral endoderm; its expression became restricted to the posterior region before gastrulation.
Common genetic variation in chromosome 10 q22.1 shows a strong sex bias in human embryonic stem cell lines, and directly controls the novel alternative splicing of human NODAL which is associated with XIST expression in female cell lines.
New
Postovit et al., Edmonton, Canada. In Stem Cells, Jan 2016
We demonstrate that the minor allele of the human single nucleotide polymorphism (SNP) rs2231947 found within the NODAL gene locus is under-represented in male but not female human embryonic stem cell lines.
MSX2 mediates entry of human pluripotent stem cells into mesendoderm by simultaneously suppressing SOX2 and activating NODAL signaling.
New
Zhou et al., Tianjin, China. In Cell Res, Dec 2015
Furthermore, MSX2 destabilizes the pluripotency circuitry through direct binding to the SOX2 promoter and repression of SOX2 transcription, while MSX2 controls mesendoderm lineage commitment by simultaneous suppression of SOX2 and induction of NODAL expression through direct binding and activation of the Nodal promoter.
NOTCH activation interferes with cell fate specification in the gastrulating mouse embryo.
New
Cohen-Tannoudji et al., Paris, France. In Development, Dec 2015
In addition, we show that forced NOTCH activation results in misregulation of NODAL signalling, a major determinant of early embryonic patterning.
Defining the three cell lineages of the human blastocyst by single-cell RNA-seq.
New
Niakan et al., Farmington, United States. In Development, Oct 2015
For example, we identify several genes exclusively expressed in the human pluripotent epiblast, including the transcription factor KLF17. Key components of the TGF-β signalling pathway, including NODAL, GDF3, TGFBR1/ALK5, LEFTY1, SMAD2, SMAD4 and TDGF1, are also enriched in the human epiblast.
Morphogenesis and molecular considerations on congenital cardiac septal defects.
Review
Jongbloed et al., Leiden, Netherlands. In Ann Med, 2014
NODAL and GATA4) may lead to defects at all levels.
A Combination of Culture Conditions and Gene Expression Analysis Can Be Used to Investigate and Predict hES Cell Differentiation Potential towards Male Gonadal Cells.
Stukenborg et al., Stockholm, Sweden. In Plos One, 2014
This potential was associated with important factors directing the fate of the male primordial germ cells in vivo to form gonocytes, such as SOX17 or genes involved in the NODAL/ACTIVIN pathway, for example.
The effects of long-term daily folic acid and vitamin B12 supplementation on genome-wide DNA methylation in elderly subjects.
Steegenga et al., Wageningen, Netherlands. In Clin Epigenetics, 2014
Pronounced changes were found for regions in the DIRAS3, ARMC8, and NODAL genes, implicated in carcinogenesis and early embryonic development.
NODAL signaling components regulate essential events in the establishment of pregnancy.
Review
Dufort et al., Montréal, Canada. In Reproduction, 2013
NODAL, a morphogen in the transforming growth factor β superfamily, is well known for its critical functions during embryogenesis; however, recent studies have demonstrated an emerging role for NODAL signaling during early mammalian reproduction.
Yin-Yang1 is required for epithelial-to-mesenchymal transition and regulation of Nodal signaling during mammalian gastrulation.
GeneRIF
Mager et al., Amherst Center, United States. In Dev Biol, 2012
Results show that Yin-Yang1 (YY1) is required for developmental processes, including epithelial to mesenchymal transition (EMT) and Nodal signaling.
Embryonic protein nodal promotes breast cancer vascularization.
GeneRIF
Postovit et al., London, Canada. In Cancer Res, 2012
Nodal is a potential target for the treatment of breast cancer angiogenesis and progression.
Nodal induces apoptosis through activation of the ALK7 signaling pathway in pancreatic INS-1 β-cells.
GeneRIF
Wang et al., Toronto, Canada. In Am J Physiol Endocrinol Metab, 2012
Data suggest that expression of Nodal in pancreas is localized to islet beta-cells; up-regulation of Nodal expression increases apoptosis of beta cells and is associated with increased Alk7 expression.
Defective Nodal and Cerl2 expression in the Arl13b(hnn) mutant node underlie its heterotaxia.
GeneRIF
Caspary et al., Atlanta, United States. In Dev Biol, 2012
Study shows the cilia protein Arl13b is required for left right axis specification as its absence results in heterotaxia; the defect originates in the node where Cerl2 is not downregulated and asymmetric expression of Nodal is not maintained resulting in symmetric expression of both genes.
Microenvironmental regulation of cancer stem cell phenotypes.
Review
Postovit et al., London, Canada. In Curr Stem Cell Res Ther, 2012
In this review we describe specific embryo-associated proteins such as NODAL, NOTCH, and canonical WNT, which cooperate to maintain stem cell phenotypes in cancer.
Nodal expression and detection in cancer: experience and challenges.
GeneRIF
Hendrix et al., Chicago, United States. In Cancer Res, 2012
we discuss certain characteristics related to Nodal expression and function and how these can facilitate acquisition and interpretation of expression data, contributing to our understanding of the potential role of Nodal in human cancer[human]
Bridging endometrial receptivity and implantation: network of hormones, cytokines, and growth factors.
Review
Asselin et al., Trois-Rivières, Canada. In J Endocrinol, 2011
The purpose of this review is to describe the potential roles of embryonic and uterine factors in implantation process such as prostaglandins, cyclooxygenases, leukemia inhibitory factor, interleukin (IL) 6, IL11, transforming growth factor-β, IGF, activins, NODAL, epidermal growth factor (EGF), and heparin binding-EGF.
Trophoblast stem cells.
Review
Fisher et al., Columbia, United States. In Biol Reprod, 2011
Mouse TSC self-renewal can be sustained by culture on mitotically inactivated feeder cells, which provide one or more factors related to the NODAL pathway, and a medium supplemented with FGF4, heparin, and fetal bovine serum.
Derivation of pluripotent epiblast stem cells from mammalian embryos.
Impact
Vallier et al., Cambridge, United Kingdom. In Nature, 2007
Mouse ES cells depend on leukaemia inhibitory factor and bone morphogenetic protein, whereas their human counterparts rely on activin (INHBA)/nodal (NODAL) and fibroblast growth factor (FGF).
Mutations in TGIF cause holoprosencephaly and link NODAL signalling to human neural axis determination.
Impact
Elledge et al., Philadelphia, United States. In Nat Genet, 2000
In animal models, genes in the Nodal signalling pathway, such as those mutated in the zebrafish mutants cyclops (refs 9,10), squint (ref.
Immunologic phenotype in 30 patients with diffuse large-cell lymphoma.
Impact
Levy et al., In N Engl J Med, 1980
Frozen sections of 30 diffuse large-cell ("histiocytic") lymphomas that had arisen in both nodal and extranodal sites were stained with immunoglobulin light-chain and heavy-chain reagents, with nonoclonal antibodies to THAT HAD ARISEN IN BOTH NODAL AND EXTRANODAL SITES WERE STAINED WITH IMMUNOGLOBULIN LIGHT-CHAIN AND HEAVY-CHAIN REAGENTS, WITH MONOCLONAL ANTIBODIES TO T and B-cell antigens, and with an esterase marker for macrophages.
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