The microbiome and its implications in intestinal transplantation.
Al Manşūrah, Egypt. In Curr Opin Organ Transplant, Feb 2016
RECENT FINDINGS: Recent findings highlight the importance of Paneth cells as crucial producers of antimicrobial peptides that control the intestinal host-microbial interface as well as the essential role of NOD2 as a master regulator of antimicrobial host defenses.
Dysbiotic gut microbiome: A key element of Crohn's disease.
Budapest, Hungary. In Comp Immunol Microbiol Infect Dis, Dec 2015
The presence of Crohn's-associated variants of NOD2 and ATG16L genes appears to be associated not only with alterations of mucosal barrier functions, and bacterial killing, but the gut microbiota, as well, reflecting a potential relationship between the host's genotype and intestinal dysbiosis, involved in disease etiology.
NOD1 and NOD2: signaling, host defense, and inflammatory disease.
Ann Arbor, United States. In Immunity, 2015
The nucleotide-binding oligomerization domain (NOD) proteins NOD1 and NOD2, the founding members of the intracellular NOD-like receptor family, sense conserved motifs in bacterial peptidoglycan and induce proinflammatory and antimicrobial responses.